{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:00:33Z","timestamp":1789563633400,"version":"build-2803163510"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Candidiasis in cancer patients remains largely unexplored in China. This study examines risk factors and antifungal susceptibility patterns of <jats:italic>Candida<\/jats:italic> in cancer patients from Jiangxi, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical and demographic data on <jats:italic>Candida<\/jats:italic> in cancer patients (2018\u20132024) were retrospectively collected at Jiangxi Cancer Hospital, Nanchang, China. <jats:italic>Candida<\/jats:italic> distribution across cancers and antifungal susceptibility patterns were analyzed. Risk factors were identified via logistic regression, and antifungal consumption was correlated with <jats:italic>Candida<\/jats:italic> distribution. Survival probabilities were compared between patients with <jats:italic>C. albicans<\/jats:italic> and those with non-<jats:italic>albicans Candida<\/jats:italic> (NAC) infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 2,761 <jats:italic>Candida<\/jats:italic> isolates, 1,703 (61.68%) were <jats:italic>C. albicans<\/jats:italic> and 1,058 (38.31%) were NAC, with a year-wise trend showing a decline in <jats:italic>C. albicans<\/jats:italic> and a rise in NAC. <jats:italic>C. albicans<\/jats:italic> was significantly higher in lung (40.57%) and nasopharyngeal (11.33%) cancers, while NAC were more common in gastric (7.56%), colon (8.69%), and urogenital (14.65%) cancers. NAC risk factors included inappropriate empirical therapy (OR 13.8, <jats:italic>P<\/jats:italic> &amp;lt; 0.001), hypoproteinemia (OR 1.35), anemia (OR 1.28), urinary tract infection (OR 1.71), and indwelling catheters (OR 1.27) (all <jats:italic>P<\/jats:italic> &amp;lt; 0.05). Radiotherapy, targeted therapy, glucocorticoids, chest tube insertion, and parenteral nutrition were associated with <jats:italic>C. albicans<\/jats:italic> (<jats:italic>P<\/jats:italic> \u2264 0.01). Amphotericin B (&amp;gt;99%) and echinocandins (&amp;gt;96%) showed the highest efficacy. <jats:italic>C. tropicalis<\/jats:italic> displayed notable azole resistance (40.9\u201374.45%). Caspofungin use negatively correlated with <jats:italic>C. albicans<\/jats:italic> (<jats:italic>r<\/jats:italic> = \u22120.84, <jats:italic>P<\/jats:italic> = 0.02) and positively with <jats:italic>C. tropicalis<\/jats:italic> (<jats:italic>r<\/jats:italic> = 0.78, <jats:italic>P<\/jats:italic> = 0.04) and <jats:italic>N. glabrata<\/jats:italic> (<jats:italic>r<\/jats:italic> = 0.85, <jats:italic>p<\/jats:italic> = 0.02). NAC infections showed 1.5-fold higher mortality rate than <jats:italic>C. albicans<\/jats:italic> (95% CI: 1.1\u20132.0; <jats:italic>P<\/jats:italic> = 0.0075).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings may aid healthcare officials in improving <jats:italic>Candida<\/jats:italic> management in the region and similar settings.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmicb.2025.1630226","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T05:31:16Z","timestamp":1753162276000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Epidemiology risk factors and antifungal resistance patterns of Candida in cancer patients in Jiangxi China"],"prefix":"10.3389","volume":"16","author":[{"given":"Hazrat","family":"Bilal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunsong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Nadeem","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Shafiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanman","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao-Li","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.ijid.2020.10.092","article-title":"Candida colonization as a predictor of invasive candidiasis in non-neutropenic icu patients with sepsis: A systematic review and meta-analysis.","volume":"102","author":"Alenazy","year":"2021","journal-title":"Int. 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