{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T14:19:38Z","timestamp":1793715578835,"version":"4.6.1"},"reference-count":148,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p><jats:italic>Mycoplasma pneumoniae<\/jats:italic> is a leading cause of community-acquired pneumonia (CAP) and upper respiratory tract infections, particularly in children and immunocompromised individuals. The growing global prevalence of macrolide-resistant <jats:italic>M. pneumoniae<\/jats:italic> (MRMP) further emphasizes the urgent need to elucidate its pathogenic mechanisms. Among these, adhesion plays a central role, serving as a prerequisite for colonization and disease progression, and thus warrants detailed investigation. The terminal organelle of <jats:italic>M. pneumoniae<\/jats:italic> mediates both adhesion and gliding motility, facilitating colonization, tissue invasion, and potential systemic spread. In the lung, adhesion triggers cytotoxic effects through the release of hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) and CARDS toxin (CARDS TX), promotes excessive inflammatory responses, and enables immune evasion via antigenic variation. Extrapulmonary manifestations may also arise either from direct bacterial dissemination or autoimmune responses induced by molecular mimicry between bacterial and host antigens. In addition, recent advances suggest that therapies and vaccines directed at the adhesion mechanism of <jats:italic>M. pneumoniae<\/jats:italic> may offer promising strategies for combating MRMP infections. Although progress has been made, the adhesion-related pathogenesis of <jats:italic>M. pneumoniae<\/jats:italic>, as well as the prospects for therapies and vaccines targeting this mechanism, remains incompletely defined. This review synthesizes current insights into adhesion-mediated mechanisms and highlights emerging therapeutic strategies targeting adhesion, aiming to support more effective treatment and prevention of <jats:italic>M. pneumoniae<\/jats:italic> infection.<\/jats:p>","DOI":"10.3389\/fmicb.2025.1613760","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T05:36:25Z","timestamp":1753248985000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Advances in adhesion-related pathogenesis in Mycoplasma pneumoniae infection"],"prefix":"10.3389","volume":"16","author":[{"given":"Bingyue","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaozheng","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zige","family":"Jie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanzheng","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"5572","DOI":"10.1093\/nar\/gkae188","article-title":"Molecular insights into the fine-tuning of pH-dependent ArsR-mediated regulation of the SabA adhesin in Helicobacter pylori.","volume":"52","author":"Aberg","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e0193940","DOI":"10.1371\/journal.pone.0193940","article-title":"Bioinformatic analysis of meningococcal Msf and Opc to inform vaccine antigen design.","volume":"13","author":"Andreae","year":"2018","journal-title":"PLoS One"},{"key":"B3","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1080\/14787210.2020.1782739","article-title":"Role of vacuolating cytotoxin A in Helicobacter pylori infection and its impact on gastric pathogenesis.","volume":"18","author":"Ansari","year":"2020","journal-title":"Expert. Rev. Anti. Infect. Ther."},{"key":"B4","doi-asserted-by":"publisher","first-page":"3116","DOI":"10.1128\/IAI.00173-08","article-title":"The surface-exposed carboxyl region of Mycoplasma pneumoniae elongation factor Tu interacts with fibronectin.","volume":"76","author":"Balasubramanian","year":"2008","journal-title":"Infect. Immun."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3675","DOI":"10.1128\/JB.01865-14","article-title":"Mycoplasma pneumoniae, an underutilized model for bacterial cell biology.","volume":"196","author":"Balish","year":"2014","journal-title":"J. Bacteriol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1046\/j.1365-2958.2003.03282.x","article-title":"Localization of Mycoplasma pneumoniae cytadherence-associated protein HMW2 by fusion with green fluorescent protein: Implications for attachment organelle structure.","volume":"47","author":"Balish","year":"2003","journal-title":"Mol. Microbiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1273154","DOI":"10.3389\/fonc.2023.1273154","article-title":"The relationship between cancer and biomechanics.","volume":"13","author":"Bao","year":"2023","journal-title":"Front. Oncol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"5165","DOI":"10.1073\/pnas.1420308112","article-title":"Structure of CARDS toxin, a unique ADP-ribosylating and vacuolating cytotoxin from Mycoplasma pneumoniae.","volume":"112","author":"Becker","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B9","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/s41580-023-00682-z","article-title":"Patterning of the cell cortex by Rho GTPases.","volume":"25","author":"Bement","year":"2024","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1093\/femsre\/fux033","article-title":"Glycerol metabolism and its implication in virulence in Mycoplasma.","volume":"41","author":"Blotz","year":"2017","journal-title":"FEMS Microbiol. Rev."},{"key":"B11","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/s41580-024-00777-1","article-title":"The role and regulation of integrins in cell migration and invasion.","volume":"26","author":"Chastney","year":"2025","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"7","DOI":"10.4103\/0255-0857.174112","article-title":"Pathogenesis of Mycoplasma pneumoniae: An update.","volume":"34","author":"Chaudhry","year":"2016","journal-title":"Indian J. Med. Microbiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1128\/JCM.43.1.321-325.2005","article-title":"Expression and immunological characterization of the carboxy-terminal region of the P1 adhesin protein of Mycoplasma pneumoniae.","volume":"43","author":"Chaudhry","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"592","DOI":"10.2174\/0929866523666160502155414","article-title":"Designing, expression and immunological characterization of a chimeric protein of Mycoplasma pneumoniae.","volume":"23","author":"Chen","year":"2016","journal-title":"Protein. Pept. Lett."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1007\/s10072-017-2922-9","article-title":"Isolated optic neuritis associated with Mycoplasma pneumoniae infection: Report of two cases and literature review.","volume":"38","author":"Choi","year":"2017","journal-title":"Neurol. Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/j.1365-2958.2010.07196.x","article-title":"Functional domain analysis of the Mycoplasma pneumoniae co-chaperone TopJ.","volume":"77","author":"Cloward","year":"2010","journal-title":"Mol. Microbiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1111\/j.1365-2958.2011.07712.x","article-title":"Loss of co-chaperone TopJ impacts adhesin P1 presentation and terminal organelle maturation in Mycoplasma pneumoniae.","volume":"81","author":"Cloward","year":"2011","journal-title":"Mol. Microbiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"4163","DOI":"10.1128\/iai.58.12.4163-4165.1990","article-title":"Characterization of the gene for a 30-kilodalton adhesion-related protein of Mycoplasma pneumoniae.","volume":"58","author":"Dallo","year":"1990","journal-title":"Infect. Immun."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1046\/j.1365-2958.2002.03207.x","article-title":"Elongation factor Tu and E1 beta subunit of pyruvate dehydrogenase complex act as fibronectin binding proteins in Mycoplasma pneumoniae.","volume":"46","author":"Dallo","year":"2002","journal-title":"Mol. Microbiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2100129","DOI":"10.1183\/13993003.00129-2021","article-title":"Mycoplasma pneumoniae carriage evades induction of protective mucosal antibodies.","volume":"59","author":"de Groot","year":"2022","journal-title":"Eur. Respir. J."},{"key":"B21","doi-asserted-by":"publisher","first-page":"S95","DOI":"10.1016\/S0163-4453(17)30198-6","article-title":"Things that could be Mycoplasma pneumoniae.","volume":"74","author":"de Groot","year":"2017","journal-title":"J. Infect."},{"key":"B22","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.micpath.2018.04.058","article-title":"Three polypeptides screened from phage display random peptide library may be the receptor polypeptide of Mycoplasma genitalium adhesion protein.","volume":"120","author":"Deng","year":"2018","journal-title":"Microb. Pathog."},{"key":"B23","doi-asserted-by":"publisher","first-page":"6308","DOI":"10.4049\/jimmunol.177.9.6308","article-title":"Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces.","volume":"177","author":"Ferreira","year":"2006","journal-title":"J. Immunol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"e2000711","DOI":"10.1002\/cbdv.202000711","article-title":"Mollicute anti-adhesive and growth inhibition properties of the methanolic extract of propolis from the brazilian native bee melipona quadrifasciata.","volume":"18","author":"Galgowski","year":"2021","journal-title":"Chem. Biodivers."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2386636","DOI":"10.1080\/07853890.2024.2386636","article-title":"Laboratory diagnosis and treatment of Mycoplasma pneumoniae infection in children: A review.","volume":"56","author":"Gao","year":"2024","journal-title":"Ann. Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.micres.2018.09.006","article-title":"Organization of multi-binding to host proteins: The glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of Mycoplasma pneumoniae.","volume":"218","author":"Grimmer","year":"2019","journal-title":"Microbiol. Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1128\/IAI.01212-12","article-title":"Implication of glycerol and phospholipid transporters in Mycoplasma pneumoniae growth and virulence.","volume":"81","author":"Grosshennig","year":"2013","journal-title":"Infect. Immun."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e0126600","DOI":"10.1371\/journal.pone.0126600","article-title":"Subunits of the pyruvate dehydrogenase cluster of mycoplasma pneumoniae are surface-displayed proteins that bind and activate human plasminogen.","volume":"10","author":"Grundel","year":"2015","journal-title":"PLoS One"},{"key":"B29","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.ijmm.2016.09.001","article-title":"Interactions of surface-displayed glycolytic enzymes of Mycoplasma pneumoniae with components of the human extracellular matrix.","volume":"306","author":"Grundel","year":"2016","journal-title":"Int. J. Med. Microbiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1128\/iai.01071-15","article-title":"Network of surface-displayed glycolytic enzymes in mycoplasma pneumoniae and their interactions with human plasminogen.","volume":"84","author":"Gr\u00fcndel","year":"2015","journal-title":"Infect. Immun."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1128\/JB.180.5.1270-1276.1998","article-title":"HMW1 is required for cytadhesin P1 trafficking to the attachment organelle in Mycoplasma pneumoniae.","volume":"180","author":"Hahn","year":"1998","journal-title":"J. Bacteriol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1159\/000096470","article-title":"Regulation of carbon metabolism in the mollicutes and its relation to virulence.","volume":"12","author":"Halbedel","year":"2007","journal-title":"J. Mol. Microbiol. Biotechnol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"7442","DOI":"10.1128\/JB.00867-07","article-title":"Proteins P24 and P41 function in the regulation of terminal-organelle development and gliding motility in Mycoplasma pneumoniae.","volume":"189","author":"Hasselbring","year":"2007","journal-title":"J. Bacteriol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"6281","DOI":"10.1128\/JB.187.18.6281-6289.2005","article-title":"Mutant analysis reveals a specific requirement for protein P30 in Mycoplasma pneumoniae gliding motility.","volume":"187","author":"Hasselbring","year":"2005","journal-title":"J. Bacteriol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.micpath.2013.07.004","article-title":"Development of protective anti-Mycoplasma pneumoniae antibodies after immunization of guinea pigs with the combination of a P1-P30 chimeric recombinant protein and chitosan.","volume":"64","author":"Hausner","year":"2013","journal-title":"Microb. Pathog."},{"key":"B36","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1097\/MOP.0b013e328341579c","article-title":"Constrictive pericarditis secondary to infection with Mycoplasma pneumoniae.","volume":"23","author":"Hawkins","year":"2011","journal-title":"Curr. Opin. Pediatr."},{"key":"B37","doi-asserted-by":"publisher","first-page":"4030","DOI":"10.3892\/mmr.2016.5765","article-title":"Insights into the pathogenesis of Mycoplasma pneumoniae (Review).","volume":"14","author":"He","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"B38","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1007\/s10753-013-9743-7","article-title":"Binding of CD14 to Mycoplasma genitalium-derived lipid-associated membrane proteins upregulates TNF-alpha.","volume":"37","author":"He","year":"2014","journal-title":"Inflammation"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1128\/CVI.00281-09","article-title":"Mycoplasma genitalium-derived lipid-associated membrane proteins activate NF-kappaB through toll-like receptors 1, 2, and 6 and CD14 in a MyD88-dependent pathway.","volume":"16","author":"He","year":"2009","journal-title":"Clin. Vaccine Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.chom.2016.07.019","article-title":"Streptococcus pneumoniae senses a human-like sialic acid profile via the response regulator CiaR.","volume":"20","author":"Hentrich","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B41","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.micpath.2005.07.004","article-title":"A role for the Mycoplasma pneumoniae adhesin P1 in interleukin (IL)-4 synthesis and release from rodent mast cells.","volume":"39","author":"Hoek","year":"2005","journal-title":"Microb. Pathog."},{"key":"B42","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/s41423-022-00845-6","article-title":"Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells.","volume":"19","author":"Hong","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s00284-022-03103-0","article-title":"Insight into the pathogenic mechanism of Mycoplasma pneumoniae.","volume":"80","author":"Hu","year":"2022","journal-title":"Curr. Microbiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"e023719","DOI":"10.1136\/bmjopen-2018-023719","article-title":"Independent predictors for longer radiographic resolution in patients with refractory Mycoplasma pneumoniae pneumonia: A prospective cohort study.","volume":"8","author":"Huang","year":"2018","journal-title":"BMJ Open"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1128\/IAI.00141-07","article-title":"Synthesis and characterization of a dipalmitoylated lipopeptide derived from paralogous lipoproteins of Mycoplasma pneumoniae.","volume":"75","author":"Into","year":"2007","journal-title":"Infect. Immun."},{"key":"B46","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.jgar.2021.10.003","article-title":"Genotype and mutation patterns of macrolide resistance genes of Mycoplasma pneumoniae from children with pneumonia in Qingdao. China, in 2019.","volume":"27","author":"Jiang","year":"2021","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"B47","doi-asserted-by":"publisher","first-page":"123090","DOI":"10.1016\/j.biomaterials.2025.123090","article-title":"Nano-polymeric platinum activates PAR2 gene editing to suppress tumor metastasis.","volume":"317","author":"Jiang","year":"2025","journal-title":"Biomaterials"},{"key":"B48","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3390\/pathogens10020119","article-title":"Mycoplasma pneumoniae infections: Pathogenesis and vaccine development.","volume":"10","author":"Jiang","year":"2021","journal-title":"Pathogens"},{"key":"B49","doi-asserted-by":"publisher","first-page":"e22877","DOI":"10.1371\/journal.pone.0022877","article-title":"Cellular vacuoles induced by Mycoplasma pneumoniae CARDS toxin originate from Rab9-associated compartments.","volume":"6","author":"Johnson","year":"2011","journal-title":"PLoS One"},{"key":"B50","doi-asserted-by":"publisher","first-page":"20180227","DOI":"10.1098\/rstb.2018.0227","article-title":"Connections between the cell cycle, cell adhesion and the cytoskeleton.","volume":"374","author":"Jones","year":"2019","journal-title":"Philos. Trans. R Soc. Lond. B Biol. Sci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1128\/IAI.01344-06","article-title":"Protein P200 is dispensable for Mycoplasma pneumoniae hemadsorption but not gliding motility or colonization of differentiated bronchial epithelium.","volume":"75","author":"Jordan","year":"2007","journal-title":"Infect. Immun."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.3390\/cells11162521","article-title":"Cell cycle regulation by integrin-mediated adhesion.","volume":"11","author":"Kamranvar","year":"2022","journal-title":"Cells"},{"key":"B53","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/s41580-022-00531-5","article-title":"Organization, dynamics and mechanoregulation of integrin-mediated cell-ECM adhesions.","volume":"24","author":"Kanchanawong","year":"2023","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.cell.2012.09.018","article-title":"Selective protein synthesis by ribosomes with a drug-obstructed exit tunnel.","volume":"151","author":"Kannan","year":"2012","journal-title":"Cell"},{"key":"B55","doi-asserted-by":"publisher","first-page":"6724","DOI":"10.1073\/pnas.0510644103","article-title":"ADP-ribosylating and vacuolating cytotoxin of Mycoplasma pneumoniae represents unique virulence determinant among bacterial pathogens.","volume":"103","author":"Kannan","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B56","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1111\/mmi.12680","article-title":"Functional mapping of community-acquired respiratory distress syndrome (CARDS) toxin of Mycoplasma pneumoniae defines regions with ADP-ribosyltransferase, vacuolating and receptor-binding activities.","volume":"93","author":"Kannan","year":"2014","journal-title":"Mol. Microbiol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1111\/j.1365-2958.2010.07092.x","article-title":"Mycoplasma pneumoniae community acquired respiratory distress syndrome toxin expression reveals growth phase and infection-dependent regulation.","volume":"76","author":"Kannan","year":"2010","journal-title":"Mol. Microbiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"6850","DOI":"10.1111\/febs.15776","article-title":"A guide to the composition and functions of the extracellular matrix.","volume":"288","author":"Karamanos","year":"2021","journal-title":"FEBS J."},{"key":"B59","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1128\/JB.01141-12","article-title":"Role of binding in Mycoplasma mobile and Mycoplasma pneumoniae gliding analyzed through inhibition by synthesized sialylated compounds.","volume":"195","author":"Kasai","year":"2013","journal-title":"J. Bacteriol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"75","DOI":"10.4103\/0970-2113.63611","article-title":"Mycoplasma pneumonia: Clinical features and management.","volume":"27","author":"Kashyap","year":"2010","journal-title":"Lung India"},{"key":"B61","doi-asserted-by":"publisher","first-page":"2352","DOI":"10.1128\/JB.00160-16","article-title":"Structural study of MPN387, an essential protein for gliding motility of a human-pathogenic bacterium, Mycoplasma pneumoniae.","volume":"198","author":"Kawakita","year":"2016","journal-title":"J. Bacteriol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"e00243-16","DOI":"10.1128\/mBio.00243-16","article-title":"Periodicity in attachment organelle revealed by electron cryotomography suggests conformational changes in gliding mechanism of mycoplasma pneumoniae.","volume":"7","author":"Kawamoto","year":"2016","journal-title":"mBio"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.bbrc.2018.11.132","article-title":"Production and characterization of recombinant P1 adhesin essential for adhesion, gliding, and antigenic variation in the human pathogenic bacterium, Mycoplasma pneumoniae.","volume":"508","author":"Kenri","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B64","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1099\/jmm.0.47634-0","article-title":"Genotyping analysis of Mycoplasma pneumoniae clinical strains in Japan between 1995 and 2005: Type shift phenomenon of M. pneumoniae clinical strains.","volume":"57","author":"Kenri","year":"2008","journal-title":"J. Med. Microbiol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"104868","DOI":"10.1016\/j.ebiom.2023.104868","article-title":"Mycoplasma pneumoniae carriage in children with recurrent respiratory tract infections is associated with a less diverse and altered microbiota.","volume":"98","author":"Koenen","year":"2023","journal-title":"EBioMedicine"},{"key":"B66","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1111\/mmi.13937","article-title":"Electron cryotomography of Mycoplasma pneumoniae mutants correlates terminal organelle architectural features and function.","volume":"108","author":"Krause","year":"2018","journal-title":"Mol. Microbiol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"e62706","DOI":"10.1371\/journal.pone.0062706","article-title":"Mycoplasma pneumoniae CARDS toxin is internalized via clathrin-mediated endocytosis.","volume":"8","author":"Krishnan","year":"2013","journal-title":"PLoS One"},{"key":"B68","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1128\/CMR.8.1.34","article-title":"The family of bacterial ADP-ribosylating exotoxins.","volume":"8","author":"Krueger","year":"1995","journal-title":"Clin. Microbiol. Rev."},{"key":"B69","doi-asserted-by":"publisher","first-page":"23","DOI":"10.4103\/ijmr.IJMR_1582_16","article-title":"Mycoplasma pneumoniae: A significant but underrated pathogen in paediatric community-acquired lower respiratory tract infections.","volume":"147","author":"Kumar","year":"2018","journal-title":"Indian J. Med. Res."},{"key":"B70","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1186\/s12864-019-6306-9","article-title":"Comparative genomics of Mycoplasma pneumoniae isolated from children with pneumonia: South Korea, 2010-2016.","volume":"20","author":"Lee","year":"2019","journal-title":"BMC Genomics"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(23)00405-6","article-title":"Resurgence of Mycoplasma pneumonia by macrolide-resistant epidemic clones in China.","volume":"5","author":"Li","year":"2024","journal-title":"Lancet Microbe"},{"key":"B72","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.3389\/fimmu.2020.02052","article-title":"Mycoplasma genitalium protein of adhesion induces inflammatory cytokines via cyclophilin A-CD147 activating the ERK-NF-kappaB pathway in human urothelial cells.","volume":"11","author":"Li","year":"2020","journal-title":"Front. Immunol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1186\/s12879-022-07715-6","article-title":"Molecular beacon based real-time PCR p1 gene genotyping, macrolide resistance mutation detection and clinical characteristics analysis of Mycoplasma pneumoniae infections in children.","volume":"22","author":"Li","year":"2022","journal-title":"BMC Infect. Dis."},{"key":"B74","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1007\/s00431-011-1609-0","article-title":"Ciliary ultrastructural abnormalities in Mycoplasma pneumoniae pneumonia in 22 pediatric patients.","volume":"171","author":"Liang","year":"2012","journal-title":"Eur. J. Pediatr."},{"key":"B75","doi-asserted-by":"publisher","first-page":"ftab053","DOI":"10.1093\/femspd\/ftab053","article-title":"Identification of histone H2B as a potential receptor for Mycoplasma genitalium protein of adhesion.","volume":"79","author":"Liao","year":"2021","journal-title":"Pathog. Dis."},{"key":"B76","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1172\/JCI72948","article-title":"RSV-encoded NS2 promotes epithelial cell shedding and distal airway obstruction.","volume":"124","author":"Liesman","year":"2014","journal-title":"J. Clin. Invest."},{"key":"B77","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1146\/annurev-biochem-062917-011942","article-title":"Ribosome-targeting antibiotics: modes of action, mechanisms of resistance, and implications for drug design.","volume":"87","author":"Lin","year":"2018","journal-title":"Annu. Rev. Biochem."},{"key":"B78","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12879-020-4774-9","article-title":"Mycoplasma pneumoniae pneumonia associated thrombosis at Beijing Children\u2019s hospital.","volume":"20","author":"Liu","year":"2020","journal-title":"BMC Infect. Dis."},{"key":"B79","doi-asserted-by":"publisher","first-page":"127252","DOI":"10.1016\/j.ijbiomac.2023.127252","article-title":"Revolutionizing medicine with toll-like receptors: A path to strengthening cellular immunity.","volume":"253","author":"Malik","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/s41541-020-0181-x","article-title":"Lipid moieties of Mycoplasma pneumoniae lipoproteins are the causative factor of vaccine-enhanced disease.","volume":"5","author":"Mara","year":"2020","journal-title":"NPJ Vaccines"},{"key":"B81","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s41541-022-00513-w","article-title":"Vaccination with Mycoplasma pneumoniae membrane lipoproteins induces IL-17A driven neutrophilia that mediates vaccine-enhanced disease.","volume":"7","author":"Mara","year":"2022","journal-title":"NPJ Vaccines"},{"key":"B82","doi-asserted-by":"publisher","first-page":"2522","DOI":"10.3390\/molecules23102522","article-title":"New N-(oxazolylmethyl)-thiazolidinedione active against Candida albicans biofilm: Potential als proteins inhibitors.","volume":"23","author":"Marc","year":"2018","journal-title":"Molecules"},{"key":"B83","doi-asserted-by":"publisher","first-page":"135277","DOI":"10.1016\/j.ijbiomac.2024.135277","article-title":"Molecular basis of bacterial lectin recognition of eukaryotic glycans: The case of Mycoplasma pneumoniae and Mycoplasma genitalium cytoadhesins.","volume":"279","author":"Marseglia","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"103514","DOI":"10.1016\/j.redox.2025.103514","article-title":"Redox regulation of focal adhesions.","volume":"80","author":"Matrullo","year":"2025","journal-title":"Redox Biol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"S382","DOI":"10.1093\/infdis\/jix172","article-title":"The unique microbiology and molecular pathogenesis of Mycoplasma genitalium.","volume":"216","author":"McGowin","year":"2017","journal-title":"J. Infect. Dis."},{"key":"B86","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.etap.2017.01.001","article-title":"The effect of Platycodin D on the expression of cytoadherence proteins P1 and P30 in Mycoplasma pneumoniae models.","volume":"49","author":"Meng","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/s1567-1348(02)00151-x","article-title":"Mycoplasma pneumoniae: A reduced-genome intracellular bacterial pathogen.","volume":"3","author":"Meseguer","year":"2003","journal-title":"Infect. Genet. Evol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1093\/infdis\/jix559","article-title":"The role of B cells in carriage and clearance of Mycoplasma pneumoniae from the respiratory tract of mice.","volume":"217","author":"Meyer Sauteur","year":"2018","journal-title":"J. Infect. Dis."},{"key":"B89","doi-asserted-by":"publisher","first-page":"e1003983","DOI":"10.1371\/journal.ppat.1003983","article-title":"Antibody responses to Mycoplasma pneumoniae: role in pathogenesis and diagnosis of encephalitis?","volume":"10","author":"Meyer Sauteur","year":"","journal-title":"PLoS Pathog."},{"key":"B90","doi-asserted-by":"publisher","first-page":"e0074821","DOI":"10.1128\/JCM.00748-21","article-title":"Mycoplasma pneumoniae genotypes and clinical outcome in children.","volume":"59","author":"Meyer Sauteur","year":"2021","journal-title":"J. Clin. Microbiol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3389\/fmicb.2016.00329","article-title":"Infection with and carriage of Mycoplasma pneumoniae in children.","volume":"7","author":"Meyer Sauteur","year":"2016","journal-title":"Front. Microbiol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1097\/QCO.0000000000000063","article-title":"Mycoplasma pneumoniae in children: Carriage, pathogenesis, and antibiotic resistance.","volume":"27","author":"Meyer Sauteur","year":"","journal-title":"Curr. Opin. Infect. Dis."},{"key":"B93","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.tim.2007.11.002","article-title":"Centipede and inchworm models to explain Mycoplasma gliding.","volume":"16","author":"Miyata","year":"2008","journal-title":"Trends Microbiol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"960","DOI":"10.3389\/fmicb.2016.00960","article-title":"Integrated information and prospects for gliding mechanism of the pathogenic bacterium Mycoplasma pneumoniae.","volume":"7","author":"Miyata","year":"2016","journal-title":"Front. Microbiol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"e1005299","DOI":"10.1371\/journal.ppat.1005299","article-title":"Systematic structural analyses of attachment organelle in Mycoplasma pneumoniae.","volume":"11","author":"Nakane","year":"2015","journal-title":"PLoS Pathog."},{"key":"B96","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1007\/s10156-010-0044-x","article-title":"Pathogenesis of extrapulmonary manifestations of Mycoplasma pneumoniae infection with special reference to pneumonia.","volume":"16","author":"Narita","year":"2010","journal-title":"J. Infect. Chemother."},{"key":"B97","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3389\/fmicb.2016.00023","article-title":"Classification of extrapulmonary manifestations due to Mycoplasma pneumoniae infection on the basis of possible pathogenesis.","volume":"7","author":"Narita","year":"2016","journal-title":"Front. Microbiol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"e1001219","DOI":"10.1371\/journal.ppat.1001219","article-title":"Is Mycoplasma pneumoniae adherence to erythrocytes a factor in extrapulmonary dissemination?","volume":"6","author":"Neimark","year":"2010","journal-title":"PLoS Pathog."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1038\/s41564-024-01713-x","article-title":"Influenza virus uses mGluR2 as an endocytic receptor to enter cells.","volume":"9","author":"Ni","year":"2024","journal-title":"Nat. Microbiol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1126\/science.abb3758","article-title":"In-cell architecture of an actively transcribing-translating expressome.","volume":"369","author":"O\u2019Reilly","year":"2020","journal-title":"Science"},{"key":"B101","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1128\/JB.02277-12","article-title":"Protein kinase\/phosphatase function correlates with gliding motility in Mycoplasma pneumoniae.","volume":"195","author":"Page","year":"2013","journal-title":"J. Bacteriol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41392-022-01259-6","article-title":"Targeting integrin pathways: Mechanisms and advances in therapy.","volume":"8","author":"Pang","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"B103","doi-asserted-by":"publisher","first-page":"471","DOI":"10.3892\/ijmm.2012.1215","article-title":"The effects of exogenous H2O2 on cell death, reactive oxygen species and glutathione levels in calf pulmonary artery and human umbilical vein endothelial cells.","volume":"31","author":"Park","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"B104","doi-asserted-by":"publisher","first-page":"974","DOI":"10.3389\/fmicb.2016.00974","article-title":"Mycoplasma pneumoniae: Current knowledge on macrolide resistance and treatment.","volume":"7","author":"Pereyre","year":"2016","journal-title":"Front. Microbiol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1111\/j.1365-2958.2006.05187.x","article-title":"Mycoplasma genitalium mg200 and mg386 genes are involved in gliding motility but not in cytadherence.","volume":"60","author":"Pich","year":"2006","journal-title":"Mol. Microbiol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1097\/BOR.0000000000000494","article-title":"Extra-pulmonary diseases related to Mycoplasma pneumoniae in children: Recent insights into the pathogenesis.","volume":"30","author":"Poddighe","year":"2018","journal-title":"Curr. Opin. Rheumatol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1128\/IAI.01036-13","article-title":"In vitro spatial and temporal analysis of Mycoplasma pneumoniae colonization of human airway epithelium.","volume":"82","author":"Prince","year":"2014","journal-title":"Infect. Immun."},{"key":"B108","doi-asserted-by":"publisher","first-page":"12810","DOI":"10.1111\/cmi.12810","article-title":"Modelling persistent Mycoplasma pneumoniae infection of human airway epithelium.","volume":"20","author":"Prince","year":"2018","journal-title":"Cell Microbiol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/s41586-023-06599-z","article-title":"Sialoglycan binding triggers spike opening in a human coronavirus.","volume":"624","author":"Pronker","year":"2023","journal-title":"Nature"},{"key":"B110","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1006\/mpat.1996.0014","article-title":"Correlations between Mycoplasma pneumoniae sensitivity to cyclosporin A and cyclophilin-mediated regulation of mycoplasma cytadherence.","volume":"20","author":"Reddy","year":"1996","journal-title":"Microb. Pathog."},{"key":"B111","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1128\/IAI.00958-09","article-title":"The stability of cytadherence proteins in Mycoplasma pneumoniae requires activity of the protein kinase PrkC.","volume":"78","author":"Schmidl","year":"2010","journal-title":"Infect. Immun."},{"key":"B112","doi-asserted-by":"publisher","first-page":"e1002263","DOI":"10.1371\/journal.ppat.1002263","article-title":"A trigger enzyme in Mycoplasma pneumoniae: impact of the glycerophosphodiesterase GlpQ on virulence and gene expression.","volume":"7","author":"Schmidl","year":"2011","journal-title":"PLoS Pathog."},{"key":"B113","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1055\/s-0031-1299740","article-title":"A 12-year-old boy with severe mucositis: Extrapulmonary manifestation of Mycoplasma pneumoniae infection.","volume":"224","author":"Schomburg","year":"2012","journal-title":"Klin. Padiatr."},{"key":"B114","doi-asserted-by":"publisher","first-page":"5007","DOI":"10.1128\/IAI.00268-09","article-title":"Strategy to create chimeric proteins derived from functional adhesin regions of Mycoplasma pneumoniae for vaccine development.","volume":"77","author":"Schurwanz","year":"2009","journal-title":"Infect. Immun."},{"key":"B115","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1128\/JB.187.5.1875-1877.2005","article-title":"Involvement of P1 adhesin in gliding motility of Mycoplasma pneumoniae as revealed by the inhibitory effects of antibody under optimized gliding conditions.","volume":"187","author":"Seto","year":"2005","journal-title":"J. Bacteriol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1111\/j.1365-2567.2007.02594.x","article-title":"Triacylated lipoproteins derived from Mycoplasma pneumoniae activate nuclear factor-kappaB through toll-like receptors 1 and 2.","volume":"121","author":"Shimizu","year":"2007","journal-title":"Immunology"},{"key":"B117","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1128\/IAI.00955-07","article-title":"Mycoplasma pneumoniae-derived lipopeptides induce acute inflammatory responses in the lungs of mice.","volume":"76","author":"Shimizu","year":"2008","journal-title":"Infect. Immun."},{"key":"B118","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/j.1365-2567.2011.03408.x","article-title":"Cytoadherence-dependent induction of inflammatory responses by Mycoplasma pneumoniae.","volume":"133","author":"Shimizu","year":"2011","journal-title":"Immunology"},{"key":"B119","doi-asserted-by":"publisher","first-page":"3076","DOI":"10.1128\/IAI.01961-14","article-title":"Cytadherence of Mycoplasma pneumoniae induces inflammatory responses through autophagy and toll-like receptor 4.","volume":"82","author":"Shimizu","year":"2014","journal-title":"Infect. Immun."},{"key":"B120","doi-asserted-by":"publisher","first-page":"4905","DOI":"10.1128\/IAI.00747-09","article-title":"The Mycoplasma pneumoniae MPN490 and Mycoplasma genitalium MG339 genes encode reca homologs that promote homologous DNA strand exchange.","volume":"77","author":"Sluijter","year":"2009","journal-title":"Infect. Immun."},{"key":"B121","doi-asserted-by":"publisher","first-page":"e01497-14","DOI":"10.1128\/mBio.01497-14","article-title":"Annexin A2 mediates Mycoplasma pneumoniae community-acquired respiratory distress syndrome toxin binding to eukaryotic cells.","volume":"5","author":"Somarajan","year":"2014","journal-title":"mBio"},{"key":"B122","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3389\/fcimb.2011.00005","article-title":"Structure and function of the Haemophilus influenzae autotransporters.","volume":"1","author":"Spahich","year":"2011","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1099\/mic.0.028506-0","article-title":"Sequence variations in RepMP2\/3 and RepMP4 elements reveal intragenomic homologous DNA recombination events in Mycoplasma pneumoniae.","volume":"155","author":"Spuesens","year":"2009","journal-title":"Microbiology (Reading)"},{"key":"B124","doi-asserted-by":"publisher","first-page":"e1001444","DOI":"10.1371\/journal.pmed.1001444","article-title":"Carriage of Mycoplasma pneumoniae in the upper respiratory tract of symptomatic and asymptomatic children: An observational study.","volume":"10","author":"Spuesens","year":"2013","journal-title":"PLoS Med."},{"key":"B125","doi-asserted-by":"publisher","first-page":"S42","DOI":"10.1016\/j.jinf.2014.07.017","article-title":"Mycoplasma pneumoniae infections\u2013does treatment help?","volume":"69","author":"Spuesens","year":"2014","journal-title":"J. Infect."},{"key":"B126","doi-asserted-by":"publisher","first-page":"eab8964","DOI":"10.1126\/science.abp8964","article-title":"The extracellular matrix and the immune system: A mutually dependent relationship.","volume":"379","author":"Sutherland","year":"2023","journal-title":"Science"},{"key":"B127","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1164\/rccm.201001-0080OC","article-title":"Variation in colonization, ADP-ribosylating and vacuolating cytotoxin, and pulmonary disease severity among mycoplasma pneumoniae strains.","volume":"182","author":"Techasaensiri","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B128","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1099\/mic.0.061184-0","article-title":"Characterization of pyruvate dehydrogenase subunit B and enolase as plasminogen-binding proteins in Mycoplasma pneumoniae.","volume":"159","author":"Thomas","year":"2013","journal-title":"Microbiology (Reading)"},{"key":"B129","doi-asserted-by":"publisher","first-page":"e0141421","DOI":"10.1128\/mBio.01414-21","article-title":"Chained structure of Dimeric F(1)-like ATPase in mycoplasma mobile gliding machinery.","volume":"12","author":"Toyonaga","year":"2021","journal-title":"mBio"},{"key":"B130","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s00430-019-00644-3","article-title":"Interaction with the host: the role of fibronectin and extracellular matrix proteins in the adhesion of Gram-negative bacteria.","volume":"209","author":"Vaca","year":"2020","journal-title":"Med. Microbiol. Immunol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"5188","DOI":"10.1038\/s41467-020-18777-y","article-title":"Immunodominant proteins P1 and P40\/P90 from human pathogen Mycoplasma pneumoniae.","volume":"11","author":"Vizarraga","year":"2020","journal-title":"Nat. Commun."},{"key":"B132","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.tim.2021.01.011","article-title":"The sialoglycan binding adhesins of Mycoplasma genitalium and Mycoplasma pneumoniae.","volume":"29","author":"Vizarraga","year":"2021","journal-title":"Trends Microbiol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1128\/CMR.00114-16","article-title":"Mycoplasma pneumoniae from the respiratory tract and beyond.","volume":"30","author":"Waites","year":"2017","journal-title":"Clin. Microbiol. Rev."},{"key":"B134","doi-asserted-by":"publisher","first-page":"6384","DOI":"10.1038\/s41598-020-63136-y","article-title":"Cell surface processing of the P1 adhesin of Mycoplasma pneumoniae identifies novel domains that bind host molecules.","volume":"10","author":"Widjaja","year":"2020","journal-title":"Sci. Rep."},{"key":"B135","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.1128\/JB.184.11.3061-3068.2002","article-title":"Characterization of a Mycoplasma pneumoniae hmw3 mutant: Implications for attachment organelle assembly.","volume":"184","author":"Willby","year":"2002","journal-title":"J. Bacteriol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"e00392-20","DOI":"10.1128\/IAI.00392-20","article-title":"Distinct Mycoplasma pneumoniae interactions with sulfated and sialylated receptors.","volume":"88","author":"Williams","year":"2020","journal-title":"Infect. Immun."},{"key":"B137","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.diagmicrobio.2013.08.008","article-title":"Detection of Mycoplasma pneumoniae P1 subtype variations by denaturing gradient gel electrophoresis.","volume":"78","author":"Xiao","year":"2014","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"B138","doi-asserted-by":"publisher","first-page":"e13015","DOI":"10.1111\/cmi.13015","article-title":"Mycoplasma pneumoniae protects infected epithelial cells from hydrogen peroxide-induced cell detachment.","volume":"21","author":"Yamamoto","year":"2019","journal-title":"Cell. Microbiol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"693","DOI":"10.3389\/fmicb.2016.00693","article-title":"Epidemiology of Mycoplasma pneumoniae infections in Japan and therapeutic strategies for Macrolide-Resistant M. pneumoniae.","volume":"7","author":"Yamazaki","year":"2016","journal-title":"Front. Microbiol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1080\/21505594.2021.1889813","article-title":"Infection strategies of mycoplasmas: Unraveling the panoply of virulence factors.","volume":"12","author":"Yiwen","year":"2021","journal-title":"Virulence"},{"key":"B141","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1186\/s12879-017-2500-z","article-title":"Radiologic findings as a determinant and no effect of macrolide resistance on clinical course of Mycoplasma pneumoniae pneumonia.","volume":"17","author":"Yoon","year":"2017","journal-title":"BMC Infect. Dis."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1080\/21505594.2020.1806664","article-title":"Mycoplasma hyopneumoniae evades complement activation by binding to factor H via elongation factor thermo unstable (EF-Tu).","volume":"11","author":"Yu","year":"2020","journal-title":"Virulence"},{"key":"B143","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1080\/21505594.2022.2095741","article-title":"Pathogenicity and virulence of Mycoplasma genitalium: Unraveling Ariadne\u2019s Thread.","volume":"13","author":"Yueyue","year":"2022","journal-title":"Virulence"},{"key":"B144","doi-asserted-by":"publisher","first-page":"e0214024","DOI":"10.1128\/spectrum.02140-24","article-title":"Protective immunity induced by a novel P1 adhesin C-terminal anchored mRNA vaccine against Mycoplasma pneumoniae infection in BALB\/c mice.","volume":"13","author":"Zeng","year":"2025","journal-title":"Microbiol. Spectr."},{"key":"B145","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.21037\/apm-19-497","article-title":"An analysis of 20 clinical cases of refractory mycoplasma pneumonia in children.","volume":"9","author":"Zhai","year":"2020","journal-title":"Ann. Palliat. Med."},{"key":"B146","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1007\/s11596-020-2261-6","article-title":"Correlation between the clinical severity, bacterial load, and inflammatory reaction in children with Mycoplasma Pneumoniae Pneumonia.","volume":"40","author":"Zhang","year":"2020","journal-title":"Curr. Med. Sci."},{"key":"B147","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1631\/jzus.B0820256","article-title":"Mycoplasma lipoproteins and Toll-like receptors.","volume":"10","author":"Zuo","year":"2009","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"B148","doi-asserted-by":"publisher","first-page":"1515291","DOI":"10.3389\/fmicb.2024.1515291","article-title":"Reviewing advancement in Mycoplasma pneumoniae P30 adhesin protein provides insights for future diagnosis and treatment.","volume":"15","author":"Zuo","year":"2024","journal-title":"Front. Microbiol."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2025.1613760\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T05:36:27Z","timestamp":1753248987000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2025.1613760\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,23]]},"references-count":148,"alternative-id":["10.3389\/fmicb.2025.1613760"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2025.1613760","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,23]]},"article-number":"1613760"}}