{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:43:33Z","timestamp":1790999013272,"version":"4.1.0"},"reference-count":85,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Salmonella enterica<\/jats:italic> Serovar Typhimurium (<jats:italic>S<\/jats:italic>. Typhimurium) infection can cause inflammation and oxidative stress in the body, leading to gastroenteritis, fever and other diseases in humans and animals. More and more studies have emphasized the broad prospects of probiotics in improving inflammation and oxidative stress, but the ability and mechanism of <jats:italic>Lactobacillus acidophilus<\/jats:italic> (LA) to alleviate the inflammatory\/oxidative reaction caused by pathogens are still unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>In this study, we treated the mice with LA for 14\u202fdays, infected them with <jats:italic>S<\/jats:italic>. Typhimurium for 24\u202fh, and sacrificed the mice to collect samples. We found that the early intervention of LA alleviated the pathological injury and reversed the down-regulation of the duodenal and hepatic tight junction protein mRNA levels caused by <jats:italic>S<\/jats:italic>. Typhimurium infection. Compared with <jats:italic>S<\/jats:italic>. Typhimurium group, LA early intervention increased the expression of antioxidant enzymes, but decreased the levels of serum malondialdehyde (MDA), interleukin-8 and tumor necrosis factor-\u03b1 (TNF-\u03b1). Additionally, LA early intervention significantly increased <jats:italic>Nrf2<\/jats:italic> mRNA expression in the liver and decreased <jats:italic>Keap1<\/jats:italic> mRNA expression in the duodenum compared to the <jats:italic>S<\/jats:italic>. Typhimurium group. Furthermore, early LA treatment reduced the abundance of <jats:italic>Bacteroides acidificiens<\/jats:italic>, increased the abundance of <jats:italic>Akkermansia<\/jats:italic>, and alleviated the decrease in SCFAs levels in the cecum of <jats:italic>S<\/jats:italic>. Typhimurium-infected mice. Spearman correlation analysis showed that there was a certain correlation between cecal flora and serum indicators and short chain fatty acids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Taken together, the results indicate that LA early intervention may alleviates <jats:italic>S<\/jats:italic>. Typhimurium-induced inflammation and oxidative responses in mice by activating the p62-Keap1-Nrf2 signaling pathway and regulating the gut microbial community.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance and impact of the study<\/jats:title><jats:p>Exploring the ability of LA to resist animal oxidative stress and microflora regulation caused by pathogenic microbes, so as to provide more options for developing healthy disease-resistant feed additives.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmicb.2024.1483705","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T19:27:06Z","timestamp":1737055626000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Lactobacillus acidophilus alleviate Salmonella enterica Serovar Typhimurium-induced murine inflammatory\/oxidative responses via the p62-Keap1-Nrf2 signaling pathway and cecal microbiota"],"prefix":"10.3389","volume":"15","author":[{"given":"Haihua","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayun","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nature12726","article-title":"Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation","volume":"504","author":"Arpaia","year":"2013","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/cdd.2012.81","article-title":"The pathways of mitophagy for quality control and clearance of mitochondria","volume":"20","author":"Ashrafi","year":"2013","journal-title":"Cell Death Differ."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"5315","DOI":"10.1128\/AEM.70.9.5315-5322.2004","article-title":"Identification and inactivation of genetic loci involved with Lactobacillus acidophilus acid tolerance","volume":"70","author":"Azcarate-Peril","year":"2004","journal-title":"Appl. Environ. Microb."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.it.2014.12.003","article-title":"Exploiting host immunity: the Salmonella paradigm","volume":"36","author":"Behnsen","year":"2015","journal-title":"Trends Immunol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"39387","DOI":"10.1074\/jbc.M111.279893","article-title":"Translocation of heme oxygenase-1 to mitochondria is a novel cytoprotective mechanism against non-steroidal anti-inflammatory drug-induced mitochondrial oxidative stress, apoptosis, and gastric mucosal injury","volume":"286","author":"Bindu","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1093\/oxfordjournals.bmb.a072188","article-title":"Free radicals in biological systems--a review orientated to inflammatory processes","volume":"43","author":"Blake","year":"1987","journal-title":"Brit. Med. Bull."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"16215","DOI":"10.1038\/nmicrobiol.2016.215","article-title":"Genome-guided design of a defined mouse microbiota that confers colonization resistance against Salmonella enterica serovar typhimurium","volume":"2","author":"Brugiroux","year":"2016","journal-title":"Nat. Microbiol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.freeradbiomed.2019.02.032","article-title":"Feeding practice influences gut microbiome composition in very low birth weight preterm infants and the association with oxidative stress: a prospective cohort study","volume":"142","author":"Cai","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10715762.2019.1702656","article-title":"Hormones and oxidative stress: an overview","volume":"54","author":"Chainy","year":"2020","journal-title":"Free Radic. Res."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1038\/s41467-020-15604-2","article-title":"Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of \u0394pH","volume":"11","author":"Chakraborty","year":"2020","journal-title":"Nat. Commun."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e1700903","DOI":"10.1002\/mnfr.201700903","article-title":"Sugary kefir strain Lactobacillus mali APS1 ameliorated hepatic steatosis by regulation of SIRT-1\/Nrf-2 and gut microbiota in rats","volume":"62","author":"Chen","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"548","DOI":"10.3390\/ani10040548","article-title":"Supplementation of Lactobacillus plantarum or Macleaya cordata extract alleviates oxidative damage induced by weaning in the lower gut of Young goats","volume":"10","author":"Chen","year":"2020","journal-title":"Animals"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"760","DOI":"10.3389\/fnins.2019.00760","article-title":"Melatonin prevents mice cortical astrocytes from hemin-induced toxicity through activating PKC\u03b1\/Nrf2\/HO-1 signaling in vitro","volume":"13","author":"Cheng","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"113607","DOI":"10.1016\/j.bcp.2019.08.009","article-title":"Propionate relieves pentylenetetrazol-induced seizures, consequent mitochondrial disruption, neuron necrosis and neurological deficits in mice","volume":"169","author":"Cheng","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1001\/archsurg.1970.01340280030009","article-title":"Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal","volume":"101","author":"Chiu","year":"1970","journal-title":"Arch. Surg."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.medmal.2013.02.004","article-title":"Regulation of oxidative stress by Nrf2 in the pathophysiology of infectious diseases","volume":"43","author":"Deramaudt","year":"2013","journal-title":"Med. Mal. Infect."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.3748\/wjg.v10.i16.2373","article-title":"Intestinal barrier damage caused by trauma and lipopolysaccharide","volume":"10","author":"Ding","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e00007","DOI":"10.1128\/MMBR.00007-19","article-title":"Gut microbiota and colonization resistance against bacterial enteric infection","volume":"83","author":"Ducarmon","year":"2019","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.4049\/jimmunol.166.2.1248","article-title":"Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction","volume":"166","author":"Eaves-Pyles","year":"2001","journal-title":"J. Immunol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1128\/CMR.00066-12","article-title":"Salmonella enterica serovar Typhimurium skills to succeed in the host: virulence and regulation","volume":"26","author":"F\u00e0brega","year":"2013","journal-title":"Clin. Microbiol. Rev."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/s40168-018-0603-4","article-title":"A comparative study of the gut microbiota in immune-mediated inflammatory diseases-does a common dysbiosis exist?","volume":"6","author":"Forbes","year":"2018","journal-title":"Microbiome"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e00088","DOI":"10.1128\/CMR.00088-18","article-title":"Persistent infection and Long-term carriage of Typhoidal and Nontyphoidal salmonellae","volume":"32","author":"Gal-Mor","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1172\/JCI10501","article-title":"Salmonella Typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response","volume":"107","author":"Gewirtz","year":"2001","journal-title":"J. Clin. Invest."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s12934-014-0094-3","article-title":"Insights into glycogen metabolism in Lactobacillus acidophilus: impact on carbohydrate metabolism, stress tolerance and gut retention","volume":"13","author":"Goh","year":"2014","journal-title":"Microb. Cell Factories"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1101\/gr.112730.110","article-title":"Chimeric 16S rRNA sequence formation and detection in sanger and 454\u2013pyrosequenced PCR amplicons","volume":"21","author":"Haas","year":"2011","journal-title":"Genome Res."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1083\/jcb.200309161","article-title":"A Salmonella protein causes macrophage cell death by inducing autophagy","volume":"163","author":"Hernandez","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.fm.2017.04.016","article-title":"Salmonella Typhimurium metabolism affects virulence in the host-a mini-review","volume":"71","author":"Herrero-Fresno","year":"2018","journal-title":"Food Microbiol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.redox.2013.07.006","article-title":"Biological markers of oxidative stress: applications to cardiovascular research and practice","volume":"1","author":"Ho","year":"2013","journal-title":"Redox Biol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"4107","DOI":"10.1083\/jcb.201701107","article-title":"Type I interferon enhances necroptosis of Salmonella Typhimurium-infected macrophages by impairing antioxidative stress responses","volume":"216","author":"Hos","year":"2017","journal-title":"J. Cell Biol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.3390\/nu12082315","article-title":"Lactobacillus plantarum PS128 improves physiological adaptation and performance in triathletes through gut microbiota modulation","volume":"12","author":"Huang","year":"2020","journal-title":"Nutrients"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.molcel.2013.08.003","article-title":"Phosphorylation of p62 activates the Keap1\u2013Nrf2 pathway during selective autophagy","volume":"51","author":"Ichimura","year":"2013","journal-title":"Mol. Cell"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.chom.2018.07.002","article-title":"A gut commensal-produced metabolite mediates colonization resistance to Salmonella infection","volume":"24","author":"Jacobson","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.3389\/fmicb.2018.02425","article-title":"Lactobacillus brevis 23017 relieves mercury toxicity in the Colon by modulation of oxidative stress and inflammation through the interplay of MAPK and NF\u2013\u03baB signaling cascades","volume":"9","author":"Jiang","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref37","first-page":"185","article-title":"Development of villous damage in mouse small intestine after local hyperthermia or irradiation","volume":"20","author":"Kamel","year":"1988","journal-title":"J. Submicrosc. Cytol. Pathol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"e1900574","DOI":"10.1002\/mnfr.201900574","article-title":"Punicalagin, a pomegranate\u2013derived ellagitannin, suppresses obesity and obesity\u2013induced inflammatory responses via the Nrf2\/Keap1 signaling pathway","volume":"63","author":"Kang","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1146\/annurev-immunol-070119-115104","article-title":"Interaction between the microbiota, epithelia, and immune cells in the intestine","volume":"38","author":"Kayama","year":"2020","journal-title":"Annu. Rev. Immunol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/s41418-019-0481-8","article-title":"Autophagy and microbial pathogenesis","volume":"27","author":"Keller","year":"2020","journal-title":"Cell Death Differ."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.tcb.2015.08.010","article-title":"Ubiquitin-dependent and independent signals in selective autophagy","volume":"26","author":"Khaminets","year":"2016","journal-title":"Trends Cell Biol."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.3390\/cells8101163","article-title":"Anti-inflammatory mechanisms of Koreanaside a, a Lignan isolated from the flower of Forsythia koreana, against LPS-induced macrophage activation and DSS-induced colitis mice: the crucial role of AP-1, NF-\u03baB, and JAK\/STAT signaling","volume":"8","author":"Kim","year":"2019","journal-title":"Cells"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.ejphar.2018.06.023","article-title":"Urolithin a attenuates pro\u2013inflammatory mediator production by suppressing PI3\u2013K\/Akt\/NF\u2013\u03baB and JNK\/AP\u20131 signaling pathways in lipopolysaccharide\u2013stimulated RAW264 macrophages: possible involvement of NADPH oxidase\u2013derived reactive oxygen species","volume":"833","author":"Komatsu","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/nm0302-240","article-title":"Heme oxygenase\u20131 mediates the anti\u2013inflammatory effect of interleukin\u201310 in mice","volume":"8","author":"Lee","year":"2002","journal-title":"Nat. Med."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.3389\/fmicb.2018.01439","article-title":"Lactobacillus acidophilus attenuates Salmonella-induced stress of epithelial cells by modulating tight-junction genes and cytokine responses","volume":"9","author":"L\u00e9pine","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3390\/antiox8090381","article-title":"Antioxidant effects of Apocynum venetum tea extracts on d\u2013galactose\u2013induced aging model in mice","volume":"8","author":"Li","year":"2019","journal-title":"Antioxidants"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1186\/s12866-016-0862-9","article-title":"Lactobacillus acidophilus alleviates the inflammatory response to enterotoxigenic Escherichia coli K88 via inhibition of the NF\u2013\u03baB and p38 mitogen\u2013activated protein kinase signaling pathways in piglets","volume":"16","author":"Li","year":"2016","journal-title":"BMC Microbiol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.expneurol.2017.12.016","article-title":"Ulinastatin protects brain against cerebral ischemia\/reperfusion injury through inhibiting MMP\u20139 and alleviating loss of ZO\u20131 and occludin proteins in mice","volume":"302","author":"Li","year":"2018","journal-title":"Exp. Neurol."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1128\/IAI.70.1.192-198.2002","article-title":"Comparison of inflammation, organ damage, and oxidant stress induced by Salmonella enterica Serovar Muenchen flagellin and serovar Enteritidis lipopolysaccharide","volume":"70","author":"Liaudet","year":"2002","journal-title":"Infect. Immun."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.bbamcr.2008.01.002","article-title":"NF-kappaB\/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK","volume":"1783","author":"Liu","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"4730539","DOI":"10.1155\/2019\/4730539","article-title":"Gut microbiota in Alzheimer's disease, depression, and type 2 diabetes mellitus: the role of oxidative stress","volume":"2019","author":"Luca","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","article-title":"FLASH: fast length adjustment of short reads to improve genome assemblies","volume":"27","author":"Mago\u010d","year":"2011","journal-title":"Bioinformatics"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"379","DOI":"10.3390\/ijms21020379","article-title":"Recent advances in lipopolysaccharide recognition systems","volume":"21","author":"Mazgaeen","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.3390\/nu10101457","article-title":"Gut Microbiota's relationship with liver disease and role in Hepatoprotection by dietary natural products and probiotics","volume":"10","author":"Meng","year":"2018","journal-title":"Nutrients"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3389\/fimmu.2019.00277","article-title":"Short chain fatty acids (SCFAs)\u2013mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases","volume":"10","author":"Parada Venegas","year":"2019","journal-title":"Front. Immunol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"4624","DOI":"10.1128\/JB.00337-07","article-title":"Characterization of a novel bile\u2013inducible operon encoding a two\u2013component regulatory system in Lactobacillus acidophilus","volume":"189","author":"Pfeiler","year":"2007","journal-title":"J. Bacteriol."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s10482-015-0380-z","article-title":"Effects of Lactobacillus acidophilus dietary supplementation on the performance, intestinal barrier function, rectal microflora and serum immune function in weaned piglets challenged with Escherichia coli lipopolysaccharide","volume":"107","author":"Qiao","year":"2015","journal-title":"Antonie Van Leeuwenhoek"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"Quast","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"4396","DOI":"10.1242\/jcs.148098","article-title":"CFTR interacts with ZO\u20131 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway","volume":"127","author":"Ruan","year":"2014","journal-title":"J. Cell Sci."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1681\/ASN.2019080790","article-title":"Interaction between epithelial Sodium Channel \u03b3\u2013subunit and Claudin\u20138 modulates Paracellular sodium permeability in renal collecting duct","volume":"31","author":"Sassi","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1136\/gut.47.3.397","article-title":"Butyrate inhibits inflammatory responses through NF\u2013kappaB inhibition: implications for Crohn's disease","volume":"47","author":"Segain","year":"2000","journal-title":"Gut"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1016\/j.apjtm.2017.10.028","article-title":"Reverse effect of curcumin on CDDP-induced drug-resistance via Keap1\/p62-Nrf2 signaling in A549\/CDDP cell","volume":"10","author":"Shen","year":"2017","journal-title":"Asian Pac J Trop Med"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1089\/ars.2008.2253","article-title":"3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain","volume":"11","author":"Shibuya","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.phrs.2018.06.013","article-title":"Canonical and non-canonical mechanisms of Nrf2 activation","volume":"134","author":"Silva-Islas","year":"2018","journal-title":"Pharmacol. Res."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nrmicro2974","article-title":"The gut microbiota\u2013\u2013masters of host development and physiology","volume":"11","author":"Sommer","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/cei.13236","article-title":"Colonization of preterm gnotobiotic piglets with probiotic Lactobacillus rhamnosus GG and its interference with Salmonella Typhimurium","volume":"195","author":"Splichalova","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1111\/1574-6976.12024","article-title":"Colonization resistance and microbial ecophysiology: using gnotobiotic mouse models and single\u2013cell technology to explore the intestinal jungle","volume":"37","author":"Stecher","year":"2013","journal-title":"FEMS Microbiol. Rev."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"547425","DOI":"10.3389\/fvets.2020.547425","article-title":"Lactobacillus salivarius, a potential probiotic to improve the health of LPS-challenged piglet intestine by alleviating inflammation as well as oxidative stress in a dose-dependent manner during weaning transition","volume":"7","author":"Sun","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1002\/hep.28251","article-title":"Activation of the p62\u2013Keap1\u2013NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells","volume":"63","author":"Sun","year":"2016","journal-title":"Hepatology"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"10664","DOI":"10.3168\/jds.2018-14758","article-title":"Lactobacillus paracasei ssp. paracasei YBJ01 reduced d-galactose-induced oxidation in male Kuming mice","volume":"101","author":"Suo","year":"2018","journal-title":"J. Dairy Sci."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.tips.2013.04.005","article-title":"Toward clinical application of the Keap1-Nrf2 pathway","volume":"34","author":"Suzuki","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1097\/00007890-199306000-00011","article-title":"Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Modulating effects of FK506 and cyclosporine","volume":"55","author":"Suzuki","year":"1993","journal-title":"Transplantation"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1161\/CIRCRESAHA.117.309715","article-title":"Gut microbiota in cardiovascular health and disease","volume":"120","author":"Tang","year":"2017","journal-title":"Circ. Res."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s10096-015-2543-2","article-title":"Visual detection technique for efficient screening and isolation of Salmonella based on a novel enrichment assay using chromatography membrane","volume":"35","author":"Tang","year":"2016","journal-title":"Eur. J. Clin. Microbiol. Infect. 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