{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:36:11Z","timestamp":1787506571600,"version":"build-2736575974"},"reference-count":102,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    In recent years, the role of gut microbiota in the regulation of the gut-brain axis has garnered increasing attention, with\n                    <jats:italic>Muribaculum intestinale<\/jats:italic>\n                    (\n                    <jats:italic>M. intestinale<\/jats:italic>\n                    ) emerging as a novel member of the gut microbiota, exhibiting unique biological characteristics and potential therapeutic value. This article systematically reviews the regulatory mechanisms of\n                    <jats:italic>M. intestinale<\/jats:italic>\n                    in the gut-brain axis and its associations with various diseases.\n                    <jats:italic>M. intestinale<\/jats:italic>\n                    modulates host neurotransmitter synthesis, immune responses, and intestinal barrier function through metabolites such as short-chain fatty acids, succinate, and 3-hydroxybutyrate, thereby influencing the progression of neurodegenerative disorders, psychiatric diseases, and metabolic diseases. Additionally, this article explores the distribution differences of\n                    <jats:italic>M. intestinale<\/jats:italic>\n                    in the intestines of mice and humans, as well as its susceptibility to external factors like diet, antibiotics, and exercise. Although current research has unveiled the potential roles of\n                    <jats:italic>M. intestinale<\/jats:italic>\n                    , its clinical translation still faces challenges such as technical bottlenecks and individual variability. Future studies should focus on humanized model construction, synthetic biology modifications, and multi-target intervention strategies to achieve precise microbiota-targeted therapies.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1723051","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T06:40:51Z","timestamp":1771569651000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Muribaculum intestinale in brain-gut axis regulation: promises and limitations for therapeutic applications"],"prefix":"10.3389","volume":"17","author":[{"given":"Ruijun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot","place":["Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanbiao","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot","place":["Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqi","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Research Center, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute, Capital Medical University, Tongzhou","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanming","family":"Pan","sequence":"additional","affiliation":[{"name":"Cancer Research Center, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute, Capital Medical University, Tongzhou","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot","place":["Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"108275","DOI":"10.1016\/j.micpath.2026.108275","article-title":"Fecal microbiota transplantation attenuates neuropathic pain in rats via gut microbiota-mediated immunomodulation of ion channels and nociceptors.","volume":"212","author":"Allani","year":"2026","journal-title":"Microbial. 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