{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:27:00Z","timestamp":1791473220885,"version":"4.3.4"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    The purpose of this study was to identify whether the gut microbiota and metabolites of newly diagnosed acute myeloid leukemia (AML) patients displayed specific characteristic alterations and whether these changes could be used as potential biomarkers for predicting the disease. Notably, the gut microbiota and metabolites of AML patients exhibited significant structural and quantitative alterations at the time of their initial diagnosis. Beneficial bacteria, including\n                    <jats:italic>Faecalibacterium<\/jats:italic>\n                    ,\n                    <jats:italic>Collinsella<\/jats:italic>\n                    ,\n                    <jats:italic>Lacticaseibacillus<\/jats:italic>\n                    , and\n                    <jats:italic>Roseburia<\/jats:italic>\n                    , as well as butyric acid and acetic acid, were found to be considerably reduced in newly diagnosed AML patients. In contrast,\n                    <jats:italic>Enterococcus<\/jats:italic>\n                    and\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    , especially\n                    <jats:italic>Enterococcus<\/jats:italic>\n                    , were significantly enriched. Further investigation indicated that\n                    <jats:italic>Enterococcus<\/jats:italic>\n                    could serve as a potential intestinal marker, showing a strong negative correlation with the levels of acetic and butyric acid. Importantly, assays aimed at identifying AML demonstrated that\n                    <jats:italic>Enterococcus<\/jats:italic>\n                    , butyric acid, and acetatic acid exhibited excellent predictive effectiveness. Colonizing\n                    <jats:italic>Enterococcus<\/jats:italic>\n                    from patients were isolated for pathogen investigation, which revealed that these bacteria possess several strong virulence factors and multiple drug-resistance gene characteristics. Therefore, we speculate that the increase of\n                    <jats:italic>Enterococcus<\/jats:italic>\n                    may contribute to the development and progression of AML.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2025.1559033","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T05:14:02Z","timestamp":1743484442000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Significant changes in gut microbiota and SCFAs among patients with newly diagnosed acute myeloid leukemia"],"prefix":"10.3389","volume":"16","author":[{"given":"Shujuan","family":"An","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinli","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuancheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjia","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1038\/s41598-022-25968-8","article-title":"Virulence and antibiotic-resistance genes in Enterococcus faecalis associated with streptococcosis disease in fish","volume":"13","author":"Akter","year":"2023","journal-title":"Sci. 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Microbiol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"778","DOI":"10.3390\/antibiotics12040778","article-title":"Enterococcal urinary tract infections: a review of the pathogenicity, epidemiology, and treatment","volume":"12","author":"Codelia-Anjum","year":"2023","journal-title":"Antibiotics (Basel)"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/1471-2180-6-60","article-title":"Enterococcal colonization of the gastro-intestinal tract: role of biofilm and environmental oligosaccharides","volume":"6","author":"Creti","year":"2006","journal-title":"BMC Microbiol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"4932","DOI":"10.1016\/j.cub.2020.09.063","article-title":"Newly explored Faecalibacterium diversity is connected to age, lifestyle, geography, and disease","volume":"30","author":"De Filippis","year":"2020","journal-title":"Curr. 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Infect."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1128\/AEM.72.1.334-345.2006","article-title":"Construction of improved temperature-sensitive and mobilizable vectors and their use for constructing mutations in the adhesin-encoding acm gene of poorly transformable clinical Enterococcus faecium strains","volume":"72","author":"Nallapareddy","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"n2026","DOI":"10.1136\/bmj.n2026","article-title":"Advances in acute myeloid leukemia","volume":"375","author":"Newell","year":"2021","journal-title":"BMJ"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"15948","DOI":"10.1038\/s41598-017-15769-9","article-title":"Rapid in situ imaging and whole genome sequencing of biofilm in neonatal feeding tubes: a clinical proof of concept","volume":"7","author":"Ogrodzki","year":"2017","journal-title":"Sci. Rep."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1056\/NEJMoa1900623","article-title":"Microbiota as predictor of mortality in allogeneic hematopoietic-cell transplantation","volume":"382","author":"Peled","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref9002","doi-asserted-by":"publisher","first-page":"e0007422","DOI":"10.1128\/jcm.00074-22","article-title":"Guiding antimicrobial stewardship through thoughtful antimicrobial susceptibility testing and reporting strategies: an updated approach in 2023","volume":"61","author":"Pierce","year":"2023","journal-title":"J Clin Microbiol."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"3194","DOI":"10.3324\/haematol.2023.284138","article-title":"Gut microbiome alterations at acute myeloid leukemia diagnosis are associated with muscle weakness and anorexia","volume":"109","author":"P\u00f6tgens","year":"2024","journal-title":"Haematologica"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.1016\/j.clnu.2023.09.021","article-title":"Gut microbiota alterations induced by intensive chemotherapy in acute myeloid leukaemia patients are associated with gut barrier dysfunction and body weight loss","volume":"42","author":"P\u00f6tgens","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2021.1921927","article-title":"Fecal microbiota composition associates with the capacity of human peripheral blood monocytes to differentiate into immunogenic dendritic cells in vitro","volume":"13","author":"Radojevi\u0107","year":"2021","journal-title":"Gut Microbes"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"572912","DOI":"10.3389\/fcimb.2020.572912","article-title":"Antibiotics as major disruptors of gut microbiota","volume":"10","author":"Ramirez","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"3451","DOI":"10.1182\/bloodadvances.2021006783","article-title":"Lasting shift in the gut microbiota in patients with acute myeloid leukemia","volume":"6","author":"Rashidi","year":"2022","journal-title":"Blood Adv."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/s41597-022-01600-2","article-title":"Compilation of longitudinal gut microbiome, serum metabolome, and clinical data in acute myeloid leukemia","volume":"9","author":"Rashidi","year":"2022","journal-title":"Sci Data"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"5306","DOI":"10.1200\/JCO.22.02366","article-title":"Randomized double-blind phase II trial of fecal microbiota transplantation versus placebo in allogeneic hematopoietic cell transplantation and AML","volume":"41","author":"Rashidi","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"e0236460","DOI":"10.1371\/journal.pone.0236460","article-title":"Gut microbiota profiles of treatment-na\u00efve adult acute myeloid leukemia patients with neutropenic fever during intensive chemotherapy","volume":"15","author":"Rattanathammethee","year":"2020","journal-title":"PLoS One"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1038\/s41467-022-28525-z","article-title":"Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial","volume":"13","author":"Reyman","year":"2022","journal-title":"Nat. Commun."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"599285","DOI":"10.3389\/fpubh.2021.599285","article-title":"The role of whole genome sequencing in the surveillance of antimicrobial resistant Enterococcus spp.: a scoping review. 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Sci."},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10091082","article-title":"Biofilm producing Enterococcus isolates from vaginal microbiota","volume":"10","author":"Sengupta","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s41522-020-0125-2","article-title":"The biofilm-associated surface protein Esp of Enterococcus faecalis forms amyloid-like fibers","volume":"6","author":"Taglialegna","year":"2020","journal-title":"NPJ Biofilms Microbiomes"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228730","article-title":"Network analysis of gut microbiome and metabolome to discover microbiota-linked biomarkers in patients affected by non-small cell lung Cancer","volume":"21","author":"Vernocchi","year":"2020","journal-title":"Int. J. Mol. 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