{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:43:14Z","timestamp":1792798994677,"version":"4.5.0"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070073"],"award-info":[{"award-number":["32070073"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p><jats:italic>Akkermansia muciniphila<\/jats:italic> (<jats:italic>A. muciniphila<\/jats:italic>), known as a next-generation probiotic, has been widely recognized for its beneficial effects in various metabolic diseases. While there is not much research whether live or pasteurized <jats:italic>A. muciniphila<\/jats:italic> has different effects on intestinal health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present study, a strain of <jats:italic>A. muciniphila<\/jats:italic> was isolated from healthy individuals, with the live and pasteurized <jats:italic>A. muciniphila<\/jats:italic> named Timepie001 and Timepie001+, respectively. They were administered to dextran sulfate sodium-induced ulcerative colitis mice to investigate their influences on the host intestinal health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and conclusion<\/jats:title><jats:p>The results showed that prophylactic supplementation with live and pasteurized <jats:italic>A. muciniphila<\/jats:italic> alleviates ulcerative colitis symptoms by retarding weight loss, preserving intestinal tissue structure, modulating inflammatory cytokines (TNF-\u03b1, IL-1\u03b2), and enhance the colonic mucosal barrier by upregulating the expression of tight junction protein Claudin-1. Interestingly, pasteurized <jats:italic>A. muciniphila<\/jats:italic> has a better effect compared with live <jats:italic>A. muciniphila<\/jats:italic>. Moreover, pasteurized <jats:italic>A. muciniphila<\/jats:italic> can regulates the gut microbiome to maintain intestinal homeostasis. This provides theoretical support for the widespread application of postbiotics in the food industry.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmicb.2025.1542522","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T06:53:12Z","timestamp":1739947992000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Pasteurized Akkermansia muciniphila Timepie001 ameliorates DSS-induced ulcerative colitis in mice by alleviating intestinal injury and modulating gut microbiota"],"prefix":"10.3389","volume":"16","author":[{"given":"Huan","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunzhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxiang","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewei","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"ref1","volume-title":"Guide for the care and use of laboratory animals","year":"1996"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1038\/ismej.2012.39","article-title":"Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis","volume":"6","author":"Berry","year":"2012","journal-title":"ISME J."},{"key":"ref9001","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.3389\/fmicb.2019.02259","article-title":"Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice","volume":"10","author":"Bian","year":"2019","journal-title":"Front Microbiol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"105855","DOI":"10.1016\/j.fitote.2024.105855","article-title":"Effect of Polygonatum sibiricum saponins on gut microbiota of mice with ulcerative colitis","volume":"174","author":"Cao","year":"2024","journal-title":"Fitoterapia"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.bbrc.2021.06.018","article-title":"The outer membrane protein Amuc_1100 of Akkermansia muciniphila alleviates the depression-like behavior of depressed mice induced by chronic stress","volume":"566","author":"Cheng","year":"2021","journal-title":"Biochem. 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