{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:30:39Z","timestamp":1792067439904,"version":"4.4.0"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["No.2021YFH0188 (ML)"],"award-info":[{"award-number":["No.2021YFH0188 (ML)"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["No.2020YJ0240 (JH)"],"award-info":[{"award-number":["No.2020YJ0240 (JH)"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p><jats:italic>Streptococcus mutans<\/jats:italic> (<jats:italic>S. mutans<\/jats:italic>) is the main pathogenic bacterium causing dental caries, and the modes in which its traits, such as acid production, acid tolerance, and adhesion that contribute to the dental caries process, has been clarified. However, a growing number of animal experiments and clinical revelations signify that these traits of <jats:italic>S. mutans<\/jats:italic> are not restricted to the detriment of dental tissues. These traits can assist <jats:italic>S. mutans<\/jats:italic> in evading the immune system within body fluids; they empower <jats:italic>S. mutans<\/jats:italic> to adhere not merely to the surface of teeth but also to other tissues such as vascular endothelium; they can additionally trigger inflammatory reactions and inflict damage on various organs, thereby leading to the occurrence of systemic diseases. These traits mostly originate from some correlative findings, lacking a comprehensive evaluation of the impact of <jats:italic>S. mutans<\/jats:italic> on systemic diseases. Therefore, this review mainly centers on the dissemination route of <jats:italic>S. mutans<\/jats:italic>: \u201cEntering the blood circulation - Occurrence of tissue adhesion - Extensive possible proinflammatory mechanisms - Concentration in individual organs\u201d and analyses the specific effects and possible mechanisms of <jats:italic>S. mutans<\/jats:italic> in systemic diseases such as cerebral hemorrhage, inflammatory bowel disease, tumors, and infective endocarditis that have been identified hitherto.<\/jats:p>","DOI":"10.3389\/fmicb.2024.1503657","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T06:26:40Z","timestamp":1734589600000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":39,"title":["Roles of Streptococcus mutans in human health: beyond dental caries"],"prefix":"10.3389","volume":"15","author":[{"given":"Yanke","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Hung","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ollie Yiru","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1369\/0022155413501677","article-title":"Laminin and type IV collagen isoform substitutions occur in temporally and spatially distinct patterns in developing kidney glomerular basement membranes.","volume":"61","author":"Abrahamson","year":"2013","journal-title":"J. Histochem. Cytochem."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1128\/IAI.00767-10","article-title":"The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cells.","volume":"79","author":"Abranches","year":"2011","journal-title":"Infect. Immun."},{"key":"B3","first-page":"408","article-title":"Streptococcus mutans-induced nephritis in rabbits.","volume":"118","author":"Albini","year":"1985","journal-title":"Am. J. Pathol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1016\/s0002-9149(02)02353-6","article-title":"Usefulness of cytokines interleukin-6 and interleukin-2R concentrations in diagnosing active infective endocarditis involving native valves.","volume":"89","author":"Alter","year":"2002","journal-title":"Am. J. Cardiol."},{"key":"B5","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1365-2958.2010.07212.x","article-title":"The changing faces of Streptococcus antigen I\/II polypeptide family adhesins.","volume":"77","author":"Brady","year":"2010","journal-title":"Mol. Microbiol."},{"key":"B6","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1152\/physrev.00003.2012","article-title":"Regulation of small GTPases by GEFs, GAPs, and GDIs.","volume":"93","author":"Cherfils","year":"2013","journal-title":"Physiol. Rev."},{"key":"B7","first-page":"892","article-title":"Induction of cytokines by glucosyltransferases of streptococcus mutans.","volume":"9","author":"Chia","year":"2002","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"B8","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1128\/IAI.68.4.1864-1870.2000","article-title":"Identification of a fibronectin binding protein from Streptococcus mutans.","volume":"68","author":"Chia","year":"2000","journal-title":"Infect. Immun."},{"key":"B9","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1128\/CDLI.8.2.441-445.2001","article-title":"Human T-cell responses to the glucosyltransferases of Streptococcus mutans.","volume":"8","author":"Chia","year":"2001","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/s0016-5085(98)70599-2","article-title":"Steatohepatitis: a tale of two \u201chits\u201d?","volume":"114","author":"Day","year":"1998","journal-title":"Gastroenterology."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1016\/S0022-5223(95)70038-2","article-title":"Surgical management of infective endocarditis associated with cerebral complications. Multi-center retrospective study in Japan.","volume":"110","author":"Eishi","year":"1995","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"B12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nrneph.2015.208","article-title":"The mucosa-kidney axis in IgA nephropathy.","volume":"12","author":"Floege","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"B13","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1399-302X.2007.00351.x","article-title":"Biological functions of glucan-binding protein B of Streptococcus mutans.","volume":"22","author":"Fujita","year":"2007","journal-title":"Oral Microbiol. Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/ncb1526","article-title":"Shigella IpgB1 promotes bacterial entry through the ELMO-Dock180 machinery.","volume":"9","author":"Handa","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"3632","DOI":"10.1161\/STROKEAHA.120.029607","article-title":"Oral carriage of Streptococcus mutans Harboring the cnm gene relates to an increased incidence of cerebral microbleeds.","volume":"51","author":"Hosoki","year":"2020","journal-title":"Stroke"},{"key":"B16","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1053\/ajkd.2001.27690","article-title":"Tonsillectomy and steroid pulse therapy significantly impact on clinical remission in patients with IgA nephropathy.","volume":"38","author":"Hotta","year":"2001","journal-title":"Am. J. Kidney Dis."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56679-2","article-title":"Specific strains of Streptococcus mutans, a pathogen of dental caries, in the tonsils, are associated with IgA nephropathy.","volume":"9","author":"Ito","year":"2019","journal-title":"Sci. Rep."},{"key":"B18","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1111\/j.1365-2958.2009.06903.x","article-title":"Streptococcus mutans autolysin AtlA is a fibronectin-binding protein and contributes to bacterial survival in the bloodstream and virulence for infective endocarditis.","volume":"74","author":"Jung","year":"2009","journal-title":"Mol. Microbiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"20520","DOI":"10.1074\/jbc.M113.454462","article-title":"Collagen-binding microbial surface components recognizing adhesive matrix molecule (MSCRAMM) of Gram-positive bacteria inhibit complement activation via the classical pathway.","volume":"288","author":"Kang","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1471-4906(02)00013-3","article-title":"IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation.","volume":"24","author":"Kaplanski","year":"2003","journal-title":"Trends Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1177\/0022034511435101","article-title":"Increased atherogenesis during Streptococcus mutans infection in ApoE-null mice.","volume":"91","author":"Kesavalu","year":"2012","journal-title":"J. Dent. Res."},{"key":"B22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.2041-1014.2012.00639.x","article-title":"Tumor necrosis factor-\u03b1 and interleukin-1\u03b2 expression pathway induced by Streptococcus mutans in macrophage cell line RAW 264.7.","volume":"27","author":"Kim","year":"2012","journal-title":"Mol. Oral Microbiol."},{"key":"B23","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1128\/iai.58.2.289-296.1990","article-title":"Surface hydrophobicity, adherence, and aggregation of cell surface protein antigen mutants of Streptococcus mutans serotype c.","volume":"58","author":"Koga","year":"1990","journal-title":"Infect. Immun."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/srep00332","article-title":"Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis.","volume":"2","author":"Kojima","year":"2012","journal-title":"Sci. Rep."},{"key":"B25","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1111\/odi.12125","article-title":"Aggravation of inflammatory bowel diseases by oral streptococci.","volume":"20","author":"Kojima","year":"2014","journal-title":"Oral Dis."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1681\/ASN.V9112048","article-title":"Protective role of IgA1 glycans against IgA1 self-aggregation and adhesion to extracellular matrix proteins.","volume":"9","author":"Kokubo","year":"1998","journal-title":"J. Am. Soc. Nephrol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.2215\/CJN.00310108","article-title":"Effect of tonsillectomy plus steroid pulse therapy on clinical remission of IgA nephropathy: a controlled study.","volume":"3","author":"Komatsu","year":"2008","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"B28","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1258\/0007142001903229","article-title":"Pathology of small vessel stroke.","volume":"56","author":"Lammie","year":"2000","journal-title":"Br. Med. Bull."},{"key":"B29","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1099\/jmm.0.033415-0","article-title":"Multilocus sequence typing analysis of Streptococcus mutans strains with the cnm gene encoding collagen-binding adhesin.","volume":"60","author":"Lapirattanakul","year":"2011","journal-title":"J. Med. Microbiol."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.gpp3-0051-2018","article-title":"The biology of Streptococcus mutans.","volume":"7","author":"Lemos","year":"2019","journal-title":"Microbiol Spectr."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10091047","article-title":"A qualitative and comprehensive analysis of caries susceptibility for dental fluorosis patients.","volume":"10","author":"Li","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"B32","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1128\/CMR.13.4.547","article-title":"Systemic diseases caused by oral infection.","volume":"13","author":"Li","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2878","DOI":"10.1161\/01.CIR.0000129303.90488.29","article-title":"Impact of amoxicillin prophylaxis on the incidence, nature, and duration of bacteremia in children after intubation and dental procedures.","volume":"109","author":"Lockhart","year":"2004","journal-title":"Circulation"},{"key":"B34","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1111\/j.1399-302X.2009.00521.x","article-title":"Contribution of cell surface protein antigen c of Streptococcus mutans to platelet aggregation.","volume":"24","author":"Matsumoto-Nakano","year":"2009","journal-title":"Oral Microbiol. Immunol."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/srep36455","article-title":"Presence of Streptococcus mutans strains harbouring the cnm gene correlates with dental caries status and IgA nephropathy conditions.","volume":"6","author":"Misaki","year":"2016","journal-title":"Sci. Rep."},{"key":"B36","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1111\/odi.12360","article-title":"Relationship between Cnm-positive Streptococcus mutans and cerebral microbleeds in humans.","volume":"21","author":"Miyatani","year":"2015","journal-title":"Oral Dis."},{"key":"B37","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/j.1365-2958.1993.tb01210.x","article-title":"Sucrose-derived exopolysaccharides of Streptococcus mutans V403 contribute to infectivity in endocarditis.","volume":"8","author":"Munro","year":"1993","journal-title":"Mol. Microbiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/omi.12159","article-title":"Invasive Streptococcus mutans induces inflammatory cytokine production in human aortic endothelial cells via regulation of intracellular toll-like receptor 2 and nucleotide-binding oligomerization domain 2.","volume":"32","author":"Nagata","year":"2017","journal-title":"Mol. Oral Microbiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1111\/j.1399-302X.2006.00317.x","article-title":"Serotype-specific polysaccharide of Streptococcus mutans contributes to infectivity in endocarditis.","volume":"21","author":"Nagata","year":"2006","journal-title":"Oral Microbiol. Immunol."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/srep36886","article-title":"Contributions of Streptococcus mutans Cnm and PA antigens to aggravation of non-alcoholic steatohepatitis in mice.","volume":"6","author":"Naka","year":"2016","journal-title":"Sci. Rep."},{"key":"B41","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1111\/odi.12191","article-title":"A specific Streptococcus mutans strain aggravates non-alcoholic fatty liver disease.","volume":"20","author":"Naka","year":"2014","journal-title":"Oral Dis."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85196-4","article-title":"Streptococcus mutans induces IgA nephropathy-like glomerulonephritis in rats with severe dental caries.","volume":"11","author":"Naka","year":"2021","journal-title":"Sci. Rep."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.micinf.2005.04.012","article-title":"Contribution of biofilm regulatory protein A of Streptococcus mutans, to systemic virulence.","volume":"7","author":"Nakano","year":"2005","journal-title":"Microbes Infect."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1491","article-title":"The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke.","volume":"2","author":"Nakano","year":"2011","journal-title":"Nat. Commun."},{"key":"B45","doi-asserted-by":"publisher","first-page":"3313","DOI":"10.1128\/JCM.00377-06","article-title":"Detection of cariogenic Streptococcus mutans in extirpated heart valve and atheromatous plaque specimens.","volume":"44","author":"Nakano","year":"","journal-title":"J. Clin. Microbiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.1128\/JCM.02343-06","article-title":"Streptococcus mutans clonal variation revealed by multilocus sequence typing.","volume":"45","author":"Nakano","year":"","journal-title":"J. Clin. Microbiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1177\/0810376","article-title":"Attenuation of glucan-binding protein C reduces the cariogenicity of Streptococcus mutans: analysis of strains isolated from human blood.","volume":"81","author":"Nakano","year":"2002","journal-title":"J. Dent. Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1099\/jmm.0.47051-0","article-title":"Serotype distribution of Streptococcus mutans a pathogen of dental caries in cardiovascular specimens from Japanese patients.","volume":"56","author":"Nakano","year":"","journal-title":"J. Med. Microbiol."},{"key":"B49","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1399-302X.2008.00479.x","article-title":"Detection of oral bacteria in cardiovascular specimens.","volume":"24","author":"Nakano","year":"2009","journal-title":"Oral Microbiol. Immunol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1128\/JCM.42.1.198-202.2004","article-title":"Demonstration of Streptococcus mutans with a cell wall polysaccharide specific to a new serotype, k, in the human oral cavity.","volume":"42","author":"Nakano","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"B51","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1177\/154405910808701001","article-title":"Protein antigen in serotype k Streptococcus mutans clinical isolates.","volume":"87","author":"Nakano","year":"2008","journal-title":"J. Dent. Res."},{"key":"B52","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1099\/jmm.0.47335-0","article-title":"Detection of novel serotype k Streptococcus mutans in infective endocarditis patients.","volume":"56","author":"Nakano","year":"","journal-title":"J. Med. Microbiol."},{"key":"B53","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.micinf.2005.06.005","article-title":"Contribution of cell surface protein antigen PAc of Streptococcus mutans to bacteremia.","volume":"8","author":"Nakano","year":"","journal-title":"Microbes Infect."},{"key":"B54","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s10157-008-0054-5","article-title":"Pathogenetic significance of aberrant glycosylation of IgA1 in IgA nephropathy.","volume":"12","author":"Narita","year":"2008","journal-title":"Clin. Exp. Nephrol."},{"key":"B55","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1099\/jmm.0.47836-0","article-title":"Molecular characterization of Streptococcus mutans strains isolated from the heart valve of an infective endocarditis patient.","volume":"57","author":"Nemoto","year":"2008","journal-title":"J. Med. Microbiol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"e00897","DOI":"10.1128\/IAI.00897-19","article-title":"Contribution of severe dental caries induced by Streptococcus mutans to the pathogenicity of infective endocarditis.","volume":"88","author":"Nomura","year":"","journal-title":"Infect. Immun."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1016\/j.archoralbio.2013.06.008","article-title":"Potential high virulence for infective endocarditis in Streptococcus mutans strains with collagen-binding proteins but lacking PA expression.","volume":"58","author":"Nomura","year":"2013","journal-title":"Arch. Oral Biol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.archoralbio.2004.04.001","article-title":"Contribution of glucan-binding protein C of Streptococcus mutans to bacteremia occurrence.","volume":"49","author":"Nomura","year":"2004","journal-title":"Arch. Oral Biol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1111\/j.2041-1014.2012.00649.x","article-title":"Identification and characterization of a collagen-binding protein, Cbm, in Streptococcus mutans.","volume":"27","author":"Nomura","year":"2012","journal-title":"Mol. Oral Microbiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1099\/jmm.0.46609-0","article-title":"Isolation and characterization of Streptococcus mutans in heart valve and dental plaque specimens from a patient with infective endocarditis.","volume":"55","author":"Nomura","year":"2006","journal-title":"J. Med. Microbiol."},{"key":"B61","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1099\/jmm.0.007559-0","article-title":"Molecular and clinical analyses of the gene encoding the collagen-binding adhesin of Streptococcus mutans.","volume":"58","author":"Nomura","year":"2009","journal-title":"J. Med. Microbiol."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75933-6","article-title":"Potential involvement of Streptococcus mutans possessing collagen binding protein Cnm in infective endocarditis.","volume":"10","author":"Nomura","year":"","journal-title":"Sci. Rep."},{"key":"B63","doi-asserted-by":"publisher","first-page":"5223","DOI":"10.1128\/IAI.02164-14","article-title":"Contribution of the interaction of Streptococcus mutans serotype k strains with fibrinogen to the pathogenicity of infective endocarditis.","volume":"82","author":"Nomura","year":"2014","journal-title":"Infect. Immun."},{"key":"B64","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1111\/omi.12257","article-title":"DMBT1 involvement in the human aortic endothelial cell response to Streptococcus mutans.","volume":"34","author":"Oho","year":"2019","journal-title":"Mol. Oral Microbiol."},{"key":"B65","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000002067","article-title":"Molecular analysis of oral bacteria in heart valve of patients with cardiovascular disease by real-time polymerase chain reaction.","volume":"94","author":"Oliveira","year":"2015","journal-title":"Medicine"},{"key":"B66","doi-asserted-by":"publisher","first-page":"5967","DOI":"10.1128\/JB.185.20.5967-5975.2003","article-title":"The sloABCR operon of Streptococcus mutans encodes an Mn and Fe transport system required for endocarditis virulence and its Mn-dependent repressor.","volume":"185","author":"Paik","year":"2003","journal-title":"J. Bacteriol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1083\/jcb.200605144","article-title":"Differential activation and function of Rho GTPases during Salmonella-host cell interactions.","volume":"175","author":"Patel","year":"2006","journal-title":"J. Cell Biol."},{"key":"B68","first-page":"705","article-title":"Evaluation of serum cytokine concentrations in patients with infective endocarditis.","volume":"9","author":"Rawczynska-Englert","year":"2000","journal-title":"J. Heart Valve Dis."},{"key":"B69","doi-asserted-by":"crossref","first-page":"677","DOI":"10.2215\/CJN.07420716","article-title":"IgA nephropathy.","volume":"12","author":"Rodrigues","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1242\/jcs.040345","article-title":"Yersinia enterocolitica differentially modulates RhoG activity in host cells.","volume":"122","author":"Roppenser","year":"2009","journal-title":"J. Cell Sci."},{"key":"B71","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1177\/154405910408300705","article-title":"Streptococcus mutans strains harboring collagen-binding adhesin.","volume":"83","author":"Sato","year":"2004","journal-title":"J. Dent. Res."},{"key":"B72","doi-asserted-by":"publisher","first-page":"821","DOI":"10.3390\/jfb15020032","article-title":"The inflammasomes.","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"B73","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1128\/IAI.73.6.3261-3270.2005","article-title":"Glucosyltransferases of viridans streptococci are modulins of interleukin-6 induction in infective endocarditis.","volume":"73","author":"Shun","year":"2005","journal-title":"Infect. Immun."},{"key":"B74","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/j.1399-302X.2008.00492.x","article-title":"Prevalence, intensity and identity of bacteraemia following conservative dental procedures in children.","volume":"24","author":"Sonbol","year":"2009","journal-title":"Oral Microbiol. Immunol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1172\/JCI5535","article-title":"Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies.","volume":"104","author":"Tomana","year":"1999","journal-title":"J. Clin. Invest."},{"key":"B76","doi-asserted-by":"crossref","DOI":"10.1038\/srep20074","article-title":"Intracerebral hemorrhage and deep microbleeds associated with cnm-positive Streptococcus mutans; a hospital cohort study.","volume":"6","author":"Tonomura","year":"2016","journal-title":"Sci. Rep."},{"key":"B77","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.7150\/jca.73310","article-title":"Streptococcus mutans promotes tumor progression in oral squamous cell carcinoma.","volume":"13","author":"Tsai","year":"2022","journal-title":"J. Cancer"},{"key":"B78","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1128\/IAI.68.2.644-650.2000","article-title":"Role of serotype-specific polysaccharide in the resistance of Streptococcus mutans to phagocytosis by human polymorphonuclear leukocytes.","volume":"68","author":"Tsuda","year":"2000","journal-title":"Infect. Immun."},{"key":"B79","doi-asserted-by":"crossref","first-page":"302","DOI":"10.5114\/ceji.2016.63131","article-title":"The relationship between the immune system and oral manifestations of inflammatory bowel disease: a review.","volume":"41","author":"Vasovic","year":"2016","journal-title":"Central Eur. J. Immunol."},{"key":"B80","doi-asserted-by":"crossref","first-page":"6556","DOI":"10.1128\/JB.181.20.6556-6559.1999","article-title":"A novel gene required for rhamnose-glucose polysaccharide synthesis in Streptococcus mutans.","volume":"181","author":"Yamashita","year":"1999","journal-title":"J. Bacteriol."},{"key":"B81","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nrc2734","article-title":"STATs in cancer inflammation and immunity: a leading role for STAT3.","volume":"9","author":"Yu","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"B82","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.1111\/cas.15538","article-title":"The oral bacterium Streptococcus mutans promotes tumor metastasis by inducing vascular inflammation.","volume":"113","author":"Yu","year":"2022","journal-title":"Cancer Sci."},{"key":"B83","doi-asserted-by":"publisher","first-page":"936","DOI":"10.7150\/ijms.8277","article-title":"Potential dual immunomodulatory role of VEGF in ulcerative colitis and colorectal carcinoma.","volume":"11","author":"Zdravkovic","year":"2014","journal-title":"Int. J. Med. Sci."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2024.1503657\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T06:26:56Z","timestamp":1734589616000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2024.1503657\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":83,"alternative-id":["10.3389\/fmicb.2024.1503657"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2024.1503657","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,19]]},"article-number":"1503657"}}