{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:04:01Z","timestamp":1787587441208,"version":"build-2736575974"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    <jats:italic>Alphavirus chikungunya<\/jats:italic>\n                    virus (CHIKV) is an arbovirus, belonging to the\n                    <jats:italic>Togaviridae<\/jats:italic>\n                    family. The disease caused by CHIKV generally evolves with spontaneous resolution in a few weeks; however, progression to a chronic disease may occur. The most common symptoms are fever, myalgia, and arthralgia; however, skin manifestations may occur in 40 to 80% of infected individuals. Morbilliform and maculopapular erythematous eruptions, vesiculobullous lesions, generalized erythema, maculopapular eruption and skin peeling, hypermelanosis, painful oral lesions, and urticarial lesions have been reported. Usually, these manifestations disappear, but they can become sequelae. Since the skin is the first line of defense against CHIKV infection, in this study, we aimed to investigate the immunohistopathological aspects of the skin of infected individuals during the acute phase of the disease by performing histopathological and ultrastructural analysis, detection and quantification of the viral genome, detection of viral antigen and immune cells, and cytokines\/chemokines\u2019 characterization. The main histopathological findings were perivascular and inflammatory infiltrates, blood capillary ectasia, and interstitial edema. The immunohistochemistry revealed CHIKV antigen in the epidermis, endothelial cells, fibroblasts, and macrophages in the reticular and papillary dermis; inflammatory cells infiltrate; arrector pili muscle; sweat and sebaceous glands; and hair follicle. Moreover, inflammatory infiltrates were composed of lymphocytes (CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    ) and macrophages (CD68\n                    <jats:sup>+<\/jats:sup>\n                    ) in the dermis and perivascular infiltrate. TNF-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , IL-6, RANTES, and VEGFR2 were expressed in the epidermis, blood vessels, sweat glands, and migrating cells. Loss of contact among adjacent keratinocytes, epidermis presenting necrotic cells, and fibroblasts with dilated cisternae in the endoplasmic reticulum and mitochondria with few cristae was observed by transmission electron microscopy. Studies involving skin immunopathogenesis during CHIKV infection are still scarce; therefore, the findings presented here can contribute to a better understanding of the disease immunopathogenesis.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2025.1497354","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T01:45:00Z","timestamp":1738028700000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Chikungunya virus infection in the skin: histopathology and cutaneous immunological response"],"prefix":"10.3389","volume":"16","author":[{"given":"Nat\u00e1lia Gede\u00e3o","family":"Salom\u00e3o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Jos\u00e9","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Luiza Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Bas\u00edlio-de-Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Panno","family":"Bas\u00edlio-de-Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Jos\u00e9","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla Conrado Guerra","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Fernandes","family":"da Silva Amorim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas Valiati dos Santos","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marciano Viana","family":"Paes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00edssila","family":"Rabelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2022.1001129","article-title":"Non-cytotoxic functions of Cd8 T cells: \u201crepentance of a serial killer.\u201d","volume":"13","author":"Al Moussawy","year":"2022","journal-title":"Front. Immunol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"64","DOI":"10.4103\/0019-5154.60356","article-title":"Mucocutaneous Manifestations of Chikungunya Fever","volume":"55","author":"Bandyopadhyay","year":"2010","journal-title":"Indian J. Dermatol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"32633","DOI":"10.1074\/jbc.M400642200","article-title":"Effects of tumor necrosis factor-\u03b1 (TNF\u03b1) in epidermal keratinocytes revealed using global transcriptional profiling","volume":"279","author":"Banno","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S13256-021-03197-3\/FIGURES\/4","article-title":"Atypical skin manifestation in severe acute chikungunya infection in a pregnant woman: a case report","volume":"16","author":"Benjamanukul","year":"2022","journal-title":"J. Med. Case Rep."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/j.1365-2230.1994.tb02687.x","article-title":"Correlated increases of tumour necrosis factor-\u03b1, interleukin-6 and granulocyte monocyte-colony stimulating factor levels in suction blister fluids and sera of psoriatic patients relationships with disease severity","volume":"19","author":"Bonifati","year":"1994","journal-title":"Clin. Exp. Dermatol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1086\/517537","article-title":"Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients","volume":"44","author":"Borgherini","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"ref9003","doi-asserted-by":"publisher","first-page":"eaax2421","DOI":"10.1126\/scitranslmed.aax2421","article-title":"Pan-viral protection against arboviruses by activating skin macrophages at the inoculation site","volume":"12","author":"Bryden","year":"2020","journal-title":"Science Translational Medicine"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e107","DOI":"10.1016\/S1473-3099(16)30385-1","article-title":"Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen","volume":"17","author":"Burt","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/JTM\/TAAA040","article-title":"Oral lesions are frequent in patients with chikungunya infection","volume":"27","author":"Casais","year":"2020","journal-title":"J. Travel Med."},{"key":"ref7001","year":"2019","journal-title":"N\u00famero de Casos de Chikungunya* por m\u00eas, \u00c1reas de Planejamento, Regi\u00f5es Administrativas e Bairros, Munic\u00edpio do Rio de Janeiro \u2013 2019"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsi.2012.11.001","article-title":"Skin as an immune organ","volume":"30","author":"Chu","year":"2012","journal-title":"Dermatol. Sin."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e29","DOI":"10.1371\/journal.ppat.0040029","article-title":"A mouse model for chikungunya: Young age and inefficient type-I interferon signaling are risk factors for severe disease","volume":"4","author":"Couderc","year":"2008","journal-title":"PLoS Pathog."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1590\/0074-02760170044","article-title":"Chikungunya virus: clinical aspects and treatment - a review","volume":"112","author":"da Cunha","year":"2017","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e0010142","DOI":"10.1371\/JOURNAL.PNTD.0010142","article-title":"Long-term chikungunya sequelae and quality of life 2.5 years post-acute disease in a prospective cohort in Cura\u00e7ao","volume":"16","author":"Doran","year":"2022","journal-title":"PLoS Negl. Trop. Dis."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/J.MEEGID.2015.03.025","article-title":"Inflammasome signaling pathways exert antiviral effect against chikungunya virus in human dermal fibroblasts","volume":"32","author":"Ekchariyawat","year":"2015","journal-title":"Infect. Genet. Evol."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e20190015","DOI":"10.1590\/0037-8682-0015-2019","article-title":"Extensive vesiculobullous exanthema following chikungunya fever in a 13-year-old patient","volume":"52","author":"Farias","year":"2019","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"826","DOI":"10.3390\/pathogens4040826","article-title":"Antimicrobial mechanisms of macrophages and the immune evasion strategies of Staphylococcus aureus","volume":"4","author":"Flannagan","year":"2015","journal-title":"Pathogens"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"S446","DOI":"10.1093\/infdis\/jiw362","article-title":"Chikungunya pathogenesis: from the clinics to the bench","volume":"214","author":"Gasque","year":"2016","journal-title":"J. Infect. Dis."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"6720","DOI":"10.3390\/ijms14046720","article-title":"Cytokines and the skin barrier","volume":"14","author":"H\u00e4nel","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2007.05.013","article-title":"Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition","volume":"19","author":"Holmes","year":"2007","journal-title":"Cellular Signal."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/J.1365-4632.2008.03478.X","article-title":"Cutaneous manifestations of chikungunya fever: observations made during a recent outbreak in South India","volume":"47","author":"Inamadar","year":"2008","journal-title":"Int. J. Dermatol."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e00969","DOI":"10.1016\/J.IDCR.2020.E00969","article-title":"Perinatal chikungunya induced scalded skin syndrome","volume":"22","author":"Jebain","year":"2020","journal-title":"IDCases"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1172\/jci.insight.142067","article-title":"Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin","volume":"5","author":"Jiang","year":"2020","journal-title":"JCI Insight"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3390\/BIOMEDICINES8050101","article-title":"The role of IL-6 in skin fibrosis and cutaneous wound healing","volume":"8","author":"Johnson","year":"2020","journal-title":"Biomedicines"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1159\/000091170","article-title":"Increased expression of RANTES, CCR3 and CCR5 in the lesional skin of patients with atopic eczema","volume":"139","author":"Kato","year":"2006","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3390\/dermatopathology7010002","article-title":"Clinical and histopathological features and potential pathological mechanisms of skin lesions in COVID-19: Review of the Literature","volume":"7","author":"Kaya","year":"2020","journal-title":"Dermatopathology"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1111\/ALL.15104","article-title":"T-cell subsets in the skin and their role in inflammatory skin disorders","volume":"77","author":"Kortekaas Krohn","year":"2022","journal-title":"Allergy"},{"key":"ref27","volume-title":"Cutaneous manifestations of chikungunya fever: Observations from an outbreak at a tertiary Care Hospital in Southeast Rajasthan","author":"Kumar","year":"2017"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"764","DOI":"10.3201\/eid1305.070015","article-title":"Chikungunya virus in US travelers returning from India, 2006","volume":"13","author":"Lanciotti","year":"2007","journal-title":"Emerg. Infect. Dis."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1189\/jlb.0802397","article-title":"Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice","volume":"73","author":"Lin","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/J.ANTIVIRAL.2015.06.009","article-title":"Cellular and molecular mechanisms of chikungunya pathogenesis","volume":"120","author":"Lum","year":"2015","journal-title":"Antivir. Res."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/j.1582-4934.2007.00112.x","article-title":"Overexpression of vascular endothelial growth factor (VEGF) receptors on keratinocytes in psoriasis: regulated by calcium independent of VEGF","volume":"12","author":"Man","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1517\/14728222.2013.837886","article-title":"Targeting CCL5 in inflammation","volume":"17","author":"Marques","year":"2013","journal-title":"Expert Opinion Therapeutic Targets"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/S1473-3099(07)70091-9","article-title":"Chikungunya epidemic in India: a major public-health disaster","volume":"7","author":"Mavalankar","year":"2007","journal-title":"Lancet Infect. Dis."},{"key":"ref34","year":"2017"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"e4261","DOI":"10.1371\/journal.pone.0004261","article-title":"IL-1\u03b2, IL-6, and RANTES as biomarkers of chikungunya severity","volume":"4","author":"Ng","year":"2009","journal-title":"PLoS One"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"100066","DOI":"10.1016\/j.xjidi.2021.100066","article-title":"Identification of keratinocyte mitogens: implications for Hyperproliferation in psoriasis and atopic dermatitis","volume":"2","author":"Niehues","year":"2022","journal-title":"JID Innovations"},{"key":"ref37","volume-title":"Chikungunya Fever","author":"Ojeda Rodriguez","year":"2023"},{"key":"ref9002","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/j.1365-4632.2010.04644.x","article-title":"Purpuric macules with vesiculobullous lesions: a novel manifestation of Chikungunya","volume":"50","author":"Pakran","year":"2011","journal-title":"Int J Dermatol."},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13793","article-title":"Cutaneous features of Zika virus infection: a clinicopathological overview","volume":"44","author":"Paniz-Mondolfi","year":"2019","journal-title":"Clin Exp Dermatol"},{"key":"ref39","first-page":"240","article-title":"Chikungunya infection in neonates","volume":"45","author":"Passi","year":"2008","journal-title":"Indian Pediatr."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"171","DOI":"10.12932\/AP0810","article-title":"Activation of dengue virus-specific T cells modulates vascular endothelial growth factor receptor 2 expression","volume":"35","author":"Rattanamahaphoom","year":"2017","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"671","DOI":"10.4103\/0378-6323.72466","article-title":"Cutaneous manifestations of chikungunya during a recent epidemic in Calicut, North Kerala, South India","volume":"76","author":"Riyaz","year":"2010","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s00431-009-0986-0","article-title":"Severe bullous skin lesions associated with chikungunya virus infection in small infants","volume":"169","author":"Robin","year":"2010","journal-title":"Eur. J. Pediatr."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"L399","DOI":"10.1152\/AJPLUNG.1989.257.6.L399","article-title":"Tumor necrosis factor and interleukin 1 alpha increase vascular endothelial permeability","volume":"257","author":"Royall","year":"1989","journal-title":"Am. J. Phys."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1080\/22221751.2019.1678366","article-title":"Demographic and clinical characteristics of chikungunya patients from six Colombian cities, 2014-2015","volume":"8","author":"Rueda","year":"2018","journal-title":"Emerg Microbes Infect"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"13420","DOI":"10.1073\/pnas.1611391113","article-title":"How social structures, space, and behaviors shape the spread of infectious diseases using chikungunya as a case study","volume":"113","author":"Salje","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1002\/9781119680642.ch1","article-title":"The skin as an immune organ","author":"Santoro","year":"2021","journal-title":"Diag. Ther. Vet. Dermatol."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"689979","DOI":"10.3389\/fmicb.2021.689979","article-title":"Molecular Epidemiology, Evolution and Reemergence of Chikungunya Virus in South Asia","volume":"12","author":"Sharif","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref48","first-page":"e345","article-title":"Clinical Characteristics, Histopathology, and Tissue Immunolocalization of Chikungunya Virus Antigen in Fatal Cases","volume-title":"Clin Infect Dis","author":"Sharp","year":"2021"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1093\/jb\/mvs136","article-title":"Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases. In","volume":"153","author":"Shibuya","year":"2013","journal-title":"J. Biochem."},{"key":"ref9001","doi-asserted-by":"publisher","first-page":"106872","DOI":"10.1016\/j.actatropica.2023.106872","article-title":"Prevalence and epidemiological aspects of Chikungunya fever in states of the Northeast region of Brazil: A systematic review","volume":"241","author":"Silva","year":"2023","journal-title":"Acta Trop."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/J.MCNA.2008.07.008","article-title":"Chikungunya: a paradigm of emergence and globalization of vector-borne diseases","volume":"92","author":"Simon","year":"2008","journal-title":"Med. Clin. North Am."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"119","DOI":"10.4103\/2229-5178.146188","article-title":"Vesiculobullous viral exanthem due to chikungunya in an infant","volume":"5","author":"Singh","year":"2014","journal-title":"Indian Dermatol. Online J."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1002\/CCR3.1831","article-title":"Diffuse maculopapular rash: a family cluster during the last chikungunya virus epidemic in Italy","volume":"6","author":"Spoto","year":"2018","journal-title":"Clin. Case Reports"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2012.01825.x","article-title":"The cell biology of chikungunya virus infection","volume":"14","author":"Tang","year":"2012","journal-title":"Cell. Microbiol."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"79","DOI":"10.4103\/0019-5154.60359","article-title":"Mucocutaneous manifestations of dengue fever","volume":"55","author":"Thomas","year":"2010","journal-title":"Indian J. Dermatol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"e00421","DOI":"10.1016\/J.IDCR.2018.E00421","article-title":"Morbilliform skin rash with prominent involvement of the palms in chikungunya fever","volume":"13","author":"Tini","year":"2018","journal-title":"IDCases"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ijid.2016.09.009","article-title":"Congenital and perinatal complications of chikungunya fever: a Latin American experience","volume":"51","author":"Torres","year":"2016","journal-title":"Int. J. Infect. Dis."},{"key":"ref57","first-page":"288","article-title":"Chikungunya: a rare skin manifestation Case report","volume-title":"Correo Cient\u00edfico M\u00e9dico.","author":"Turtos","year":"2019"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/S12098-009-0045-X","article-title":"Clinical profile of chikungunya in infants","volume":"76","author":"Valamparampil","year":"2009","journal-title":"Indian J. Pediatr."},{"key":"ref9004","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1093\/infdis\/jiq006","article-title":"The acute phase of Chikungunya virus infection in humans is associated with strong innate immunity and T CD8 cell activation","volume":"204","author":"Wauquier","year":"2011","journal-title":"J Infect Dis"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"e1007993","DOI":"10.1371\/journal.ppat.1007993","article-title":"Dermal and muscle fibroblasts and skeletal myofibers survive chikungunya virus infection and harbor persistent RNA","volume":"15","author":"Young","year":"2019","journal-title":"PLoS Pathog."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2025.1497354\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T01:45:05Z","timestamp":1738028705000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2025.1497354\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,28]]},"references-count":63,"alternative-id":["10.3389\/fmicb.2025.1497354"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2025.1497354","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,28]]},"article-number":"1497354"}}