{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:02:38Z","timestamp":1788566558005,"version":"build-2803163510"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Enterotoxigenic <jats:italic>Escherichia coli<\/jats:italic> (ETEC), producing heat-stable (ST) and\/or heat-labile (LT) enterotoxins, is a major cause of diarrhea in children and travelers in developing countries. Surveillance in cholera-endemic regions is crucial for timely public health response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between May and November 2022, a cross-sectional study was conducted in Puri, India. Rectal swabs from 256 hospitalized diarrhea patients were analyzed for diarrheagenic <jats:italic>E. coli<\/jats:italic> and <jats:italic>Vibrio cholerae<\/jats:italic> using microbiological and molecular methods. Antimicrobial susceptibility of ETEC isolates was also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ETEC was detected in 20.3% of cases, making it the most prevalent pathogen. No Vibrio cholerae was isolated. EAEC and EPEC were identified in 6.2% and 2.3% of cases, respectively. ETEC was significantly more common in children under 2 years (<jats:italic>p<\/jats:italic> &amp;lt; 0.00001), though overall age correlation was weak (<jats:italic>R<\/jats:italic> = \u20130.013). Symptoms included watery stool, vomiting, abdominal pain, and dehydration, with dehydration significantly associated with adults (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). ETEC strains were susceptible to streptomycin, chloramphenicol, gentamicin, and amikacin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>ETEC has emerged as the dominant diarrheal pathogen in a cholera-endemic area, posing a risk to both children and adults. These findings highlight the need for continued epidemiological monitoring and age-targeted interventions.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmicb.2025.1470783","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T05:39:41Z","timestamp":1749015581000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["High prevalence of enterotoxigenic Escherichia coli strains in hospitalized diarrhea patients: a preliminary study from a cholera-endemic area in India (2022)"],"prefix":"10.3389","volume":"16","author":[{"given":"Hemant Kumar","family":"Khuntia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabir","family":"Manna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak Kumar","family":"Barik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhojeet","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanta Kumar","family":"Bramha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghamitra","family":"Pati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoranjan","family":"Ranjit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhusmita","family":"Bal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Salomi","family":"Kerketta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1128\/jcm.33.4.973-977.1995","article-title":"Controlled study of Escherichia coli diarrheal infections in Bangladeshi children","volume":"33","author":"Albert","year":"1995","journal-title":"J. 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