{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:21:05Z","timestamp":1793312465288,"version":"4.5.0"},"reference-count":93,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>Severe fever with thrombocytopenia syndrome (SFTS) is an acute infectious disease caused by the SFTS virus (SFTSV). Since the first reported case, SFTSV has spread globally, particularly in Asian regions such as China, South Korea, and Japan, with an increasing number of cases and a high mortality rate among severe patients. SFTSV is an RNA virus capable of rapid biological evolution through genetic mutations, reassortment, and homologous recombination. The disease primarily occurs in mountainous, forested, and hilly areas. Due to limited clinical research, the clinical characteristics and pathogenesis of SFTS remain incompletely understood. This review summarizes recent advances in the regional epidemiological characteristics, clinical features, genotyping, pathogenesis, and rapid detection methods of SFTSV.<\/jats:p>","DOI":"10.3389\/fmicb.2025.1622394","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T05:36:21Z","timestamp":1753248981000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Advances in research on severe fever with thrombocytopenia syndrome virus"],"prefix":"10.3389","volume":"16","author":[{"given":"Yu","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhu","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"687","DOI":"10.46234\/ccdcw2023.132","article-title":"Advancements in the worldwide detection of severe fever with thrombocytopenia syndrome virus infection from 2009 to 2023","volume":"5","author":"Ai","year":"2023","journal-title":"China CDC Wkly."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/s12276-021-00610-1","article-title":"Severe fever with thrombocytopenia syndrome virus: emerging novel phlebovirus and their control strategy","volume":"53","author":"Casel","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"975398","DOI":"10.3389\/fcimb.2022.975398","article-title":"Serological cross-reactivity among common flaviviruses","volume":"12","author":"Chan","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e2400163121","DOI":"10.1073\/pnas.2400163121","article-title":"Bispecific antibodies targeting two glycoproteins on SFTSV exhibit synergistic neutralization and protection in a mouse model","volume":"121","author":"Chang","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"940","DOI":"10.3390\/v15040940","article-title":"Recent advances in the study of the immune escape mechanism of SFTSV and its therapeutic agents","volume":"15","author":"Chen","year":"2023","journal-title":"Viruses"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ijid.2018.11.017","article-title":"Animals as amplification hosts in the spread of severe fever with thrombocytopenia syndrome virus: a systematic review and meta-analysis","volume":"79","author":"Chen","year":"2019","journal-title":"Int. J. Infect. Dis."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e0172744","DOI":"10.1371\/journal.pone.0172744","article-title":"Severe fever with thrombocytopenia syndrome virus inhibits exogenous type I IFN signaling pathway through its NSs in vitro","volume":"12","author":"Chen","year":"2017","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"852","DOI":"10.3760\/cma.j.cn112338-20220325-00228","article-title":"Epidemiological characteristics of severe fever with thtrombocytopenia syndrome in China, 2011-2021","volume":"43","author":"Chen","year":"2022","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"295","DOI":"10.31662\/jmaj.2019-0073","article-title":"Severe fever with thrombocytopenia syndrome: Japan under threat from life-threatening emerging tick-borne disease","volume":"3","author":"Crump","year":"2020","journal-title":"JMA J."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"101133","DOI":"10.1016\/j.lanwpc.2024.101133","article-title":"Global epidemiology of severe fever with thrombocytopenia syndrome virus in human and animals: a systematic review and meta-analysis","volume":"48","author":"Cui","year":"2024","journal-title":"Lancet Reg. Health. Western Pacific."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1080\/22221751.2022.2081617","article-title":"Effect of genomic variations in severe fever with thrombocytopenia syndrome virus on the disease lethality","volume":"11","author":"Dai","year":"2022","journal-title":"Emerg Microbes Infect."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"e0007242","DOI":"10.1371\/journal.pntd.0007242","article-title":"Seroprevalance of antibodies specific for severe fever with thrombocytopenia syndrome virus and the discovery of asymptomatic infections in Henan Province, China","volume":"13","author":"Du","year":"2019","journal-title":"PLoS Neglected Tropical Diseases."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"6333","DOI":"10.1038\/s41467-023-41804-7","article-title":"Cryo-EM structure of severe fever with thrombocytopenia syndrome virus","volume":"14","author":"Du","year":"2023","journal-title":"Nat. Commun."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"19563","DOI":"10.1038\/srep19563","article-title":"Phylogeographic analysis of severe fever with thrombocytopenia syndrome virus from Zhoushan Islands, China: implication for transmission across the ocean","volume":"6","author":"Fu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1093\/jme\/tjw080","article-title":"Transmission of heartland virus (Bunyaviridae: Phlebovirus) by experimentally infected Amblyomma americanum (Acari: Ixodidae)","volume":"53","author":"Godsey","year":"2016","journal-title":"J. Med. Entomol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"101454","DOI":"10.1016\/j.ttbdis.2020.101454","article-title":"Severe fever with thrombocytopenia syndrome in canines from the Republic of Korea","volume":"11","author":"Han","year":"2020","journal-title":"Ticks Tick Borne Dis."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"4704","DOI":"10.1002\/jmv.26877","article-title":"Changes in peripheral blood cytokines in patients with severe fever with thrombocytopenia syndrome","volume":"93","author":"He","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"8479","DOI":"10.1128\/JVI.00724-14","article-title":"Interleukin-6 (IL-6) and IL-17 synergistically promote viral persistence by inhibiting cellular apoptosis and cytotoxic T cell function","volume":"88","author":"Hou","year":"2014","journal-title":"J. Virol."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3760\/cma.j.cn112338-20230504-00274","article-title":"Epidemiological characteristics of severe fever with thrombocytopenia syndrome in China, 2018-2021","volume":"45","author":"Huang","year":"2024","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s40249-019-0569-x","article-title":"Prevalence of severe fever with thrombocytopenia syndrome virus in animals in Henan Province, China","volume":"8","author":"Huang","year":"2019","journal-title":"Inf. Dis. Poverty."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"3092","DOI":"10.3390\/ijerph18063092","article-title":"Epidemiological characteristics of severe fever with thrombocytopenia syndrome from 2010 to 2019 in mainland China","volume":"18","author":"Huang","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1002\/bio.3588","article-title":"Rapid detection of severe fever with thrombocytopenia syndrome virus (SFTSV) total antibodies by up-converting phosphor technology-based lateral-flow assay","volume":"34","author":"Huang","year":"2019","journal-title":"Luminescence"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e0048924","DOI":"10.1128\/spectrum.00489-24","article-title":"Seasonal dynamics of Haemaphysalis tick species as SFTSV vectors in South Korea","volume":"12","author":"Jang","year":"2024","journal-title":"Microbiol. Spectr."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"e0262302","DOI":"10.1371\/journal.pone.0262302","article-title":"Developing a multiplex loop-mediated isothermal amplification assay (LAMP) to determine severe fever with thrombocytopenia syndrome (SFTS) and scrub typhus","volume":"17","author":"Jang","year":"2022","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"107279","DOI":"10.1016\/j.actatropica.2024.10727","article-title":"First detection of Bandavirus dabieense in ticks collected from migratory birds in the Republic of Korea","volume":"257","author":"Ji","year":"2024","journal-title":"Acta Trop."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1146\/annurev-immunol-032712-100001","article-title":"Control of human viral infections by natural killer cells","volume":"31","author":"Jost","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"876","DOI":"10.3390\/v13050876","article-title":"The role of non-structural protein NSs in the pathogenesis of severe fever with thrombocytopenia syndrome","volume":"13","author":"Khalil","year":"2021","journal-title":"Viruses"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3390\/v16010128","article-title":"Current Progress of severe fever with thrombocytopenia syndrome virus (SFTSV) vaccine development","volume":"16","author":"Kim","year":"2024","journal-title":"Viruses"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.3390\/microorganisms11092309","article-title":"Emerging tick-borne Dabie bandavirus: virology, epidemiology, and prevention","volume":"11","author":"Kim","year":"2023","journal-title":"Microorganisms"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.micinf.2018.05.007","article-title":"Nonstructural protein of severe fever with thrombocytopenia syndrome phlebovirus targets STAT2 and not STAT1 to inhibit type I interferon-stimulated JAK-STAT signaling","volume":"20","author":"Kitagawa","year":"2018","journal-title":"Microbes Infect."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"692","DOI":"10.3201\/eid2604.191011","article-title":"Severe fever with thrombocytopenia syndrome, Japan, 2013-2017","volume":"26","author":"Kobayashi","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"ofae508","DOI":"10.1093\/ofid\/ofae508","article-title":"Effect of severe fever with thrombocytopenia syndrome virus genotype on disease severity, viral load, and cytokines in South Korea","volume":"11","author":"Kwon","year":"2024","journal-title":"Open Forum Infect. Dis."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.3389\/fimmu.2018.02061","article-title":"The dual nature of type I and type II interferons","volume":"9","author":"Lee","year":"2018","journal-title":"Front. Immunol."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"661","DOI":"10.4269\/ajtmh.24-0062","article-title":"Severe fever with thrombocytopenia syndrome in South Korea, 2016-2021: clinical features of severe progression and complications","volume":"111","author":"Lee","year":"2024","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"110039","DOI":"10.1016\/j.celrep.2021.110039","article-title":"Single-cell landscape of peripheral immune responses to fatal SFTS","volume":"37","author":"Li","year":"2021","journal-title":"Cell Rep."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1080\/1040841X.2020.1847037","article-title":"Severe fever with thrombocytopenia syndrome virus: a highly lethal bunyavirus","volume":"47","author":"Li","year":"2021","journal-title":"Crit. Rev. Microbiol."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"e0175592","DOI":"10.1371\/journal.pone.0175592","article-title":"Seroprevalence of severe fever with thrombocytopenia syndrome virus in China: a systematic review and meta-analysis","volume":"12","author":"Li","year":"2017","journal-title":"PLoS One"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1007\/s12250-020-00224-3","article-title":"Depletion but activation of CD56dimCD16+\u202fNK cells in acute infection with severe fever with thrombocytopenia syndrome virus","volume":"35","author":"Li","year":"2020","journal-title":"Virol. Sin."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.clim.2018.07.009","article-title":"CD4 T cell loss and Th2 and Th17 bias are associated with the severity of severe fever with thrombocytopenia syndrome (SFTS)","volume":"195","author":"Li","year":"2018","journal-title":"Clin. Immunol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1186\/s12889-023-15379-3","article-title":"Epidemiological and spatiotemporal analysis of severe fever with thrombocytopenia syndrome in eastern China, 2011-2021","volume":"23","author":"Liang","year":"2023","journal-title":"BMC Public Health"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1097\/CCM.0000000000006367","article-title":"The association between elevated myocardial injury-related biomarker (TnI) and increased mortality in patients with severe fever with thrombocytopenia syndrome","volume":"52","author":"Liang","year":"2024","journal-title":"Crit. Care Med."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1080\/22221751.2019.1710436","article-title":"The first discovery of severe fever with thrombocytopenia syndrome virus in Taiwan","volume":"9","author":"Lin","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/S1473-3099(14)70718-2","article-title":"Severe fever with thrombocytopenia syndrome, an emerging tick-borne zoonosis","volume":"14","author":"Liu","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1007\/s12250-019-00162-9","article-title":"Proteasome inhibitor PS-341 effectively blocks infection by the severe fever with thrombocytopenia syndrome virus","volume":"34","author":"Liu","year":"2019","journal-title":"Virol. Sin."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"e1803788","DOI":"10.1002\/smll.201803788","article-title":"Single-particle tracking reveals the sequential entry process of the Bunyavirus severe fever with thrombocytopenia syndrome virus","volume":"15","author":"Liu","year":"2019","journal-title":"Small"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"e0151677","DOI":"10.1371\/journal.pone.0151677","article-title":"Molecular evolution and spatial transmission of severe fever with thrombocytopenia syndrome virus based on complete genome sequences","volume":"11","author":"Liu","year":"2016","journal-title":"PLoS One"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.ttbdis.2016.12.015","article-title":"Novel sub-lineages, recombinants and reassortants of severe fever with thrombocytopenia syndrome virus","volume":"8","author":"Lv","year":"2017","journal-title":"Ticks Tick Borne Dis."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"292","DOI":"10.3390\/microorganisms13020292","article-title":"Analysis of gene differences between F and B epidemic lineages of Bandavirus Dabieense","volume":"13","author":"Ma","year":"2025","journal-title":"Microorganisms."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1080\/21645515.2019.1633875","article-title":"Severe fever and thrombocytopenia syndrome virus infection: considerations for vaccine evaluation of a rare disease","volume":"15","author":"Maslow","year":"2019","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1080\/22221751.2020.1748521","article-title":"Mapping the global potential transmission hotspots for severe fever with thrombocytopenia syndrome by machine learning methods","volume":"9","author":"Miao","year":"2020","journal-title":"Emerg. Microbes Inf."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"9691","DOI":"10.1074\/jbc.RA120.013973","article-title":"A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination","volume":"295","author":"Min","year":"2020","journal-title":"J. Biol. Chem."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.3390\/microorganisms11092288","article-title":"Genetic diversity, regional distribution, and clinical characteristics of severe fever with thrombocytopenia syndrome virus in Gangwon Province, Korea, a highly prevalent region, 2019-2021","volume":"11","author":"Moon","year":"2023","journal-title":"Microorganisms."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1348836","DOI":"10.3389\/fimmu.2024.1348836","article-title":"Antiviral immunity of severe fever with thrombocytopenia syndrome: current understanding and implications for clinical treatment","volume":"15","author":"Niu","year":"2024","journal-title":"Front. Immunol."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3390\/v13010033","article-title":"The polarity of an amino acid at position 1891 of severe fever with thrombocytopenia syndrome virus L protein is critical for the polymerase activity","volume":"13","author":"Noda","year":"2020","journal-title":"Viruses"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"veae054","DOI":"10.1093\/ve\/veae054","article-title":"Deciphering the evolutionary landscape of severe fever with thrombocytopenia syndrome virus across East Asia","volume":"10","author":"Park","year":"2024","journal-title":"Virus Evol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"2520343","DOI":"10.1080\/21505594.2025.2520343","article-title":"Bandavirus dabieense: a review of epidemiology, clinical characteristics, pathophysiology, treatment and prevention","volume":"16","author":"Peng","year":"2025","journal-title":"Virulence"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"msae173","DOI":"10.1093\/molbev\/msae173","article-title":"Ecological changes exacerbating the spread of invasive ticks has driven the dispersal of severe fever with thrombocytopenia syndrome virus throughout Southeast Asia","volume":"41","author":"P\u00e9rez","year":"2024","journal-title":"Mol. Biol. Evol."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"e01926-19","DOI":"10.1128\/JCM.01926-19","article-title":"Diagnostic approach for arboviral infections in the United States","volume":"58","author":"Piantadosi","year":"2020","journal-title":"J. Clin. Microbiol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"2572","DOI":"10.3201\/eid2812.221183","article-title":"Severe fever with thrombocytopenia syndrome virus infection, Thailand, 2019-2020","volume":"28","author":"Rattanakomol","year":"2022","journal-title":"Emerg. Infect. Dis."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"709517","DOI":"10.3389\/fmicb.2021.709517","article-title":"Non-structural proteins of severe fever with thrombocytopenia syndrome virus suppress RNA synthesis in a transcriptionally active cDNA-derived viral RNA synthesis system","volume":"12","author":"Ren","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1146\/annurev-anchem-061622-015112","article-title":"The present and future landscapes of molecular diagnostics","volume":"17","author":"Rolando","year":"2024","journal-title":"Ann. Rev. Anal. Chem."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"217","DOI":"10.7883\/yoken.JJID.2021.851","article-title":"Severe fever with thrombocytopenia syndrome, a viral hemorrhagic fever, endemic to Japan: achievements in and directions for medical research","volume":"75","author":"Saijo","year":"2022","journal-title":"Jpn. J. Infect. Dis."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1146\/annurev-immunol-032713-120231","article-title":"Interferon-stimulated genes: a complex web of host defenses","volume":"32","author":"Schneider","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.3390\/v13071213","article-title":"Clinical update of severe fever with thrombocytopenia syndrome","volume":"13","author":"Seo","year":"2021","journal-title":"Viruses"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.meegid.2016.11.015","article-title":"Migration, recombination, and reassortment are involved in the evolution of severe fever with thrombocytopenia syndrome bunyavirus","volume":"47","author":"Shi","year":"2017","journal-title":"Infect. Genet. Evol."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/s12985-024-02403-0","article-title":"Cytokines and lymphocyte subsets are associated with disease severity of severe fever with thrombocytopenia syndrome","volume":"21","author":"Song","year":"2024","journal-title":"Virol. J."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3390\/v8070202","article-title":"The role of Phlebovirus glycoproteins in viral entry, assembly and release","volume":"8","author":"Spiegel","year":"2016","journal-title":"Viruses"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"ofaa125","DOI":"10.1093\/ofid\/ofaa125","article-title":"Investigation of heartland virus disease throughout the United States, 2013-2017","volume":"7","author":"Staples","year":"2020","journal-title":"Open Forum Infect. Dis."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1093\/infdis\/jit603","article-title":"The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan","volume":"209","author":"Takahashi","year":"2014","journal-title":"J. Infect. Dis."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.virol.2019.06.014","article-title":"Identification of the amino acid residue important for fusion of severe fever with thrombocytopenia syndrome virus glycoprotein","volume":"535","author":"Tani","year":"2019","journal-title":"Virology"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.3201\/eid2505.181463","article-title":"Endemic severe fever with thrombocytopenia syndrome","volume":"25","author":"Tran","year":"2019","journal-title":"Vietnam. Emerg Infect Dis."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2220\/biomedres.38.89","article-title":"The amino acid at position 624 in the glycoprotein of SFTSV (severe fever with thrombocytopenia virus) plays a critical role in low-pH-dependent cell fusion activity","volume":"38","author":"Tsuda","year":"2017","journal-title":"Biomed. Res."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.3390\/microorganisms11051159","article-title":"Latest advances in arbovirus diagnostics","volume":"11","author":"Varghese","year":"2023","journal-title":"Microorganisms"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1093\/infdis\/jiab343","article-title":"Propagation of activated B cells by in vitro severe fever with thrombocytopenia syndrome virus infection of human peripheral blood mononuclear cells","volume":"225","author":"Wada","year":"2022","journal-title":"J. Infect. Dis."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"808098","DOI":"10.3389\/fcimb.2022.808098","article-title":"The endless wars: severe fever with thrombocytopenia syndrome virus, host immune and genetic factors","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1093\/nar\/gkac1249","article-title":"Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein","volume":"51","author":"Williams","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref77","doi-asserted-by":"publisher","first-page":"E7564","DOI":"10.1073\/pnas.1705176114","article-title":"Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope","volume":"114","author":"Wu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"174","DOI":"10.3390\/v8060174","article-title":"Phleboviruses and the type I interferon response","volume":"8","author":"Wuerth","year":"2016","journal-title":"Viruses"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"e0006547","DOI":"10.1371\/journal.pntd.0006547","article-title":"Polymorphisms and haplotypes in the promoter of the TNF-\u03b1 gene are associated with disease severity of severe fever with thrombocytopenia syndrome in Chinese Han population","volume":"12","author":"Xing","year":"2018","journal-title":"PLoS Negl. Trop. Dis."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"e1009587","DOI":"10.1371\/journal.ppat.1009587","article-title":"Infection of humanized mice with a novel phlebovirus presented pathogenic features of severe fever with thrombocytopenia syndrome","volume":"17","author":"Xu","year":"2021","journal-title":"PLoS Pathog."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s12250-016-3858-6","article-title":"Entry of severe fever with thrombocytopenia syndrome virus","volume":"32","author":"Yuan","year":"2017","journal-title":"Virol. Sin."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"257","DOI":"10.20199\/j.issn.1672-2302.2024.05.001","article-title":"Epidemic characteristics of fatal cases of severe fever with thrombocytopenia syndrome in China from 2010 to 2023","volume":"22","author":"Yue","year":"2024","journal-title":"J. Trop. Dis. Parasitol."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"e17701","DOI":"10.1097\/MD.0000000000017701","article-title":"Comparison of chest radiographic findings between severe fever with thrombocytopenia syndrome and scrub typhus: single center observational cross-sectional study in South Korea","volume":"98","author":"Yun","year":"2019","journal-title":"Medicine"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"e129531","DOI":"10.1172\/jci.insight.129531","article-title":"Genetic and pathogenic diversity of severe fever with thrombocytopenia syndrome virus (SFTSV) in South Korea","volume":"5","author":"Yun","year":"2020","journal-title":"JCI Insight"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"116400","DOI":"10.1016\/j.bios.2024.116400","article-title":"Preamplification-free ultra-fast and ultra-sensitive point-of-care testing via LwaCas13a","volume":"259","author":"Zeng","year":"2024","journal-title":"Biosens. Bioelectron."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1111\/trf.12953","article-title":"A study of seroprevalence and rates of asymptomatic viremia of severe fever with thrombocytopenia syndrome virus among Chinese blood donors","volume":"55","author":"Zeng","year":"2015","journal-title":"Transfusion"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.3389\/fimmu.2019.01095","article-title":"Severe fever with thrombocytopenia syndrome virus-induced macrophage differentiation is regulated by mi R-146","volume":"10","author":"Zhang","year":"2019","journal-title":"Front. Immunol."},{"key":"ref88","doi-asserted-by":"publisher","first-page":"e70095","DOI":"10.1002\/jmv.70095","article-title":"Rhabdomyolysis in severe fever with thrombocytopenia syndrome: associations with acute kidney injury and mortality","volume":"96","author":"Zhang","year":"2024","journal-title":"J. Med. Virol."},{"key":"ref89","doi-asserted-by":"publisher","first-page":"e0012068","DOI":"10.1371\/journal.pntd.0012068","article-title":"Association of liver function and prognosis in patients with severe fever with thrombocytopenia syndrome","volume":"18","author":"Zhang","year":"2024","journal-title":"PLoS Negl. Trop. Dis."},{"key":"ref90","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.3201\/eid2812.220668","article-title":"Hedgehogs as amplifying hosts of severe fever with thrombocytopenia syndrome virus, China","volume":"28","author":"Zhao","year":"2022","journal-title":"Emerg. Infect. Dis."},{"key":"ref91","doi-asserted-by":"publisher","first-page":"101580","DOI":"10.1016\/j.mcp.2020.101580","article-title":"Development and evaluation of a rapid detection assay for severe fever with thrombocytopenia syndrome virus based on reverse-transcription recombinase polymerase amplification","volume":"52","author":"Zhou","year":"2020","journal-title":"Mol. Cell. Probes"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1080\/22221751.2019.1645573","article-title":"First case of laboratory-confirmed severe fever with thrombocytopenia syndrome disease revealed the risk of SFTSV infection in Xinjiang, China","volume":"8","author":"Zhu","year":"2019","journal-title":"Emerg. Microbes Infect."},{"key":"ref93","doi-asserted-by":"publisher","first-page":"15399","DOI":"10.1021\/acsomega.8b02366","article-title":"Rapid detection of severe fever with thrombocytopenia syndrome virus via colloidal gold Immunochromatography assay","volume":"3","author":"Zuo","year":"2018","journal-title":"ACS Omega."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2025.1622394\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T05:36:24Z","timestamp":1753248984000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2025.1622394\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,23]]},"references-count":93,"alternative-id":["10.3389\/fmicb.2025.1622394"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2025.1622394","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,23]]},"article-number":"1622394"}}