{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:44:15Z","timestamp":1793191455026,"version":"4.5.0"},"reference-count":160,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Sterols are essential for eukaryotic cells and are crucial in cellular membranes\u2019 structure, function, fluidity, permeability, adaptability to environmental stressors, and host-pathogen interactions. Fungal sterol, such as ergosterol metabolism, involves several organelles, including the mitochondria, lipid droplets, endoplasmic reticulum, and peroxisomes that can be regulated mainly by feedback mechanisms and transcriptionally. The majority of sterol transport in yeast occurs via non-vesicular transport pathways mediated by lipid transfer proteins, which determine the quantity of sterol present in the cell membrane. Pathogenic fungi\n                    <jats:italic>Candida<\/jats:italic>\n                    ,\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    , and\n                    <jats:italic>Cryptococcus<\/jats:italic>\n                    species can cause a range of superficial to potentially fatal systemic and invasive infections that are more common in immunocompromised patients. There is a significant risk of morbidity and mortality from these infections, which are very difficult to cure. Several antifungal drugs with different modes of action have received clinical approval to treat fungal infections. Antifungal drugs targeting the ergosterol biosynthesis pathway are well-known for their antifungal activity; however, an imbalance in the regulation and transport of ergosterol could lead to resistance to antifungal therapy. This study summarizes how fungal sterol metabolism and regulation can modulate sterol-targeting antifungal drug resistance.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2024.1409085","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:35:32Z","timestamp":1728606932000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":41,"title":["Insights into the role of sterol metabolism in antifungal drug resistance: a mini-review"],"prefix":"10.3389","volume":"15","author":[{"given":"Sunita","family":"Tanwar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapna","family":"Kalra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay Kumar","family":"Bari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1093\/genetics\/157.3.1169","article-title":"Regulatory mechanisms controlling expression of the DAN\/TIR mannoprotein genes during anaerobic remodeling of the cell wall in Saccharomyces cerevisiae","volume":"157","author":"Abramova","year":"2001","journal-title":"Genetics"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1128\/AAC.01900-18","article-title":"ERG6 and ERG2 are major targets conferring reduced susceptibility to amphotericin B in clinical Candida glabrata isolates in Kuwait","volume":"63","author":"Ahmad","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/apm.13389","article-title":"Antifungal drug resistance in Candida: a special emphasis on amphotericin B","volume":"132","author":"Ahmady","year":"2024","journal-title":"APMIS"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1586\/14787210.2015.1032939","article-title":"Azole antifungals: 35 years of invasive fungal infection management","volume":"13","author":"Allen","year":"2015","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"ref9003","doi-asserted-by":"publisher","first-page":"19176","DOI":"10.1016\/s0021-9258(19)47284-0","article-title":"Farnesyl diphosphate synthetase. Molecular cloning, sequence, and expression of an essential gene from Saccharomyces cerevisiae","volume":"264","author":"Anderson","year":"1989","journal-title":"J. Biol. Chem."},{"key":"ref9002","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1093\/genetics\/163.4.1287","article-title":"Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiae","volume":"163","author":"Anderson","year":"2003","journal-title":"Genetics"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1091\/mbc.11.8.2673","article-title":"Distinct roles for the yeast phosphatidylinositol 4-kinases, Stt4p and Pik1p, in secretion, cell growth, and organelle membrane dynamics","volume":"11","author":"Audhya","year":"2000","journal-title":"Mol Bio Cell"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"4989","DOI":"10.1128\/AAC.49.12.4989-4992.2005","article-title":"Comparison of the fungicidal activities of caspofungin and amphotericin B against Candida glabrata","volume":"49","author":"Barchiesi","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"5563","DOI":"10.1073\/pnas.83.15.5563","article-title":"Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme a reductase","volume":"83","author":"Basson","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1093\/genetics\/157.3.1117","article-title":"Overlapping functions of the yeast oxysterol-binding protein homologues","volume":"157","author":"Beh","year":"2001","journal-title":"Genetics"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1242\/jcs.01157","article-title":"A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution","volume":"117","author":"Beh","year":"2004","journal-title":"J. Cell Sci."},{"key":"ref9004","doi-asserted-by":"publisher","first-page":"4664","DOI":"10.1128\/jb.179.15.4664-4670.1997","article-title":"The Saccharomyces cerevisiae mevalonate diphosphate decarboxylase is essential for viability, and a single Leu-to-Pro mutation in a conserved sequence leads to thermosensitivity","volume":"179","author":"Berges","year":"1997","journal-title":"J. Bacteriol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e01291","DOI":"10.1128\/mBio.01291-18","article-title":"Overexpression or deletion of Ergosterol biosynthesis genes alters doubling time, response to stress agents, and drug susceptibility in Saccharomyces cerevisiae","volume":"9","author":"Bhattacharya","year":"2018","journal-title":"mBio"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"5052","DOI":"10.1038\/s41598-019-41513-6","article-title":"Gene duplication associated with increased fluconazole tolerance in Candida auris cells of advanced generational age","volume":"9","author":"Bhattacharya","year":"2019","journal-title":"Sci. Rep."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"312","DOI":"10.3390\/antibiotics9060312","article-title":"Candidiasis and mechanisms of antifungal resistance","volume":"9","author":"Bhattacharya","year":"2020","journal-title":"Antibiotics"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1128\/EC.00358-09","article-title":"Sterol regulatory element binding proteins in fungi: hypoxic transcription factors linked to pathogenesis","volume":"9","author":"Bien","year":"2010","journal-title":"Eukaryot. Cell"},{"key":"ref9005","doi-asserted-by":"publisher","DOI":"10.1038\/srep21874","article-title":"A common mechanism involving the TORC1 pathway can lead to amphotericin B-persistence in biofilm and planktonic Saccharomyces cerevisiae populations","volume":"21874","author":"Bojsen","year":"2016","journal-title":"Sci. Rep."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3390\/jof3040057","article-title":"Global and multi-national prevalence of fungal diseases\u2014estimate precision","volume":"3","author":"Bongomin","year":"2017","journal-title":"J Fungi (Basel)"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"575.e1","DOI":"10.1016\/j.cmi.2017.02.002","article-title":"Impact of ERG3 mutations and expression of ergosterol genes controlled by UPC2 and NDT80 in Candida parapsilosis azole resistance","volume":"23","author":"Branco","year":"2017","journal-title":"Clin. Microbiol. Infect."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"165rv13","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: human fungal infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/S0092-8674(00)80213-5","article-title":"The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor","volume":"89","author":"Brown","year":"1997","journal-title":"Cell"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1128\/EC.00027-15","article-title":"Functional analysis of sterol transporter orthologues in the filamentous fungus Aspergillus nidulans","volume":"14","author":"B\u00fchler","year":"2015","journal-title":"Eukaryot. Cell"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.plipres.2011.07.002","article-title":"Regulation of HMG-CoA reductase in mammals and yeast","volume":"50","author":"Burg","year":"2011","journal-title":"Prog. Lipid Res."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1128\/mBio.03333-20","article-title":"Genome-wide analysis of experimentally evolved Candida auris reveals multiple novel mechanisms of multidrug resistance","volume":"12","author":"Carolus","year":"2021","journal-title":"MBio"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s40121-020-00382-7","article-title":"Sixty years of amphotericin B: an overview of the Main antifungal agent used to treat invasive fungal infections","volume":"10","author":"Cavassin","year":"2021","journal-title":"Infect. Dis. Ther."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1128\/EC.00207-09","article-title":"Conservation of the sterol regulatory element-binding protein pathway and its pathobiological importance in Cryptococcus neoformans","volume":"8","author":"Chang","year":"2009","journal-title":"Eukaryot. Cell"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1517\/14728214.10.1.21","article-title":"Emerging azole antifungals","volume":"10","author":"Chen","year":"2005","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"20351","DOI":"10.1074\/jbc.M113.482224","article-title":"Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast","volume":"288","author":"Chong","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e1006290","DOI":"10.1371\/journal.ppat.1006290","article-title":"Candida auris: a rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally","volume":"13","author":"Chowdhary","year":"2017","journal-title":"PLoS Pathog."},{"key":"ref9001","doi-asserted-by":"publisher","first-page":"e0135323","DOI":"10.1128\/mbio.01353-23","article-title":"Ergosterol distribution controls surface structure formation and fungal pathogenicity","volume":"14","author":"Choy","year":"2003","journal-title":"mBio"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1007\/s00253-017-8732-4","article-title":"Anaerobiosis revisited: growth of Saccharomyces cerevisiae under extremely low oxygen availability","volume":"102","author":"da Costa","year":"2018","journal-title":"Appl. Microbiol. 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Physiol."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"251525642094662","DOI":"10.1177\/2515256420946627","article-title":"Structural and functional specialization of OSBP-related proteins","volume":"3","author":"Delfosse","year":"2020","journal-title":"Contact"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1155\/2014\/615958","article-title":"Non-albicans Candida infection: an emerging threat","volume":"2014","author":"Deorukhkar","year":"2014","journal-title":"Interdiscip Perspect Infect Dis"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.1128\/aem.63.9.3341-3344.1997","article-title":"Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme a reductase on squalene synthesis in Saccharomyces cerevisiae","volume":"63","author":"Donald","year":"1997","journal-title":"Appl. Environ. Microbiol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.celrep.2015.06.022","article-title":"Lam6 regulates the extent of contacts between organelles","volume":"12","author":"Elbaz-Alon","year":"2015","journal-title":"Cell Rep."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1146\/annurev.genet.41.110306.130315","article-title":"Regulation of sterol synthesis in eukaryotes","volume":"41","author":"Espenshade","year":"2007","journal-title":"Annu. Rev. Genet."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1089\/mdr.2016.0095","article-title":"Mutations and\/or Overexpressions of ERG4 and ERG11 genes in clinical azoles-resistant isolates of Candida albicans","volume":"23","author":"Feng","year":"2017","journal-title":"Microb. Drug Resist."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"e00953","DOI":"10.7554\/eLife.00953","article-title":"Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10\/Teb4","volume":"2","author":"Foresti","year":"2013","journal-title":"eLife"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/lam.12820","article-title":"Antifungals discovery: an insight into new strategies to combat antifungal resistance","volume":"66","author":"Fuentefria","year":"2018","journal-title":"Lett. Appl. Microbiol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.jointm.2024.01.005","article-title":"Fungal infections in immunocompromised critically ill patients","volume":"4","author":"Garnacho-Montero","year":"2024","journal-title":"J. Intensive Med."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"e07253","DOI":"10.7554\/eLife.07253","article-title":"A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport","volume":"4","author":"Gatta","year":"2015","journal-title":"eLife"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1194\/jlr.RA120000975","article-title":"Sterol regulatory element-binding protein Sre1 regulates carotenogenesis in the red yeast Xanthophyllomyces dendrorhous","volume":"61","author":"G\u00f3mez","year":"2020","journal-title":"J. Lipid Res."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.3390\/membranes12121171","article-title":"Allylamines, Benzylamines, and fungal cell permeability: a review of mechanistic effects and usefulness against fungal pathogens","volume":"12","author":"Hammoudi Halat","year":"2022","journal-title":"Membranes"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"12944","DOI":"10.1073\/pnas.94.24.12944","article-title":"Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase","volume":"94","author":"Hampton","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"42","DOI":"10.2174\/1871526515666150320162036","article-title":"Candidiasis: a fungal infection- current challenges and Progress in prevention and treatment","volume":"15","author":"Hani","year":"2015","journal-title":"Infect. Disord. Drug Targets"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"a004762","DOI":"10.1101\/cshperspect.a004762","article-title":"Distribution and functions of sterols and sphingolipids","volume":"3","author":"Hannich","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"e0136185","DOI":"10.1371\/journal.pone.0136185","article-title":"Overexpression of both ERG11 and ABC2 genes might be responsible for itraconazole resistance in clinical isolates of Candida krusei","volume":"10","author":"He","year":"2015","journal-title":"PLoS One"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1128\/AAC.44.10.2693-2700.2000","article-title":"Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors","volume":"44","author":"Henry","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1007\/s12088-017-0657-1","article-title":"Recent advances in Ergosterol biosynthesis and regulation mechanisms in Saccharomyces cerevisiae","volume":"57","author":"Hu","year":"2017","journal-title":"Indian J. Microbiol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"e202201612","DOI":"10.26508\/lsa.202201612","article-title":"Lipid saturation induces degradation of squalene epoxidase for sterol homeostasis and cell survival","volume":"6","author":"Huang","year":"2023","journal-title":"Life Sci. Alliance"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.cell.2005.01.012","article-title":"SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast","volume":"120","author":"Hughes","year":"2005","journal-title":"Cell"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1099\/mic.0.2007\/011155-0","article-title":"Multiple functions of ergosterol in the fission yeast Schizosaccharomyces pombe","volume":"154","author":"Iwaki","year":"2008","journal-title":"Microbiol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.devcel.2016.09.030","article-title":"Lipids and their trafficking: an integral part of cellular organization","volume":"39","author":"Jackson","year":"2016","journal-title":"Dev. Cell"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1242\/jcs.076836","article-title":"Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae","volume":"124","author":"Jacquier","year":"2011","journal-title":"J. Cell Sci."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jsbmb.2010.11.014","article-title":"Mechanisms of sterol uptake and transport in yeast","volume":"129","author":"Jacquier","year":"2012","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1111\/apm.13336","article-title":"Azole resistance in Candida auris: mechanisms and combinatorial therapy","volume":"131","author":"Jangir","year":"2023","journal-title":"APMIS"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"4950","DOI":"10.1128\/JB.183.17.4950-4957.2001","article-title":"Transcriptional regulation of the two sterol esterification genes in the yeast Saccharomyces cerevisiae","volume":"183","author":"Jensen-Pergakes","year":"2001","journal-title":"J. Bacteriol."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"5248","DOI":"10.1111\/1462-2920.16157","article-title":"Transcriptional regulation of ergosterol biosynthesis genes in response to iron deficiency","volume":"24","author":"Jord\u00e1","year":"2022","journal-title":"Environ. Microbiol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"795","DOI":"10.3390\/genes11070795","article-title":"Regulation of Ergosterol biosynthesis in Saccharomyces cerevisiae","volume":"11","author":"Jord\u00e1","year":"2020","journal-title":"Genes"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"772","DOI":"10.3390\/ijms18040772","article-title":"From lipid homeostasis to differentiation: old and new functions of the zinc cluster proteins Ecm22, Upc2, Sut1 and Sut2","volume":"18","author":"Joshua","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"143","DOI":"10.15698\/mic2020.06.718","article-title":"Fungal infections in humans: the silent crisis","volume":"7","author":"Kainz","year":"2020","journal-title":"Microb Cell"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"5678","DOI":"10.1016\/j.bmc.2012.04.045","article-title":"The biology and chemistry of antifungal agents: a review","volume":"20","author":"Kathiravan","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/j.1574-6968.1994.tb07140.x","article-title":"Resistance to amphotericin B associated with defective sterol \u03948\u21927 isomerase in a Cryptococcus neoformans strain from an AIDS patient","volume":"122","author":"Kelly","year":"1994","journal-title":"FEMS Microbiol. Lett."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"e0139306","DOI":"10.1371\/journal.pone.0139306","article-title":"Changes in the sterol composition of the plasma membrane affect membrane potential, salt tolerance and the activity of multidrug resistance pumps in Saccharomyces cerevisiae","volume":"10","author":"Kodedov\u00e1","year":"2015","journal-title":"PLoS One"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"4959","DOI":"10.1242\/jcs.01372","article-title":"Nvj1p is the outer-nuclear-membrane receptor for oxysterol-binding protein homolog Osh1p in Saccharomyces cerevisiae","volume":"117","author":"Kvam","year":"2004","journal-title":"J. Cell Sci."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/0022-2836(82)90515-0","article-title":"A simple method for displaying the hydropathic character of a protein","volume":"157","author":"Kyte","year":"1982","journal-title":"J. Mol. Biol."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41572-024-00503-3","article-title":"Invasive candidiasis","volume":"10","author":"Lass-Fl\u00f6rl","year":"2024","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.bbalip.2012.09.012","article-title":"Characterization of a mutation that results in independence of oxidosqualene cyclase (Erg7) activity from the downstream 3-ketoreductase (Erg27) in the yeast ergosterol biosynthetic pathway","volume":"1831","author":"Layer","year":"2013","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1091\/mbc.9.2.375","article-title":"Dual localization of squalene epoxidase, Erg1p, in yeast reflects a relationship between the endoplasmic reticulum and lipid particles","volume":"9","author":"Leber","year":"1998","journal-title":"Mol. Biol. 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J."},{"key":"ref121","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1128\/AAC.47.8.2404-2412.2003","article-title":"Candida albicans mutations in the Ergosterol biosynthetic pathway and resistance to several antifungal agents","volume":"47","author":"Sanglard","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref122","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/myc.12330","article-title":"Antifungal drug resistance among Candida species: mechanisms and clinical impact","volume":"58","author":"Sanguinetti","year":"2015","journal-title":"Mycoses"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.bbalip.2007.03.003","article-title":"Sterol transport in yeast and the oxysterol binding protein homologue (OSH) family","volume":"1771","author":"Schulz","year":"2007","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. 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Agents Chemother."},{"key":"ref134","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.bbalip.2008.04.017","article-title":"Genetic analyses involving interactions between the ergosterol biosynthetic enzymes, lanosterol synthase (Erg7p) and 3-ketoreductase (Erg27p), in the yeast Saccharomyces cerevisiae","volume":"1781","author":"Teske","year":"2008","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"8519","DOI":"10.1074\/jbc.M112.404517","article-title":"Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast","volume":"288","author":"Theesfeld","year":"2013","journal-title":"J. Biol. 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Biol."},{"key":"ref139","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/j.1574-6968.2001.tb10580.x","article-title":"Anaerobiosis induces complex changes in sterol esterification pattern in the yeast Saccharomyces cerevisiae","volume":"197","author":"Valachovic","year":"2001","journal-title":"FEMS Microbiol. Lett."},{"key":"ref140","doi-asserted-by":"publisher","first-page":"3701","DOI":"10.1128\/AAC.00423-08","article-title":"A nonsense mutation in the ERG6 gene leads to reduced susceptibility to polyenes in a clinical isolate of Candida glabrata","volume":"52","author":"Vandeputte","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref141","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.bpj.2011.12.038","article-title":"Role of unsaturated lipid and ergosterol in ethanol tolerance of model yeast biomembranes","volume":"102","author":"Vanegas","year":"2012","journal-title":"Biophys. J."},{"key":"ref142","doi-asserted-by":"publisher","first-page":"6395","DOI":"10.1128\/mcb.21.19.6395-6405.2001","article-title":"Upc2p and Ecm22p, dual regulators of sterol biosynthesis in Saccharomyces cerevisiae","volume":"21","author":"Vik","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"ref143","doi-asserted-by":"publisher","first-page":"3249","DOI":"10.1007\/s00253-019-09711-4","article-title":"Naturally occurring of \u03b1, \u03b2-diepoxy-containing compounds: origin, structures, and biological activities","volume":"103","author":"Vil","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref144","doi-asserted-by":"publisher","first-page":"e1001692","DOI":"10.1371\/journal.pbio.1001692","article-title":"Fitness trade-offs restrict the evolution of resistance to amphotericin B","volume":"11","author":"Vincent","year":"2013","journal-title":"PLoS Biol."},{"key":"ref145","doi-asserted-by":"publisher","first-page":"10782","DOI":"10.1074\/jbc.RA118.001781","article-title":"Altered sterol metabolism in budding yeast affects mitochondrial iron\u2013sulfur (Fe-S) cluster synthesis","volume":"293","author":"Ward","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref146","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.bcp.2013.02.016","article-title":"Oxysterol-binding proteins: functions in cell regulation beyond lipid metabolism","volume":"86","author":"Weber-Boyvat","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"ref147","doi-asserted-by":"publisher","first-page":"4543","DOI":"10.1128\/AAC.02217-13","article-title":"UPC2A is required for high-level azole antifungal resistance in Candida glabrata","volume":"58","author":"Whaley","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref148","doi-asserted-by":"publisher","first-page":"e1000200","DOI":"10.1371\/journal.ppat.1000200","article-title":"A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus","volume":"4","author":"Willger","year":"2008","journal-title":"PLoS Pathog."},{"key":"ref149","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41580-018-0071-5","article-title":"Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes","volume":"20","author":"Wong","year":"2019","journal-title":"Nat. Rev. Mol. 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Microbiol."},{"key":"ref155","doi-asserted-by":"publisher","first-page":"251525642110424","DOI":"10.1177\/25152564211042451","article-title":"Regulation of plasma membrane sterol homeostasis by nonvesicular lipid transport","volume":"4","author":"Zheng Koh","year":"2021","journal-title":"Contact"},{"key":"ref156","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.1128\/jb.175.10.2853-2858.1993","article-title":"Sterol composition of yeast organelle membranes and subcellular distribution of enzymes involved in sterol metabolism","volume":"175","author":"Zinser","year":"1993","journal-title":"J. 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