{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T22:54:24Z","timestamp":1772232864927,"version":"3.50.1"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease of unknown etiology. Recent studies have indicated a potential relationship between the oral microbiome and the onset and progression of RA. However, research trends in this area have not been comprehensively examined. The aim of this study was to conduct a bibliometric analysis of the relationship between RA and the oral microbiome from January 1, 1995, to January 10, 2024, to elucidate the research landscape, including hot topics and emerging trends.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We extracted literature related to RA and the oral microbiome from the Web of Science database. Utilizing CiteSpace software, we analyzed publications, countries, institutions, authors, and keywords through a visual knowledge graph to assess research hotspots and trends.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 833 articles were identified, revealing a consistent increase in the number of annual publications in this field over the study period. The United States has emerged as the leading country in terms of publication volume, with Harvard University being the most prolific institution. Among the authors, Jan Potempa has the highest number of publications. Keyword analysis indicated that current research hotspots concerning the relationship between RA and the oral microbiome primarily focus on <jats:italic>Porphyromonas gingivalis<\/jats:italic>, periodontitis, inflammation, expression, and peptidylarginine deiminase. Investigating the mechanisms by which oral and intestinal microorganisms influence RA, as well as developing intervention strategies targeting these microbiotas, is anticipated to be a significant future research direction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study characterized the trends in the literature regarding the relationship between RA and the oral microbiome, providing valuable insights for scholars pursuing further research.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmicb.2025.1589331","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T05:39:20Z","timestamp":1752644360000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Bibliometric and visualized analysis of the relationship between rheumatoid arthritis and periodontitis-related bacteria using CiteSpace software"],"prefix":"10.3389","volume":"16","author":[{"given":"Tianqiong","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiali","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biying","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoyan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/pro.3571","article-title":"Structure, function, and inhibition of a genomic\/clinical variant of Porphyromonas gingivalis peptidylarginine deiminase","volume":"28","author":"Bereta","year":"2019","journal-title":"Protein Sci."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.cellimm.2005.04.018","article-title":"The role of toll-like receptor signalling in the pathogenesis of arthritis","volume":"233","author":"Brentano","year":"2005","journal-title":"Cell. 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Microbiol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e594","DOI":"10.1016\/S2665-9913(23)00211-4","article-title":"Global, regional, and national burden of rheumatoid arthritis, 1990\u20132020, and projections to 2050: a systematic analysis of the global burden of disease study 2021","volume":"5","year":"2023","journal-title":"Lancet Rheumatol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e72","DOI":"10.1136\/annrheumdis-2020-217897","article-title":"Comment on: \u2018Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population\u2019 by Kishikawa et al.","volume":"81","author":"Kishikawa","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jdsr.2023.08.002","article-title":"Periodontitis and periodontopathic bacteria as risk factors for rheumatoid arthritis: a review of the last 10 years","volume":"59","author":"Kobayashi","year":"2023","journal-title":"Jpn. Dent. Sci. 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