{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T22:35:01Z","timestamp":1776983701778,"version":"3.51.4"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["xyz012025007"],"award-info":[{"award-number":["xyz012025007"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Xizang Autonomous Region","award":["XZ202501R0137"],"award-info":[{"award-number":["XZ202501R0137"]}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"crossref","award":["2025JC-YBMS-877"],"award-info":[{"award-number":["2025JC-YBMS-877"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2024M762571"],"award-info":[{"award-number":["2024M762571"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Alcoholic liver disease (ALD), induced by chronic and excessive alcohol consumption, poses a significant health risk, with higher female susceptibility. This study investigated Lactobacillus plantarum fermented persimmon juice (Fj) against ALD in female C57BL\/6 mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The model mice were orally treated with Fj or unfermented persimmon juice (Pj). The bioactive compound profiles of Fj and Pj were detected by HPLC-MS. The hepatoprotective effects was evaluated through assessments of hepatic lipid metabolism, Keap1\/Nrf2 pathway proteins, and ferroptosis markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HPLC-MS analysis confirmed Fj was enriched in bioactive compounds including elevated antioxidants such as chlorogenic acid and p-hydrobenzoic acid. Daily Fj administration (10 \u03bcg\/g BW) significantly improved hepatic lipid metabolism and regulated Keap1\/Nrf2 signaling pathway, ultimately mitigating hepatic ferroptosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings demonstrate that probiotic fermentation as a strategic approach to develop postbiotic-based functional beverages for mitigating alcohol-induced liver injury, offering translational potential against ALD progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmicb.2026.1679233","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T06:45:06Z","timestamp":1770360306000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Lactobacillus plantarum-fermented persimmon juice alleviates alcohol-induced hepatic ferroptosis by activating the Keap1\/Nrf2 antioxidant axis"],"prefix":"10.3389","volume":"17","author":[{"given":"Huijuan","family":"Kuang","sequence":"first","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Xi\u2019an Jiaotong University","place":["Xi\u2019an, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyuan","family":"Ye","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Digital Dentistry Center, School of Stomatology, The Fourth Military Medical University","place":["Xi\u2019an, China"]},{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University","place":["Xi\u2019an, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Tong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University","place":["Xi\u2019an, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Fu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University","place":["Xi\u2019an, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Medical Affairs, School of Stomatology, The Fourth Military Medical University","place":["Xi\u2019an, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Outpatient Department, General Hospital of the Xizang Military Command","place":["Lhasa, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guotai","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Pharmaceutical Sciences, Faculty of Life Science and Technology, Kunming University of Science and Technology, Chenggong Campus","place":["Kunming, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.cld.2023.01.019","article-title":"Hepatic outcomes of nonalcoholic fatty liver disease including cirrhosis and hepatocellular carcinoma","volume":"27","author":"Alqahtani","year":"2023","journal-title":"Clin. 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