{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T06:41:29Z","timestamp":1793169689299,"version":"4.5.0"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Alzheimer\u2019s disease (AD) is a progressive neurodegenerative disorder with limited treatment options, underscoring the need for novel therapeutic targets. The gut-brain axis has emerged as a critical bidirectional communication system, with growing evidence establishing gut dysbiosis as a causal factor in AD pathogenesis. This dysbiosis, characterized by a reduction in beneficial microbes and an increase in pro-inflammatory taxa, compromises intestinal and blood\u2013brain barrier integrity, promoting systemic inflammation and the translocation of neurotoxic agents like lipopolysaccharide (LPS). Consequently, the balance of key microbial metabolites is disrupted, reducing neuroprotective short-chain fatty acids (SCFAs) and indoles while elevating inflammatory mediators, which collectively exacerbate neuroinflammation, amyloid-\n                    <jats:italic>\u03b2<\/jats:italic>\n                    (A\u03b2) deposition, and tau pathology. This review evaluates promising interventions, including probiotics, anti-inflammatory diets, exercise, and phytochemicals that can restore microbial balance, enhance barrier function, and improve cognitive outcomes in preclinical and early clinical studies. However, clinical translation is hindered by an overreliance on animal models, short-term studies, and insufficient mechanistic insight. Future research must prioritize large-scale human trials, multi-omics integration to elucidate signaling pathways, and personalized approaches that account for host genetics and baseline microbiome composition to fully harness the therapeutic potential of the gut-brain axis for AD.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2025.1729708","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T06:29:54Z","timestamp":1764916194000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Microbiome-targeted Alzheimer\u2019s interventions via gut-brain axis"],"prefix":"10.3389","volume":"16","author":[{"given":"Ruiqi","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"110886","DOI":"10.1016\/j.jinorgbio.2019.110886","article-title":"Aluminum-induced generation of lipopolysaccharide (LPS) from the human gastrointestinal (GI)-tract microbiome-resident Bacteroides fragilis","volume":"203","author":"Alexandrov","year":"2020","journal-title":"J. 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Tradit. Chin. Med."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1111\/joim.12959","article-title":"Current and emerging avenues for Alzheimer's disease drug targets","volume":"286","author":"Loera-Valencia","year":"2019","journal-title":"J. Intern. Med."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"525","DOI":"10.4172\/2161-0460.1000525","article-title":"Gastrointestinal (GI)-tract microbiome derived neurotoxins and their potential contribution to inflammatory neurodegeneration in Alzheimer's disease (AD)","volume":"11","author":"Lukiw","year":"2021","journal-title":"J. Alzheimers Dis. Parkinsonism."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"119797","DOI":"10.1016\/j.jep.2025.119797","article-title":"Integrated multi-omics analysis and experimental validation reveals the mechanism of tenuifoliside a activity in Alzheimer's disease","volume":"347","author":"Ma","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"6670","DOI":"10.1038\/s41598-018-25190-5","article-title":"Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice","volume":"8","author":"Ma","year":"2018","journal-title":"Sci. Rep."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"683","DOI":"10.3233\/JAD-200306","article-title":"Short-chain fatty acids and lipopolysaccharide as mediators between gut Dysbiosis and amyloid pathology in Alzheimer's disease","volume":"78","author":"Marizzoni","year":"2020","journal-title":"J. Alzheimer's Dis."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s13195-023-01218-5","article-title":"A peripheral signature of Alzheimer's disease featuring microbiota-gut-brain axis markers","volume":"15","author":"Marizzoni","year":"2023","journal-title":"Alzheimer's Res. Ther."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1007\/s00702-021-02457-2","article-title":"Challenges of repurposing tetracyclines for the treatment of Alzheimer's and Parkinson's disease","volume":"129","author":"Markulin","year":"2022","journal-title":"J. Neural Transm. (Vienna)"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s13668-019-0271-4","article-title":"Diet and inflammation in cognitive ageing and Alzheimer's disease","volume":"8","author":"McGrattan","year":"2019","journal-title":"Curr. Nutr. Rep."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"32","DOI":"10.20517\/mrr.2023.24","article-title":"Microbiota-gut-brain axis and ketogenic diet: how close are we to tackling epilepsy?","volume":"2","author":"Mengoli","year":"2023","journal-title":"Microbiome Res. Rep."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.brainresbull.2021.08.004","article-title":"Antibiotic-induced gut microbiota depletion from early adolescence exacerbates spatial but not recognition memory impairment in adult male C57BL\/6 mice with Alzheimer-like disease","volume":"176","author":"Mosaferi","year":"","journal-title":"Brain Res. Bull."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"22941","DOI":"10.1038\/s41598-021-02231-0","article-title":"Gut microbiota depletion from early adolescence alters anxiety and depression-related behaviours in male mice with Alzheimer-like disease","volume":"11","author":"Mosaferi","year":"","journal-title":"Sci. Rep."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.3390\/life14101234","article-title":"The microbiota-gut-brain Axis and neurological disorders: a comprehensive review","volume":"14","author":"Nakhal","year":"2024","journal-title":"Life"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"100364","DOI":"10.1016\/j.foohum.2024.100364","article-title":"Ketogenic diets: answer to life-threatening neurological diseases","volume":"3","author":"Nanda","year":"2024","journal-title":"Food Humanity"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/s41398-024-02904-0","article-title":"Exercise mitigates a gut microbiota-mediated reduction in adult hippocampal neurogenesis and associated behaviours in rats","volume":"14","author":"Nicolas","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41387-020-0115-8","article-title":"Protective effects of Akkermansia muciniphila on cognitive deficits and amyloid pathology in a mouse model of Alzheimer's disease","volume":"10","author":"Ou","year":"2020","journal-title":"Nutr. Diabetes"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"150344","DOI":"10.1016\/j.bbrc.2024.150344","article-title":"Recent advances on cyanidin-3-O-glucoside in preventing obesity-related metabolic disorders: a comprehensive review","volume":"729","author":"Oumeddour","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"248","DOI":"10.3390\/nu14020248","article-title":"Post-ischemic brain neurodegeneration in the form of Alzheimer's disease Proteinopathy: possible therapeutic role of curcumin","volume":"14","author":"Pluta","year":"2022","journal-title":"Nutrients"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1038\/s41598-024-84780-8","article-title":"Protection of Alzheimer's disease progression by a human-origin probiotics cocktail","volume":"15","author":"Prajapati","year":"2025","journal-title":"Sci. Rep."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"112791","DOI":"10.1016\/j.bbr.2020.112791","article-title":"Prophylactic effect of physical exercise on Abeta(1-40)-induced depressive-like behavior and gut dysfunction in mice","volume":"393","author":"Rosa","year":"2020","journal-title":"Behav. Brain Res."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"e1900890","DOI":"10.1002\/mnfr.201900890","article-title":"Flavonoid-derived human phenyl-gamma-Valerolactone metabolites selectively detoxify amyloid-beta oligomers and prevent memory impairment in a mouse model of Alzheimer's disease","volume":"64","author":"Ruotolo","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"678","DOI":"10.3390\/biom11050678","article-title":"Dysbiosis and Alzheimer's disease: a role for chronic stress?","volume":"11","author":"Sharma","year":"2021","journal-title":"Biomolecules"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"e0038122","DOI":"10.1128\/msystems.00381-22","article-title":"MetaProClust-MS1: an MS1 profiling approach for large-scale microbiome screening","volume":"7","author":"Simopoulos","year":"2022","journal-title":"mSystems"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.14336\/ad.2025.0108","article-title":"Gut microbiota modulation of dementia related complications","author":"Su","year":"2025","journal-title":"Aging Dis."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"e0286086","DOI":"10.1371\/journal.pone.0286086","article-title":"Clostridium butyricum improves cognitive dysfunction in ICV-STZ-induced Alzheimer's disease mice via suppressing TLR4 signaling pathway through the gut-brain axis","volume":"18","author":"Su","year":"2023","journal-title":"PLoS One"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"849","DOI":"10.3233\/JAD-190872","article-title":"A review of the brain-gut-microbiome axis and the potential role of microbiota in Alzheimer's disease","volume":"73","author":"Sun","year":"2020","journal-title":"J. Alzheimer's Dis."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"e1900636","DOI":"10.1002\/mnfr.201900636","article-title":"Effect of Clostridium butyricum against microglia-mediated neuroinflammation in Alzheimer's disease via regulating gut microbiota and metabolites butyrate","volume":"64","author":"Sun","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"961","DOI":"10.3233\/JAD-215493","article-title":"Interaction between diet and microbiota in the pathophysiology of Alzheimer's disease: focus on polyphenols and dietary fibers","volume":"86","author":"Ticinesi","year":"2022","journal-title":"J. Alzheimer's Dis."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.3390\/cells11081367","article-title":"Blood-based biomarkers for Alzheimer's disease diagnosis and progression: an overview","volume":"11","author":"Varesi","year":"2022","journal-title":"Cells"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.freeradbiomed.2022.01.003","article-title":"Effect of oral and intraperitoneal administration of walnut-derived pentapeptide PW5 on cognitive impairments in APP(SWE)\/PS1(DeltaE9) mice","volume":"180","author":"Wang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"e2106504118","DOI":"10.1073\/pnas.2106504118","article-title":"Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration","volume":"118","author":"Wang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"15333175231174193","DOI":"10.1177\/15333175231174193","article-title":"Alterations of spatial memory and gut microbiota composition in Alzheimer's disease triple-transgenic mice at 3, 6, and 9 months of age","volume":"38","author":"Wei","year":"2023","journal-title":"Am. J. Alzheimers Dis. Other Dement."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"e0214985","DOI":"10.1371\/journal.pone.0214985","article-title":"A novel synbiotic delays Alzheimer's disease onset via combinatorial gut-brain-axis signaling in Drosophila melanogaster","volume":"14","author":"Westfall","year":"2019","journal-title":"PLoS One"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.apsb.2019.07.001","article-title":"Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice","volume":"10","author":"Yang","year":"2020","journal-title":"Acta Pharm. Sin. 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