{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:12:49Z","timestamp":1792631569243,"version":"4.5.0"},"reference-count":183,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>The review aimed to investigate the diversity of oral microbiota and its influencing factors, as well as the association of oral microbiota with oral health and the possible effects of dysbiosis and oral disorder. The oral cavity harbors a substantial microbial burden, which is particularly notable compared to other organs within the human body. In usual situations, the microbiota exists in a state of equilibrium; however, when this balance is disturbed, a multitude of complications arise. Dental caries, a prevalent issue in the oral cavity, is primarily caused by the colonization and activity of bacteria, particularly streptococci. Furthermore, this environment also houses other pathogenic bacteria that are associated with the onset of gingival, periapical, and periodontal diseases, as well as oral cancer. Various strategies have been employed to prevent, control, and treat these disorders. Recently, techniques utilizing microbiota, like probiotics, microbiota transplantation, and the replacement of oral pathogens, have caught the eye. This extensive examination seeks to offer a general view of the oral microbiota and their metabolites concerning oral health and disease, and also the resilience of the microbiota, and the techniques used for the prevention, control, and treatment of disorders in this specific area.<\/jats:p>","DOI":"10.3389\/fmicb.2024.1431785","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:50:14Z","timestamp":1724115014000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":66,"title":["Oral microbiota and metabolites: key players in oral health and disorder, and microbiota-based therapies"],"prefix":"10.3389","volume":"15","author":[{"given":"Narjess","family":"Bostanghadiri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mobina","family":"Kouhzad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elahe","family":"Taki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Elahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Khoshbayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahereh","family":"Navidifar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davood","family":"Darban-Sarokhalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/MRM.0000000000000295","article-title":"A review on antiviral efficacy of Bifidobacterium species","volume":"33","author":"Abdi","year":"2022","journal-title":"Rev. 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Spectr."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1038\/ismej.2012.174","article-title":"The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation","volume":"7","author":"Abusleme","year":"2013","journal-title":"ISME J."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/prd.12362","article-title":"Microbial signatures of health, gingivitis, and periodontitis","volume":"86","author":"Abusleme","year":"2021","journal-title":"Periodontology"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40168-015-0108-3","article-title":"Microbiota of the indoor environment: a meta-analysis","volume":"3","author":"Adams","year":"2015","journal-title":"Microbiome"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"208","DOI":"10.15171\/joddd.2017.037","article-title":"The prophylactic effect of Acetobacter syzygii probiotic species against squamous cell carcinoma","volume":"11","author":"Aghazadeh","year":"2017","journal-title":"J. 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Periodontics Restorative Dent."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"196","DOI":"10.4161\/21505594.2014.983783","article-title":"Non-conventional therapeutics for oral infections","volume":"6","author":"Allaker","year":"2015","journal-title":"Virulence"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"880961","DOI":"10.3389\/fimmu.2022.880961","article-title":"Upregulating human cathelicidin antimicrobial peptide LL-37 expression May prevent severe COVID-19 inflammatory responses and reduce microthrombosis","volume":"13","author":"Aloul","year":"2022","journal-title":"Front. Immunol."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.jpeds.2014.09.041","article-title":"Intestinal microbiota development in preterm neonates and effect of perinatal antibiotics","volume":"166","author":"Arboleya","year":"2015","journal-title":"J. Pediatr."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.chom.2012.10.012","article-title":"Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications","volume":"12","author":"B\u00e4ckhed","year":"2012","journal-title":"Cell Host Microbe"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"112514","DOI":"10.1016\/j.fct.2021.112514","article-title":"Deoxynivalenol exposure induces liver damage in mice: inflammation and immune responses, oxidative stress, and protective effects of Lactobacillus rhamnosus GG","volume":"156","author":"Bai","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"3323","DOI":"10.3389\/fmicb.2018.03323","article-title":"Exploiting the Oral microbiome to prevent tooth decay: has evolution already provided the best tools?","volume":"9","author":"Baker","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"fuab039","DOI":"10.1093\/femsre\/fuab039","article-title":"Metabolites of the oral microbiome: important mediators of multikingdom interactions","volume":"46","author":"Barbour","year":"2022","journal-title":"FEMS Microbiol. Rev."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/prd.12314","article-title":"Advances in precision oral health","volume":"82","author":"Beck","year":"2020","journal-title":"Periodontol."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"320","DOI":"10.3390\/biom14030320","article-title":"LL-37: structures, antimicrobial activity, and influence on amyloid-related diseases","volume":"14","author":"Bhattacharjya","year":"2024","journal-title":"Biomol. Ther."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"551","DOI":"10.5177\/ntvt.2020.10.19094","article-title":"The importance of saliva to oral health; from haddock to histatin","volume":"127","author":"Bikker","year":"2020","journal-title":"Ned. Tijdschr. Tandheelkd."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.3390\/nu12082252","article-title":"Insight into the possible use of the predator Bdellovibrio bacteriovorus as a probiotic","volume":"12","author":"Bonfiglio","year":"2020","journal-title":"Nutrients"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.archoralbio.2011.10.006","article-title":"Isolation and characterization of probiotic strains for improving oral health","volume":"57","author":"Bosch","year":"2012","journal-title":"Arch. Oral Biol."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"625229","DOI":"10.3389\/fcimb.2021.625229","article-title":"Dysbiosis of the human Oral microbiome during the menstrual cycle and vulnerability to the external exposures of smoking and dietary sugar","volume":"11","author":"Bostanci","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1302719","DOI":"10.3389\/fmicb.2023.1302719","article-title":"Exploring the interplay between Fusobacterium nucleatum with the expression of microRNA, and inflammatory mediators in colorectal cancer","volume":"14","author":"Bostanghadiri","year":"2023","journal-title":"Front. Microbiol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.tim.2017.09.008","article-title":"Oral biofilms: pathogens, matrix, and polymicrobial interactions in microenvironments","volume":"26","author":"Bowen","year":"2018","journal-title":"Trends Microbiol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nrmicro1098","article-title":"Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?","volume":"3","author":"Brogden","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"103497","DOI":"10.1016\/j.jdent.2020.103497","article-title":"Current uses of chlorhexidine for management of oral disease: a narrative review","volume":"103","author":"Brookes","year":"2020","journal-title":"J. Dent."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.anifeedsci.2011.12.014","article-title":"Mycotoxin contamination of the feed supply chain: implications for animal productivity and feed security","volume":"173","author":"Bryden","year":"2012","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1016\/j.actbio.2009.11.003","article-title":"Adhesion of Candida albicans to various dental implant surfaces and the influence of salivary pellicle proteins","volume":"6","author":"B\u00fcrgers","year":"2010","journal-title":"Acta Biomater."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"16265","DOI":"10.1021\/jacs.0c05546","article-title":"Discovery and biosynthesis of Streptosactin, a Sactipeptide with an alternative topology encoded by commensal Bacteria in the human microbiome","volume":"142","author":"Bushin","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1159\/000016541","article-title":"In vitro adhesion to enamel and in vivo colonization of tooth surfaces by lactobacilli from a bio-yoghurt","volume":"33","author":"Busscher","year":"1999","journal-title":"Caries Res."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1080\/00016350600801709","article-title":"Salivary mutans streptococci and lactobacilli levels after ingestion of the probiotic bacterium Lactobacillus reuteri ATCC 55730 by straws or tablets","volume":"64","author":"Caglar","year":"2006","journal-title":"Acta Odontol. Scand."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1080\/00016350510020070","article-title":"Effect of yogurt with Bifidobacterium DN-173 010 on salivary mutans streptococci and lactobacilli in young adults","volume":"63","author":"Caglar","year":"2005","journal-title":"Acta Odontol. 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Treat."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s00784-010-0423-9","article-title":"Probiotic Lactobacillus paracasei effect on cariogenic bacterial flora","volume":"15","author":"Chuang","year":"2011","journal-title":"Clin. Oral Investig."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s10266-019-00413-x","article-title":"Modulation of the oral microbiome by the host to promote ecological balance","volume":"107","author":"Cornejo Ulloa","year":"2019","journal-title":"Odontology"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"38993","DOI":"10.1038\/srep38993","article-title":"Comparative metagenomics reveals taxonomically idiosyncratic yet functionally congruent communities in periodontitis","volume":"6","author":"Dabdoub","year":"2016","journal-title":"Sci. Rep."},{"key":"ref38","first-page":"i","article-title":"Possible use of essential oils in dentistry","volume":"6","author":"Dagli","year":"2014","journal-title":"J. Int. Oral Health"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1034\/j.1600-0714.2001.300601.x","article-title":"Defensin antimicrobial peptides in the oral cavity","volume":"30","author":"Dale","year":"2001","journal-title":"J. Oral Pathol. Med."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1186\/1472-6831-6-S1-S13","article-title":"Oral antimicrobial peptides and biological control of caries","volume":"6","author":"Dale","year":"2006","journal-title":"BMC Oral Health"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"104606","DOI":"10.1016\/j.archoralbio.2019.104606","article-title":"Presence of Archaea in dental caries biofilms","volume":"110","author":"Dame-Teixeira","year":"2020","journal-title":"Arch. Oral Biol."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.archoralbio.2012.12.011","article-title":"An evolutionary perspective of mammal salivary peptide families: cystatins, histatins, statherin and PRPs","volume":"58","author":"De Sousa-Pereira","year":"2013","journal-title":"Arch. Oral Biol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.dental.2018.11.016","article-title":"Physical properties and cytotoxicity of antimicrobial dental resin adhesives containing dimethacrylate oligomers of ciprofloxacin and metronidazole","volume":"35","author":"Delaviz","year":"2019","journal-title":"Dent. Mater."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1021\/pr700764j","article-title":"The proteomes of human parotid and submandibular\/sublingual gland salivas collected as the ductal secretions","volume":"7","author":"Denny","year":"2008","journal-title":"J. Proteome Res."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"122","DOI":"10.4103\/jomfp.JOMFP_304_18","article-title":"Oral microbiome: unveiling the fundamentals","volume":"23","author":"Deo","year":"2019","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"5002","DOI":"10.1128\/JB.00542-10","article-title":"The human oral microbiome","volume":"192","author":"Dewhirst","year":"2010","journal-title":"J. Bacteriol."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"511","DOI":"10.3109\/14767058.2013.820698","article-title":"Azurocidin levels in maternal serum in the first trimester can predict preterm prelabor rupture of membranes","volume":"27","author":"Dhaifalah","year":"2014","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1111\/odi.13688","article-title":"Oral manifestations and the role of the oral healthcare workers in COVID-19","volume":"28","author":"Di Spirito","year":"2022","journal-title":"Oral Dis."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.3390\/nu10091196","article-title":"Chemical composition and biological activities of essential oils of Curcuma species","volume":"10","author":"Dosoky","year":"2018","journal-title":"Nutrients"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1080\/21691401.2020.1822855","article-title":"Efficiency of Bacillus subtilis metabolism of sugar alcohols governs its probiotic effect against cariogenic Streptococcus mutans","volume":"48","author":"Duanis-Assaf","year":"2020","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/prd.12350","article-title":"Metatranscriptomic analyses of the oral microbiome","volume":"85","author":"Duran-Pinedo","year":"2021","journal-title":"Periodontology"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"194","DOI":"10.5114\/ceji.2015.51358","article-title":"Archaea prevalence in inflamed pulp tissues","volume":"40","author":"Efenberger","year":"2015","journal-title":"Cent. Eur. J. Immunol."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"3659432","DOI":"10.1155\/2019\/3659432","article-title":"Extraction of essential oils of Rosmarinus officinalis L. by two different methods: Hydrodistillation and microwave assisted Hydrodistillation","volume":"2019","author":"Elyemni","year":"2019","journal-title":"ScientificWorldJournal"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1159\/000529162","article-title":"The role of oral nitrate-reducing bacteria in the prevention of caries: a review related to caries and nitrate metabolism","volume":"57","author":"Feng","year":"2023","journal-title":"Caries Res."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.fitote.2009.04.006","article-title":"Anti-cariogenic effects of polyphenols from plant stimulant beverages (cocoa, coffee, tea)","volume":"80","author":"Ferrazzano","year":"2009","journal-title":"Fitoterapia"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/689492","article-title":"The central role of the gut microbiota in chronic inflammatory diseases","volume":"2014","author":"Ferreira","year":"2014","journal-title":"J Immunol Res"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"E2930","DOI":"10.1073\/pnas.1423854112","article-title":"Identifying personal microbiomes using metagenomic codes","volume":"112","author":"Franzosa","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"e12189","DOI":"10.1111\/jicd.12189","article-title":"Significant increase of oral bacteria in the early pregnancy period in Japanese women","volume":"8","author":"Fujiwara","year":"2017","journal-title":"J. Investig. Clin. Dent."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"3532","DOI":"10.3390\/ma8063532","article-title":"The use of quaternary ammonium to combat dental caries","volume":"8","author":"Ge","year":"2015","journal-title":"Materials (Basel)"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3389\/fimmu.2017.00353","article-title":"Antimicrobial and attractant roles for chemerin in the oral cavity during inflammatory gum disease","volume":"8","author":"Godlewska","year":"2017","journal-title":"Front. Immunol."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"43481","DOI":"10.1038\/srep43481","article-title":"Antibiotic treatment at delivery shapes the initial oral microbiome in neonates","volume":"7","author":"Gomez-Arango","year":"2017","journal-title":"Sci. Rep."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1080\/02713680590968637","article-title":"A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs","volume":"30","author":"Gordon","year":"2005","journal-title":"Curr. Eye Res."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/j.1600-0757.2009.00310.x","article-title":"Antimicrobial peptides of the oral cavity","volume":"51","author":"Gorr","year":"2009","journal-title":"Periodontol."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1159\/000329673","article-title":"Antimicrobial peptides in periodontal innate defense","volume":"15","author":"Gorr","year":"2012","journal-title":"Front. Oral Biol."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1159\/000494146","article-title":"The human salivary antimicrobial peptide profile according to the oral microbiota in health, periodontitis and smoking","volume":"11","author":"Grant","year":"2019","journal-title":"J. Innate Immun."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3389\/fcimb.2015.00099","article-title":"Salivary antimicrobial peptides in early detection of periodontitis","volume":"5","author":"G\u00fcnc\u00fc","year":"2015","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3389\/fmicb.2018.00107","article-title":"Beneficial Oral biofilms as smart bioactive interfaces","volume":"9","author":"Gutt","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.3390\/jcm9082484","article-title":"The role of oral microbiota in intra-oral halitosis","volume":"9","author":"Hampelska","year":"2020","journal-title":"J. Clin. Med."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.archoralbio.2017.04.001","article-title":"The mucosal pellicle\u2013an underestimated factor in oral physiology","volume":"80","author":"Hannig","year":"2017","journal-title":"Arch. Oral Biol."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"585","DOI":"10.2174\/138920309789630589","article-title":"Anionic antimicrobial peptides from eukaryotic organisms","volume":"10","author":"Harris","year":"2009","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/s41579-021-00569-w","article-title":"The microbiome-shaping roles of bacteriocins","volume":"19","author":"Heilbronner","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s40168-022-01262-7","article-title":"The oral microbiome, pancreatic cancer and human diversity in the age of precision medicine","volume":"10","author":"Herremans","year":"2022","journal-title":"Microbiome"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"4633","DOI":"10.1128\/IAI.66.10.4633-4639.1998","article-title":"Binding properties of Streptococcus gordonii SspA and SspB (antigen I\/II family) polypeptides expressed on the cell surface of Lactococcus lactis MG1363","volume":"66","author":"Holmes","year":"1998","journal-title":"Infect. Immun."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"104389","DOI":"10.1016\/j.jdent.2022.104389","article-title":"Proteomic profile of in situ acquired pellicle on tooth and restorative material surfaces","volume":"129","author":"Hu","year":"2023","journal-title":"J. Dent."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1128\/AEM.03887-15","article-title":"A highly Arginolytic Streptococcus species that potently antagonizes Streptococcus mutans","volume":"82","author":"Huang","year":"2016","journal-title":"Appl. Environ. Microbiol."},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.3390\/ph16091313","article-title":"The benefits of probiotics on Oral health: Systematic Review of the Literature","volume":"16","author":"Inchingolo","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/0-306-48382-3_38","article-title":"Antimicrobial activity of synthetic human CAP18 peptides to Streptococcus sanguis isolated from patients with Beh\u00e7et's disease","volume":"528","author":"Isogai","year":"2003","journal-title":"Adv. Exp. Med. 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Soc."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"658203","DOI":"10.3389\/fcimb.2021.658203","article-title":"Association between oral microbiota and cigarette smoking in the Chinese population","volume":"11","author":"Jia","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"e0124631","DOI":"10.1371\/journal.pone.0124631","article-title":"The impact of various time intervals on the supragingival plaque dynamic core microbiome","volume":"10","author":"Jiang","year":"2015","journal-title":"PLoS One"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3389\/fimmu.2020.00282","article-title":"Crosstalk between gut microbiota and innate immunity and its implication in autoimmune diseases","volume":"11","author":"Jiao","year":"2020","journal-title":"Front. 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Biol."},{"key":"ref173","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1186\/1471-2180-9-259","article-title":"Defining the healthy \"core microbiome\" of oral microbial communities","volume":"9","author":"Zaura","year":"2009","journal-title":"BMC Microbiol."},{"key":"ref174","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3390\/dj10100184","article-title":"Oral microbiome and dental caries development","volume":"10","author":"Zhang","year":"2022","journal-title":"Dent. J."},{"key":"ref175","doi-asserted-by":"publisher","first-page":"806463","DOI":"10.3389\/fcimb.2022.806463","article-title":"Probiotic species in the Management of Periodontal Diseases: an overview","volume":"12","author":"Zhang","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref176","doi-asserted-by":"publisher","first-page":"476","DOI":"10.3389\/fcimb.2019.00476","article-title":"The oral microbiota may have influence on oral cancer","volume":"9","author":"Zhang","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref177","doi-asserted-by":"publisher","first-page":"774","DOI":"10.3389\/fmicb.2020.00774","article-title":"Inhibition of Streptococcus mutans biofilm formation and virulence by Lactobacillus plantarum K41 isolated from traditional Sichuan pickles","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref178","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.3390\/metabo13101040","article-title":"The role of indoor microbiome and metabolites in shaping Children\u2019s nasal and Oral microbiota: a pilot multi-Omic analysis","volume":"13","author":"Zhang","year":"2023","journal-title":"Meta"},{"key":"ref179","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1158\/1940-6207.CAPR-12-0427","article-title":"Lactobacillus salivarius REN inhibits rat oral cancer induced by 4-nitroquioline 1-oxide","volume":"6","author":"Zhang","year":"2013","journal-title":"Cancer Prev. Res. (Phila.)"},{"key":"ref180","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.biopha.2018.01.146","article-title":"Human oral microbiota and its modulation for oral health","volume":"99","author":"Zhang","year":"2018","journal-title":"Biomed. 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