{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:53:47Z","timestamp":1788357227201,"version":"build-2803163510"},"reference-count":261,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>Since December 2019, coronavirus disease 2019 (COVID-19) has been spreading worldwide with devastating immediate or long-term effects on people\u2019s health. Although the lungs are the primary organ affected by COVID-19, individuals infected with SARS-CoV-2 also develop systemic lesions involving multiple organs throughout the body, such as the cardiovascular system. Emerging evidence reveals that COVID-19 could generate myocardial fibrosis, termed \u201cCOVID-19-associated myocardial fibrosis.\u201d It can result from the activation of fibroblasts via the renin-angiotensin-aldosterone system (RAAS), transforming growth factor-\u03b21 (TGF-\u03b21), microRNAs, and other pathways, and can also occur in other cellular interactions with SARS-CoV-2, such as immunocytes, endothelial cells. Nonetheless, to gain a more profound insight into the natural progression of COVID-19-related myocardial fibrosis, additional investigations are necessary. This review delves into the underlying mechanisms contributing to COVID-19-associated myocardial fibrosis while also examining the antifibrotic potential of current COVID-19 treatments, thereby offering guidance for future clinical trials of these medications. Ultimately, we propose future research directions for COVID-19-associated myocardial fibrosis in the post-COVID-19 era, such as artificial intelligence (AI) telemedicine. We also recommend that relevant tests be added to the follow-up of COVID-19 patients to detect myocardial fibrosis promptly.<\/jats:p>","DOI":"10.3389\/fmicb.2024.1470953","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T04:40:50Z","timestamp":1728362450000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Possible mechanisms of SARS-CoV-2-associated myocardial fibrosis: reflections in the post-pandemic era"],"prefix":"10.3389","volume":"15","author":[{"given":"Zhan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengrui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengpeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"bvac 017","DOI":"10.1210\/jendso\/bvac017","article-title":"A randomized Trial of Sitagliptin and spironolactone with combination therapy in hospitalized adults with COVID-19","volume":"6","author":"Abbasi","year":"2022","journal-title":"J. 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Pathol."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1089\/ars.2015.6498","article-title":"Angiotensin-(1-7) improves liver fibrosis by regulating the NLRP3 Inflammasome via redox balance modulation","volume":"24","author":"Cai","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/iub.1967","article-title":"Angiotensin II confers resistance to apoptosis in cardiac myofibroblasts through the AT1\/ERK1\/2\/RSK1 pathway","volume":"71","author":"Cai","year":"2019","journal-title":"IUBMB Life"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1038\/s41401-023-01119-1","article-title":"Phenome-wide association study and precision medicine of cardiovascular diseases in the post-COVID-19 era","volume":"44","author":"Cao","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"101756","DOI":"10.1016\/j.molmet.2023.101756","article-title":"The SARS-CoV-2 spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice","volume":"74","author":"Cao","year":"2023","journal-title":"Mol. Metab."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"3502","DOI":"10.3748\/wjg.v27.i24.3502","article-title":"COVID-19 and its effects on the digestive system","volume":"27","author":"Cao","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/imr.12619","article-title":"Interleukin-33 (IL-33): a nuclear cytokine from the IL-1 family","volume":"281","author":"Cayrol","year":"2018","journal-title":"Immunol. Rev."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"104472","DOI":"10.1016\/j.ebiom.2023.104472","article-title":"Early peripheral blood MCEMP1 and HLA-DRA expression predicts COVID-19 prognosis","volume":"89","author":"Chan","year":"2023","journal-title":"EBioMedicine"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s12933-016-0430-5","article-title":"Telmisartan improves cardiac fibrosis in diabetes through peroxisome proliferator activated receptor delta (PPARdelta): from bedside to bench","volume":"15","author":"Chang","year":"2016","journal-title":"Cardiovasc. Diabetol."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"701745","DOI":"10.3389\/fcvm.2021.701745","article-title":"Glycolysis inhibition alleviates cardiac fibrosis after myocardial infarction by suppressing cardiac fibroblast activation","volume":"8","author":"Chen","year":"2021","journal-title":"Front. Cardiovasc. 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Neuroinflammation"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"94634","DOI":"10.21203\/rs.3.rs-94634\/v1","article-title":"SARS-CoV-2 infected cardiomyocytes recruit monocytes by secreting CCL2","volume":"17","author":"Chen","year":"2020","journal-title":"Res. Sq."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e64909","DOI":"10.7554\/eLife.64909","article-title":"Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation","volume":"10","author":"Chioh","year":"2021","journal-title":"eLife"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1093\/cvr\/cvy013","article-title":"IL-6 trans-signalling contributes to aldosterone-induced cardiac fibrosis","volume":"114","author":"Chou","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1161\/CIRCRESAHA.121.317997","article-title":"COVID-19 and cardiovascular disease: from bench to bedside","volume":"128","author":"Chung","year":"2021","journal-title":"Circ. Res."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1097\/HJH.0b013e3283232838","article-title":"Effects of antihypertensive treatment on ultrasound measures of myocardial fibrosis in hypertensive patients with left ventricular hypertrophy: results of a randomized trial comparing the angiotensin receptor antagonist, candesartan and the angiotensin-converting enzyme inhibitor, enalapril","volume":"27","author":"Ciulla","year":"2009","journal-title":"J. Hypertens."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.cmet.2020.07.007","article-title":"Elevated glucose levels favor SARS-CoV-2 infection and monocyte response through a HIF-1alpha\/glycolysis-dependent Axis","volume":"32","author":"Codo","year":"2020","journal-title":"Cell Metab."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1146\/annurev-med-042921-100438","article-title":"Primary Aldosteronism and the role of mineralocorticoid receptor antagonists for the heart and kidneys","volume":"74","author":"Cohen","year":"2023","journal-title":"Annu. Rev. 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Immunol."},{"key":"ref207","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/j.cell.2020.08.002","article-title":"Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19","volume":"182","author":"Silvin","year":"2020","journal-title":"Cell"},{"key":"ref208","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.celrep.2017.12.072","article-title":"Single-cell transcriptional profiling reveals cellular diversity and intercommunication in the mouse heart","volume":"22","author":"Skelly","year":"2018","journal-title":"Cell Rep."},{"key":"ref209","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1161\/CIRCRESAHA.109.201400","article-title":"Origin of cardiac fibroblasts and the role of periostin","volume":"105","author":"Snider","year":"2009","journal-title":"Circ. 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Med."},{"key":"ref216","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.tibs.2004.03.008","article-title":"New insights into TGF-beta-Smad signalling","volume":"29","author":"Ten Dijke","year":"2004","journal-title":"Trends Biochem. Sci."},{"key":"ref217","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1038\/nature07511","article-title":"Micro RNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts","volume":"456","author":"Thum","year":"2008","journal-title":"Nature"},{"key":"ref218","doi-asserted-by":"publisher","first-page":"102306","DOI":"10.1016\/j.ceca.2020.102306","article-title":"ANO1 regulates cardiac fibrosis via ATI-mediated MAPK pathway","volume":"92","author":"Tian","year":"2020","journal-title":"Cell Calcium"},{"key":"ref219","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1093\/ajh\/5.6.406","article-title":"Angiotensin II receptor subtypes","volume":"5","author":"Timmermans","year":"1992","journal-title":"Am. J. 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Res."},{"key":"ref222","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.1002\/ehf2.12887","article-title":"Modulation of the acute defence reaction by eplerenone prevents cardiac disease progression in viral myocarditis","volume":"7","author":"Tschope","year":"2020","journal-title":"ESC Heart Fail."},{"key":"ref223","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1172\/JCI29919","article-title":"Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites","volume":"117","author":"Tsou","year":"2007","journal-title":"J. Clin. Invest."},{"key":"ref224","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1002\/ehf2.14228","article-title":"Fulminant myocarditis with COVID-19 infection having normal C-reactive protein and serial magnetic resonance follow-up","volume":"10","author":"Usui","year":"2023","journal-title":"ESC Heart Fail."},{"key":"ref225","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s13578-019-0362-3","article-title":"TGF-beta in fibrosis by acting as a conductor for contractile properties of myofibroblasts","volume":"9","author":"Vallee","year":"2019","journal-title":"Cell Biosci."},{"key":"ref226","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.yjmcc.2015.11.025","article-title":"Mechanical control of cardiac myofibroblasts","volume":"93","author":"Van Putten","year":"2016","journal-title":"J. Mol. Cell. 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Ethnopharmacol."},{"key":"ref235","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1161\/hh0901.089987","article-title":"Role of NADPH oxidase in the vascular hypertrophic and oxidative stress response to angiotensin II in mice","volume":"88","author":"Wang","year":"2001","journal-title":"Circ. Res."},{"key":"ref236","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.ebiom.2018.08.022","article-title":"TRPA1 inhibition ameliorates pressure overload-induced cardiac hypertrophy and fibrosis in mice","volume":"36","author":"Wang","year":"2018","journal-title":"EBioMedicine"},{"key":"ref237","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/2138387","article-title":"Clinical features of COVID-19 patients with different outcomes in Wuhan: a retrospective observational study","volume":"2020","author":"Wang","year":"2020","journal-title":"Biomed. Res. 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Renin-Angiotensin-Aldosterone Syst."},{"key":"ref242","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1186\/s13054-020-03015-0","article-title":"Elevation of plasma angiotensin II level is a potential pathogenesis for the critically ill COVID-19 patients","volume":"24","author":"Wu","year":"2020","journal-title":"Crit. Care"},{"key":"ref243","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.21037\/apm-21-972","article-title":"The divergent protective effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on clinical outcomes of coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis","volume":"11","author":"Xie","year":"2022","journal-title":"Ann. Palliat. Med."},{"key":"ref244","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.cmi.2020.09.023","article-title":"Clinical sequelae of COVID-19 survivors in Wuhan, China: a single-Centre longitudinal study","volume":"27","author":"Xiong","year":"2021","journal-title":"Clin. Microbiol. Infect."},{"key":"ref245","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1038\/aps.2017.184","article-title":"SND p 102 promotes extracellular matrix accumulation and cell proliferation in rat glomerular mesangial cells via the AT1R\/ERK\/Smad 3 pathway","volume":"39","author":"Xu","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"ref246","doi-asserted-by":"publisher","first-page":"626510","DOI":"10.3389\/fphar.2021.626510","article-title":"Remdesivir inhibits Tubulointerstitial fibrosis in obstructed kidneys","volume":"12","author":"Xu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref247","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.1016\/j.stemcr.2021.07.012","article-title":"Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2","volume":"16","author":"Yang","year":"2021","journal-title":"Stem Cell Rep."},{"key":"ref248","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1080\/22221751.2022.2059405","article-title":"Clinical efficacy and safety of interleukin-6 receptor antagonists (tocilizumab and sarilumab) in patients with COVID-19: a systematic review and meta-analysis","volume":"11","author":"Yu","year":"2022","journal-title":"Emerg. Microbes Infect."},{"key":"ref249","doi-asserted-by":"publisher","first-page":"2738","DOI":"10.3390\/molecules17032738","article-title":"Inhibitory effects of enalaprilat on rat cardiac fibroblast proliferation via ROS\/P38MAPK\/TGF-\u03b21 signaling pathway","volume":"17","author":"Yu","year":"2012","journal-title":"Molecules"},{"key":"ref250","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat. Med."},{"key":"ref251","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.2217\/bmm-2020-0410","article-title":"Serum-soluble ST2 as a novel biomarker reflecting inflammatory status and illness severity in patients with COVID-19","volume":"14","author":"Zeng","year":"2020","journal-title":"Biomark. Med"},{"key":"ref252","doi-asserted-by":"publisher","first-page":"a022129","DOI":"10.1101\/cshperspect.a022129","article-title":"Non-Smad signaling pathways of the TGF-beta family","volume":"9","author":"Zhang","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref253","doi-asserted-by":"publisher","first-page":"643149","DOI":"10.3389\/fimmu.2021.643149","article-title":"Inflammasomes and fibrosis","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"key":"ref254","doi-asserted-by":"publisher","first-page":"e0305927","DOI":"10.1371\/journal.pone.0305927","article-title":"Remdesivir alleviates skin fibrosis by suppressing TGF-beta 1 signaling pathway","volume":"19","author":"Zhang","year":"2024","journal-title":"PLoS One"},{"key":"ref255","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.2174\/1568026623666230829164156","article-title":"Natural products: a potential new Hope to defeat post-acute sequelae of COVID-19","volume":"23","author":"Zhao","year":"2023","journal-title":"Curr. Top. Med. Chem."},{"key":"ref256","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/s41569-020-0360-5","article-title":"COVID-19 and the cardiovascular system","volume":"17","author":"Zheng","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"ref257","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.2147\/DDDT.S100095","article-title":"Spirolactone provides protection from renal fibrosis by inhibiting the endothelial-mesenchymal transition in isoprenaline-induced heart failure in rats","volume":"10","author":"Zhou","year":"2016","journal-title":"Drug Des. Devel. Ther."},{"key":"ref258","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"ref259","doi-asserted-by":"publisher","first-page":"e75557","DOI":"10.1371\/journal.pone.0075557","article-title":"Smad 3 inactivation and MiR-29b upregulation mediate the effect of carvedilol on attenuating the acute myocardium infarction-induced myocardial fibrosis in rat","volume":"8","author":"Zhu","year":"2013","journal-title":"PLoS One"},{"key":"ref260","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1038\/s42003-022-03986-6","article-title":"SARS-CoV-2 Nsp 6 damages Drosophila heart and mouse cardiomyocytes through MGA\/MAX complex-mediated increased glycolysis","volume":"5","author":"Zhu","year":"2022","journal-title":"Commun. Biol."},{"key":"ref261","article-title":"ACE2\/ADAM17\/TMPRSS2 interplay may be the Main risk factor for COVID-19","author":"Zipeto","year":"2020","journal-title":"Front. 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