{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:22:50Z","timestamp":1792174970879,"version":"4.4.0"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Selenium is a vital trace mineral that regulates essential physiological functions, and the development of sustainable methods for synthesizing selenium nanoparticles (SeNPs) is an active area of research. This study reported the mycosynthesis of SeNPs using the aqueous extract of the edible mushroom\n                    <jats:italic>Pleurotus ostreatus<\/jats:italic>\n                    . The synthesized SeNPs were characterized using various analytical techniques, including UV\u2013visible spectroscopy, dynamic light scattering, transmission electron microscopy (TEM), and Fourier-transform infrared spectroscopy (FTIR). The results revealed that the SeNPs exhibited spherical morphology with a diameter range of 72\u2013148\u202fnm, moderate stability with a zeta potential of \u221210.5\u202fmV, and a polydispersity index of 0.27. The myco-synthesized SeNPs demonstrated potent antioxidant activity with a DPPH radical scavenging IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 662.1\u202f\u00b1\u202f1.05\u202f\u03bcg\/mL, comparable to the standard antioxidant Trolox (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u202f=\u202f24.42\u202f\u00b1\u202f0.87\u202f\u03bcM). Furthermore, SeNPs exhibited considerable antimicrobial efficacy against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (17\u202f\u00b1\u202f0.02\u202fmm inhibition zone), followed by\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (16\u202f\u00b1\u202f1.04\u202fmm) and\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    (12\u202f\u00b1\u202f0.3\u202fmm). Additionally, SeNPs displayed moderate antiviral activity against a low-pathogenic coronavirus (229E) strain, with a selectivity index (SI) of 5. In agriculture, the application of SeNPs at 10\u202f\u03bcM significantly increased primary metabolite production in wheat (\n                    <jats:italic>Triticum aestivum<\/jats:italic>\n                    ), with total soluble sugars reaching 54.32\u202fmg\/g and soluble proteins increasing to 139.66\u202fmg\/g, promoting both shoot and root growth. The comprehensive characterization and evaluation of SeNPs provide valuable insights into their multifunctionality, paving the way for further exploration in medicine, agriculture, and environmental applications.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2025.1565907","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T18:59:47Z","timestamp":1741978787000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Exploring the multifunctionality of myco-synthesized selenium nanoparticles: biological, docking study and plant growth-promoting perspectives"],"prefix":"10.3389","volume":"16","author":[{"given":"Hana","family":"Sonbol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman Zakaria","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eslam T.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa F.","family":"Abdelmonem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba","family":"El-Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3390\/biology12111361","article-title":"Biogenic selenium nanoparticles: anticancer, antimicrobial, insecticidal properties and their impact on soybean (Glycine max L.) seed germination and seedling growth","volume":"12","author":"Abdelsalam","year":"2023","journal-title":"Biology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"101683","DOI":"10.1016\/j.bcab.2020.101683","article-title":"Rapid mycosynthesis and characterization of phenols-capped crystal gold nanoparticles from Ganoderma applanatum, Ganodermataceae","volume":"27","author":"Abdul-Hadi","year":"2020","journal-title":"Biocatal. 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Fungi"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/978-981-99-2489-9_14","article-title":"New bioremediation technologies to remove heavy metals and radionuclides","volume-title":"Industrial wastewater reuse: Applications, prospects and challenges","author":"Bhatt","year":"2023"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1039\/D1MA00639H","article-title":"Selenium nanoparticles: a review on synthesis and biomedical applications","volume":"3","author":"Bisht","year":"2022","journal-title":"Mater. Adv."},{"key":"ref8","first-page":"29","article-title":"DPPH free radical scavenging activity of two extracts from Agelanthus dodoneifolius (Loranthaceae) leaves","volume":"8","author":"Boly","year":"2016","journal-title":"Int. J. Toxicol. Pharmacol. Res."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1002\/cmdc.202000147","article-title":"Synthesis of novel pyridine-carboxylates as small-molecule inhibitors of human aspartate\/asparagine-$\u03b2$-hydroxylase","volume":"15","author":"Brewitz","year":"2020","journal-title":"ChemMedChem"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.3390\/molecules24101991","article-title":"Recent developments in antibacterial therapy: focus on stimuli-responsive drug-delivery systems and therapeutic nanoparticles","volume":"24","author":"Canaparo","year":"2019","journal-title":"Molecules"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1038\/s41598-020-80327-9","article-title":"Green synthesis of selenium nanoparticles mediated from Ceropegia bulbosa Roxb extract and its cytotoxicity, antimicrobial, mosquitocidal and photocatalytic activities","volume":"11","author":"Cittrarasu","year":"2021","journal-title":"Sci. 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