{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:15:09Z","timestamp":1777601709869,"version":"3.51.4"},"reference-count":94,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Over the past 25 years, antimicrobial resistance (AMR) has become a significant global health threat and a major cause of mortality. Foodborne diseases caused by drug-resistant bacteria capable of forming biofilms present serious health risks, necessitating innovative solutions for infectious disease management. Cellulose nanoparticles (CNPs), biocompatible and biodegradable, have found applications in targeted drug delivery, regenerative medicine, and tissue engineering. This study focuses on the synthesis and characterization of curcumin-loaded cellulose nanoparticles (CLCN) and their effects on quorum sensing (QS) and biofilm formation in both Gram-negative and Gram-positive foodborne bacteria (\n                    <jats:italic>Escherichia coli, Pseudomonas aeruginosa, Serratia marcescens<\/jats:italic>\n                    ,\n                    <jats:italic>Chromobacterium violaceum<\/jats:italic>\n                    , and\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    ). FTIR confirmed molecular interactions between cellulose hydroxyl groups and curcumin. Thermal analysis (TGA\/DSC) demonstrated enhanced structural stability with a gradual mass loss profile. Further, elemental composition analysis showed presence of carbon (50.6%) and oxygen (49.4%) in CLCN. CLCN exhibited MICs of 2\u202fmg\/mL against all test strains except in\n                    <jats:italic>L. monocytogenes<\/jats:italic>\n                    (8\u202fmg\/mL). At highest tested sub-MIC, violacein pigment was inhibited by over 58% in\n                    <jats:italic>C. violaceum<\/jats:italic>\n                    12,472. CLCN disrupted pyocyanin, pyoverdin, LasB elastase, and rhamnolipid production by 53, 44, 39, and 47%, respectively. Exoprotease activity in test pathogens decreased by up to 58%. Biofilm production in all pathogens was significantly inhibited in the range of 48\u201368% at 0.5xMICs. Also, CLCN effectively removed preformed biofilms up to 46%. This study demonstrates that CLCN disrupt QS-regulated virulence traits and destabilizing biofilm architecture. By targeting virulence rather than growth, CLCN minimize the likelihood of resistance development and may serve as an adjunct or alternative to conventional antibiotic therapy. Thus, CLCN offer a biocompatible and sustainable antimicrobial strategy for food packaging systems, that limits surface-associated contamination and enhance food safety.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2025.1680409","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:52:42Z","timestamp":1768978362000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis and characterization of curcumin-loaded cellulose nanoparticles targeting bacterial quorum sensing and biofilms in foodborne bacteria"],"prefix":"10.3389","volume":"16","author":[{"given":"Mohammad","family":"Zubair","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Tabuk","place":["Tabuk, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fohad Mabood","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, College of Food and Agriculture Sciences, King Saud University","place":["Riyadh, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahid Hameed","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, University of Tabuk","place":["Tabuk, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Altaf","family":"Khan Athar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, King Saud University","place":["Riyadh, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marai","family":"Alamri","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, University of Tabuk","place":["Tabuk, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoug","family":"Faisal Muhammad Ali Albudair","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Tabuk","place":["Tabuk, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.ijbiomac.2019.08.153","article-title":"Wound healing potential of curcumin cross-linked chitosan\/polyvinyl alcohol","volume":"140","author":"Abbas","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-981-13-9871-1_1","article-title":"Antibacterial drug discovery: perspective insights","volume-title":"Antibacterial drug discovery to combat MDR","author":"Ahmad","year":"2019"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.3390\/coatings10121171","article-title":"Bio-inspired facile synthesis of graphene-based nanocomposites: elucidation of antimicrobial and biofilm inhibitory potential against foodborne pathogenic bacteria","volume":"10","author":"Aljaafari","year":"2020","journal-title":"Coatings"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01680","article-title":"Phyto-mediated synthesis of porous titanium dioxide nanoparticles from Withania somnifera root extract: broad-Spectrum attenuation of biofilm and cytotoxic properties against HepG2 cell lines","volume":"11","author":"Al-Shabib","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.3390\/microbiolres14040114","article-title":"Control of biofilm and virulence in Pseudomonas aeruginosa by green-synthesized titanium\u2013cerium nanocomposites","volume":"14","author":"Altaf","year":"2023","journal-title":"Microbiol. Res."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1002\/elsc.202100050","article-title":"Acceleration of antibacterial activity of curcumin loaded biopolymers against methicillin-resistant Staphylococcus aureus: synthesis, optimization, and evaluation","volume":"22","author":"Anbari","year":"2022","journal-title":"Eng. Life Sci."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1128\/iai.49.1.132-140.1985","article-title":"Effects of siderophores on the growth of Pseudomonas aeruginosa in human serum and transferrin","volume":"49","author":"Ankenbauer","year":"1985","journal-title":"Infect. Immun."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"127597","DOI":"10.1016\/j.foodchem.2020.127597","article-title":"Characterization of bacterial cellulose nanocrystals: effect of acid treatments and neutralization","volume":"336","author":"Arserim-U\u00e7ar","year":"2021","journal-title":"Food Chem."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"4453","DOI":"10.1167\/iovs.06-0288","article-title":"Salicylic acid reduces the production of several potential virulence factors of Pseudomonas aeruginosa associated with microbial keratitis","volume":"47","author":"Bandara","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.2147\/IJN.S124318","article-title":"Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery","volume":"12","author":"Bhandari","year":"2017","journal-title":"Int. J. Nanomedicine"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0142-9612(96)85758-9","article-title":"Role of material surfaces in regulating bone and cartilage cell response","volume":"17","author":"Boyan","year":"1996","journal-title":"Biomaterials"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1063\/1.430558","article-title":"Infrared and Raman spectroscopy of carbohydrates. Paper V. Normal coordinate analysis of cellulose I","volume":"62","author":"Cael","year":"1975","journal-title":"J. Chem. Phys."},{"key":"ref13","first-page":"799","article-title":"Biosynthesis of extracellular polymeric substances (EPS) and its role in microbial biofilm formation","volume":"16","author":"Czaczyk","year":"2007","journal-title":"Pol. J. Environ. Stud."},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/srep08398","article-title":"Phenazine virulence factor binding to extracellular DNA is important for Pseudomonas aeruginosa biofilm formation","volume":"5","author":"Das","year":"2015","journal-title":"Sci. Rep."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"23347","DOI":"10.1038\/srep23347","article-title":"Attenuation of Pseudomonas aeruginosa biofilm formation by Vitexin: a combinatorial study with azithromycin and gentamicin","volume":"6","author":"Das","year":"2016","journal-title":"Sci. Rep."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"045011","DOI":"10.1088\/1748-6041\/11\/4\/045011","article-title":"Curcumin cross-linked collagen aerogels with controlled anti-proteolytic and pro-angiogenic efficacy","volume":"11","author":"Dharunya","year":"2016","journal-title":"Biomed. Mater."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"4866","DOI":"10.3390\/molecules26164866","article-title":"Antimicrobial and Antibiofilm activity of curcumin-loaded electrospun nanofibers for the prevention of the biofilm-associated infections","volume":"26","author":"Di Salle","year":"2021","journal-title":"Molecules"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1021\/ac60111a017","article-title":"Colorimetric method for determination of sugars and related substances","volume":"28","author":"DuBois","year":"1956","journal-title":"Anal. Chem."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"725","DOI":"10.3390\/vaccines11040725","article-title":"An overview of the public health challenges in diagnosing and controlling human foodborne pathogens","volume":"11","author":"Elbehiry","year":"2023","journal-title":"Vaccine"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"3655","DOI":"10.3390\/polym14173655","article-title":"Attenuation of Pseudomonas aeruginosa quorum sensing virulence of biofilm and Pyocyanin by mBTL-loaded calcium alginate nanoparticles","volume":"14","author":"Eltayb","year":"2022","journal-title":"Polymers"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"23050","DOI":"10.1021\/acsami.9b07499","article-title":"Selective antimicrobial effects of curcumin@Halloysite Nanoformulation: a Caenorhabditis elegans study","volume":"11","author":"Fakhrullina","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"7945","DOI":"10.1128\/JB.00858-07","article-title":"The EPS matrix: the \u201chouse of biofilm cells.\u201d","volume":"189","author":"Flemming","year":"2007","journal-title":"J. Bacteriol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nrmicro2415","article-title":"The biofilm matrix","volume":"8","author":"Flemming","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/1471-2180-7-45","article-title":"Widespread pyocyanin over-production among isolates of a cystic fibrosis epidemic strain","volume":"7","author":"Fothergill","year":"2007","journal-title":"BMC Microbiol."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2018.00898","article-title":"Biofilms in the food industry: health aspects and control methods","volume":"9","author":"Gali\u00e9","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s13568-020-01045-z","article-title":"Inhibitory activity of metal-curcumin complexes on quorum sensing related virulence factors of Pseudomonas aeruginosa PAO1","volume":"10","author":"Gholami","year":"2020","journal-title":"AMB Express"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/j.1574-6968.1995.tb07858.x","article-title":"Association of colony variation in Serratia marcescens with the differential expression of protease and type 1 fimbriae","volume":"133","author":"Goluszko","year":"1995","journal-title":"FEMS Microbiol. Lett."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/jam.13476","article-title":"Potentiation of antibiotic against Pseudomonas aeruginosa biofilm: a study with plumbagin and gentamicin","volume":"123","author":"Gupta","year":"2017","journal-title":"J. Appl. Microbiol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.matdes.2018.08.031","article-title":"Low density and high strength nanofibrillated cellulose aerogel for thermal insulation application","volume":"158","author":"Gupta","year":"2018","journal-title":"Mater. Des."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1016\/j.jclepro.2019.05.157","article-title":"Eco-friendly green synthesis of dextrin based poly (methyl methacrylate) grafted silver nanocomposites and their antibacterial and antibiofilm efficacy against multi-drug resistance pathogens","volume":"230","author":"Hasan","year":"2019","journal-title":"J. Clean. Prod."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"55","DOI":"10.4248\/IJOS11026","article-title":"The clinical impact of bacterial biofilms","volume":"3","author":"H\u00f8iby","year":"2011","journal-title":"Int. J. Oral Sci."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1016\/j.cherd.2013.10.023","article-title":"Modified supercritical CO2 extraction of amine template from hexagonal mesoporous silica (HMS) materials: effects of template identity and matrix Al\/Si molar ratio","volume":"92","author":"Huang","year":"2014","journal-title":"Chem. Eng. Res. Des."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1165\/rcmb.2012-0088OC","article-title":"Phenazine content in the cystic fibrosis respiratory tract negatively correlates with lung function and microbial complexity","volume":"47","author":"Hunter","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"727","DOI":"10.3389\/fmicb.2017.00727","article-title":"Leaf extracts of Mangifera indica L. inhibit quorum sensing - regulated production of virulence factors and biofilm in test bacteria","volume":"8","author":"Husain","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.3390\/ijms24021719","article-title":"Bacterial cellulose\u2014Carboxymethylcellulose composite loaded with turmeric extract for antimicrobial wound dressing applications","volume":"24","author":"Isopencu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1007\/s13204-022-02461-2","article-title":"The influence of nanomaterials on pyocyanin production by Pseudomonas aeruginosa","volume":"12","author":"Jab\u0142o\u0144ska","year":"2022","journal-title":"Appl. Nanosci."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"4186","DOI":"10.1007\/s10904-022-02431-9","article-title":"Green synthesis of chitosan\u2013selenium bionanocomposite with high biocompatibility and its marked impact on las B and RhII genes expression in Pseudomonas aeruginosa","volume":"32","author":"Karthick Raja Namasivayam","year":"2022","journal-title":"J. Inorg. Organomet. Polym. Mater."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1128\/iai.38.2.716-723.1982","article-title":"In vitro inhibition of Pseudomonas aeruginosa elastase by metal-chelating peptide derivatives","volume":"38","author":"Kessler","year":"1982","journal-title":"Infect. Immun."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"132719","DOI":"10.1016\/j.ijbiomac.2024.132719","article-title":"Multifunctional chitosan-cross linked- curcumin-tannic acid biocomposites disrupt quorum sensing and biofilm formation in pathogenic bacteria","volume":"271","author":"Khan","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1007\/s00253-018-09602-0","article-title":"Applications of cellulose and chitin\/chitosan derivatives and composites as antibacterial materials: current state and perspectives","volume":"103","author":"Khattak","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"3358","DOI":"10.1002\/anie.200460587","article-title":"Cellulose: fascinating biopolymer and sustainable raw material","volume":"44","author":"Klemm","year":"2005","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"5990","DOI":"10.1128\/JB.182.21.5990-5996.2000","article-title":"Swarming of Pseudomonas aeruginosa is dependent on cell-to-cell signaling and requires flagella and pili","volume":"182","author":"K\u00f6hler","year":"2000","journal-title":"J. Bacteriol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/0032-3861(96)82908-9","article-title":"A fourier transform infra-red spectroscopic analysis of the character of hydrogen bonds in amorphous cellulose","volume":"37","author":"Kondo","year":"1996","journal-title":"Polymer"},{"key":"ref44","first-page":"174","article-title":"Studies on the biosynthesis of pyocyanine. II. Isolation and determination of pyocyanine","volume":"36","author":"Kurachi","year":"1958","journal-title":"Bull. Inst. Chem. Res. Kyoto Univ."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"4069","DOI":"10.3390\/molecules25184069","article-title":"Antibacterial activity of bacterial cellulose loaded with bacitracin and amoxicillin: in vitro studies","volume":"25","author":"Lemnaru","year":"2020","journal-title":"Molecules"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"22684","DOI":"10.1021\/acsomega.0c02294","article-title":"Mechanisms and control measures of mature biofilm resistance to antimicrobial agents in the clinical context","volume":"5","author":"Li","year":"2020","journal-title":"ACS Omega"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.3390\/molecules28062432","article-title":"Biofilm formation and control of foodborne pathogenic Bacteria","volume":"28","author":"Liu","year":"2023","journal-title":"Molecules"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"623","DOI":"10.3390\/polym10060623","article-title":"Cellulose aerogels: synthesis, applications, and prospects","volume":"10","author":"Long","year":"2018","journal-title":"Polymers"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1016\/j.ijbiomac.2022.08.198","article-title":"Gelatin-based nanofiber membranes loaded with curcumin and borneol as a sustainable wound dressing","volume":"219","author":"Lv","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"103406","DOI":"10.1016\/j.jksus.2024.103406","article-title":"Curcumin loaded starch-based aerogels interfere with quorum sensing regulated virulence functions and biofilm of bacterial pathogens","volume":"36","author":"Mabood Husain","year":"2024","journal-title":"J. King Saud Univ. Sci."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.cej.2016.04.098","article-title":"Recent advances in aerogels for environmental remediation applications: a review","volume":"300","author":"Maleki","year":"2016","journal-title":"Chem. Eng. J."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1128\/AEM.70.3.1593-1599.2004","article-title":"Impact of Violacein-producing Bacteria on survival and feeding of bacterivorous Nanoflagellates","volume":"70","author":"Matz","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1093\/femsle\/fnx120","article-title":"Matrix exopolysaccharides; the sticky side of biofilm formation","volume":"364","author":"Maunders","year":"2017","journal-title":"FEMS Microbiol. Lett."},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.2174\/0118715265304913240826065228","article-title":"Antibacterial effect of co-loaded curcumin and rutin in mesoporous silica nanoparticles compared to their loading alone","volume":"25","author":"Memar","year":"2025","journal-title":"Infect. Disord. Drug Targets"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1146\/annurev.micro.55.1.165","article-title":"Quorum sensing in Bacteria","volume":"55","author":"Miller","year":"2001","journal-title":"Ann. Rev. Microbiol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"6339","DOI":"10.1128\/AEM.00593-07","article-title":"Inhibition of quorum sensing in Serratia marcescens AS-1 by synthetic analogs of N-Acylhomoserine lactone","volume":"73","author":"Morohoshi","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","author":"Murray","year":"2022","journal-title":"Lancet"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.3390\/polym13152533","article-title":"Functionalized chitosan nanomaterials: a jammer for quorum sensing","volume":"13","author":"Nag","year":"2021","journal-title":"Polymers"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"350","DOI":"10.3390\/foods12020350","article-title":"Recent advances in cellulose-based hydrogels: food applications","volume":"12","author":"Nath","year":"2023","journal-title":"Foods"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.colsurfa.2014.01.015","article-title":"Advanced thermal insulation and absorption properties of recycled cellulose aerogels","volume":"445","author":"Nguyen","year":"2014","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"449","DOI":"10.3390\/pharmaceutics12050449","article-title":"New trends in bio-based aerogels","volume":"12","author":"Nita","year":"2020","journal-title":"Pharmaceutics"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.1128\/AEM.02677-10","article-title":"The swarming motility of Pseudomonas aeruginosa is blocked by cranberry Proanthocyanidins and other tannin-containing materials","volume":"77","author":"O\u2019May","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"18360","DOI":"10.1021\/acsami.3c18061","article-title":"Glycol chitosan-poly(lactic acid) conjugate nanoparticles encapsulating ciprofloxacin: a Mucoadhesive, Antiquorum-sensing, and biofilm-disrupting treatment modality for bacterial keratitis","volume":"16","author":"Padaga","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/843509","article-title":"Pyoverdine, the major Siderophore in Pseudomonas aeruginosa, evades NGAL recognition","volume":"2012","author":"Peek","year":"2012","journal-title":"Interdiscip. Perspect. Infect. Dis."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"100","DOI":"10.3389\/fmicb.2019.01100","article-title":"Relationship between quorum sensing and secretion systems","volume":"10","author":"Pena","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1007\/s10570-016-0896-z","article-title":"Impact of selected solvent systems on the pore and solid structure of cellulose aerogels","volume":"23","author":"Pircher","year":"2016","journal-title":"Cellulose"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"3399","DOI":"10.1021\/acs.molpharmaceut.9b00179","article-title":"ZnO\/curcumin nanocomposites for enhanced inhibition of Pseudomonas aeruginosa virulence via LasR-RhlR quorum sensing systems","volume":"16","author":"Prateeksha","year":"2019","journal-title":"Mol. Pharm."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1080\/08927014.2021.1955250","article-title":"Plumbagin inhibits quorum sensing-regulated virulence and biofilms of gram-negative bacteria: in vitro and in silico investigations","volume":"37","author":"Qais","year":"2021","journal-title":"Biofouling"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1049\/iet-nbt.2017.0193","article-title":"Broad-spectrum inhibitory effect of green synthesised silver nanoparticles from Withania somnifera (L.) on microbial growth, biofilm and respiration: a putative mechanistic approach","volume":"12","author":"Qais","year":"2018","journal-title":"IET Nanobiotechnol."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"5467","DOI":"10.1038\/srep05467","article-title":"RNA-Seq-based transcriptome analysis of methicillin-resistant Staphylococcus aureus biofilm inhibition by ursolic acid and resveratrol","volume":"4","author":"Qin","year":"2015","journal-title":"Sci. Rep."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"14315","DOI":"10.1073\/pnas.2332354100","article-title":"Human targets of Pseudomonas aeruginosa pyocyanin","volume":"100","author":"Ran","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.bjm.2017.12.012","article-title":"Cost-effective production of bacterial cellulose using acidic food industry by-products","volume":"49","author":"Revin","year":"2018","journal-title":"Braz. J. Microbiol."},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.603407","article-title":"Production of bacterial cellulose aerogels with improved Physico-mechanical properties and antibacterial effect","volume":"8","author":"Revin","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1021\/acs.biomac.8b01816","article-title":"A study of the physical and mechanical properties of aerogels obtained from bacterial cellulose","volume":"20","author":"Revin","year":"2019","journal-title":"Biomacromolecules"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1574-6968.1980.tb05599.x","article-title":"Adherence of bacteria to hydrocarbons: a simple method for measuring cell-surface hydrophobicity","volume":"9","author":"Rosenberg","year":"1980","journal-title":"FEMS Microbiol. Lett."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"6261","DOI":"10.1007\/s10570-022-04630-6","article-title":"Drug loaded cellulose\u2013chitosan aerogel microfibers for wound dressing applications","volume":"29","author":"Rostamitabar","year":"2022","journal-title":"Cellulose"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1080\/21505594.2017.1313372","article-title":"Strategies for combating bacterial biofilms: a focus on anti-biofilm agents and their mechanisms of action","volume":"9","author":"Roy","year":"2018","journal-title":"Virulence"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1007\/s10570-015-0650-y","article-title":"Physical and chemical reinforcement of chitosan film using nanocrystalline cellulose and tannic acid","volume":"22","author":"Rubentheren","year":"2015","journal-title":"Cellulose"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"a012427","DOI":"10.1101\/cshperspect.a012427","article-title":"Bacterial quorum sensing: its role in virulence and possibilities for its control","volume":"2","author":"Rutherford","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.3390\/microorganisms10091755","article-title":"Effect of biogenic silver nanoparticles on the quorum-sensing system of Pseudomonas aeruginosa PAO1 and PA14","volume":"10","author":"Saeki","year":"2022","journal-title":"Microorganisms"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/femspd\/ftv038","article-title":"Interference of quorum sensing in urinary pathogen Serratia marcescens by Anethum graveolens","volume":"73","author":"Salini","year":"2015","journal-title":"Pathog. Dis."},{"key":"ref84","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1002\/jbm.b.33650","article-title":"Polydimethyl siloxane based nanocomposites with antibiofilm properties for biomedical applications","volume":"105","author":"Sankar","year":"2017","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref85","doi-asserted-by":"publisher","first-page":"6579","DOI":"10.1128\/JB.183.22.6579-6589.2001","article-title":"Characterization of phenotypic changes Inpseudomonas putida in response to surface-associated growth","volume":"183","author":"Sauer","year":"2001","journal-title":"J. Bacteriol."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"926363","DOI":"10.3389\/fcimb.2022.926363","article-title":"PLGA-based Nanoplatforms in drug delivery for inhibition and destruction of microbial biofilm","volume":"12","author":"Shariati","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref87","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1046\/j.1365-2958.2003.03295.x","article-title":"Phosphate availability regulates biosynthesis of two antibiotics, prodigiosin and carbapenem, in Serratia via both quorum-sensing-dependent and -independent pathways","volume":"47","author":"Slater","year":"2008","journal-title":"Mol. Microbiol."},{"key":"ref88","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/S1369-5274(03)00008-0","article-title":"P. aeruginosa quorum-sensing systems and virulence","volume":"6","author":"Smith","year":"2003","journal-title":"Curr. Opin. Microbiol."},{"key":"ref89","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0168-3659(94)00035-2","article-title":"Enhanced vascularization and tissue granulation by basic fibroblast growth factor impregnated in gelatin hydrogels","volume":"31","author":"Tabata","year":"1994","journal-title":"J. Control. Release"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.3390\/ijms22137130","article-title":"Antimicrobial activity of curcumin in nanoformulations: a comprehensive review","volume":"22","author":"Trigo-Gutierrez","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref91","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.carbpol.2019.05.008","article-title":"Bacterial cellulose production, properties and applications with different culture methods \u2013 a review","volume":"219","author":"Wang","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref92","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S0924-8579(00)00301-0","article-title":"Selective pressure by antibiotic use in livestock","volume":"16","author":"Witte","year":"2000","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1007\/s13213-011-0288-4","article-title":"Subdivision of the genus Gluconacetobacter Yamada, Hoshino and Ishikawa 1998: the proposal of Komagatabacter gen. Nov., for strains accommodated to the Gluconacetobacter xylinus group in the \u03b1-Proteobacteria","volume":"62","author":"Yamada","year":"2012","journal-title":"Ann. Microbiol."},{"key":"ref94","doi-asserted-by":"publisher","first-page":"16158","DOI":"10.1038\/srep16158","article-title":"Tea polyphenols as an antivirulence compound disrupt quorum-sensing regulated pathogenicity of Pseudomonas aeruginosa","volume":"5","author":"Yin","year":"2015","journal-title":"Sci. Rep."},{"key":"ref95","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.2147\/IJN.S238005","article-title":"Engineering of aerogel-based biomaterials for biomedical applications","volume":"15","author":"Zheng","year":"2020","journal-title":"Int. J. Nanomedicine"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/186864","article-title":"A review on antibacterial, antiviral, and antifungal activity of curcumin","volume":"2014","author":"Zorofchian Moghadamtousi","year":"2014","journal-title":"Biomed. Res. Int."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2025.1680409\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:52:44Z","timestamp":1768978364000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2025.1680409\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,21]]},"references-count":94,"alternative-id":["10.3389\/fmicb.2025.1680409"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2025.1680409","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,21]]},"article-number":"1680409"}}