{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T21:13:24Z","timestamp":1781817204897,"version":"3.54.5"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The human gut microbiota plays a key role in intestinal homeostasis and inflammatory diseases, prompting the search for novel probiotic strains with strain-specific functional properties. Differences in dietary habits and cultural backgrounds represent a valuable source for isolating previously uncharacterized gut bacteria. Given the increasing use of probiotics, rigorous safety assessment, including antimicrobial resistance (AMR) evaluation, is required, and the integration of whole-genome sequencing with phenotypic characterization is recommended.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      This study evaluated the probiotic potential of\n                      <jats:italic>Pediococcus acidilactici<\/jats:italic>\n                      strain 46A, isolated from fecal samples of healthy Chinese student volunteers, through whole-genome analysis and\n                      <jats:italic>in vitro<\/jats:italic>\n                      and\n                      <jats:italic>in vivo<\/jats:italic>\n                      functional assessments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Strain identification was performed by MALDI-TOF mass spectrometry and 16S rRNA gene sequencing.\n                      <jats:italic>In vitro<\/jats:italic>\n                      assays assessed tolerance to simulated gastrointestinal conditions, bile salt resistance, antimicrobial activity, and adhesion to HT-29 intestinal epithelial cells. Whole-genome sequencing was used to evaluate safety- and functionality-related genetic traits. The protective effect of\n                      <jats:italic>P. acidilactici<\/jats:italic>\n                      46A was investigated in a dextran sulphate sodium (DSS)-induced murine model of colitis, including histological evaluation, inflammatory marker analysis, and gut microbiota profiling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>P. acidilactici<\/jats:italic>\n                      46A showed high survival under simulated gastrointestinal conditions and bile exposure, antimicrobial activity against Gram-positive and Gram-negative bacteria and yeasts, and strong adhesion to HT-29 cells compared with other tested strains. Genomic analysis confirmed the absence of virulence factors and clinically relevant antibiotic resistance genes. In DSS-treated mice, oral administration of\n                      <jats:italic>P. acidilactici<\/jats:italic>\n                      46A significantly reduced colitis severity, preserved colonic mucosal architecture, and decreased inflammatory markers, including IL-1\u03b2 and IL-6.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Pediococcus acidilactici<\/jats:italic>\n                      46A is a safe and functionally active probiotic candidate that attenuates intestinal inflammation and preserves mucosal integrity in a murine model of colitis, supporting its potential application in the prevention or adjunctive treatment of inflammatory gut disorders.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmicb.2026.1725578","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T13:43:45Z","timestamp":1771249425000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of probiotic properties and genome analysis of the new Pediococcus acidilactici strain 46A isolated from Chinese young adults: in vitro and in vivo studies"],"prefix":"10.3389","volume":"17","author":[{"given":"Polina","family":"Makarycheva","sequence":"first","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino","place":["Camerino, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Bellitto","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino","place":["Camerino, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristide Toussaint","family":"Nguele","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino","place":["Camerino, Italy"]},{"name":"Institut Sup\u00e9rieur des Sciences de la Sant\u00e9, Universit\u00e9 Adventiste Cosendai","place":["Nanga Eboko, Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Salvesi","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino","place":["Camerino, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Mozzicafreddo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Sciences, Marche Polytechnic University","place":["Ancona, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Rita","family":"Attili","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino","place":["Camerino, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Fiorini","sequence":"additional","affiliation":[{"name":"School of Sciences and Technologies, University of Camerino","place":["Camerino, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Tomassoni","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino","place":["Camerino, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Silvi","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino","place":["Camerino, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Miceli","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino","place":["Camerino, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"D517","DOI":"10.1093\/nar\/gkz935","article-title":"CARD 2020: Antibiotic resistome surveillance with the comprehensive antibiotic resistance database","volume":"48","author":"Alcock","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3354\/dao02992","article-title":"Characterization of Pediococcus acidilactici strains isolated from rainbow trout (Oncorhynchus mykiss) feed and larvae: Safety, DNA fingerprinting, and bacteriocinogenicity","volume":"119","author":"Ara\u00fajo","year":"2016","journal-title":"Dis. 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