{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:36:09Z","timestamp":1791549369760,"version":"4.3.4"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Metabolic dysfunction-associated steatotic liver disease (MASLD) affects nearly 25% of the population and is the leading cause for liver-related mortality. Bariatric surgery is a well-known treatment for MASLD and obesity. Understanding the fundamental mechanisms by which bariatric surgery can alter MASLD can lead to new avenues of therapy and research. Previous studies have identified the microbiome\u2019s role in bariatric surgery and in inflammatory immune cell populations. The host innate immune system modulates hepatic inflammation and fibrosis, and thus the progression of MASLD. The precise role of immune cell types in the pathogenesis of MASLD remains an active area of investigation. The aim of this study was to understand the interplay between microbiota composition post-bariatric surgery and the immune system in MASLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighteen morbidly obese females undergoing sleeve gastrectomy were followed pre-and post-surgery. Stool from four patients, showing resolved MASLD post-surgery with sustained weight loss, was transplanted into antibiotic treated mice. Mice received pre-or post-surgery stool and were fed a standard or high-fat diet. Bodyweight, food intake, and physiological parameters were tracked weekly. Metabolic parameters were measured post-study termination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The human study revealed that bariatric surgery led to significant weight loss (<jats:italic>p<\/jats:italic>\u2009&amp;gt;\u20090.05), decreased inflammatory markers, and improved glucose levels six months post-surgery. Patients with weight loss of 20% or more showed distinct changes in blood metabolites and gut microbiome composition, notably an increase in <jats:italic>Bacteroides<\/jats:italic>. The mouse model confirmed surgery-induced microbiome changes to be a major factor in the reduction of markers and attenuation of MASLD progression. Mice receiving post-surgery fecal transplants had significantly less weight gain and liver steatosis compared to pre-surgery recipients. There was also a significant decrease in inflammatory cytokines interferon gamma, interleukin 2, interleukin 15, and mig. This was accompanied by alterations in liver immunophenotype, including an increase in natural killer T cells and reduction of Kupfer cells in the post-surgery transplant group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our findings suggest surgery induced microbial changes significantly reduce inflammatory markers and fatty liver progression. The results indicate a potential causal link between the microbiome and the host immune system, possibly mediated through modulation of liver NKT and Kupffer cells.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmicb.2024.1407555","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T11:49:09Z","timestamp":1723204149000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Bariatric-induced microbiome changes alter MASLD development in association with changes in the innate immune system"],"prefix":"10.3389","volume":"15","author":[{"given":"Simer","family":"Shera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Katzka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julianne C.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Arias-Jayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venu","family":"Lagishetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Balioukova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Dutson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeran A.","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Pisegna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sanmiguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrey","family":"Pawar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madelaine","family":"Leitman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien S.","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"999001","DOI":"10.3389\/fmicb.2022.999001","article-title":"Human gut microbiota in health and disease: unveiling the relationship","volume":"13","author":"Afzaal","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3746\/pnf.2020.25.2.113","article-title":"The influence of the gut microbiome on obesity in adults and the role of probiotics, prebiotics, and synbiotics for weight loss","volume":"25","author":"Aoun","year":"2020","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1133543","DOI":"10.3389\/fimmu.2023.1133543","article-title":"Revealing immune infiltrate characteristics and potential immune-related genes in hepatic fibrosis: based on bioinformatics, transcriptomics and q-PCR experiments","volume":"14","author":"Bai","year":"2023","journal-title":"Front. Immunol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.molmet.2016.06.003","article-title":"Non-alcoholic fatty liver and the gut microbiota","volume":"5","author":"Bashiardes","year":"2016","journal-title":"Mol. Metab."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B Methodol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: high-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat. Methods"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"867940","DOI":"10.3389\/fendo.2022.867940","article-title":"Hepatic stellate cell-immune interactions in NASH","volume":"13","author":"Carter","year":"2022","journal-title":"Front. Endocrinol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/osp4.396","article-title":"Reduction of IL-6 gene expression in human adipose tissue after sleeve gastrectomy surgery","volume":"6","author":"Casimiro","year":"2020","journal-title":"Obes. Sci. Pract."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"10096","DOI":"10.1038\/srep10096","article-title":"Interferon gamma-induced protein 10 is associated with insulin resistance and incident diabetes in patients with nonalcoholic fatty liver disease","volume":"5","author":"Chang","year":"2015","journal-title":"Sci. Rep."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"G697","DOI":"10.1152\/ajpgi.00426.2010","article-title":"Obesity, diabetes mellitus, and liver fibrosis","volume":"300","author":"Chiang","year":"2011","journal-title":"Am. J. Physiol-Gastrointest. Liver Physiol."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1053\/j.gastro.2020.04.077","article-title":"Contribution of the intestinal microbiome and gut barrier to hepatic disorders","volume":"159","author":"Chopyk","year":"2020","journal-title":"Gastroenterology"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1001\/jamasurg.2014.2440","article-title":"Long-term outcomes of bariatric surgery: a National Institutes of Health Symposium","volume":"149","author":"Courcoulas","year":"2014","journal-title":"JAMA Surg."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"3303","DOI":"10.2147\/DMSO.S431251","article-title":"Clinical classification of obesity and implications for metabolic dysfunction-associated fatty liver disease and treatment","volume":"16","author":"Ding","year":"2023","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2771","DOI":"10.1038\/s41598-020-59535-w","article-title":"A microbial signature identifies advanced fibrosis in patients with chronic liver disease mainly due to NAFLD","volume":"10","author":"Dong","year":"2020","journal-title":"Sci. Rep."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"718661","DOI":"10.3389\/fnut.2021.718661","article-title":"The intestinal microbiome predicts weight loss on a calorie-restricted diet and is associated with improved hepatic steatosis","volume":"8","author":"Dong","year":"2021","journal-title":"Front. Nutr."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1515\/hsz-2013-0220","article-title":"Lipid antigens in immunity","volume":"395","author":"Dowds","year":"2014","journal-title":"Biol. Chem."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"880298","DOI":"10.3389\/fimmu.2022.880298","article-title":"Association of inflammatory cytokines with non-alcoholic fatty liver disease","volume":"13","author":"Duan","year":"2022","journal-title":"Front. Immunol."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1084\/jem.20180448","article-title":"The gut microbiome: relationships with disease and opportunities for therapy","volume":"216","author":"Durack","year":"2019","journal-title":"J. Exp. Med."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"179","DOI":"10.7861\/clinmedicine.11-2-179","article-title":"Pathogenesis and treatment of hepatic fibrosis: is cirrhosis reversible?","volume":"11","author":"Fallowfield","year":"2011","journal-title":"Clin. Med."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1016\/j.jcmgh.2021.02.007","article-title":"Regulation of intestinal barrier function by microbial metabolites","volume":"11","author":"Ghosh","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"506","DOI":"10.3945\/an.113.004341","article-title":"Mineral malnutrition following bariatric surgery","volume":"4","author":"Gletsu-Miller","year":"2013","journal-title":"Adv. Nutr."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2202\/1557-4679.1103","article-title":"Exact calculations of average power for the Benjamini-Hochberg procedure","volume":"4","author":"Glueck","year":"2008","journal-title":"Int. J. Biostat."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"4504","DOI":"10.12998\/wjcc.v11.i19.4504","article-title":"Long-term effectiveness, outcomes and complications of bariatric surgery","volume":"11","author":"Gulinac","year":"2023","journal-title":"World J. Clin. Cases"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"112141","DOI":"10.1016\/j.celrep.2023.112141","article-title":"Sterile liver injury induces a protective tissue-resident cDC1-ILC1 circuit through cDC1-intrinsic cGAS-STING-dependent IL-12 production","volume":"42","author":"Hildreth","year":"2023","journal-title":"Cell Rep."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s40273-014-0243-x","article-title":"The epidemiology of obesity: a big picture","volume":"33","author":"Hruby","year":"2015","journal-title":"PharmacoEconomics"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/s41577-021-00639-3","article-title":"Immune cell-mediated features of non-alcoholic steatohepatitis","volume":"22","author":"Huby","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.3390\/nu12051395","article-title":"Dietary protein, fiber and coffee are associated with small intestine microbiome composition and diversity in patients with liver cirrhosis","volume":"12","author":"Hussain","year":"2020","journal-title":"Nutrients"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"72","DOI":"10.4103\/1319-3767.45072","article-title":"Reversal of liver fibrosis","volume":"15","author":"Ismail","year":"2009","journal-title":"Saudi J. Gastroenterol."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.3389\/fphys.2018.01534","article-title":"Mouse microbiota models: comparing germ-free mice and antibiotics treatment as tools for modifying gut bacteria","volume":"9","author":"Kennedy","year":"2018","journal-title":"Front. Physiol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"7413","DOI":"10.3748\/wjg.v12.i46.7413","article-title":"Role of Kupffer cells in the pathogenesis of liver disease","volume":"12","author":"Kolios","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3389\/fimmu.2018.00367","article-title":"The role of natural killer T cells in Cancer\u2014a phenotypical and functional approach","volume":"9","author":"Krijgsman","year":"2018","journal-title":"Front. Immunol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1111\/imm.12247","article-title":"Different subsets of natural killer T cells may vary in their roles in health and disease","volume":"142","author":"Kumar","year":"2014","journal-title":"Immunology"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"979370","DOI":"10.3389\/fimmu.2022.979370","article-title":"Roles and therapeutic potential of CD1d-restricted NKT cells in inflammatory skin diseases","volume":"13","author":"Lee","year":"2022","journal-title":"Front. Immunol."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.jhep.2023.10.025","article-title":"CD1d protects against hepatocyte apoptosis in non-alcoholic steatohepatitis","volume":"80","author":"Lei","year":"2024","journal-title":"J. Hepatol."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"8228","DOI":"10.1128\/AEM.71.12.8228-8235.2005","article-title":"UniFrac: a new phylogenetic method for comparing microbial communities","volume":"71","author":"Lozupone","year":"2005","journal-title":"Appl. Environ. Microbiol."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.immuni.2012.06.016","article-title":"Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production","volume":"37","author":"Lynch","year":"2012","journal-title":"Immunity"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1126\/science.aan5931","article-title":"Gut microbiome\u2013mediated bile acid metabolism regulates liver cancer via NKT cells","volume":"360","author":"Ma","year":"2018","journal-title":"Science"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"e1009442","DOI":"10.1371\/journal.pcbi.1009442","article-title":"Multivariable association discovery in population-scale meta-omics studies","volume":"17","author":"Mallick","year":"2021","journal-title":"PLoS Comput. Biol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e00016-19","DOI":"10.1128\/mSystems.00016-19","article-title":"A novel sparse compositional technique reveals microbial perturbations","volume":"4","author":"Martino","year":"2019","journal-title":"mSystems"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"13829","DOI":"10.3390\/ijms232213829","article-title":"Multiplex analysis of serum cytokine profiles in systemic lupus erythematosus and multiple sclerosis","volume":"23","author":"Melamud","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/s41598-017-00199-4","article-title":"Hepatocyte growth factor prevented high-fat diet-induced obesity and improved insulin resistance in mice","volume":"7","author":"Muratsu","year":"2017","journal-title":"Sci. Rep."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"21778","DOI":"10.1038\/s41598-020-78688-2","article-title":"NKT cells promote both type 1 and type 2 inflammatory responses in a mouse model of liver fibrosis","volume":"10","author":"Nilsson","year":"2020","journal-title":"Sci. Rep."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1161\/ATVBAHA.109.198614","article-title":"Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice","volume":"30","author":"Ohmura","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.diabres.2004.11.007","article-title":"Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6","volume":"69","author":"Park","year":"2005","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12902-022-00980-1","article-title":"Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss","volume":"22","author":"Pouwels","year":"2022","journal-title":"BMC Endocr. Disord."},{"key":"ref47","year":"2008"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"74","DOI":"10.7326\/M21-1962","article-title":"Gastric bypass versus sleeve gastrectomy in type 2 diabetes: effects on hepatic steatosis and fibrosis: a randomized controlled trial","volume":"175","author":"Seeberg","year":"2022","journal-title":"Ann. Intern. Med."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"510","DOI":"10.3390\/ijms19020510","article-title":"Deficiency of invariant natural killer T cells does not protect against obesity but exacerbates atherosclerosis in Ldlr\u2212\/\u2212 mice","volume":"19","author":"Subramanian","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"634962","DOI":"10.3389\/fmed.2021.634962","article-title":"Age and Interleukin-15 levels are independently associated with intima-media thickness in obesity-related NAFLD patients","volume":"8","author":"Tarantino","year":"2021","journal-title":"Front. Med."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"345","DOI":"10.4049\/jimmunol.0901693","article-title":"CD1d-dependent NKT cells play a protective role in acute and chronic arthritis models by ameliorating antigen-specific Th1 responses","volume":"185","author":"Teige","year":"2010","journal-title":"J. Immunol."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health effects of overweight and obesity in 195 countries over 25 years","volume":"377","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"7.41.1","DOI":"10.1002\/0471142735.im0741s107","article-title":"Sampling of intestinal microbiota and targeted amplification of bacterial 16S rRNA genes for microbial ecologic analysis","volume":"107","author":"Tong","year":"2014","journal-title":"Curr. Protoc. Immunol."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.cmet.2015.07.009","article-title":"Roux-en-Y gastric bypass and vertical banded gastroplasty induce long-term changes on the human gut microbiome contributing to fat mass regulation","volume":"22","author":"Tremaroli","year":"2015","journal-title":"Cell Metab."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease\u2014meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2020.1848158","article-title":"Gut Bacteroides species in health and disease","volume":"13","author":"Zafar","year":"2021","journal-title":"Gut Microbes"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.3389\/fimmu.2020.01086","article-title":"Role of Kupffer cells in driving hepatic inflammation and fibrosis in HIV infection","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Immunol."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/s41422-020-0332-7","article-title":"Interaction between microbiota and immunity in health and disease","volume":"30","author":"Zheng","year":"2020","journal-title":"Cell Res."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.1080\/07853890.2022.2108894","article-title":"A comparative study on roles of natural killer T cells in two diet-induced non-alcoholic steatohepatitis-related fibrosis in mice","volume":"54","author":"Zheng","year":"2022","journal-title":"Ann. Med."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1015130","DOI":"10.3389\/fmicb.2022.1015130","article-title":"Bacteroides fragilis participates in the therapeutic effect of methotrexate on arthritis through metabolite regulation","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. 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