{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:26:37Z","timestamp":1774509997917,"version":"3.50.1"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The benefits and risks of bifid triple viable preparations in patients with acute ischemic stroke (AIS) are still controversial. This study aimed to assess the efficacy and safety of bifid triple viable preparations in combination with enteral nutrition for the management of AIS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight public databases including China National Knowledge Infrastructure, China Biology Medicine, VIP, WanFang, EBSCO, PubMed, Cochrane Library, and Web of Science were searched for relevant clinical literature, published through January 2024. These data were then used in the present meta-analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 15 studies involving 1,544 patients were included in the meta-analysis. In terms of nutritional status, the results showed that compared with enteral nutrition alone, the bifid triple viable preparation combination group increased the levels of total protein (mean difference [MD], 5.53; 95%confidence interval [CI], 1.94\u20139.12; <jats:italic>p<\/jats:italic> =\u20090.003), albumin (MD, 4.01; 95%CI, 2.96\u20135.06; <jats:italic>p<\/jats:italic> &amp;lt;\u20090.00001), prealbumin (MD, 23.08; 95%CI, 16.22\u201329.95; <jats:italic>p<\/jats:italic> &amp;lt;\u20090.00001), hemoglobin (MD, 9.31; 95%CI, 6.34\u201312.27; <jats:italic>p<\/jats:italic> &amp;lt;\u20090.00001), and transferrin (MD, 0.64; 95%CI, 0.23\u20131.05; <jats:italic>p<\/jats:italic> =\u20090.002); in terms of neurological function, it improved the Glasgow Coma Scale (MD, 2.09; 95%CI, 0.69\u20133.49; <jats:italic>p<\/jats:italic> =\u20090.003), National Institute of Health Stroke Scale (MD, \u22123.07; 95%CI, \u22123.73 to \u22122.40; <jats:italic>p<\/jats:italic> &amp;lt;\u20090.00001), and Neurological Disability Score (MD, \u22126.68; 95%CI, -7.29 to \u22126.08; <jats:italic>p<\/jats:italic> &amp;lt;\u20090.00001); in terms of intestinal barrier function, it reduced the levels of endotoxin (MD, \u22120.55; 95%CI, \u22120.71 to \u22120.39; <jats:italic>p<\/jats:italic> &amp;lt;\u20090.00001), D-lactic acid (MD, \u22123.17; 95%CI, \u22124.07 to \u22122.26; <jats:italic>p<\/jats:italic> &amp;lt;\u20090.00001), diamine oxidase (MD, \u22124.39; 95%CI, \u22126.20 to \u22122.57; <jats:italic>p<\/jats:italic> &amp;lt;\u20090.00001), and endothelin (MD, \u221221.35; 95%CI, \u221227.86 to \u221214.83; <jats:italic>p<\/jats:italic> &amp;lt;\u20090.00001); in terms of immune function, it increased the levels of immunoglobulin G (MD, 1.01; 95%CI, 0.20\u20131.82; <jats:italic>p<\/jats:italic> =\u20090.01) and immunoglobulin M (MD, 0.16; 95%CI, 0.02\u20130.30; <jats:italic>p<\/jats:italic> =\u20090.03). Additionally, it reduced the incidence of pulmonary infection, vomiting, constipation, and diarrhea, while there were no significant differences in total adverse events, abdominal distension, anorexia, reflux, gastrointestinal bleeding, or electrolyte disturbance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The addition of bifid triple viable preparation to enteral nutrition improved the nutritional status, neurological function, intestinal barrier function, and immune function of patients with AIS, and reduced the risk of infection and gastrointestinal events.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmicb.2024.1408960","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T16:40:01Z","timestamp":1720629601000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Bifid triple viable preparation combined with enteral nutrition as a supportive treatment for acute ischemic stroke: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"15","author":[{"given":"Yumeng","family":"Kong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfeng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e167898","DOI":"10.1155\/2011\/167898","article-title":"Malnutrition in patients with acute stroke","volume":"2011","author":"Bouziana","year":"2011","journal-title":"J. Nutr. Metab."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.3389\/fmicb.2017.01725","article-title":"Safety of novel microbes for human consumption: practical examples of assessment in the European Union","volume":"8","author":"Brodmann","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/s41430-021-00986-3","article-title":"Effect of early enteral nutrition combined with probiotics in patients with stroke: a meta-analysis of randomized controlled trials","volume":"76","author":"Chen","year":"2022","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"104245","DOI":"10.1016\/j.jff.2020.104245","article-title":"Dose-response efficacy and mechanisms of orally administered CLA-producing Bifidobacterium breve CCFM683 on DSS-induced colitis in mice","volume":"75","author":"Chen","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3969\/j.issn.1008-9691.2019.03.019","article-title":"Effects of early enteral nutrition combined with probiotics on intestinal flora and immune function in patients with severe ischemic stroke","volume":"26","author":"Chen","year":"2019","journal-title":"Chin. Assoc. Integr. Med."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"666","DOI":"10.3760\/cma.j.issn.1006-7876.2018.09.004","article-title":"Chinese guidelines for diagnosis and treatment of acute ischemic stroke 2018","volume":"51","year":"2018","journal-title":"Chin. J. Neurol."},{"key":"ref7","article-title":"The effect of early enteral nutrition combined with probiotics on gut microbiota and immune function in elderly patients with ischemic stroke","volume":"68","author":"Gao","year":"2021","journal-title":"Diet Health"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"Expert consensus document. The international scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic","volume":"11","author":"Hill","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"398","DOI":"10.3969\/j.issn.1672-2159.2019.04.018","article-title":"Early enteral nutrition reconstruction of intestinal microbiota to promote the rehabilitation of ischemic stroke","volume":"24","author":"Huang","year":"2019","journal-title":"Modern Dig. Interv."},{"key":"ref10","first-page":"77","article-title":"Effects of enteral nutrition combined with probiotics on early neurological function in patients with ischemic stroke and analysis of related factors","volume":"44","author":"Li","year":"2023","journal-title":"J. Med. Forum"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3760\/cma.j.issn.1673-4165.2021.04.013","article-title":"Intestinal flora and ischemic stroke","volume":"29","author":"Li","year":"2021","journal-title":"Int. J. Cerebrovasc. Dis."},{"key":"ref12","first-page":"44","article-title":"The effects of Bifidobacterium on immune function, nutritional status, and inflammatory cytokine levels in patients with severe cerebral infarction","volume":"5","author":"Li","year":"2021","journal-title":"Modern Med. Health Res."},{"key":"ref13","volume-title":"Neurology","author":"Liu","year":"2014"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e25657","DOI":"10.1097\/MD.0000000000025657","article-title":"Effect of probiotics on the nutritional status of severe stroke patients with nasal feeding that receive enteral nutrition: a protocol for systematic review and meta-analysis of randomized controlled trials","volume":"100","author":"Liu","year":"2021","journal-title":"Medicine"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2323540","DOI":"10.1155\/2019\/2323540","article-title":"Intestinal immunomodulation and shifts on the gut microbiota of BALB\/c mice promoted by two Bifidobacterium and lactobacillus strains isolated from human samples","volume":"2019","author":"Nogacka","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"ref16","volume-title":"Notice on Implementing Clinical Pathways for Related Diseases","year":"2016"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"700","DOI":"10.13381\/j.cnki.cjm.201606018","article-title":"Application of enteric bifid triple viable capsules combined withearly enteral nutrition on massive hemispheric infarction","volume":"28","author":"Pang","year":"2016","journal-title":"Chin. J. Microecol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"915","DOI":"10.3390\/ijms22020915","article-title":"The role of gut microbiota in an ischemic stroke","volume":"22","author":"Pluta","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.neubiorev.2021.02.016","article-title":"PRISMA 2020 - an updated checklist for systematic reviews and meta-analyses","volume":"124","author":"Radua","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1007\/s12028-017-0436-1","article-title":"Malnutrition in stroke patients: risk factors, assessment, and management","volume":"29","author":"Sabbouh","year":"2018","journal-title":"Neurocrit. Care."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"715","DOI":"10.3390\/life11070715","article-title":"Microbiota gut-brain Axis in ischemic stroke: a narrative review with a focus about the relationship with inflammatory bowel disease","volume":"11","author":"Sinagra","year":"2021","journal-title":"Life"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"238","DOI":"10.16150\/j.1671-2870.2023.03.06","article-title":"Interpretation on the report of global stroke data 2022","volume":"22","author":"Tang","year":"2023","journal-title":"J. Diagn. Concepts Pract."},{"key":"ref23","first-page":"242","article-title":"Effect of probiotics combined with enteral nutrition on prognosis of patients with severe cerebral infarction","volume-title":"Chinese Science and Technology Journal Database (Citation Edition) Medical and Health","author":"Wan","year":""},{"key":"ref24","doi-asserted-by":"publisher","first-page":"65","DOI":"10.12346\/pmr.v3i2.3432","article-title":"The effect of microecological intervention on the nutritional status and immune function of patients with severe cerebral infarction","volume":"3","author":"Wan","year":"","journal-title":"Med. Chem. Res."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3969\/j.issn.1006-1959.2021.15.047","article-title":"The effect of enteral nutrition combined with live Bifidobacterium triple bacteria on diamine oxidase and nutritional indicators in patients with acute ischemic stroke after neurointerventional therapy","volume":"34","author":"Wang","year":"2021","journal-title":"J. Med. Inform."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3969\/j.issn.1674-2257.2021.01.007","article-title":"Effects of enteral nutrition combined with probiotics on nutritional status in patients with acute ischemic stroke after neural intervention therapy","volume":"16","author":"Wang","year":"2021","journal-title":"J. Chengdu Med. College"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1323920","DOI":"10.3389\/fmicb.2023.1323920","article-title":"Clinical research with probiotics as an indicator of global valorization since the year 2000","volume":"14","author":"Wiegers","year":"2023","journal-title":"Front. Microbiol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/S1474-4422(18)30500-3","article-title":"Stroke in China: advances and challenges in epidemiology, prevention, and management","volume":"18","author":"Wu","year":"2019","journal-title":"Lancet Neurol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"118","DOI":"10.16286\/j.1003-5052.2021.09.046","article-title":"Effect of probiotics combined with early enteral nutrition in the treatment of elderly patients with ACI","volume":"36","author":"Yang","year":"2021","journal-title":"Chin. J. Urban Rural Enterprise Hyg."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"721156","DOI":"10.3389\/fphar.2021.721156","article-title":"Challenges and improvements of novel therapies for ischemic stroke","volume":"12","author":"Yang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3969\/j.issn.1674-9308.2018.26.073","article-title":"Clinical efficacy of bifidous triple live bacteria in the treatment of large-scale cerebral infarction","volume":"10","author":"Yang","year":"2018","journal-title":"China Continuing Med. Educ."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"100","DOI":"10.12037\/YXQY.2020.02-22","article-title":"Observation on the effect of bifid triple viable bacteria capsule combined with early enteral nutrition on elderly patients with acute cerebral infarction","volume":"12","author":"Yu","year":"2020","journal-title":"Chin. J. Front. Med. Sci."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"805","DOI":"10.13381\/j.cnki.cjm.201507016","article-title":"Influence of saccharomyces boulardii combined with enteral nutrition support on nutrition state and cellular immune function of patients with severe stroke","volume":"27","author":"Zeng","year":"2015","journal-title":"Chin. J. Microecol."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"114056","DOI":"10.1016\/j.biopha.2022.114056","article-title":"Progress on traditional Chinese medicine in treatment of ischemic stroke via the gut-brain axis","volume":"157","author":"Zhai","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref35","volume-title":"Based on the effect of the triple viable bifidobacterium on the intestinal flora of patients with coronary heart disease and the correlation analysisof the prognosis","author":"Zhang","year":"2022"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3969\/j.issn.1007-614x.2023.15.016","article-title":"Clinical effect of probiotics combined with enteral nutrition in treatment of cerebral infarction and type 2 diabetes mellitus","volume":"39","author":"Zhang","year":"2023","journal-title":"Chin. Community Doctors"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3969\/j.issn.1674-4721.2017.21.056","article-title":"Influence of bifid triple viable capsules combined with early enteral nutrition on nutritional status and gastrointestinal function for patients with acute cerebral infarction","volume":"24","author":"Zhao","year":"2017","journal-title":"China Modern Med."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"e4877311","DOI":"10.1155\/2021\/4877311","article-title":"The effect of probiotics in stroke treatment","volume":"2021","author":"Zhong","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.3390\/nu13082704","article-title":"Nutritional supplements and neuroprotective diets and their potential clinical significance in post-stroke rehabilitation","volume":"13","author":"Zieli\u0144ska-Nowak","year":"2021","journal-title":"Nutrients"}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2024.1408960\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T16:40:35Z","timestamp":1720629635000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2024.1408960\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,10]]},"references-count":39,"alternative-id":["10.3389\/fmicb.2024.1408960"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2024.1408960","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,10]]},"article-number":"1408960"}}