{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:26:22Z","timestamp":1768321582182,"version":"3.49.0"},"reference-count":98,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018525","name":"Key Research and Development Program of Sichuan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018525","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Tuberculosis (TB) is a serious disease that poses a significant threat to the health of children and adolescents, with\n                    <jats:italic>pulmonary tuberculosis<\/jats:italic>\n                    (PTB) being the most common type. Due to the lack of specificity in clinical manifestations and symptoms, early screening and diagnosis of pediatric pulmonary tuberculosis present significant challenges. In recent years, the\n                    <jats:italic>artificial intelligence<\/jats:italic>\n                    (AI) healthcare industry has emerged as a major driving force for transformation in the global healthcare sector. Through technologies such as deep learning, natural language processing, computer vision and multimodal fusion, intelligent solutions are brought to medical links such as clinical auxiliary diagnosis. The combination mode of AI with medical imaging, laboratory diagnosis, pathology examination and other data has also been gradually applied to tuberculosis screening and diagnosis. However, its development is constrained by bottlenecks such as the scarcity of high-quality data on children, insufficient interpretability of models, lack of external validation, and unclear clinical translation paths. Moreover, most of the existing related studies focus on adult pulmonary tuberculosis, and there is a lack of sufficient research and reporting on pediatric pulmonary tuberculosis. This article aims to systematically review the research and application status of AI in the auxiliary diagnosis of pediatric pulmonary tuberculosis in recent years, critically analyze the current limitations, and explore that in the future, efforts should be made to build cross-institutional and multi-center collaborative datasets and carry out explainable AI verification centered on clinical efficacy. Explore the development path of the application of AI in the full-chain management of \u201cprevention\u2014diagnosis\u2014treatment\u2014management\u201d of pediatric pulmonary tuberculosis.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2025.1738926","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T10:21:31Z","timestamp":1768299691000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Applications and prospects of artificial intelligence in the auxiliary diagnosis of pediatric pulmonary tuberculosis"],"prefix":"10.3389","volume":"16","author":[{"given":"Xingyu","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Healthcare-Associated Infection Management, West China Second University Hospital of Sichuan University\/West China Women's and Children's Hospital","place":["Chengdu, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiyi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Healthcare-Associated Infection Management, West China Second University Hospital of Sichuan University\/West China Women's and Children's Hospital","place":["Chengdu, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Healthcare-Associated Infection Management, West China Second University Hospital of Sichuan University\/West China Women's and Children's Hospital","place":["Chengdu, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Healthcare-Associated Infection Management, West China Second University Hospital of Sichuan University\/West China Women's and Children's Hospital","place":["Chengdu, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiyang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Healthcare-Associated Infection Management, West China Second University Hospital of Sichuan University\/West China Women's and Children's Hospital","place":["Chengdu, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingyu","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Healthcare-Associated Infection Management, West China Second University Hospital of Sichuan University\/West China Women's and Children's Hospital","place":["Chengdu, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Healthcare-Associated Infection Management, West China Second University Hospital of Sichuan University\/West China Women's and Children's Hospital","place":["Chengdu, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1145\/3678182","article-title":"Federated learning survey: a multi-level taxonomy of aggregation techniques, experimental insights, and future frontiers","author":"Arbaoui","year":"2025","journal-title":"arXiv"},{"key":"B2","doi-asserted-by":"publisher","first-page":"S85","DOI":"10.1093\/jpids\/piac082","article-title":"Pediatric tuberculosis diagnostics: present and future","volume":"11","author":"Basile","year":"2022","journal-title":"J. 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