{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:13:46Z","timestamp":1777929226539,"version":"3.51.4"},"reference-count":112,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700496"],"award-info":[{"award-number":["81700496"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Inflammatory bowel diseases (IBD) are chronic inflammation conditions affecting the gastrointestinal tract. Studies point out an association between <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) infection and IBD. This study aims to visually assess the research trends and hotspots in the field of <jats:italic>H. pylori<\/jats:italic> infection and IBD, review mainstream perspectives in this field, and provide a foundation for future research and treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the Web of Science Core Collection Database for literature related to <jats:italic>H. pylori<\/jats:italic> and IBD, using VOS viewer to generate visual charts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 246 publications were included, with articles being the predominant type of document. A significant increase in the number of publications was observed after 2011. China contributed the most of researches. Keyword clusters revealed that the researches primarily focused on immune mechanism, gut microbiome, diagnosis and treatment of IBD. Time trend results indicated that current researches centered on gut microbiota and immune mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>H. pylori<\/jats:italic> infection may have a protective effect on IBD. The exact mechanisms remain unclear and may involve immunomodulation and changes of gut microbiota. Further researches are necessary for better understanding this relationship and its implications for clinical practice. Further researches and clinical practice should pay attention to this topic.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmicb.2024.1479941","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T06:12:07Z","timestamp":1730873527000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Debate on the relationship between Helicobacter pylori infection and inflammatory bowel disease: a bibliometric analysis"],"prefix":"10.3389","volume":"15","author":[{"given":"Ziye","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotian","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yahan","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/s41575-022-00658-y","article-title":"The metabolic nature of inflammatory bowel diseases","volume":"19","author":"Adolph","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/nrgastro.2017.136","article-title":"Environmental triggers in IBD: a review of progress and evidence","volume":"15","author":"Ananthakrishnan","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1159\/000525925","article-title":"Alteration of the gut microbiome in inflammatory bowel disease","volume":"104","author":"Andoh","year":"2023","journal-title":"Digestion"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1159\/000445985","article-title":"Helicobacter pylori: does gastritis prevent colitis?","volume":"1","author":"Arnold","year":"2016","journal-title":"Inflamm. Intest. Dis."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1111\/bph.13428","article-title":"ROS in gastrointestinal inflammation: rescue or sabotage?","volume":"174","author":"Aviello","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1097\/CM9.0000000000002008","article-title":"Helicobacter pylori may participate in the development of inflammatory bowel disease by modulating the intestinal microbiota","volume":"135","author":"Bai","year":"2022","journal-title":"Chin. Med. J."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"4604","DOI":"10.3748\/wjg.v29.i30.4604","article-title":"Immune response modulation in inflammatory bowel diseases by Helicobacter pylori infection","volume":"29","author":"Balani","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.16720","article-title":"Antibiotic use and risk of Clostridioides difficile infection in patients with inflammatory bowel disease","author":"Bejcek","year":"2024","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1089\/ars.2012.4530","article-title":"Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets","volume":"19","author":"Biasi","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3390\/antibiotics13030267","article-title":"Helicobacter pylori in inflammatory bowel diseases: active protagonist or innocent bystander?","volume":"13","author":"Bretto","year":"2024","journal-title":"Antibiotics"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/s41577-019-0268-7","article-title":"Host-microbiota interactions in inflammatory bowel disease","volume":"20","author":"Caruso","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1136\/gutjnl-2015-310545","article-title":"Dual role of Helicobacter and Campylobacter species in IBD: a systematic review and meta-analysis","volume":"66","author":"Casta\u00f1o-Rodr\u00edguez","year":"2017","journal-title":"Gut"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1056\/NEJMra2002697","article-title":"Pathophysiology of inflammatory bowel diseases","volume":"383","author":"Chang","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0126-x","article-title":"Mechanisms regulating intestinal barrier integrity and its pathological implications","volume":"50","author":"Chelakkot","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"107012","DOI":"10.1016\/j.intimp.2020.107012","article-title":"Serum exosomes derived from Hp-positive gastritis patients inhibit MCP-1 and MIP-1\u03b1 expression via NLRP12-notch signaling pathway in intestinal epithelial cells and improve DSS-induced colitis in mice","volume":"88","author":"Chen","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"111228","DOI":"10.1016\/j.foodres.2022.111228","article-title":"Probiotics and dairy products in dentistry: a bibliometric and critical review of randomized clinical trials","volume":"151","author":"da Cruz","year":"2022","journal-title":"Food Res. Int."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1388940","DOI":"10.3389\/fmed.2024.1388940","article-title":"Case report and review of literature: IgG4-gastroduodenitis in upper GI Crohn\u2019s disease: two separate entities or just a marker of disease severity?","volume":"11","author":"Desmedt","year":"2024","journal-title":"Front. Med."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1186\/s12887-024-04902-z","article-title":"Helicobacter pylori infection in children with inflammatory bowel disease: a prospective multicenter study","volume":"24","author":"Dilaghi","year":"2024","journal-title":"BMC Pediatr."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.jcmgh.2021.03.002","article-title":"Neutrophil extracellular traps in inflammatory bowel disease: pathogenic mechanisms and clinical translation","volume":"12","author":"Drury","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s15010-023-02115-7","article-title":"Helicobacter pylori and oral-gut microbiome: clinical implications","volume":"52","author":"Elghannam","year":"2024","journal-title":"Infection"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1097\/MIB.0000000000000318","article-title":"Helicobacter pylori-specific protection against inflammatory bowel disease requires the NLRP3 inflammasome and IL-18","volume":"21","author":"Engler","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1136\/gutjnl-2022-327845","article-title":"Antibiotic use as a risk factor for inflammatory bowel disease across the ages: a population-based cohort study","volume":"72","author":"Faye","year":"2023","journal-title":"Gut"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1159\/000443014","article-title":"Practical considerations and the intestinal microbiome in disease: antibiotics for IBD therapy","volume":"34","author":"Fedorak","year":"2016","journal-title":"Dig. Dis."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"e6226","DOI":"10.7759\/cureus.6226","article-title":"Helicobacter pylori is associated with less fistulizing, stricturing, and active colitis in Crohn\u2019s disease patients","volume":"11","author":"Fialho","year":"2019","journal-title":"Cureus"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"8040","DOI":"10.3748\/wjg.v27.i47.8040","article-title":"Progress in elucidating the relationship between Helicobacter pylori infection and intestinal diseases","volume":"27","author":"Fujimori","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jaci.2019.11.003","article-title":"The microbiome and inflammatory bowel disease","volume":"145","author":"Glassner","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s41586-020-2025-2","article-title":"Pathway paradigms revealed from the genetics of inflammatory bowel disease","volume":"578","author":"Graham","year":"2020","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"818902","DOI":"10.3389\/fnut.2021.818902","article-title":"Gut microbiota is a potential biomarker in inflammatory bowel disease.","volume":"8","author":"Guo","year":"2022","journal-title":"Front. Nutr."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"3817","DOI":"10.3390\/ijms24043817","article-title":"Inflammatory bowel diseases and gut microbiota","volume":"24","author":"Haneishi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"e100362","DOI":"10.1371\/journal.pone.0100362","article-title":"Helicobacter pylori induced gastric immunopathology is associated with distinct microbiota changes in the large intestines of long-term infected Mongolian gerbils","volume":"9","author":"Heimesaat","year":"2014","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.3748\/wjg.v20.i5.1192","article-title":"Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years?","volume":"20","author":"Hold","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1002\/jpn3.12314","article-title":"Updated joint ESPGHAN\/NASPGHAN guidelines for management of Helicobacter pylori infection in children and adolescents (2023)","volume":"79","author":"Homan","year":"2024","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"e0020624","DOI":"10.1128\/msystems.00206-24","article-title":"Dual RNA sequencing of Helicobacter pylori and host cell transcriptomes reveals ontologically distinct host-pathogen interaction","volume":"9","author":"Hu","year":"2024","journal-title":"mSystems"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"70","DOI":"10.5114\/ceji.2024.136376","article-title":"Immunological relationship between Helicobacter pylori and anti-tumor necrosis factor \u03b1 agents in inflammatory bowel disease","volume":"49","author":"Huang","year":"2024","journal-title":"Cent. Eur. J. Immunol."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1111\/j.1463-1318.2009.02164.x","article-title":"A meta-analysis of randomized controlled trials comparing antibacterial therapy with placebo in Crohn\u2019s disease","volume":"13","author":"Huang","year":"2011","journal-title":"Colorectal Dis."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1136\/gutjnl-2016-312297","article-title":"Antibiotics as deep modulators of gut microbiota: between good and evil","volume":"65","author":"Ianiro","year":"2016","journal-title":"Gut"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"485","DOI":"10.20524\/aog.2020.0507","article-title":"The relationship between inflammatory bowel disease and Helicobacter pylori across East Asian, European and Mediterranean countries: a meta-analysis","volume":"33","author":"Imawana","year":"2020","journal-title":"Ann. Gastroenterol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"13139","DOI":"10.3748\/wjg.v20.i36.13139","article-title":"Identification of pathologic features associated with \u201culcerative colitis-like\u201d Crohn\u2019s disease","volume":"20","author":"James","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref39","first-page":"137","article-title":"Clinical onset of the Crohn\u2019s disease after eradication therapy of Helicobacter pylori infection. Does Helicobacter pylori infection interact with natural history of inflammatory bowel diseases?","volume":"7","author":"Jovanovic","year":"2001","journal-title":"Med. Sci. Monit."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e37345","DOI":"10.7759\/cureus.37345","article-title":"Trends and complication rates in ulcerative colitis patients with and without Helicobacter pylori infections","volume":"15","author":"Kahlam","year":"2023","journal-title":"Cureus"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1038\/nrgastro.2015.150","article-title":"The global burden of IBD: from 2015 to 2025","volume":"12","author":"Kaplan","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41575-020-00360-x","article-title":"The four epidemiological stages in the global evolution of inflammatory bowel disease","volume":"18","author":"Kaplan","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"81","DOI":"10.23750\/abm.v89i9-S.7878","article-title":"Inverse association between Helicobacter pylori and inflammatory bowel disease: myth or fact?","volume":"89","author":"Kayali","year":"2018","journal-title":"Acta Biomed."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/ajg.2011.72","article-title":"Antibiotic therapy in inflammatory bowel disease: a systematic review and meta-analysis","volume":"106","author":"Khan","year":"2011","journal-title":"Am. J. Gastroenterol."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"2650","DOI":"10.1002\/eji.201243281","article-title":"The Cag pathogenicity island and interaction between TLR2\/NOD2 and NLRP3 regulate IL-1\u03b2 production in Helicobacter pylori infected dendritic cells","volume":"43","author":"Kim","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"e34882","DOI":"10.1097\/MD.0000000000034882","article-title":"The association between Helicobacter pylori infection and inflammatory bowel disease in children: a systematic review with meta-analysis","volume":"102","author":"Kong","year":"2023","journal-title":"Medicine"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1093\/jpids\/pis053","article-title":"Variation in antibiotic use for children hospitalized with inflammatory bowel disease exacerbation: a multicenter validation study","volume":"1","author":"Kronman","year":"2012","journal-title":"J. Pediatric Infect. Dis. Soc."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/S2468-1253(23)00070-5","article-title":"Global prevalence of Helicobacter pylori infection between 1980 and 2022: a systematic review and meta-analysis","volume":"8","author":"Li","year":"2023","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1065608","DOI":"10.3389\/fmicb.2022.1065608","article-title":"New insights into bacterial mechanisms and potential intestinal epithelial cell therapeutic targets of inflammatory bowel disease","volume":"13","author":"Liang","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e0355423","DOI":"10.1128\/spectrum.03554-23","article-title":"Clinical characteristics of ulcerative colitis patients with different types of Helicobacter pylori infection","volume":"12","author":"Liu","year":"2024","journal-title":"Microbiol. Spectr."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"dmm044040","DOI":"10.1242\/dmm.044040","article-title":"Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease","volume":"13","author":"Lloyd","year":"2020","journal-title":"Dis. Model. Mech."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/j.bpg.2014.10.004","article-title":"The gastrointestinal microbiome\u2014functional interference between stomach and intestine","volume":"28","author":"Lopetuso","year":"2014","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/jgh.14872","article-title":"The epidemiology of inflammatory bowel disease: east meets west","volume":"35","author":"Mak","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41572-023-00431-8","article-title":"Helicobacter pylori infection","volume":"9","author":"Malfertheiner","year":"2023","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref55","article-title":"The relationship of oral tetracycline use and isotretinoin therapy to the development of IBD within genetically predisposed individuals. [dissertation\/master\u2019s thesis]","author":"Maloy","year":"2012"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1111\/j.1523-5378.2008.00607.x","article-title":"Detection of enterohepatic and gastric Helicobacter species in fecal specimens of children with Crohn\u2019s disease","volume":"13","author":"Man","year":"2008","journal-title":"Helicobacter"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.3390\/microorganisms11112616","article-title":"Gut bacterial community determines the therapeutic effect of ginsenoside on canine inflammatory bowel disease by modulating the colonic mucosal barrier","volume":"11","author":"Mao","year":"2023","journal-title":"Microorganisms"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.dld.2007.11.021","article-title":"Interleukin-13 mucosal production in Helicobacter pylori-related gastric diseases","volume":"40","author":"Marotti","year":"2008","journal-title":"Dig. Liver Dis."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1007\/s005350170015","article-title":"Prevalence of Helicobacter pylori infection and correlation between severity of upper gastrointestinal lesions and H. pylori infection in Japanese patients with Crohn\u2019s disease","volume":"36","author":"Matsumura","year":"2001","journal-title":"J. Gastroenterol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1056\/NEJMcp1001110","article-title":"Clinical practice. Helicobacter pylori infection","volume":"362","author":"McColl","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"612","DOI":"10.3389\/fimmu.2014.00612","article-title":"Spatial, temporal, and functional aspects of macrophages during \u201cthe good, the bad, and the ugly\u201d phases of inflammation","volume":"5","author":"Mills","year":"2014","journal-title":"Front. Immunol."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"692","DOI":"10.3748\/wjg.v29.i4.692","article-title":"Disease trends after Helicobacter pylori eradication based on Japanese nationwide claims and the health check-up database","volume":"29","author":"Mizukami","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review","volume":"142","author":"Molodecky","year":"2012","journal-title":"Gastroenterology"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1097\/01.mog.0000231808.10773.8e","article-title":"New mediators of immunity and inflammation in inflammatory bowel disease","volume":"22","author":"Monteleone","year":"2006","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/1040841X.2024.2339260","article-title":"Periodontitis increases the risk of gastrointestinal dysfunction: an update on the plausible pathogenic molecuar mechanisms","author":"Mukherjee","year":"2024","journal-title":"Crit. Rev. Microbiol."},{"key":"ref66","first-page":"349","article-title":"Does Helicobacter pylori eradication therapy trigger or protect against Crohn\u2019s disease?","volume":"79","author":"Murad","year":"2016","journal-title":"Acta Gastro-Enterol. Belg."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.semcancer.2019.05.001","article-title":"Risk of colorectal cancer in inflammatory bowel diseases","volume":"64","author":"Nadeem","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.tips.2019.04.006","article-title":"Deciphering the chemical lexicon of host-gut microbiota interactions","volume":"40","author":"Nicolas","year":"2019","journal-title":"Trends Pharmacol. Sci."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"6374","DOI":"10.3748\/wjg.v20.i21.6374","article-title":"Helicobacter pylori infection and inflammatory bowel disease: is there a link?","volume":"20","author":"Papamichael","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1307575","DOI":"10.3389\/fimmu.2023.1307575","article-title":"Transcriptional inhibition of STAT1 functions in the nucleus alleviates Th1 and Th17 cell-mediated inflammatory diseases","volume":"14","author":"Park","year":"2023","journal-title":"Front. Immunol."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"e12741","DOI":"10.1111\/hel.12741","article-title":"Review: extragastric diseases and Helicobacter pylori","volume":"25","author":"Pellicano","year":"2020","journal-title":"Helicobacter"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1053\/j.gastro.2019.04.016","article-title":"Environmental risk factors for inflammatory bowel diseases: an umbrella review of meta-analyses","volume":"157","author":"Piovani","year":"2019","journal-title":"Gastroenterology"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"E5","DOI":"10.1093\/ibd\/izac248","article-title":"Helicobacter pylori and inflammatory bowel disease: an unresolved enigma","volume":"29","author":"Pokrotnieks","year":"2023","journal-title":"Inflamm. Bowel Dis."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"4053","DOI":"10.3748\/wjg.v28.i30.4053","article-title":"Gut microbiota, inflammatory bowel disease and colorectal cancer","volume":"28","author":"Quaglio","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"17562848231177610","DOI":"10.1177\/17562848231177610","article-title":"Helicobacter pylori in children: think before you kill the bug!","volume":"16","author":"Ravikumara","year":"2023","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref76","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1111\/jgh.15751","article-title":"Prevalence of Helicobacter pylori infection in China: a systematic review and meta-analysis","volume":"37","author":"Ren","year":"2022","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref77","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1053\/j.gastro.2005.02.064","article-title":"Helicobacter pylori cage-type IV secretion systems facilitates corpus colonization to induce precancerous conditions in Mongolian gerbils","volume":"128","author":"Rieder","year":"2005","journal-title":"Gastroenterology"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"217","DOI":"10.22088\/cjim.10.2.217","article-title":"The negative association between inflammatory bowel disease and Helicobacter pylori seropositivity","volume":"10","author":"Sayar","year":"2019","journal-title":"Caspian J. Intern. Med."},{"key":"ref79","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/icb.2016.34","article-title":"Human macrophages induce CD4+ Foxp3+ regulatory T cells via binding and re-release of TGF-\u03b2","volume":"94","author":"Schmidt","year":"2016","journal-title":"Immunol. Cell Biol."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"1013779","DOI":"10.3389\/fmed.2022.1013779","article-title":"The impact of Helicobacter pylori and intestinal helminth infections on gastric adenocarcinoma and inflammatory bowel disease in Sub-Saharan Africa","volume":"9","author":"Setshedi","year":"2022","journal-title":"Front. Med."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"e12925","DOI":"10.1111\/hel.12925","article-title":"Effect of Helicobacter pylori on immunotherapy is gaining more attention","volume":"27","author":"Shi","year":"2022","journal-title":"Helicobacter"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1097\/MCG.0000000000001415","article-title":"Association between Helicobacter pylori colonization and inflammatory bowel disease a systematic review and meta-analysis","volume":"55","author":"Shirzad-Aski","year":"2021","journal-title":"J. Clin. Gastroenterol."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"138","DOI":"10.5217\/ir.2017.15.1.138","article-title":"Pivot to Asia: inflammatory bowel disease burden","volume":"15","author":"Singh","year":"2017","journal-title":"Intest. Res."},{"key":"ref84","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nm1715","article-title":"Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells","volume":"14","author":"Stromnes","year":"2008","journal-title":"Nat. Med."},{"key":"ref85","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1093\/ibd\/izac202","article-title":"Inflammatory bowel disease and Helicobacter pylori: protective or present?","volume":"29","author":"Tanner","year":"2023","journal-title":"Inflamm. Bowel Dis."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"93","DOI":"10.4274\/BMJ.galenos.2023.2022.10-1","article-title":"Evaluation of the presence of Helicobacter pylori in inflammatory bowel disease in children","volume":"19","author":"Taskin","year":"2023","journal-title":"Med. J. Bakirkoy"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/apt.15306","article-title":"Systematic review with meta-analysis: association between Helicobacter pylori CagA seropositivity and odds of inflammatory bowel disease","volume":"50","author":"Tepler","year":"2019","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref88","doi-asserted-by":"publisher","first-page":"19446","DOI":"10.1073\/pnas.0706832104","article-title":"CD4+ CD25+ Foxp3+ regulatory T cells induce alternative activation of human monocytes\/macrophages","volume":"104","author":"Tiemessen","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref89","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1111\/j.1572-0241.2003.07434.x","article-title":"The low prevalence of Helicobacter infection in patients with inflammatory bowel disease could be attributed to previous antibiotic treatment","volume":"98","author":"Triantafillidis","year":"2003","journal-title":"Am. J. Gastroenterol."},{"key":"ref90","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s12664-013-0389-z","article-title":"Treatment of inflammatory bowel disease patients with anti-TNF-alpha factors and immunosuppressives does not influence the prevalence of Helicobacter pylori infection","volume":"33","author":"Triantafillidis","year":"2014","journal-title":"Indian J. Gastroenterol."},{"key":"ref91","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1097\/01.mib.0000235100.09231.d7","article-title":"Onset of Crohn\u2019s disease after Helicobacter pylori eradication","volume":"12","author":"Tursi","year":"2006","journal-title":"Inflamm. Bowel Dis."},{"key":"ref92","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1093\/jac\/dkv062","article-title":"Metagenomic analysis of the impact of nitrofurantoin treatment on the human faecal microbiota","volume":"70","author":"Vervoort","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"ref93","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1002\/art.39107","article-title":"A role for gut microbiota and the metabolite-sensing receptor GPR43 in a murine model of gout","volume":"67","author":"Vieira","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"ref94","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.joi.2010.07.002","article-title":"A unified approach to mapping and clustering of bibliometric networks","volume":"4","author":"Waltman","year":"2010","journal-title":"J. Informet."},{"key":"ref95","doi-asserted-by":"publisher","first-page":"833424","DOI":"10.3389\/fimmu.2022.833424","article-title":"Helicobacter pylori and autoimmune diseases: involving multiple systems","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"ref96","first-page":"3700","article-title":"MicroRNA-155 in exosomes secreted from Helicobacter pylori infection macrophages immunomodulates inflammatory response","volume":"8","author":"Wang","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"ref97","doi-asserted-by":"publisher","first-page":"e10844","DOI":"10.1371\/journal.pone.0010844","article-title":"Helicobacter pylori impairs murine dendritic cell responses to infection","volume":"5","author":"Wang","year":"2010","journal-title":"PLoS One"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"29874","DOI":"10.1074\/jbc.M203915200","article-title":"PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-\u03baB and caspase-1-dependent cytokine processing","volume":"277","author":"Wang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref99","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3390\/jcm5120118","article-title":"The dual role of neutrophils in inflammatory bowel diseases","volume":"5","author":"W\u00e9ra","year":"2016","journal-title":"J. Clin. Med."},{"key":"ref100","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.tim.2008.05.005","article-title":"Molecular mechanisms of epithelial-barrier disruption by Helicobacter pylori","volume":"16","author":"Wessler","year":"2008","journal-title":"Trends Microbiol."},{"key":"ref101","first-page":"93","article-title":"The association between Helicobacter pylori infection and its virulence classification and Crohn\u2019s disease","volume":"38","author":"Wu","year":"2023","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref102","doi-asserted-by":"publisher","first-page":"e37175","DOI":"10.1097\/MD.0000000000037175","article-title":"No potential causal link between HP infection and IBD: a 2way Mendelian randomization study","volume":"103","author":"Yang","year":"2024","journal-title":"Medicine"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"e12938","DOI":"10.1111\/hel.12938","article-title":"Discussion on the common controversies of Helicobacter pylori infection","volume":"28","author":"Yang","year":"2023","journal-title":"Helicobacter"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"952546","DOI":"10.3389\/fimmu.2022.952546","article-title":"Global research trends on the links between gut microbiota and cancer immunotherapy: a bibliometric analysis (2012\u20132021)","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Immunol."},{"key":"ref105","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1038\/s41419-018-0982-2","article-title":"Helicobacter pylori infection and inflammatory bowel disease: a crosstalk between upper and lower digestive tract","volume":"9","author":"Yu","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref106","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.ccr.2011.10.022","article-title":"The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis","volume":"20","author":"Zaki","year":"2011","journal-title":"Cancer Cell"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.imbio.2015.10.001","article-title":"NLRP12 is a neutrophil-specific, negative regulator of in vitro cell migration but does not modulate LPS-or infection-induced NF-\u03baB or ERK signalling","volume":"221","author":"Zamoshnikova","year":"2016","journal-title":"Immunobiology"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1093\/ibd\/izy107","article-title":"Helicobacter pylori colonization protects against chronic experimental colitis by regulating Th17\/Treg balance","volume":"24","author":"Zhang","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"key":"ref109","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1097\/CM9.0000000000000748","article-title":"Advances in the role of helper T cells in autoimmune diseases","volume":"133","author":"Zhang","year":"2020","journal-title":"Chin. Med. J."},{"key":"ref110","doi-asserted-by":"publisher","first-page":"317","DOI":"10.34172\/aim.2021.44","article-title":"The relationship between Helicobacter pylori and inflammatory bowel disease","volume":"24","author":"Zhong","year":"2021","journal-title":"Arch. Iran. Med."},{"key":"ref111","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1111\/1751-2980.12540","article-title":"Potential roles of neutrophils in regulating intestinal mucosal inflammation of inflammatory bowel disease","volume":"18","author":"Zhou","year":"2017","journal-title":"J. Dig. Dis."},{"key":"ref112","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.3389\/fmicb.2018.02247","article-title":"The gut microbiota in the pathogenesis and therapeutics of inflammatory bowel disease","volume":"9","author":"Zuo","year":"2018","journal-title":"Front. Microbiol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2024.1479941\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T06:12:13Z","timestamp":1730873533000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2024.1479941\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,6]]},"references-count":112,"alternative-id":["10.3389\/fmicb.2024.1479941"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2024.1479941","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,6]]},"article-number":"1479941"}}