{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:01:24Z","timestamp":1793383284828,"version":"4.5.0"},"reference-count":105,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Chronic pathogens incur a significant public health burden, contributing to the development of 1 in 5 cancer cases worldwide.\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    , a Gram-negative bacterium that colonizes the gastric mucosa, is the strongest known risk factor for gastric adenocarcinoma, the fifth leading cause of cancer-related mortality.\n                    <jats:italic>H. pylori<\/jats:italic>\n                    colonizes almost half of the world's population; however, despite its high prevalence, only approximately 1-3% of infected individuals progress to this malignancy. These data suggest that\n                    <jats:italic>H. pylori<\/jats:italic>\n                    colonization alone may be insufficient to fully drive oncogenic progression. Previously considered a sterile environment, the stomach is now recognized to harbor a diverse microbial ecosystem, which plays a crucial role in human health and disease. Emerging research highlights the complex interplay between\n                    <jats:italic>H. pylori<\/jats:italic>\n                    and the gastric microbiota, with several commensal bacterial species now identified as modulators of disease progression. Clinical data have defined key variations in gastric microbiota composition between\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -infected individuals who progress toward gastric cancer and those who simply develop gastritis alone, further suggesting that the gastric microbiota affects cancer risk in synergy with\n                    <jats:italic>H. pylori<\/jats:italic>\n                    . In this review, we will discuss microbial species identified within the stomach of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -infected persons that orchestrate detrimental or protective interactions, which influence the host response and alter cancer risk.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2025.1691080","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T06:36:45Z","timestamp":1763534205000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Microbial oncogenesis within the gastric niche: how the gastric microbiota influences H. pylori-induced disease progression"],"prefix":"10.3389","volume":"16","author":[{"given":"MaKayla S.","family":"Lowe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Richard M.","family":"Peek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1053\/j.gastro.2014.01.001","article-title":"Gastrointestinal malignancy and the microbiome","volume":"146","author":"Abreu","year":"2014","journal-title":"Gastroenterology"},{"key":"B2","unstructured":"FAQ: Human Microbiome\n          \n          2013"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1126\/science.1081919","article-title":"Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA","volume":"300","author":"Amieva","year":"2003","journal-title":"Science"},{"key":"B4","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1093\/jnci\/djx262","article-title":"The changing face of noncardia gastric cancer incidence among US non-hispanic whites","volume":"110","author":"Anderson","year":"2018","journal-title":"J. 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