{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:12:23Z","timestamp":1784121143691,"version":"3.55.0"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902124"],"award-info":[{"award-number":["81902124"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study analyzes the global prevalence and distribution of vancomycin resistance genes (<jats:italic>van<\/jats:italic>) in <jats:italic>Enterococcus faecium<\/jats:italic> and examines the genetic relationship and epidemiological characteristics of strains carrying these genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 3,256 <jats:italic>E. faecium<\/jats:italic> genome sequences were downloaded, and 2,235 high-quality genomes were retained after quality filtering. The blastn tool was used to screen these genomes for <jats:italic>van<\/jats:italic> genes, and sequence types (STs) were determined using pubMLST profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Among the 2,235 genomes, 1,071 (47.9%) harbored <jats:italic>van<\/jats:italic> genes, with eight genotypes identified, including <jats:italic>vanA<\/jats:italic>, <jats:italic>vanB<\/jats:italic>, <jats:italic>vanD<\/jats:italic>, and <jats:italic>vanM<\/jats:italic>, accounting for 47.6%. There were 83 distinct STs among the strains carrying <jats:italic>van<\/jats:italic> genes, with ST17 being the most prevalent. Most strains carrying <jats:italic>van<\/jats:italic> genes were isolated from humans, primarily in the United States, and commonly from rectal swabs. In 2015, <jats:italic>vanA<\/jats:italic> was the most prevalent <jats:italic>van<\/jats:italic> gene, particularly in ST17 strains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study highlights the widespread distribution of <jats:italic>van<\/jats:italic> genes and their significant presence in human populations and clinical settings, emphasizing the importance of monitoring and intervening in the spread of ST17 strains.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmicb.2025.1578903","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T05:28:39Z","timestamp":1755235719000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Deciphering vancomycin resistance in Enterococcus faecium: gene distribution, sequence typing, and global phylogenetic analysis"],"prefix":"10.3389","volume":"16","author":[{"given":"Ruyu","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"001160","DOI":"10.1099\/mgen.0.001160","article-title":"The population structure of vancomycin-resistant and -susceptible Enterococcus faecium in a low-prevalence antimicrobial resistance setting is highly influenced by circulating global hospital-associated clones","volume":"9","author":"Al Rubaye","year":"2023","journal-title":"Microb. 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