{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:38:31Z","timestamp":1779316711770,"version":"3.51.4"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>Nonsteroidal anti-inflammatory drug (NSAID) enteropathy is a serious clinical complication with no effective treatments available. Modulating the intestinal microbiota through dietary and nutritional targets is a promising strategy for preventing NSAID enteropathy. This study aimed to investigate the protective effect and underlying mechanisms of the probiotic <jats:italic>Clostridium butyricum<\/jats:italic> (CB) on indomethacin (IND)-induced enteropathy. C57BL\/6J mice received CB treatment for 14\u202fdays along with concurrent IND gavage for the final 7\u202fdays. Caco2 cells were stimulated with IND to evaluate the effect of CB supernatant (CBS) on the intestinal barrier function, and LS174T cells were used to validate the modulatory action of CBS on the Notch signaling pathway. Our findings revealed that CB treatment prevented anorexia and weight loss, reduced the severity of enteropathy, and decreased the inflammatory response of the small intestine. CB also increased the expression of tight junction proteins and reduced permeability in mice and Caco2 cells. Additionally, CB suppressed apoptosis and promoted proliferation in the small intestine. Further research found that CB increased the number of goblet cells and MUC2 secretion. Mechanistically, CB may promote MUC2 secretion by suppressing the Notch signaling pathway, consistent with the results of intervention in LS174T cells with CBS. In conclusion, CB might prevent NSAID enteropathy by increasing MUC2 secretion through the inhibition of the Notch pathway. Our study identified the potential efficacy of CB as a preventive strategy against NSAID enteropathy and showed promising prospects for CB as a food supplement.<\/jats:p>","DOI":"10.3389\/fmicb.2025.1509876","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T07:13:37Z","timestamp":1742368417000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clostridium butyricum ameliorates indomethacin-induced enteropathy by promoting MUC2 secretion via suppressing the Notch pathway"],"prefix":"10.3389","volume":"16","author":[{"given":"Lanping","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjie","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weilong","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinjie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.surg.2008.08.027","article-title":"Histone deacetylase inhibitors upregulate Notch-1 and inhibit growth in pheochromocytoma cells","volume":"144","author":"Adler","year":"2008","journal-title":"Surgery"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/bs.acc.2018.07.005","article-title":"Fecal calprotectin","volume":"87","author":"Ayling","year":"2018","journal-title":"Adv. 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Gastroenterol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1021\/acsinfecdis.0c00762","article-title":"Synergistic action of diclofenac with endotoxin-mediated inflammation exacerbates intestinal injury in vitro","volume":"7","author":"Chen","year":"2021","journal-title":"ACS Infect. Dis."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1001\/archsurg.1970.01340280030009","article-title":"Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal","volume":"101","author":"Chiu","year":"1970","journal-title":"Arch. Surg."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1159\/000058351","article-title":"Small bowel enterocyte apoptosis and proliferation are increased in the elderly","volume":"48","author":"Ciccocioppo","year":"2002","journal-title":"Gerontology"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1016\/j.bbrc.2020.10.014","article-title":"Interleukin-10 expands transit-amplifying cells while depleting Lgr5(+) stem cells via inhibition of Wnt and notch signaling","volume":"533","author":"Deng","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1007\/s00535-011-0410-1","article-title":"Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: a pilot randomized controlled study","volume":"46","author":"Endo","year":"2011","journal-title":"J. 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Liver Physiol."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"154403","DOI":"10.1016\/j.phymed.2022.154403","article-title":"Aloin a prevents ulcerative colitis in mice by enhancing the intestinal barrier function via suppressing the notch signaling pathway","volume":"106","author":"Jiang","year":"2022","journal-title":"Phytomedicine"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1007\/s10620-006-9443-3","article-title":"Lactobacillus rhamnosus GG exacerbates intestinal ulceration in a model of indomethacin-induced enteropathy","volume":"52","author":"Kamil","year":"2007","journal-title":"Dig. Dis. Sci."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"848344","DOI":"10.3389\/fmed.2022.848344","article-title":"The role and function of mucins and its relationship to inflammatory bowel disease","volume":"9","author":"Kang","year":"2022","journal-title":"Front. Med. 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Bowel Dis."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s00535-008-2293-3","article-title":"Involvement of reactive oxygen species in indomethacin-induced apoptosis of small intestinal epithelial cells","volume":"44","author":"Omatsu","year":"2009","journal-title":"J. Gastroenterol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.3748\/wjg.v28.i17.1725","article-title":"Gut homeostasis, injury, and healing: new therapeutic targets","volume":"28","author":"Oncel","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1159\/000452356","article-title":"Microbiota plays a key role in non-steroidal anti-inflammatory drug-induced small intestinal damage","volume":"95","author":"Otani","year":"2017","journal-title":"Digestion"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"5403","DOI":"10.1158\/1078-0432.Ccr-06-0573","article-title":"HATH1 expression in mucinous cancers of the colorectum and related lesions","volume":"12","author":"Park","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"e001319","DOI":"10.1136\/bmjdrc-2020-001319","article-title":"Improvements to postprandial glucose control in subjects with type 2 diabetes: a multicenter, double blind, randomized placebo-controlled trial of a novel probiotic formulation","volume":"8","author":"Perraudeau","year":"2020","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"L647","DOI":"10.1152\/ajplung.1992.262.6.L647","article-title":"Structure, function, and regulation of cellular tight junctions","volume":"262","author":"Schneeberger","year":"1992","journal-title":"Am. J. Phys."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1097\/00005176-200405000-00006","article-title":"Colonic expression of MUC2, MUC5AC, and TFF1 in inflammatory bowel disease in children","volume":"38","author":"Shaoul","year":"2004","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1007\/s10620-014-3076-8","article-title":"Increased gap density predicts weakness of the epithelial barrier in vivo by confocal laser endomicroscopy in indomethacin-induced enteropathy","volume":"59","author":"Shi","year":"2014","journal-title":"Dig. Dis. Sci."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1007\/s00535-010-0210-z","article-title":"Early-stage blocking of notch signaling inhibits the depletion of goblet cells in dextran sodium sulfate-induced colitis in mice","volume":"45","author":"Shinoda","year":"2010","journal-title":"J. Gastroenterol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1111\/bph.13637","article-title":"An orally administered butyrate-releasing derivative reduces neutrophil recruitment and inflammation in dextran sulphate sodium-induced murine colitis","volume":"174","author":"Simeoli","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"555","DOI":"10.3748\/wjg.v7.i4.555","article-title":"Relationship between plasma D(\u2212)-lactate and intestinal damage after severe injuries in rats","volume":"7","author":"Sun","year":"2001","journal-title":"World J. Gastroenterol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"2964","DOI":"10.1038\/s41598-018-21241-z","article-title":"The effect of Clostridium butyricum on symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial","volume":"8","author":"Sun","year":"2018","journal-title":"Sci. Rep."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1159\/000452361","article-title":"Yogurt containing Lactobacillus gasseri mitigates aspirin-induced small bowel injuries: a prospective, randomized, double-blind, placebo-controlled trial","volume":"95","author":"Suzuki","year":"2017","journal-title":"Digestion"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e1187325","DOI":"10.1080\/21688370.2016.1187325","article-title":"Indomethacin induces increase in gastric epithelial tight junction permeability via redistribution of occludin and activation of p38 MAPK in MKN-28 cells","volume":"4","author":"Thakre-Nighot","year":"2016","journal-title":"Tissue Barriers"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1007\/bf00702340","article-title":"The human intestinal cell lines Caco-2 and LS174T as models to study cell-type specific mucin expression","volume":"13","author":"van Klinken","year":"1996","journal-title":"Glycoconj. J."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1242\/dev.02733","article-title":"Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE","volume":"134","author":"Vooijs","year":"2007","journal-title":"Development"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1314-1322, 1322.e1311-1315","DOI":"10.1053\/j.gastro.2011.06.075","article-title":"Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis","volume":"141","author":"Wallace","year":"2011","journal-title":"Gastroenterology"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1002\/jcp.24872","article-title":"The role of notch receptors in transcriptional regulation","volume":"230","author":"Wang","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/s00535-019-01657-8","article-title":"Current knowledge on non-steroidal anti-inflammatory drug-induced small-bowel damage: a comprehensive review","volume":"55","author":"Watanabe","year":"2020","journal-title":"J. Gastroenterol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3164\/jcbn.10-73","article-title":"Mitochondrial disorders in NSAIDs-induced small bowel injury","volume":"48","author":"Watanabe","year":"2011","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1080\/19490976.2016.1156827","article-title":"The microbiota-derived metabolite indole decreases mucosal inflammation and injury in a murine model of NSAID enteropathy","volume":"7","author":"Whitfield-Cargile","year":"2016","journal-title":"Gut Microbes"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"6435","DOI":"10.1007\/s11033-019-05090-1","article-title":"L-arginine alleviates heat stress-induced intestinal epithelial barrier damage by promoting expression of tight junction proteins via the AMPK pathway","volume":"46","author":"Xia","year":"2019","journal-title":"Mol. Biol. 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