{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:37:02Z","timestamp":1792708622884,"version":"4.5.0"},"reference-count":289,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>The gut microbiota plays a crucial role in metabolic processes associated with host brain function. Emerging research is progressively uncovering the intricate and multifaceted relationship between the gut and the brain. The gut microbiota significantly influences immune responses, secondary metabolism, and symbiosis with the host, thereby facilitating the production of essential metabolites, neurotransmitters, and other neuroactive compounds that impact the development and treatment of central nervous system disorders. This article delineates the communication pathways and mechanisms linking the microbiota, gut, and brain, providing a comprehensive overview of current research on how the gut microbiota affects nervous system function. Furthermore, it examines factors that can alter the gut microbiota and influence metabolite profiles, as well as current intervention strategies aimed at enhancing gut-brain communication, mitigating adverse triggers that disrupt the gut microbiota, and minimizing neuro-pathological changes.<\/jats:p>","DOI":"10.3389\/fmicb.2025.1583562","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T05:48:48Z","timestamp":1749793728000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":61,"title":["The microbiota-gut-brain axis and central nervous system diseases: from mechanisms of pathogenesis to therapeutic strategies"],"prefix":"10.3389","volume":"16","author":[{"given":"Jie","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1080\/08830185.2021.1954638","article-title":"Tryptophan metabolites modulate inflammatory bowel disease and colorectal cancer by affecting immune system","volume":"41","author":"Ala","year":"2022","journal-title":"Int. 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(Beijing)"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1007\/s11481-023-10085-8","article-title":"5-HT4 receptor is protective for MPTP-induced Parkinson\u2019s disease mice via altering gastrointestinal motility or gut microbiota","volume":"18","author":"Cui","year":"2023","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"105400","DOI":"10.1016\/j.ebiom.2024.105400","article-title":"Association between seizure reduction during ketogenic diet treatment of epilepsy and changes in circulatory metabolites and gut microbiota composition","volume":"109","author":"Dahlin","year":"2024","journal-title":"EBioMedicine"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"109491","DOI":"10.1016\/j.neuropharm.2023.109491","article-title":"The gut-brain connection: exploring the influence of the gut microbiota on neuroplasticity and neurodevelopmental disorders","volume":"231","author":"Damiani","year":"2023","journal-title":"Neuropharmacology"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/ismej.2013.155","article-title":"High-fat diet alters gut microbiota physiology in mice","volume":"8","author":"Daniel","year":"2014","journal-title":"ISME J."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1064619","DOI":"10.3389\/fneur.2022.1064619","article-title":"Trends in the diagnostic delay and pathway for amyotrophic lateral sclerosis patients across different countries","volume":"13","author":"de Falc\u00e3o Campos","year":"2022","journal-title":"Front. Neurol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"114153","DOI":"10.1016\/j.foodres.2024.114153","article-title":"Prebiotics modulate the microbiota-gut-brain axis and ameliorate anxiety and depression-like behavior in HFD-fed mice","volume":"182","author":"de Paiva","year":"2024","journal-title":"Food Res. Int."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1002\/iub.2589","article-title":"The beneficial effect of synbiotics consumption on Alzheimer\u2019s disease mouse model via reducing local and systemic inflammation","volume":"74","author":"Deng","year":"2022","journal-title":"IUBMB Life"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review","volume":"19","author":"Di Vincenzo","year":"2024","journal-title":"Intern. Emerg. Med."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3390\/ijms25010038","article-title":"Our mental health is determined by an intrinsic interplay between the central nervous system, enteric nerves, and gut microbiota","volume":"25","author":"Dicks","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.psyneuen.2012.09.019","article-title":"Cortisol secretion in depressed, and at-risk adults","volume":"38","author":"Dienes","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"105828","DOI":"10.1016\/j.psyneuen.2022.105828","article-title":"Paroxetine effects in adult male rat colon: focus on gut steroidogenesis and microbiota","volume":"143","author":"Diviccaro","year":"2022","journal-title":"Psychoneuroendocrinology"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1038\/s41577-023-00874-w","article-title":"Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease","volume":"23","author":"Donald","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"109752","DOI":"10.1016\/j.clim.2023.109752","article-title":"Farnesol brain transcriptomics in CNS inflammatory demyelination","volume":"255","author":"Doyle","year":"2023","journal-title":"Clin. Immunol."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"17562864221103935","DOI":"10.1177\/17562864221103935","article-title":"Propionic acid beneficially modifies osteoporosis biomarkers in patients with multiple sclerosis","volume":"15","author":"Duscha","year":"2022","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1007\/s12031-023-02146-7","article-title":"Understanding the molecular regulation of serotonin receptor 5-HTR1B-\u03b2-Arrestin1 complex in stress and anxiety disorders","volume":"73","author":"Dutta Gupta","year":"2023","journal-title":"J. Mol. Neurosci."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"114205","DOI":"10.1016\/j.ejpb.2024.114205","article-title":"Fexofenadine-loaded chitosan coated solid lipid nanoparticles (SLNs): a potential oral therapy for ulcerative colitis","volume":"196","author":"El-Dakroury","year":"2024","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"105627","DOI":"10.1016\/j.nbd.2022.105627","article-title":"Impact of intestinal disorders on central and peripheral nervous system diseases","volume":"165","author":"El-Hakim","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"2466","DOI":"10.1007\/s11427-023-2346-1","article-title":"Gut microbiota bridges dietary nutrients and host immunity","volume":"66","author":"Fan","year":"2023","journal-title":"Sci. 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Food"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"e0139921","DOI":"10.1128\/msystems.01399-21","article-title":"Sepsis-induced gut Dysbiosis mediates the susceptibility to Sepsis-associated encephalopathy in mice","volume":"7","author":"Fang","year":"2022","journal-title":"mSystems"},{"key":"ref59","article-title":"Biochemistry, lipopolysaccharide","volume-title":"StatPearls","author":"Farhana","year":"2025"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"14609","DOI":"10.1021\/acs.jmedchem.3c01090","article-title":"Synthesis and bioevaluation of 3-(Arylmethylene)indole derivatives: discovery of a novel ALK modulator with Antiglioblastoma activities","volume":"66","author":"Feng","year":"2023","journal-title":"J. Med. Chem."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/s41579-023-00933-y","article-title":"Antibiotic perturbations to the gut microbiome","volume":"21","author":"Fishbein","year":"2023","journal-title":"Nat. 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