{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T08:28:47Z","timestamp":1793694527834,"version":"4.5.1"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"\n Introduction<\/jats:title>\n \n Urinary tract infections (UTIs) are common bacterial infections with significant health implications. This study aimed to assess the antimicrobial susceptibility (AST) patterns of\n Klebsiella pneumoniae (KPN)<\/jats:italic>\n isolated from urine samples over a decade (2014\u20132023).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The study analyzed\n Klebsiella pneumoniae<\/jats:italic>\n isolates AST pattern from urine samples at a tertiary care hospital in Mysuru (Karnataka), South India using the VITEK-2 (bioM\u00e9rieux, France) database.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 73,283 urine samples, 21,362 (29.15%) showed significant bacterial growth. The most frequently isolated organism was\n Escherichia coli<\/jats:italic>\n (\n n<\/jats:italic>\n \u202f=\u202f9,211, 43.11%), followed by\n Pseudomonas aeruginosa<\/jats:italic>\n (\n n<\/jats:italic>\n \u202f=\u202f1,108, 5.18%) and\n K. pneumoniae<\/jats:italic>\n (\n n<\/jats:italic>\n \u202f=\u202f920, 4.30%). Of the 920\n K. pneumoniae<\/jats:italic>\n isolates, 385 (41.84%) were carbapenem-resistant (CRKP). Isolation rates were higher in males (\n n<\/jats:italic>\n \u202f=\u202f229, 59.48%) than females (\n n<\/jats:italic>\n \u202f=\u202f156, 40.52%), with a statistically significant\n p<\/jats:italic>\n -value (&lt;0.0001). Carbapenem resistance rose from 3.70% in 2014 to 66.13% in 2021, then declined to 38.55% in 2023. Resistance to fluoroquinolones, aminoglycosides, and cephalosporins increased, with cephalosporin resistance exceeding 85% by 2023. These trends reflect growing drug resistance among\n K. pneumoniae<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The study reveals a significant rise in antimicrobial resistance in Klebsiella pneumoniae, particularly to carbapenems and fluoroquinolones. Effective treatment requires antibiotic stewardship, strict infection control, and ongoing surveillance to maintain therapeutic options.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fmicb.2025.1553943","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T01:29:29Z","timestamp":1750123769000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["A retrospective study of the antimicrobial susceptibility patterns of Klebsiella pneumoniae isolated from urine samples over a decade in South India"],"prefix":"10.3389","volume":"16","author":[{"given":"Mahadevaiah","family":"Neelambike Sumana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogeesh D.","family":"Maheshwarappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalyani","family":"G.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi P.","family":"Mahale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sowmya","family":"G. 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