{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:26:39Z","timestamp":1778876799007,"version":"3.51.4"},"reference-count":99,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>The infection of the central nervous system (CNS) with neurotropic viruses induces neuroinflammation and an immune response, which is associated with the development of neuroinflammatory and neurodegenerative diseases, including multiple sclerosis (MS). The activation of both innate and adaptive immune responses, involving microglia, macrophages, and T and B cells, while required for efficient viral control within the CNS, is also associated with neuropathology. Under pathological events, such as CNS viral infection, microglia\/macrophage undergo a reactive response, leading to the infiltration of immune cells from the periphery into the brain, disrupting CNS homeostasis and contributing to the pathogenesis of disease. The Theiler\u2019s murine encephalomyelitis virus (TMEV)-induced demyelination disease (TMEV-IDD), which serves as a mouse model of MS. This murine model made significant contributions to our understanding of the pathophysiology of MS following subsequent to infection. Microglia\/macrophages could be activated into two different states, classic activated state (M1 state) and alternative activated state (M2 state) during TMEV infection. M1 possesses the capacity to initiate inflammatory response and secretes pro-inflammatory cytokines, and M2-liked microglia\/macrophages are anti-inflammatory characterized by the secretion of anti-inflammatory cytokines. This review aims to discuss the roles of microglia\/macrophages M1\/M2-liked polarization during TMEV infection, and explore the potential therapeutic effect of balancing M1\/M2-liked polarization of microglia\/macrophages on MS.<\/jats:p>","DOI":"10.3389\/fmicb.2024.1452390","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T04:38:07Z","timestamp":1722573487000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Contribution of microglia\/macrophage to the pathogenesis of TMEV infection in the central nervous system"],"prefix":"10.3389","volume":"15","author":[{"given":"Qianye","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxiao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13070925","article-title":"Pharmacological inhibition of STAT3 by Stattic ameliorates clinical symptoms and reduces autoinflammation in myeloid, lymphoid, and neuronal tissue compartments in relapsing-remitting model of experimental autoimmune encephalomyelitis in SJL\/J mice","volume":"13","author":"Alhazzani","year":"2021","journal-title":"Pharmaceutics"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1002\/glia.1106","article-title":"Immune function of microglia","volume":"36","author":"Aloisi","year":"2001","journal-title":"Glia"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1186\/s12974-020-02043-5","article-title":"Reactivity and increased proliferation of NG2 cells following central nervous system infection with Theiler's murine encephalomyelitis virus","volume":"17","author":"Bell","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1002\/glia.20935","article-title":"Characterization of relapsing-remitting and chronic forms of experimental autoimmune encephalomyelitis in C57BL\/6 mice","volume":"58","author":"Berard","year":"2010","journal-title":"Glia"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s13073-021-00925-8","article-title":"Prediction of combination therapies based on topological modeling of the immune signaling network in multiple sclerosis","volume":"13","author":"Bernardo-Faura","year":"2021","journal-title":"Genome Med."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/s1074-7613(01)00154-6","article-title":"Interferons alpha and beta as immune regulators--a new look","volume":"14","author":"Biron","year":"2001","journal-title":"Immunity"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.3389\/fphar.2018.01368","article-title":"IFN-\u03b2 plays both pro- and anti-inflammatory roles in the rat cardiac fibroblast through differential STAT protein activation","volume":"9","author":"Bol\u00edvar","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"4822","DOI":"10.1111\/febs.15428","article-title":"Neuroimmune interaction in seizures and epilepsy: focusing on monocyte infiltration","volume":"287","author":"Bosco","year":"2020","journal-title":"FEBS J."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"12194","DOI":"10.1038\/s41598-017-12477-2","article-title":"Host genetic background influences diverse neurological responses to viral infection in mice","volume":"7","author":"Brinkmeyer-Langford","year":"2017","journal-title":"Sci. Rep."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.2353\/ajpath.2007.061016","article-title":"p150\/95 (CD11c\/CD18) expression is required for the development of experimental autoimmune encephalomyelitis","volume":"170","author":"Bullard","year":"2007","journal-title":"Am. J. Pathol."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1172\/jci26836","article-title":"Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis","volume":"116","author":"Butovsky","year":"","journal-title":"J. Clin. Invest."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.mcn.2005.10.006","article-title":"Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem\/progenitor cells","volume":"31","author":"Butovsky","year":"","journal-title":"Mol. Cell. Neurosci."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.bbadis.2010.07.008","article-title":"The role of antigen presenting cells in multiple sclerosis","volume":"1812","author":"Chastain","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/0042-6822(90)90249-q","article-title":"Monocytes\/macrophages isolated from the mouse central nervous system contain infectious Theiler's murine encephalomyelitis virus (TMEV)","volume":"176","author":"Clatch","year":"1990","journal-title":"Virology"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.neuint.2014.01.008","article-title":"Ventral tegmental area\/substantia nigra and prefrontal cortex rodent organotypic brain slices as an integrated model to study the cellular changes induced by oxygen\/glucose deprivation and reperfusion: effect of neuroprotective agents","volume":"66","author":"Colombo","year":"2014","journal-title":"Neurochem. Int."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1111\/j.1476-5381.2011.01302.x","article-title":"Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)","volume":"164","author":"Constantinescu","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1084\/jem.96.6.517","article-title":"Observations on encephalomyelitis of mice (DA strain)","volume":"96","author":"Daniels","year":"1952","journal-title":"J. Exp. Med."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e334","DOI":"10.1136\/amiajnl-2013-001999","article-title":"Automated extraction of clinical traits of multiple sclerosis in electronic medical records","volume":"20","author":"Davis","year":"2013","journal-title":"J. Am. Med. Inform. Assoc."},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/v16010119","article-title":"The contribution of microglia and brain-infiltrating macrophages to the pathogenesis of neuroinflammatory and neurodegenerative diseases during TMEV infection of the central nervous system","volume":"16","author":"DePaula-Silva","year":"2024","journal-title":"Viruses"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1177\/15357597211040939","article-title":"Inflammation unleashed in viral-induced Epileptogenesis","volume":"21","author":"DePaula-Silva","year":"2021","journal-title":"Epilepsy Curr."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s12974-019-1545-x","article-title":"Differential transcriptional profiles identify microglial- and macrophage-specific gene markers expressed during virus-induced neuroinflammation","volume":"16","author":"DePaula-Silva","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jneuroim.2017.02.012","article-title":"Theiler's murine encephalomyelitis virus infection of SJL\/J and C57BL\/6J mice: models for multiple sclerosis and epilepsy","volume":"308","author":"DePaula-Silva","year":"2017","journal-title":"J. Neuroimmunol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"13632","DOI":"10.1073\/pnas.2234031100","article-title":"Inflammation is detrimental for neurogenesis in adult brain","volume":"100","author":"Ekdahl","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1038\/s41573-019-0035-2","article-title":"Progressive multiple sclerosis: from pathophysiology to therapeutic strategies","volume":"18","author":"Faissner","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071836","article-title":"The influence of virus infection on microglia and accelerated brain aging","volume":"10","author":"Filgueira","year":"2021","journal-title":"Cells"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1093\/brain\/awp070","article-title":"The relation between inflammation and neurodegeneration in multiple sclerosis brains","volume":"132","author":"Frischer","year":"2009","journal-title":"Brain"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/s12974-016-0686-4","article-title":"Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis","volume":"13","author":"Gentile","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020448","article-title":"Facets of Theiler's murine encephalomyelitis virus-induced diseases: an update","volume":"20","author":"Gerhauser","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jneuroim.2012.07.018","article-title":"Theiler's murine encephalomyelitis virus induced phenotype switch of microglia in vitro","volume":"252","author":"Gerhauser","year":"2012","journal-title":"J. Neuroimmunol."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s13365-015-0369-4","article-title":"The immune response in the CNS in Theiler's virus induced demyelinating disease switches from an early adaptive response to a chronic innate-like response","volume":"22","author":"Gilli","year":"2016","journal-title":"J. Neurovirol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1126\/science.1194637","article-title":"Fate mapping analysis reveals that adult microglia derive from primitive macrophages","volume":"330","author":"Ginhoux","year":"2010","journal-title":"Science"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1099\/0022-1317-83-5-1087","article-title":"Restriction of poliovirus RNA replication in persistently infected nerve cells","volume":"83","author":"Girard","year":"2002","journal-title":"J. Gen. Virol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"726421","DOI":"10.3389\/fimmu.2021.726421","article-title":"Microglia and perivascular macrophages act as antigen presenting cells to promote CD8 T cell infiltration of the brain","volume":"12","author":"Goddery","year":"2021","journal-title":"Front. Immunol."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"815347","DOI":"10.3389\/fnagi.2022.815347","article-title":"Microglia polarization from M1 to M2 in neurodegenerative diseases","volume":"14","author":"Guo","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20071702","article-title":"Delayed astrogliosis associated with reduced M1 microglia activation in matrix metalloproteinase 12 knockout mice during Theiler's murine encephalomyelitis","volume":"20","author":"Hansmann","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1111\/bpa.12238","article-title":"Dynamic changes of microglia\/macrophage M1 and M2 polarization in Theiler's murine encephalomyelitis","volume":"25","author":"Herder","year":"2015","journal-title":"Brain Pathol."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1111\/j.1365-2990.2012.01256.x","article-title":"Impact of Theiler's virus infection on hippocampal neuronal progenitor cells: differential effects in two mouse strains","volume":"38","author":"Jafari","year":"2012","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"7213","DOI":"10.1128\/jvi.72.9.7213-7220.1998","article-title":"The neurovirulence of the DA and GDVII strains of Theiler's virus correlates with their ability to infect cultured neurons","volume":"72","author":"Jarousse","year":"1998","journal-title":"J. Virol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1099\/0022-1317-80-7-1701","article-title":"Restricted Theiler's murine encephalomyelitis virus infection in murine macrophages induces apoptosis","volume":"80","author":"Jelachich","year":"1999","journal-title":"J. Gen. Virol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e0109122","DOI":"10.1128\/spectrum.01091-22","article-title":"SARS-CoV-2 infection of microglia elicits Proinflammatory activation and apoptotic cell death","volume":"10","author":"Jeong","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"104607","DOI":"10.1016\/j.isci.2022.104607","article-title":"LncNSPL facilitates influenza a viral immune escape by restricting TRIM25-mediated K63-linked RIG-I ubiquitination","volume":"25","author":"Jiang","year":"2022","journal-title":"iScience"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12974-022-02408-y","article-title":"Central nervous system macrophages in progressive multiple sclerosis: relationship to neurodegeneration and therapeutics","volume":"19","author":"Kamma","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.expneurol.2009.07.010","article-title":"Inhibition of CXCR2 signaling promotes recovery in models of multiple sclerosis","volume":"220","author":"Kerstetter","year":"2009","journal-title":"Exp. Neurol."},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22105254","article-title":"Excessive innate immunity steers pathogenic adaptive immunity in the development of Theiler's virus-induced demyelinating disease","volume":"22","author":"Kim","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"e0176406","DOI":"10.1371\/journal.pone.0176406","article-title":"Prostaglandin E2 produced following infection with Theiler's virus promotes the pathogenesis of demyelinating disease","volume":"12","author":"Kim","year":"2017","journal-title":"PLoS One"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"01","DOI":"10.1385\/ir:31:1:01","article-title":"Innate immune response induced by Theiler's murine encephalomyelitis virus infection","volume":"31","author":"Kim","year":"2005","journal-title":"Immunol. Res."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1159\/000336563","article-title":"Periventricular demyelination and axonal pathology is associated with subependymal virus spread in a murine model for multiple sclerosis","volume":"55","author":"Kummerfeld","year":"2012","journal-title":"Intervirology"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1021\/tx900086v","article-title":"Macrophages and inflammatory mediators in chemical toxicity: a battle of forces","volume":"22","author":"Laskin","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1111\/j.1528-1167.2008.01535.x","article-title":"Seizures following picornavirus infection","volume":"49","author":"Libbey","year":"2008","journal-title":"Epilepsia"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1128\/iai.11.5.1147-1155.1975","article-title":"Theiler's virus infection in mice: an unusual biphasic disease process leading to demyelination","volume":"11","author":"Lipton","year":"1975","journal-title":"Infect. Immun."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1128\/jvi.69.4.2525-2533.1995","article-title":"The predominant virus antigen burden is present in macrophages in Theiler's murine encephalomyelitis virus-induced demyelinating disease","volume":"69","author":"Lipton","year":"1995","journal-title":"J. Virol."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/0165-5728(95)00110-n","article-title":"Release of myelin basic protein-degrading proteolytic activity from microglia and macrophages after infection with Theiler's murine encephalomyelitis virus: comparison between susceptible and resistant mice","volume":"62","author":"Liuzzi","year":"1995","journal-title":"J. Neuroimmunol."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"661935","DOI":"10.3389\/fcell.2021.661935","article-title":"Exosomes secreted by microglia during virus infection in the central nervous system activate an inflammatory response in bystander cells","volume":"9","author":"Luong","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref54","article-title":"Gender differences in multiple sclerosis epidemiology and treatment response","volume":"63","author":"Magyari","year":"2016","journal-title":"Dan. Med. J."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"6093","DOI":"10.1128\/jvi.73.7.6093-6098.1999","article-title":"The GDVII strain of Theiler's virus spreads via axonal transport","volume":"73","author":"Martinat","year":"1999","journal-title":"J. Virol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1084\/jem.182.1.75","article-title":"Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis","volume":"182","author":"McRae","year":"1995","journal-title":"J. Exp. Med."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.bbi.2018.12.013","article-title":"The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia","volume":"77","author":"Mecha","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1002\/eji.1830250723","article-title":"A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V beta expression of encephalitogenic T cells","volume":"25","author":"Mendel","year":"1995","journal-title":"Eur. J. Immunol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"172973","DOI":"10.1016\/j.ejphar.2020.172973","article-title":"Targeting Keap1\/Nrf2\/ARE signaling pathway in multiple sclerosis","volume":"873","author":"Michali\u010dkov\u00e1","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"636","DOI":"10.3389\/fimmu.2015.00636","article-title":"B cells in the multiple sclerosis central nervous system: trafficking and contribution to CNS-compartmentalized inflammation","volume":"6","author":"Michel","year":"2015","journal-title":"Front. Immunol."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1177\/1352458510379243","article-title":"Altered M1\/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration","volume":"17","author":"Mikita","year":"2011","journal-title":"Mult. Scler."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1038\/nn.3469","article-title":"M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination","volume":"16","author":"Miron","year":"2013","journal-title":"Nat. Neurosci."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.1528-1167.2008.01751.x","article-title":"Viral encephalitis and epilepsy","volume":"49","author":"Misra","year":"2008","journal-title":"Epilepsia"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.jaut.2010.06.007","article-title":"The use of mouse models to better understand mechanisms of autoimmunity and tolerance","volume":"35","author":"Miyagawa","year":"2010","journal-title":"J. Autoimmun."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1126\/science.1088417","article-title":"Inflammatory blockade restores adult hippocampal neurogenesis","volume":"302","author":"Monje","year":"2003","journal-title":"Science"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41419-023-05551-3","article-title":"Microglia and meningeal macrophages depletion delays the onset of experimental autoimmune encephalomyelitis","volume":"14","author":"Montilla","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abb1817","article-title":"T cell engagement of cross-presenting microglia protects the brain from a nasal virus infection","volume":"5","author":"Moseman","year":"2020","journal-title":"Sci Immunol"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s13365-014-0262-6","article-title":"Effect of the innate immune response on development of Theiler's murine encephalomyelitis virus-induced demyelinating disease","volume":"20","author":"Olson","year":"2014","journal-title":"J. Neurovirol."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"9780","DOI":"10.1128\/jvi.75.20.9780-9789.2001","article-title":"Direct activation of innate and antigen-presenting functions of microglia following infection with Theiler's virus","volume":"75","author":"Olson","year":"2001","journal-title":"J. Virol."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"3916","DOI":"10.4049\/jimmunol.173.6.3916","article-title":"Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs","volume":"173","author":"Olson","year":"2004","journal-title":"J. Immunol."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"5712","DOI":"10.4049\/jimmunol.0801940","article-title":"The innate immune response affects the development of the autoimmune response in Theiler's virus-induced demyelinating disease","volume":"182","author":"Olson","year":"2009","journal-title":"J. Immunol."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"21709","DOI":"10.1038\/srep21709","article-title":"Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury","volume":"6","author":"O\u00f1ate","year":"2016","journal-title":"Sci. Rep."},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020907","article-title":"Cellular and molecular targets for non-invasive, non-pharmacological therapeutic\/rehabilitative interventions in acute ischemic stroke","volume":"23","author":"Onose","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s00401-016-1605-6","article-title":"Mesenchymal stem cells enhance \u03b1-synuclein clearance via M2 microglia polarization in experimental and human parkinsonian disorder","volume":"132","author":"Park","year":"2016","journal-title":"Acta Neuropathol."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"e1002541","DOI":"10.1371\/journal.ppat.1002541","article-title":"Nonequivalence of classical MHC class I loci in ability to direct effective antiviral immunity","volume":"8","author":"Pavelko","year":"2012","journal-title":"PLoS Pathog."},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1019799","DOI":"10.3389\/fnmol.2022.1019799","article-title":"Theiler's virus-induced demyelinating disease as an infectious model of progressive multiple sclerosis","volume":"15","author":"Pike","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"ref77","doi-asserted-by":"publisher","first-page":"654284","DOI":"10.3389\/fncel.2021.654284","article-title":"Connecting neuroinflammation and neurodegeneration in multiple sclerosis: are oligodendrocyte precursor cells a Nexus of disease?","volume":"15","author":"Psenicka","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"2058738420974900","DOI":"10.1177\/2058738420974900","article-title":"Candesartan modulates microglia activation and polarization via NF-\u03baB signaling pathway","volume":"34","author":"Qie","year":"2020","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref79","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s11064-019-02922-1","article-title":"Dexmedetomidine inhibits Neuroinflammation by altering microglial M1\/M2 polarization through MAPK\/ERK pathway","volume":"45","author":"Qiu","year":"2020","journal-title":"Neurochem. Res."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/ana.410130409","article-title":"Persistent infection of oligodendrocytes in Theiler's virus-induced encephalomyelitis","volume":"13","author":"Rodriguez","year":"1983","journal-title":"Ann. Neurol."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"7286","DOI":"10.1128\/jvi.69.11.7286-7290.1995","article-title":"Gamma interferon is critical for resistance to Theiler's virus-induced demyelination","volume":"69","author":"Rodriguez","year":"1995","journal-title":"J. Virol."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3121\/cmr.1.1.57","article-title":"Multiple sclerosis: it's not the disease you thought it was","volume":"1","author":"Rolak","year":"2003","journal-title":"Clin. Med. Res."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"3336","DOI":"10.1128\/jvi.71.4.3336-3340.1997","article-title":"Role of macrophages during Theiler's virus infection","volume":"71","author":"Rossi","year":"1997","journal-title":"J. Virol."},{"key":"ref84","doi-asserted-by":"publisher","first-page":"10496","DOI":"10.1038\/s41598-017-10980-0","article-title":"T-bet, but not Gata3, overexpression is detrimental in a neurotropic viral infection","volume":"7","author":"Sato","year":"2017","journal-title":"Sci. Rep."},{"key":"ref85","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.pathophys.2010.04.011","article-title":"Theiler's virus infection: pathophysiology of demyelination and neurodegeneration","volume":"18","author":"Sato","year":"2011","journal-title":"Pathophysiology"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.3389\/fimmu.2017.01905","article-title":"Neuroinflammation: microglia and T cells get ready to tango","volume":"8","author":"Schetters","year":"2017","journal-title":"Front. Immunol."},{"key":"ref87","doi-asserted-by":"publisher","first-page":"18886","DOI":"10.1021\/acsnano.2c07798","article-title":"Neutrophil Nanovesicle protects against experimental autoimmune encephalomyelitis through enhancing myelin clearance by microglia","volume":"16","author":"Shen","year":"2022","journal-title":"ACS Nano"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"7420","DOI":"10.1128\/jvi.75.16.7420-7428.2001","article-title":"High numbers of viral RNA copies in the central nervous system of mice during persistent infection with Theiler's virus","volume":"75","author":"Trottier","year":"2001","journal-title":"J. Virol."},{"key":"ref89","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s00281-002-0105-z","article-title":"Inside-out versus outside-in models for virus induced demyelination: axonal damage triggering demyelination","volume":"24","author":"Tsunoda","year":"2002","journal-title":"Springer Semin. Immunopathol."},{"key":"ref90","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s11481-009-9179-x","article-title":"Neuropathogenesis of Theiler's murine encephalomyelitis virus infection, an animal model for multiple sclerosis","volume":"5","author":"Tsunoda","year":"2010","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref91","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1097\/01.jnen.0000229990.32795.0d","article-title":"MMP-12, MMP-3, and TIMP-1 are markedly upregulated in chronic demyelinating theiler murine encephalomyelitis","volume":"65","author":"Ulrich","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158077","article-title":"The mTOR signaling pathway in multiple sclerosis; from animal models to human data","volume":"23","author":"Vakrakou","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"ref93","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1177\/1352458520970841","article-title":"Rising prevalence of multiple sclerosis worldwide: insights from the atlas of MS","volume":"26","author":"Walton","year":"2020","journal-title":"Mult. Scler."},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010120","article-title":"GDF3 protects mice against Sepsis-induced cardiac dysfunction and mortality by suppression of macrophage pro-inflammatory phenotype","volume":"9","author":"Wang","year":"2020","journal-title":"Cells"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"101","DOI":"10.4049\/jimmunol.146.1.101","article-title":"Lymphocytes from SJL\/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating experimental autoimmune encephalomyelitis","volume":"146","author":"Whitham","year":"1991","journal-title":"J. Immunol."},{"key":"ref96","doi-asserted-by":"publisher","first-page":"8729398","DOI":"10.1155\/2022\/8729398","article-title":"Activation of LRP1 ameliorates cerebral ischemia\/reperfusion injury and cognitive decline by suppressing Neuroinflammation and oxidative stress through TXNIP\/NLRP3 signaling pathway in mice","volume":"2022","author":"Yang","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref97","doi-asserted-by":"publisher","first-page":"2358","DOI":"10.1182\/blood-2011-08-374207","article-title":"Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2\/protein kinase a signaling","volume":"119","author":"Zaslona","year":"2012","journal-title":"Blood"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1111\/cns.13948","article-title":"NG2-glia crosstalk with microglia in health and disease","volume":"28","author":"Zhang","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"ref99","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.jconrel.2022.12.026","article-title":"Resveratrol-loaded macrophage exosomes alleviate multiple sclerosis through targeting microglia","volume":"353","author":"Zheng","year":"2023","journal-title":"J. Control. 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