{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T16:53:55Z","timestamp":1775840035517,"version":"3.50.1"},"reference-count":164,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>Leptospirosis is a significant zoonosis worldwide, with disease severity ranging from a mild non-specific illness to multi-organ dysfunction and hemorrhage. The disease is caused by pathogenic bacteria of the genus <jats:italic>Leptospira<\/jats:italic>, which are classified into pathogenic and saprophytic clades. Bacterial binding to host molecules and cells, coordinated by adhesin proteins, is an important step in pathogenesis. While many leptospiral adhesins have been identified, the vast majority have not been characterized <jats:italic>in vivo<\/jats:italic>. Herein, we present an overview of the current methodologies and successes in identifying adhesins in <jats:italic>Leptospira<\/jats:italic>, including known biological roles <jats:italic>in vivo<\/jats:italic>. We will also identify and discuss potential areas for future research.<\/jats:p>","DOI":"10.3389\/fmicb.2024.1458655","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T20:55:38Z","timestamp":1723755338000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Leptospiral adhesins: from identification to future perspectives"],"prefix":"10.3389","volume":"15","author":[{"given":"Matthew C.","family":"Surdel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenifer","family":"Coburn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"ref1","volume-title":"Leptospira and leptospirosis","author":"Adler","year":"2014"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.vetmic.2009.03.012","article-title":"Leptospira and leptospirosis","volume":"140","author":"Adler","year":"2010","journal-title":"Vet. 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