{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:27:54Z","timestamp":1793986074829,"version":"4.8.0"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p><jats:italic>Campylobacter jejuni<\/jats:italic> (<jats:italic>C. jejuni<\/jats:italic>) is a zoonotic pathogen and is the most prevalent foodborne pathogen globally. The increasing antimicrobial resistance and gene mutation pose a threat to public health and trigger us to enhance surveillance. This study illustrated the antimicrobial resistance profiles, virulence factors, and multilocus sequence typing (MLST) profiles of 47 <jats:italic>C. jejuni<\/jats:italic> isolates collected from human stool and raw poultry meat samples between 2022 and 2023 in Hangzhou, China. Notably, 88.9% (16\/18) human-derived and 82.9% (24\/29) poultry-derived <jats:italic>C. jejuni<\/jats:italic> displayed multidrug resistance (MDR) profiles, nalidixic acid + ciprofloxacin + tetracycline was prevalent among them. Relatively high rates of resistance to florfenicol were observed in <jats:italic>C. jejuni<\/jats:italic>, 38.9% (7\/18) from human sources and 44.8% (13\/29) from poultry sources. Comprehensive Antibiotic Resistance Database (CARD) and ResFinder database showed <jats:italic>gyrA<\/jats:italic> (<jats:italic>T86I<\/jats:italic>) was the dominant factor in quinolones resistance while a rare <jats:italic>gyrA<\/jats:italic> (<jats:italic>T86V<\/jats:italic>) was found in one poultry-derived <jats:italic>C. jejuni<\/jats:italic>. All 37 tetracycline-resistant <jats:italic>C. jejuni<\/jats:italic> strains harbored the <jats:italic>tet(O)<\/jats:italic> gene. All 20 florfenicol-resistant <jats:italic>C. jejuni<\/jats:italic> did not have any related genes. Several key virulence factor genes associated with adherence (<jats:italic>cadF, pebA, jlpA<\/jats:italic>, and <jats:italic>porA<\/jats:italic>), invasion (<jats:italic>CiaB<\/jats:italic> and <jats:italic>CiaC<\/jats:italic>), capsule biosynthesis\/transport genes (<jats:italic>kpsF, kpsD, kpsE, kpsM, kpsC<\/jats:italic>, and <jats:italic>Cj1419c<\/jats:italic>) and lipooligosaccharide (LOS) biosynthesis genes (<jats:italic>Cj1135, waaV, waaF, htrB, gmhA<\/jats:italic>, and <jats:italic>gmhB<\/jats:italic>) were conserved in <jats:italic>C. jejuni<\/jats:italic>. MLST analysis revealed high genetic diversity, identifying 28 sequence types (STs), including 3 novel STs, 20 of which belonged to 10 clonal complexes (CCs), and 8 were unassigned. CC-464 and CC-21 strains carried the most virulence genes, correlating with clinical severity, yet represent a minority in local isolates. The most abundant CCs were CC-443 (21.3%, 10\/47) and CC-574 (19.1%, 9\/47), mainly isolated from poultry. These findings highlight that <jats:italic>C. jejuni<\/jats:italic> isolates in Hangzhou had high genetic diversity and MDR, CC-443 and CC-574 were the predominant strains. It is necessary to monitor human-poultry transmission and emerging resistance phenotypes.<\/jats:p>","DOI":"10.3389\/fmicb.2025.1599555","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T05:21:26Z","timestamp":1750656086000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Genomic analysis and antimicrobial resistance in human- and poultry-derived Campylobacter jejuni isolates from Hangzhou, China"],"prefix":"10.3389","volume":"16","author":[{"given":"Mingfang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luping","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongli","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.3390\/microorganisms12081601","article-title":"Antimicrobial resistance and genomic characterization of campylobacter jejuni and campylobacter coli isolated from retail chickens in Beijing, China.","volume":"12","author":"Bai","year":"2024","journal-title":"Microorganisms"},{"key":"B2","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1089\/cmb.2012.0021","article-title":"SPAdes: A new genome assembly algorithm and its applications to single-cell sequencing.","volume":"19","author":"Bankevich","year":"2012","journal-title":"J. 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