{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:04:49Z","timestamp":1773810289742,"version":"3.50.1"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acute hematogenous osteomyelitis is the most common form of osteomyelitis in children. In recent years, the incidence of osteomyelitis has been steadily increasing. For pediatric patients, clearly describing their symptoms can be quite challenging, which often necessitates the use of complex diagnostic methods, such as radiology. For those who have been diagnosed, the ability to culture the pathogenic bacteria significantly affects their treatment plan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 634 patients under the age of 18 were included, and the correlation between laboratory indicators and osteomyelitis, as well as several diagnoses often confused with osteomyelitis, was analyzed. Based on this, a Transformer-based deep learning model was developed to identify osteomyelitis patients. Subsequently, the correlation between laboratory indicators and the length of hospital stay for osteomyelitis patients was examined. Finally, the correlation between the successful cultivation of pathogenic bacteria and laboratory indicators in osteomyelitis patients was analyzed, and a deep learning model was established for prediction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The laboratory indicators of patients are correlated with the presence of acute hematogenous osteomyelitis, and the deep learning model developed based on this correlation can effectively identify patients with acute hematogenous osteomyelitis. The laboratory indicators of patients with acute hematogenous osteomyelitis can partially reflect their length of hospital stay. Although most laboratory indicators lack a direct correlation with the ability to culture pathogenic bacteria in patients with acute hematogenous osteomyelitis, our model can still predict whether the bacteria can be successfully cultured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Laboratory indicators, as easily accessible medical information, can identify osteomyelitis in pediatric patients. They can also predict whether pathogenic bacteria can be successfully cultured, regardless of whether the patient has received antibiotics beforehand. This not only simplifies the diagnostic process for pediatricians but also provides a basis for deciding whether to use empirical antibiotic therapy or discontinue treatment for blood cultures.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmicb.2024.1495709","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T18:10:21Z","timestamp":1730916621000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["A transformer-based deep learning model for identifying the occurrence of acute hematogenous osteomyelitis and predicting blood culture results"],"prefix":"10.3389","volume":"15","author":[{"given":"Yingtu","family":"Xia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiuhui","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1097\/bpo.0000000000000879","article-title":"Validation and modification of a severity of illness score for children with acute Hematogenous osteomyelitis","volume":"39","author":"Athey","year":"2019","journal-title":"J. Pediatr. Orthop."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e603","DOI":"10.1097\/bpo.0000000000002448","article-title":"Age and CRP associated with improved tissue pathogen identification in children with blood culture negative osteomyelitis: results from the CORTICES multicenter database","volume":"43","author":"Burns","year":"2023","journal-title":"J. Pediatr. Orthop."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1097\/inf.0000000000001309","article-title":"Epidemiology and management of acute, uncomplicated septic arthritis and osteomyelitis: Spanish multicenter study","volume":"35","author":"Calvo","year":"2016","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"113424","DOI":"10.1016\/j.jpeds.2023.113424","article-title":"Racial and ethnic differences in length of stay for US children hospitalized for acute osteomyelitis","volume":"259","author":"Campbell","year":"2023","journal-title":"J. Pediatr."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"4371","DOI":"10.21873\/anticanres.15937","article-title":"Two-phase deep learning algorithm for detection and differentiation of Ewing sarcoma and acute osteomyelitis in paediatric radiographs","volume":"42","author":"Consalvo","year":"2022","journal-title":"Anticancer Res."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1302\/0301-620x.94b5.28523","article-title":"Haematogenous acute and subacute paediatric osteomyelitis: a systematic review of the literature","volume":"94","author":"Dartnell","year":"2012","journal-title":"J. Bone Joint Surg. Br."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1001\/archpedi.1975.02120480007004","article-title":"Osteomyelitis in infants and children. A review of 163 cases","volume":"129","author":"Dich","year":"1975","journal-title":"Am. J. Dis. Child."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s12887-023-03863-z","article-title":"Clinical outcomes of pediatric osteomyelitis","volume":"23","author":"Disch","year":"2023","journal-title":"BMC Pediatr."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"e00009-19","DOI":"10.1128\/cmr.00009-19","article-title":"Practical guidance for clinical microbiology laboratories: a comprehensive update on the problem of blood culture contamination and a discussion of methods for addressing the problem","volume":"33","author":"Doern","year":"2019","journal-title":"Clin. Microbiol. Rev."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1002\/jmri.26703","article-title":"Techniques for minimizing sedation in pediatric MRI","volume":"50","author":"Dong","year":"2019","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.ocl.2016.12.007","article-title":"Acute Hematogenous osteomyelitis in children: pathogenesis, diagnosis, and treatment","volume":"48","author":"Funk","year":"2017","journal-title":"Orthop. Clin. North Am."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2337738","DOI":"10.1080\/07853890.2024.2337738","article-title":"Identification of pathogen composition in a Chinese population with iatrogenic and native vertebral osteomyelitis by using mNGS","volume":"56","author":"Gao","year":"2024","journal-title":"Ann. Med."},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/inf.0000000000004535","article-title":"Accelerated severity of illness score enhances prediction of complicated acute hematogenous osteomyelitis in children","author":"Jahan","year":"2024","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.3390\/biology11091310","article-title":"Classification model for diabetic foot, necrotizing fasciitis, and osteomyelitis","volume":"11","author":"Kim","year":"2022","journal-title":"Biology"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"837","DOI":"10.2106\/jbjs.N.01350","article-title":"Trends in the epidemiology of osteomyelitis: a population-based study, 1969 to 2009","volume":"97","author":"Kremers","year":"2015","journal-title":"J. Bone Joint Surg. Am."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jped.2023.09.003","article-title":"Bone and joint infection complicated with sepsis in neonates and infants under three months of age","volume":"100","author":"Liu","year":"2024","journal-title":"J. Pediatr."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"587740","DOI":"10.3389\/fped.2020.587740","article-title":"Long-term outcomes of acute osteoarticular infections in children","volume":"8","author":"Manz","year":"2020","journal-title":"Front. Pediatr."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1007\/s00431-018-3157-3","article-title":"Evaluation of the current use of imaging modalities and pathogen detection in children with acute osteomyelitis and septic arthritis","volume":"177","author":"Manz","year":"2018","journal-title":"Eur. J. Pediatr."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"4459","DOI":"10.2147\/idr.S257517","article-title":"Acute Hematogenous osteomyelitis in children: clinical presentation and management","volume":"13","author":"McNeil","year":"2020","journal-title":"Infect Drug Resist"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1093\/cid\/ciz109","article-title":"Clinical and microbiologic variables predictive of orthopedic complications following Staphylococcus aureus acute hematogenous osteoarticular infections in children","volume":"69","author":"McNeil","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e34","DOI":"10.15557\/JoU.2021.0005","article-title":"Role of ultrasound in the diagnosis of paediatric acute osteomyelitis","volume":"21","author":"Paliwal","year":"2021","journal-title":"J Ultrason"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1099\/jmm.0.000026","article-title":"Microbiological characteristics of acute osteoarticular infections in children","volume":"64","author":"Russell","year":"2015","journal-title":"J. Med. Microbiol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.idc.2017.01.010","article-title":"Osteomyelitis","volume":"31","author":"Schmitt","year":"2017","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"441","DOI":"10.2106\/jbjs.N.00477","article-title":"Microbiological culture methods for pediatric musculoskeletal infection: a guideline for optimal use","volume":"97","author":"Section","year":"2015","journal-title":"J. Bone Joint Surg. Am."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e209","DOI":"10.1097\/pec.0000000000002217","article-title":"Clinical presentation of acute osteomyelitis in the pediatric emergency department","volume":"38","author":"Stephan","year":"2022","journal-title":"Pediatr. Emerg. Care"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"3153","DOI":"10.1542\/peds.2023-063153","article-title":"A novel risk score to guide the evaluation of acute hematogenous osteomyelitis in children","volume":"153","author":"Stephan","year":"2024","journal-title":"Pediatrics"},{"key":"ref27","volume-title":"Attention is all you need. Advances in neural information processing systems","author":"Vaswani","year":"2017"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.3390\/children8111000","article-title":"The epidemiology of osteomyelitis in children","volume":"8","author":"Walter","year":"2021","journal-title":"Children"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"837506","DOI":"10.3389\/fpubh.2022.837506","article-title":"A nomogram for predicting Cancer-specific survival of osteosarcoma and Ewing's sarcoma in children: a SEER database analysis","volume":"10","author":"Wang","year":"2022","journal-title":"Front. Public Health"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/s13018-023-03670-3","article-title":"Comparison of diagnosis and treatment of MSSA and MRSA osteomyelitis in children: a case-control study of 64 patients","volume":"18","author":"Wen","year":"2023","journal-title":"J. Orthop. Surg. 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