{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:49:41Z","timestamp":1792680581000,"version":"4.5.0"},"reference-count":81,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>PCR and culture tests are used together to confirm the diagnosis of active tuberculosis (TB). Due to the long culture period, if the PCR test is negative, it takes a significant amount of time for the culture result to be available. Interferon-<jats:italic>\u03b3<\/jats:italic> release assays (IGRAs), which are widely used to diagnose TB or latent tuberculosis infection (LTBI), cannot effectively discriminate TB from LTBI. The purpose of this study is to analyze the diagnostic performance of various markers for differentiating between TB from LTBI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed-Medline, EMBASE, Cochrane Library, and Web of Science were searched up to the end of May 2024, without restrictions on publication date and population. Articles describing the diagnostic value of at least one biomarker for differentiating between TB and LTBI were included. The QUADAS-2 tool was used to assess study quality. Two independent researchers assessed the articles using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The network meta-analysis (NMA) was performed for diagnostic tools of 11 groups used to differentiate TB from LTBI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 164 identified articles, 159 reports were included in the systematic review and 58 in the meta-analysis. Seventy results from 58 reports accounting for 9,291 participants were included. When measuring interleukin-2 (IL-2) after stimulation with latency antigen, the most significant odds ratio was shown in terms of sensitivity, specificity, positive predictive value and negative predictive value. The values were 9.46, 18.5, 11.30, and 9.61, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study shows that the IL-2 level after stimulation with latent antigen is a potential biomarker for differentiating TB from LTBI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic review registration<\/jats:title><jats:p><jats:uri>https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42024542996<\/jats:uri>.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmicb.2024.1506127","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T06:31:48Z","timestamp":1734676308000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Diagnostic performance of biomarkers for differentiating active tuberculosis from latent tuberculosis: a systematic review and Bayesian network meta-analysis"],"prefix":"10.3389","volume":"15","author":[{"given":"Ji Hun","family":"Jeong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Ryul","family":"Shim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangah","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inhwan","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhwa","family":"Ihm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"4065","DOI":"10.1007\/s11033-020-05413-7","article-title":"Advances in diagnosis of tuberculosis: an update into molecular diagnosis of Mycobacterium tuberculosis","volume":"47","author":"Acharya","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jinf.2013.08.005","article-title":"Cytokine responses to quantiferon peptides in pediatric tuberculosis: a pilot study","volume":"68","author":"Armand","year":"2014","journal-title":"J. Infect."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.cimid.2015.11.002","article-title":"Potential novel markers to discriminate between active and latent tuberculosis infection in Chinese individuals","volume":"44","author":"Bai","year":"2016","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.tube.2018.08.006","article-title":"Diagnostic performance of gm-Csf and Il-2 in response to long-term specific-antigen cell stimulation in patients with active and latent tuberculosis infection","volume":"112","author":"Balcells","year":"2018","journal-title":"Tuberculosis (Edinb.)"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.jinf.2014.05.014","article-title":"Serologic diagnosis of tuberculosis by combining Ig classes against selected mycobacterial targets","volume":"69","author":"Baumann","year":"2014","journal-title":"J. Infect."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"13646","DOI":"10.1038\/s41598-021-93059-1","article-title":"Multi-country evaluation of Risk6, a 6-gene blood transcriptomic signature, for tuberculosis diagnosis and treatment monitoring","volume":"11","author":"Bayaa","year":"2021","journal-title":"Sci. Rep."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1111\/j.1469-0691.2009.03104.x","article-title":"Detection of interleukin-2 in addition to interferon-gamma discriminates active tuberculosis patients, latently infected individuals, and controls","volume":"16","author":"Biselli","year":"2010","journal-title":"Clin. Microbiol. Infect."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e43438","DOI":"10.1371\/journal.pone.0043438","article-title":"Immune responses to Esat-6 and Cfp-10 by fascia and multiplex Technology for Diagnosis of M. tuberculosis infection; Ip-10 is a promising marker","volume":"7","author":"Borgstr\u00f8m","year":"2012","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"515","DOI":"10.3967\/bes2018.069","article-title":"Screening of serum biomarkers for distinguishing between latent and active tuberculosis using proteome microarray","volume":"31","author":"Cao","year":"2018","journal-title":"Biomed. Environ. Sci."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.3389\/fimmu.2020.02006","article-title":"Diagnosis for latent tuberculosis infection: new alternatives","volume":"11","author":"Carranza","year":"2020","journal-title":"Front. Immunol."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1471-2334-12-10","article-title":"Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of Tb disease in a high burden setting","volume":"12","author":"Chegou","year":"2012","journal-title":"BMC Infect. Dis."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"e64226","DOI":"10.1371\/journal.pone.0064226","article-title":"Utility of host markers detected in Quantiferon supernatants for the diagnosis of tuberculosis in children in a high-burden setting","volume":"8","author":"Chegou","year":"2013","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e46041","DOI":"10.1371\/journal.pone.0046041","article-title":"Potential role of M. tuberculosis specific Ifn-\u03b3 and Il-2 Elispot assays in discriminating children with active or latent tuberculosis","volume":"7","author":"Chiappini","year":"2012","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e180579","DOI":"10.1590\/0074-02760180579","article-title":"Neutrophil Cd64 expression levels in Igra-positive individuals distinguish latent tuberculosis from active disease","volume":"114","author":"Corr\u00eca","year":"2019","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"725447","DOI":"10.3389\/fimmu.2021.725447","article-title":"Serum biomarker profile including Ccl1, Cxcl10, Vegf, and adenosine deaminase activity distinguishes active from remotely acquired latent tuberculosis","volume":"12","author":"Delemarre","year":"2021","journal-title":"Front. Immunol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"e0197825","DOI":"10.1371\/journal.pone.0197825","article-title":"Novel M. tuberculosis specific Il-2 Elispot assay discriminates adult patients with active or latent tuberculosis","volume":"13","author":"Della Bella","year":"2018","journal-title":"PLoS One"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1183\/09031936.00115110","article-title":"Interferon-\u03b3 release assays for the diagnosis of latent Mycobacterium tuberculosis infection: a systematic review and meta-analysis","volume":"37","author":"Diel","year":"2011","journal-title":"Eur. Respir. J."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ijid.2021.07.024","article-title":"Assessment of interferon gamma-induced protein 10 mrna release assay for detection of latent tuberculosis infection in Egyptian pediatric household contacts","volume":"109","author":"El-Sheikh","year":"2021","journal-title":"Int. J. Infect. Dis."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1038\/pr.2012.89","article-title":"Tnf-\u03b1\/Il-2 ratio discriminates latent from active tuberculosis in immunocompetent children: a pilot study","volume":"72","author":"Gourgouillon","year":"2012","journal-title":"Pediatr. Res."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"594376","DOI":"10.3389\/fimmu.2021.594376","article-title":"Pmn-Mdsc frequency discriminates active versus latent tuberculosis and could play a role in counteracting the immune-mediated lung damage in active disease","volume":"12","author":"Grassi","year":"2021","journal-title":"Front. Immunol."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"777","DOI":"10.7326\/M14-2385","article-title":"The Prisma extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations","volume":"162","author":"Hutton","year":"2015","journal-title":"Ann. Intern. Med."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1128\/JCM.02758-14","article-title":"Discrimination between active and latent tuberculosis based on ratio of antigen-specific to mitogen-induced Ip-10 production","volume":"53","author":"Jeong","year":"2015","journal-title":"J. Clin. Microbiol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"506","DOI":"10.30699\/ijmm.17.5.505","article-title":"Diagnosis of latent tuberculosis infection: promising antigens","volume":"17","author":"Jomehpour","year":"2023","journal-title":"Iranian J. Med. Microbiol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"101916","DOI":"10.1016\/j.tube.2020.101916","article-title":"Diagnosis of active tuberculosis and latent tuberculosis infection based on Raman spectroscopy and surface-enhanced Raman spectroscopy","volume":"121","author":"Kaewseekhao","year":"2020","journal-title":"Tuberculosis (Edinb.)"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"278","DOI":"10.5588\/ijtld.16.0176","article-title":"Potential biomarkers associated with discrimination between latent and active pulmonary tuberculosis","volume":"21","author":"Kamakia","year":"2017","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"101992","DOI":"10.1016\/j.tube.2020.101992","article-title":"Identification of a novel biomarker based on lymphocyte count, albumin level, and Tbag\/Pha ratio for differentiation between active and latent tuberculosis infection in Japan","volume":"125","author":"Katakura","year":"2020","journal-title":"Tuberculosis"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.jmoldx.2014.08.005","article-title":"Diagnostic performance of a cytokine and Ifn-\u03b3-induced chemokine mrna assay after Mycobacterium tuberculosis-specific antigen stimulation in whole blood from infected individuals","volume":"17","author":"Kim","year":"2015","journal-title":"J. Mol. Diagn."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1126\/science.290.5489.92","article-title":"Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells","volume":"290","author":"Lanzavecchia","year":"2000","journal-title":"Science"},{"key":"ref29","first-page":"34","article-title":"Application of combined Cks to differentiate active and latent tuberculosis infection","volume":"26","author":"Li","year":"2016","journal-title":"Chinese J. Modern Med."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1093\/qjmed\/hcad214","article-title":"A novel chemokine biomarker to distinguish active tuberculosis from latent tuberculosis: a cohort study","volume":"116","author":"Li","year":"2023","journal-title":"QJM"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"105002","DOI":"10.1016\/j.micinf.2022.105002","article-title":"Novel serological biomarker panel using protein microarray can distinguish active Tb from latent Tb infection","volume":"24","author":"Li","year":"2022","journal-title":"Microbes Infect."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"575650","DOI":"10.3389\/fcimb.2021.575650","article-title":"Combination of blood routine examination and T-Spot.Tb assay for distinguishing between active tuberculosis and latent tuberculosis infection","volume":"11","author":"Luo","year":"","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"641378","DOI":"10.3389\/fimmu.2021.641378","article-title":"Lymphocyte non-specific function detection facilitating the stratification of Mycobacterium tuberculosis infection","volume":"12","author":"Luo","year":"","journal-title":"Front. Immunol."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.ijid.2020.05.109","article-title":"A combination of iron metabolism indexes and tuberculosis-specific antigen\/phytohemagglutinin ratio for distinguishing active tuberculosis from latent tuberculosis infection","volume":"97","author":"Luo","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"115892","DOI":"10.1016\/j.diagmicrobio.2023.115892","article-title":"Convolutional neural network based on T-Spot.Tb assay promoting the discrimination between active tuberculosis and latent tuberculosis infection","volume":"105","author":"Luo","year":"2023","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1186\/s12879-022-07954-7","article-title":"Development of diagnostic algorithm using machine learning for distinguishing between active tuberculosis and latent tuberculosis infection","volume":"22","author":"Luo","year":"2022","journal-title":"BMC Infect. Dis."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"721013","DOI":"10.3389\/fimmu.2021.721013","article-title":"Activation phenotype of Mycobacterium tuberculosis-specific Cd4(+) T cells promoting the discrimination between active tuberculosis and latent tuberculosis infection","volume":"12","author":"Luo","year":"","journal-title":"Front. Immunol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"658843","DOI":"10.3389\/fimmu.2021.658843","article-title":"Lymphocyte-related immunological indicators for stratifying Mycobacterium tuberculosis infection","volume":"12","author":"Luo","year":"","journal-title":"Front. Immunol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"761209","DOI":"10.3389\/fimmu.2021.761209","article-title":"Combination of Hla-Dr on Mycobacterium tuberculosis-specific cells and tuberculosis antigen\/Phytohemagglutinin ratio for discriminating active tuberculosis from latent tuberculosis infection","volume":"12","author":"Luo","year":"","journal-title":"Front. Immunol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e13831","DOI":"10.1111\/ijcp.13831","article-title":"Combination of prealbumin and tuberculosis-specific antigen\/phytohemagglutinin ratio for discriminating active tuberculosis from latent tuberculosis infection","volume":"75","author":"Luo","year":"","journal-title":"Int. J. Clin. Pract."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.jinf.2018.10.017","article-title":"Diagnostic performance of plasma cytokine biosignature combination and Mcp-1 as individual biomarkers for differentiating stages Mycobacterium tuberculosis infection","volume":"78","author":"Luo","year":"2019","journal-title":"J. Infect."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"6263","DOI":"10.1007\/s11033-019-05067-0","article-title":"Diagnostic accuracy of interferon (Ifn)-\u03b3 inducible protein 10 (Ip-10) as a biomarker for the discrimination of active and latent tuberculosis","volume":"46","author":"Mamishi","year":"2019","journal-title":"Mol. Biol. Rep."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.aller.2015.09.004","article-title":"Improving T-cell assays for diagnosis of latent Tb infection: confirmation of the potential role of testing Interleukin-2 release in Iranian patients","volume":"44","author":"Mamishi","year":"2016","journal-title":"Allergol. Immunopathol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1086\/338833","article-title":"Differential T and B cell responses against Mycobacterium tuberculosis heparin-binding hemagglutinin Adhesin in infected healthy individuals and patients with tuberculosis","volume":"185","author":"Masungi","year":"2002","journal-title":"J. Infect. Dis."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"2476","DOI":"10.3389\/fimmu.2018.02476","article-title":"A systematic review on novel Mycobacterium tuberculosis antigens and their discriminatory potential for the diagnosis of latent and active tuberculosis","volume":"9","author":"Meier","year":"2018","journal-title":"Front. Immunol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"e228","DOI":"10.1016\/S1473-3099(18)30134-8","article-title":"Progression from latent infection to active disease in dynamic tuberculosis transmission models: a systematic review of the validity of modelling assumptions","volume":"18","author":"Menzies","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.diagmicrobio.2011.08.010","article-title":"Tuberculosis patients are characterized by a low\u2013Ifn-\u03b3\/high\u2013Tnf-\u03b1 response to methylated Hbha produced in M. smegmatis","volume":"71","author":"Molicotti","year":"2011","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"563","DOI":"10.3109\/23744235.2015.1031173","article-title":"Could inducible protein-10 and heparin-binding hemagglutinin improve the detection of Mycobacterium tuberculosis-infected subjects in a country with low incidence of tuberculosis?","volume":"47","author":"Molicotti","year":"2015","journal-title":"Infect. Dis."},{"key":"ref49","first-page":"275","article-title":"Ifn-\u03b3 and Il-2 responses to recombinant Aladh against Esat-6\/Cfp-10 fusion antigens in the diagnosis of latent versus active tuberculosis infection","volume":"42","author":"Movahedi","year":"2017","journal-title":"Iran J Med Sci"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.tube.2017.04.005","article-title":"Chemokines additional to Ifn-\u03b3 can be used to differentiate among Mycobacterium tuberculosis infection possibilities and provide evidence of an early clearance phenotype","volume":"105","author":"Nonghanphithak","year":"2017","journal-title":"Tuberculosis (Edinb.)"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"300060520910042","DOI":"10.1177\/0300060520910042","article-title":"Serum proteomic analysis of Mycobacterium tuberculosis antigens for discriminating active tuberculosis from latent infection","volume":"48","author":"Peng","year":"2020","journal-title":"J. Int. Med. Res."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.tube.2018.06.005","article-title":"Evaluation of Ip-10 in Quantiferon-plus as biomarker for the diagnosis of latent tuberculosis infection","volume":"111","author":"Petrone","year":"2018","journal-title":"Tuberculosis (Edinb.)"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1177\/2472555220954389","article-title":"Comparative analysis of multiple immunoassays for cytokine profiling in drug discovery","volume":"25","author":"Platchek","year":"2020","journal-title":"Slas Discovery"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.jclinepi.2005.02.022","article-title":"Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews","volume":"58","author":"Reitsma","year":"2005","journal-title":"J. Clin. Epidemiol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12874-015-0060-8","article-title":"Ranking treatments in frequentist network meta-analysis works without resampling methods","volume":"15","author":"R\u00fccker","year":"2015","journal-title":"BMC Med. Res. Methodol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"2865","DOI":"10.1002\/sim.942","article-title":"A hierarchical regression approach to meta-analysis of diagnostic test accuracy evaluations","volume":"20","author":"Rutter","year":"2001","journal-title":"Stat. Med."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jclinepi.2010.03.016","article-title":"Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial","volume":"64","author":"Salanti","year":"2011","journal-title":"J. Clin. Epidemiol."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.jinf.2018.09.011","article-title":"Combined use of Quantiferon and Hbha-based Igra supports tuberculosis diagnosis and therapy management in children","volume":"77","author":"Sali","year":"2018","journal-title":"J. Infect."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"e38080","DOI":"10.1371\/journal.pone.0038080","article-title":"Discriminating active from latent tuberculosis in patients presenting to community clinics","volume":"7","author":"Sandhu","year":"2012","journal-title":"PLoS One"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.tube.2014.04.007","article-title":"Protective efficacy of piperine against Mycobacterium tuberculosis","volume":"94","author":"Sharma","year":"2014","journal-title":"Tuberculosis"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"e2019013","DOI":"10.4178\/epih.e2019013","article-title":"Network meta-analysis: application and practice using R software","volume":"41","author":"Shim","year":"2019","journal-title":"Epidemiol. Health"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"e2019006","DOI":"10.4178\/epih.e2019006","article-title":"Dose-response meta-analysis: application and practice using the R software","volume":"41","author":"Shim","year":"2019","journal-title":"Epidemiol. Health."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"e0166501","DOI":"10.1371\/journal.pone.0166501","article-title":"Potential role for Mycobacterium tuberculosis specific Il-2 and Ifn-\u03b3 responses in discriminating between latent infection and active disease after long-term stimulation","volume":"11","author":"Sun","year":"2016","journal-title":"PLoS One"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"e12365","DOI":"10.1371\/journal.pone.0012365","article-title":"Production of Tnf-alpha, Il-12(p40) and Il-17 can discriminate between active Tb disease and latent infection in a west African cohort","volume":"5","author":"Sutherland","year":"2010","journal-title":"PLoS One"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"e0152483","DOI":"10.1371\/journal.pone.0152483","article-title":"Combined analysis of Ifn-\u03b3, Il-2, Il-5, Il-10, Il-1ra and Mcp-1 in Qft supernatant is useful for distinguishing active tuberculosis from latent infection","volume":"11","author":"Suzukawa","year":"2016","journal-title":"PLoS One"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"101966","DOI":"10.1016\/j.tube.2020.101966","article-title":"Quantiferon-Tb gold plus combined with Hbha-induced Ifn-\u03b3 release assay improves the accuracy of identifying tuberculosis disease status","volume":"124","author":"Tang","year":"2020","journal-title":"Tuberculosis (Edinb.)"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1038\/nm1090","article-title":"Methylation-dependent T cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin","volume":"10","author":"Temmerman","year":"2004","journal-title":"Nat. Med."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"e51338","DOI":"10.1371\/journal.pone.0051338","article-title":"Evaluation of the diagnostic potential of Ip-10 and Il-2 as biomarkers for the diagnosis of active and latent tuberculosis in a Bcg-vaccinated population","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"2948","DOI":"10.3389\/fimmu.2019.02948","article-title":"Transcriptional profiling of human peripheral blood mononuclear cells identifies diagnostic biomarkers that distinguish active and latent tuberculosis","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Immunol."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"e79431","DOI":"10.1371\/journal.pone.0079431","article-title":"Mycobacterium tuberculosis-specific Tnf-\u03b1 is a potential biomarker for the rapid diagnosis of active tuberculosis disease in Chinese population","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"ref71","first-page":"2352","article-title":"Discrimination between active pulmonary tuberculosis and latent tuberculosis with pneumonia based on Ip10 levels","volume":"14","author":"Wang","year":"2021","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1007\/s10096-017-2948-1","article-title":"Involvement of methylated Hbha expressed from Mycobacterium smegmatis in an Ifn-\u03b3 release assay to aid discrimination between latent infection and active tuberculosis in Bcg-vaccinated populations","volume":"36","author":"Wen","year":"2017","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref73","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"Quadas-2: a revised tool for the quality assessment of diagnostic accuracy studies","volume":"155","author":"Whiting","year":"2011","journal-title":"Ann. Intern. Med."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.jinf.2016.11.010","article-title":"Biomarkers for discrimination between latent tuberculosis infection and active tuberculosis disease","volume":"74","author":"Won","year":"2017","journal-title":"J. Infect."},{"key":"ref75","volume-title":"Global tuberculosis report 2023","year":"2023"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.tube.2016.06.001","article-title":"Multiple cytokine responses in discriminating between active tuberculosis and latent tuberculosis infection","volume":"102","author":"Wu","year":"2017","journal-title":"Tuberculosis (Edinb.)"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"17918","DOI":"10.1038\/srep17918","article-title":"Discriminating active tuberculosis from latent tuberculosis infection by flow cytometric measurement of Cd161-expressing T cells","volume":"5","author":"Yang","year":"2015","journal-title":"Sci. Rep."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.tube.2017.07.013","article-title":"Multiplex analysis of plasma cytokines\/chemokines showing different immune responses in active Tb patients, latent Tb infection and healthy participants","volume":"107","author":"Yao","year":"2017","journal-title":"Tuberculosis (Edinb.)"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"170","DOI":"10.23749\/mdl.v111i3.9983","article-title":"The diagnosis of latent tuberculosis infection (Ltbi): currently available tests, future developments, and perspectives to eliminate tuberculosis (Tb)","volume":"111","author":"Zellweger","year":"2020","journal-title":"Med. Lav."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/CM9.0000000000001858","article-title":"Mycobacterium tuberculosis latency-associated antigen Rv1733c Slp improves the accuracy of differential diagnosis of active tuberculosis and latent tuberculosis infection","volume":"135","author":"Zhang","year":"2022","journal-title":"Chin. Med. J."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"457","DOI":"10.3389\/fcimb.2017.00457","article-title":"Application of ImmunoScore model for the differentiation between active tuberculosis and latent tuberculosis infection as well as monitoring anti-tuberculosis therapy","volume":"7","author":"Zhou","year":"2017","journal-title":"Front. Cell. Infect. 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