{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:00:08Z","timestamp":1783465208764,"version":"3.55.0"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008809","name":"University of Hail","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Rumex vesicarius<\/jats:italic> is a wild leafy plant belonging to the family Polygonaceae, renowned for its therapeutic benefits. The genus Rumex comprises approximately 150 species distributed globally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The study aimed to investigate the biological activities of <jats:italic>R. vesicarius<\/jats:italic> using in vitro and <jats:italic>in silico<\/jats:italic> methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>Rumex vesicarius<\/jats:italic> was collected from the mountains in Hail and extracted with methanol. The phytochemical composition was qualitatively determined using colorimetric detection methods. Additional analyses included elemental analysis, <jats:italic>in silico<\/jats:italic> docking, antioxidant, antibacterial, and anti-biofilm properties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The extract contained various classes of phytochemicals, including flavonoids, phenolics, tannins, terpenes, and saponins. Sixteen constituents were identified through molecular docking, revealing inhibition against the filamentous temperature-sensitive protein Z (FtsZ), a crucial factor in bacterial cell division. Six compounds exhibited low binding scores ranging from \u22128.3 to \u22125.0 kcal\/mol, indicating efficient interaction at the active site. Elemental analysis identified 15 elements, with potassium being the most abundant, followed by calcium, aluminum, silicon, iron, phosphorus, sulfur, magnesium, titanium, strontium, zinc, manganese, bromine, and chromium. Antioxidant analysis revealed significant properties at lower concentrations compared to ascorbic acid, butylated hydroxytoluene, and \u03b2-carotene. Antibacterial analysis demonstrated inhibitory effects on Bacillus subtilis MTCC121 and <jats:italic>Pseudomonas aeruginosa<\/jats:italic> MTCC 741, with inhibition zones of 13.67 \u00b1 1.0 mm and 11.50 \u00b1 1.0 mm, respectively. The MIC and MBC values ranged from 250 to 500 \u03bcg\/mL. <jats:italic>R. vesicarius<\/jats:italic> also exhibited anti-biofilm activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Wild-grown <jats:italic>R. vesicarius<\/jats:italic> from the mountains of Hail is rich in bioactive phytochemicals and essential minerals, exhibiting notable antioxidant and antibacterial properties.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmicb.2024.1421143","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T04:52:39Z","timestamp":1722228759000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Bioactive profiling of Rumex vesicarius L. from the Hail region of Saudi Arabia: a study on its phytochemical and elemental analysis, antibiofilm, antibacterial, antioxidant properties, and molecular docking analysis"],"prefix":"10.3389","volume":"15","author":[{"given":"Abdel Moneim Elhadi","family":"Sulieman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad M.","family":"Abdallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naimah Asid","family":"Alanazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajo","family":"Idriss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd","family":"Adnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arshad","family":"Jamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohair A. M.","family":"Shommo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mejdi","family":"Snoussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.joad.2016.08.024","article-title":"Antibacterial activity of Hibiscus sabdariffa L. calyces against hospital isolates of multidrug-resistant Acinetobacter baumannii.","volume":"5","author":"Abdallah","year":"2016","journal-title":"J. Acute Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"7799","DOI":"10.26355\/eurrev_202112_27626","article-title":"Antibiofilm effect of probiotic lactic acid bacteria against Bacillus spp obtained from the ocular surface.","volume":"25","author":"Akova","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"10427","DOI":"10.26355\/eurrev_202402_35454","article-title":"Oral administration of naringenin and a mixture of coconut water and Arabic gum attenuate oxidative stress and lipid peroxidation in gentamicin-induced nephrotoxicity in rats.","volume":"27","author":"Al-Amer","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1007\/s11356-021-16335-7","article-title":"Chemical composition of hummayd (Rumex vesicarius) grown in Saudi Arabia.","volume":"19","author":"Alfawaz","year":"2006","journal-title":"J. Food Comp. Anal."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2023.117561","article-title":"Exploring the antibacterial mechanisms of chemically characterized essential oils from leaves and buds of Syzygium aromaticum (L.) Merr. et Perry against Staphylococcus aureus and Pseudomonas aeruginosa.","volume":"205","author":"Al-Mijalli","year":"","journal-title":"Ind. Crops Products"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e23084","article-title":"Integrated analysis of antimicrobial, antioxidant, and phytochemical properties of Cinnamomum verum: a comprehensive In vitro and In silico study.","volume":"110","author":"Al-Mijalli","year":"","journal-title":"Biochem. Syst. Ecol."},{"key":"B7","first-page":"293","article-title":"Effect of solvent extraction on total phenolics and antioxidant activity of extracts from flaxseed (Linum usitatissimum L.).","volume":"11","author":"Anwar","year":"2012","journal-title":"Acta Sci. Pol. Technol. Aliment."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.4314\/biokem.v18i1.56390","article-title":"Phytochemical screening and antimicrobial assessment of Abutilon mauritianum, Bacopa monnifera, and Datura stramonium.","volume":"18","author":"Banso","year":"2006","journal-title":"Biokemistri"},{"key":"B9","doi-asserted-by":"crossref","DOI":"10.3390\/biom12101514","article-title":"Amygdalin: a review on its characteristics, antioxidant potential, gastrointestinal microbiota intervention, anticancer therapeutic and mechanisms, toxicity, and encapsulation.","volume":"12","author":"Barakat","year":"2022","journal-title":"Biomolecules"},{"key":"B10","doi-asserted-by":"publisher","first-page":"3549","DOI":"10.1007\/s13197-014-1420-9","article-title":"Potential assessment of Rumex vesicarius L. as a source of natural antioxidants and bioactive compounds.","volume":"52","author":"Beddou","year":"2015","journal-title":"J. Food Sci. Tech."},{"key":"B11","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1201\/9781003269250-10","article-title":"Future prospect and global market demand for dried herbs, spices and medicinal plants","author":"Bhatkar","year":"2023","journal-title":"Drying of Herbs, Spices, and Medicinal Plants"},{"key":"B12","doi-asserted-by":"publisher","first-page":"5","DOI":"10.2174\/1381612820666140905114627","article-title":"Quorum sensing inhibitors as anti-biofilm agents.","volume":"21","author":"Brackman","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"B13","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1080\/13880200601113131","article-title":"Antioxidant activity and total phenolic content of some Brazilian species.","volume":"45","author":"Brighente","year":"2007","journal-title":"Pharm. Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.9734\/jamb\/2019\/v19i430199","article-title":"Screening of in vitro antibacterial activity of Rumex vesicarius (L.) leaves extract against twelve pathogenic bacteria.","volume":"19","author":"Chaity","year":"2020","journal-title":"J. Adv. Microbiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.foodchem.2010.02.012","article-title":"Sesquiterpenoids with free-radical-scavenging properties from marine macroalga Ulva fasciata Delile.","volume":"122","author":"Chakraborty","year":"2010","journal-title":"Food Chem."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3177","DOI":"10.1080\/14786419.2022.2147930","article-title":"Phytochemical analysis of Brugmansia suaveolens Bercht. & J. Presl and its therapeutic potential for topical use.","volume":"37","author":"Costa","year":"2023","journal-title":"Nat. Prod. Res."},{"key":"B17","first-page":"111","article-title":"Antioxidant activity of Rumex vesicarius L. at the vegetative stage of growth.","volume":"5","author":"El-Bakry","year":"2012","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.fochx.2022.100306","article-title":"Evaluation of some growth parameters and chemical composition of in vitro grown seedlings of Rumex vesicarius L.(Polygonaceae).","volume":"7","author":"El-Bakry","year":"2011","journal-title":"J. Am. Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"C1195","DOI":"10.1111\/j.1750-3841.2011.02370.x","article-title":"A profile of bioactive compounds of Rumex vesicarius L.","volume":"76","author":"El-Hawary","year":"2011","journal-title":"J. Food Sci."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1515\/chem-2022-0286","article-title":"Evaluation of antibiofilm and cytotoxicity effect of Rumex vesicarius methanol extract.","volume":"21","author":"Fady","year":"2023","journal-title":"Open Chem."},{"key":"B21","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26247448","article-title":"Antioxidant, antimicrobial activities and fatty acid compositions of wild berberis spp. by different techniques combined with chemometrics (PCA and HCA).","volume":"26","author":"G\u0131d\u0131k","year":"2021","journal-title":"Molecules"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1126\/science.1159961","article-title":"An inhibitor of FtsZ with potent and selective anti-staphylococcal activity.","volume":"321","author":"Haydon","year":"2008","journal-title":"Science"},{"key":"B23","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.jfca.2009.04.001","article-title":"Antioxidant capacity and total phenolic content of Malaysian underutilized fruits.","volume":"22","author":"Ikram","year":"2009","journal-title":"J. Food Comp. Anal."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2023.104731","article-title":"Antimicrobial, antioxidant, \u03b1-amylase and \u03b1-glucosidase inhibitory activities of a chemically characterized essential oil from Lavandula angustifolia Mill.: in vitro and in silico investigations.","volume":"111","author":"Jeddi","year":"2023","journal-title":"Biochem. Syst. Ecol."},{"key":"B25","first-page":"1022","article-title":"Chemical study of fatty acids in mimusops elengiseeds by GC-MS and comparison of its antibacterial activity with trimethoprim.","volume":"4","author":"Jitendra","year":"2015","journal-title":"World J. Pharm. Res."},{"key":"B26","first-page":"30","article-title":"G.C.\u2013M.S. analysis of ethanol extract of Entada pursueth D.C. seed.","volume":"3","author":"Kalpana","year":"2012","journal-title":"Biosci. Disc."},{"key":"B27","doi-asserted-by":"publisher","first-page":"538","DOI":"10.12980\/APJTB.4.2014C1168","article-title":"Antioxidant potential of Rumex vesicarius L.: in vitro approach.","volume":"4","author":"Khan","year":"2014","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.13040\/IJPSR.0975-8232","article-title":"Antioxidant and anticancer activities of ethanolic extract of Ficus glomerata roxb. In dmba induced rats.","volume":"4","author":"Kumar","year":"2013","journal-title":"Int. J. Pharma. Sci. Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1021\/acsinfecdis.9b00055","article-title":"FtsZ as an antibacterial target: status and guidelines for progressing this avenue.","volume":"5","author":"Kusuma","year":"2019","journal-title":"ACS Infect. Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.sajb.2021.06.023","article-title":"Antibacterial and antioxidant potential of GC-MS analysis of crude ethyl acetate extract from the tropical mangrove plant Avicennia officinalis L.","volume":"142","author":"Lalitha","year":"2021","journal-title":"S. Afr. J. Bot."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2023.108266","article-title":"Progress and prospect: biosynthesis of plant natural products based on plant chassis.","volume":"69","author":"Lin","year":"2023","journal-title":"Biotech. Adv."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.70902","article-title":"Free radicals, antioxidants, and functional foods: impact on human health.","volume":"4","author":"Lobo","year":"2010","journal-title":"Pharmacogn. Rev."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1093\/emboj\/18.9.2364","article-title":"Tubulin-like protofilaments in Ca2+-induced FtsZ sheets.","volume":"18","author":"L\u00f6we","year":"1999","journal-title":"EMBO J."},{"key":"B34","first-page":"8585","article-title":"The role of systemic and non systemic fungicides on the physiological and biochemical parameters in Gossypium hirsutum plant, implications for defense responses.","volume":"27","author":"Mohamed","year":"2018","journal-title":"Fresen. Environ. Bull"},{"key":"B35","first-page":"109","article-title":"Evaluation of antibacterial and antioxidant activities of different plant parts of Rumex vesicarius L.(Polygonaceae).","volume":"3","author":"Mostafa","year":"2011","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"25","DOI":"10.37819\/biosis.001.01.0044","article-title":"Antibiofilm activity of methanol extract of Rumex dentatus against Pseudomonas aeruginosa.","volume":"1","author":"Najafabadi","year":"2020","journal-title":"Biosis. Biol. Syst."},{"key":"B37","article-title":"Thymus musilii velen. methanolic extract: in vitro and in silico screening of its antimicrobial, antioxidant, anti-quorum sensing, antibiofilm, and anticancer activities.","volume":"13","author":"Noumi","year":"2023","journal-title":"Life"},{"key":"B38","doi-asserted-by":"publisher","first-page":"4316","DOI":"10.26355\/eurrev_202305_32342","article-title":"Rationale and evidence for the adjunctive use of N-acetylcysteine in multidrug-resistant infections.","volume":"27","author":"Oliva","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B39","doi-asserted-by":"crossref","DOI":"10.1007\/978-81-322-2286-6_20","article-title":"Mineral nutrition of plants","author":"Pandey","year":"2015","journal-title":"Plant Biol BiotechPlant Diversity, Organization, Function. and Improvement"},{"key":"B40","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1080\/14786419.2013.869692","article-title":"Further in vitro evaluation of antiradical and antimicrobial activities of Phytol.","volume":"28","author":"Pejin","year":"2014","journal-title":"Nat. Prod. Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.pbi.2009.04.009","article-title":"Physiological functions of beneficial elements.","volume":"12","author":"Pilon-Smits","year":"2009","journal-title":"Curr. Opin. Plant. Biol."},{"key":"B42","doi-asserted-by":"crossref","DOI":"10.59317\/9789390083404","author":"Raaman","year":"2006","journal-title":"Phytochemical Techniques."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2022.134497","article-title":"Ecofriendly phytofabrication of silver nanoparticles using aqueous extract of Cuphea carthagenensis and their antioxidant potential and antibacterial activity against clinically significant human pathogens.","volume":"300","author":"Rather","year":"2022","journal-title":"Chemosphere"},{"key":"B44","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/jobm.202000678","article-title":"Microbial biofilm: a matter of grave concern for human health and food industry.","volume":"61","author":"Rather","year":"","journal-title":"J. Basic Microbiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1007\/s42770-021-00624-x","article-title":"Microbial biofilm: formation, architecture, antibiotic resistance, and control strategies.","volume":"52","author":"Rather","year":"","journal-title":"Braz. J. Microbiol."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2023.106433","article-title":"Attenuation of biofilm and quorum sensing regulated virulence factors of an opportunistic pathogen Pseudomonas aeruginosa by phytofabricated silver nanoparticles.","volume":"185","author":"Rather","year":"2023","journal-title":"Microb. Pathogenesis"},{"key":"B47","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.foodchem.2011.09.001","article-title":"Effects of various solvents on the extraction of antioxidant phenolics from the leaves, seeds, veins, and skins of Tamarindus indica L.","volume":"131","author":"Razali","year":"2012","journal-title":"Food Chem."},{"key":"B48","first-page":"9854","article-title":"Scrutinizing the therapeutic response of Phyllanthus exmblica\u2019s different doses to restore the immunomodulation potential in immunosuppressed female albino rats.","volume":"27","author":"Riasat","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11131946","article-title":"In antimicrobial resistance: a severe growing threat for global public health.","volume":"11","author":"Salam","year":"2023","journal-title":"Healthcare"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27103177","article-title":"Investigation and biological assessment of Rumex vesicarius L. extract: characterization of the chemical components and antioxidant, antimicrobial, cytotoxic, and anti-dengue vector activity.","volume":"27","author":"Salama","year":"2022","journal-title":"Molecules"},{"key":"B51","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/978-1-4614-0668-6_4","article-title":"Accumulation of heavy metals in selected medicinal plants.","volume":"2011","author":"Sarma","year":"2011","journal-title":"Rev. Env. Cont. Tox."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1016\/j.foodres.2010.04.032","article-title":"Antioxidant properties of polyphenol-rich cocoa products industrially processed.","volume":"43","author":"Schinella","year":"2010","journal-title":"Food Res. Int."},{"key":"B53","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s40201-022-00791-5","article-title":"Isolation and characterization of bacteria from tannery effluent treatment plant and their tolerance to heavy metals and antibiotics.","volume":"3","author":"Selvi","year":"2012","journal-title":"Asian J. Exp. Biol. Sci."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.13040\/IJPSR.0975-8232.6(3).1107-14","article-title":"Antimicrobial properties of different solvents extract of Rumex Vesicarius Linn. on some selected bacterial and fungal isolates.","volume":"6","author":"Shah","year":"2015","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"B55","doi-asserted-by":"publisher","first-page":"4319","DOI":"10.1007\/s12011-020-02523-y","article-title":"Seasonal variability of elemental composition and phytochemical analysis of Moringa oleifera leaves using energy-dispersive X-ray fluorescence and other related methods.","volume":"199","author":"Shaltout","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"B56","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.ecoenv.2017.04.042","article-title":"Heavy metals translocation and accumulation from the rhizosphere soils to the edible parts of the medicinal plant Fengdan (Paeonia ostii) grown in a metal mining area in China.","volume":"143","author":"Shen","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13010064","article-title":"Chemical composition of Ducrosia flabellifolia L. methanolic extract and volatile oil: ADME properties, in vitro and in silico screening of antimicrobial, antioxidant and anticancer activities.","volume":"13","author":"Snoussi","year":"2023","journal-title":"Metabolites"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3390\/plants12061354","article-title":"Unveiling chemical, antioxidant, and antibacterial properties of Fagonia indica Grown in the hail mountains, Saudi Arabia.","volume":"12","author":"Sulieman","year":"","journal-title":"Plants"},{"key":"B59","first-page":"84","article-title":"Assessment of antimicrobial and antioxidant activity of methanolic extract from Arnebia decumbens aerial parts growing wild in Aja Mountain.","volume":"10","author":"Sulieman","year":"","journal-title":"Adv. Life Sci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41598-023-47687-4","article-title":"Characterization and antibacterial activity against Helicobacter pylori of lactic acid bacteria isolated from Thai fermented rice noodles.","volume":"11","author":"Techo","year":"2019","journal-title":"Probio. Antimicro. Prot."},{"key":"B61","first-page":"587","article-title":"Study on medicinal uses of persicaria and rumex species of Polygonaceae family.","volume":"6","author":"Tonny","year":"2017","journal-title":"J. Pharma. Phytochem."},{"key":"B62","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3923\/ajdd.2013.72.83","article-title":"Evaluation of antibacterial and antioxidant activities of different methanol extracts of Rumex vesicarius L.","volume":"3","author":"Tukappa","year":"2013","journal-title":"Am. J. Drug Discov. Dev."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.2015.0382","article-title":"Quantitative spectrometry: an overview.","volume":"374","author":"Urban","year":"2016","journal-title":"Philos. Trans. Math. Phys. Eng. Sci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s11030-022-10416-6","article-title":"Synthesis, carbonic anhydrase inhibition, anticancer activity, and molecular docking studies of 1, 3, 4-oxadiazole derivatives.","volume":"27","author":"Vanjare","year":"2023","journal-title":"Mol. Divers."},{"key":"B65","doi-asserted-by":"publisher","first-page":"25605","DOI":"10.1021\/acsomega.0c02483","article-title":"Inhibition of quorum sensing and biofilm formation in Chromobacterium violaceum by fruit extracts of Passiflora edulis.","volume":"5","author":"Venkatramanan","year":"2020","journal-title":"ACS. Omega"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fevo.2023.1145928","article-title":"Does higher demand for medicinal plants lead to more harvest? Evidence from the dual trade of Nardostachy jatamansi and Fritillaria cirrhosa and Tibetan people\u2019s harvesting behavior.","volume":"11","author":"Zhao","year":"2023","journal-title":"Front. Ecol. Evol."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8195784","article-title":"Determination of total flavonoid contents and antioxidant activity of Ginkgo biloba leaf by near-infrared reflectance method.","volume":"2018","author":"Zhao","year":"2018","journal-title":"Int. J. Analyt. Chem."},{"key":"B68","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.carbpol.2012.05.073","article-title":"Enhancement of amygdalin activated with \u03b2-D-glucosidase on HepG2 cell proliferation and apoptosis.","volume":"90","author":"Zhou","year":"2012","journal-title":"Carbohydr. Polym."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2024.1421143\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T04:52:50Z","timestamp":1722228770000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2024.1421143\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,29]]},"references-count":68,"alternative-id":["10.3389\/fmicb.2024.1421143"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2024.1421143","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,29]]},"article-number":"1421143"}}