{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:06:28Z","timestamp":1791857188711,"version":"4.3.4"},"reference-count":246,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Septic arthritis is a severe and rapidly destructive joint infection, primarily caused by\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    . The interplay between bacterial virulence factors and host immune responses determines disease progression and clinical outcomes. This review discusses the key bacterial factors that contribute to septic arthritis, including\n                    <jats:italic>S. aureus<\/jats:italic>\n                    cell wall components, surface proteins, and secreted toxins. In parallel, host-related factors, such as aging, immune responses, and genetic predispositions, are examined in conjunction with the impact of\n                    <jats:italic>S. aureus<\/jats:italic>\n                    infection on bone integrity and osteoimmunological mechanisms. Finally, this review highlights emerging therapeutic approaches, including targeted anti-virulence strategies, immune modulation, and anti-osteoclastogenic interventions, in mitigating joint damage. Understanding the multifaceted interactions between\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and the host immune system is crucial for advancing treatment strategies and reducing morbidity associated with septic arthritis.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2025.1687243","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T05:43:12Z","timestamp":1760506992000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Bacterial and host interactions in Staphylococcus aureus-induced septic arthritis\u2014understanding pathogenesis and exploring therapeutic strategies"],"prefix":"10.3389","volume":"16","author":[{"given":"Zhicheng","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Engdahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rille","family":"Pullerits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majd","family":"Mohammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"B1","volume-title":"Basic Immunology: Functions and Disorders of the Immune System, Sixth Edn","author":"Abbas","year":"2020"},{"key":"B2","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1111\/j.1365-3083.1994.tb03392.x","article-title":"Role of T lymphocytes in experimental Staphylococcus aureus arthritis","volume":"39","author":"Abdelnour","year":"","journal-title":"Scand. 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