{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T09:58:45Z","timestamp":1775555925492,"version":"3.50.1"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    The MarR family of transcription factors in\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    plays a critical role in bacterial adaptation to host stresses, yet the function of many members remains unknown. Here, we characterize the novel MarR regulator Rv0737 and its homolog Ms_1492 in\n                    <jats:italic>M. smegmatis<\/jats:italic>\n                    . Overexpression of Rv0737 severely impaired bacterial growth, cell division, and biofilm formation, while increasing susceptibility to oxidative stress and the cell wall-targeting drug isoniazid. Conversely, deletion of\n                    <jats:italic>ms_1492<\/jats:italic>\n                    altered cell envelope permeability and lipid composition, enhanced ATP synthesis, and conferred mild tolerance to H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and isoniazid. Lipid profiling and transcriptomic analysis revealed significant dysregulation of lipid metabolism genes. Crucially, electrophoretic mobility shift assays demonstrated that both Rv0737 and Ms_1492 directly bind to the promoter region of the sigL-rslA operon, which encodes an alternative sigma factor and its anti-sigma factor. Our findings establish a direct regulatory pathway wherein Rv0737\/Ms_1492 modulates bacterial growth, cell envelope integrity, and stress response by targeting the sigL-rslA operon, identifying this system as a potential therapeutic target for combating drug-resistant tuberculosis.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1727573","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T06:42:10Z","timestamp":1772779330000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mycobacterium tuberculosis MarR family transcription factor Rv0737 regulates bacterial growth and lipid synthesis by targeting the sigL-rslA operon"],"prefix":"10.3389","volume":"17","author":[{"given":"Abulimiti","family":"Abudukadier","sequence":"first","affiliation":[{"name":"School of Life Sciences, Institute of Modern Biopharmaceuticals, Southwest University","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Institute of Modern Biopharmaceuticals, Southwest University","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Institute of Modern Biopharmaceuticals, Southwest University","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiqi","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Institute of Modern Biopharmaceuticals, Southwest University","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peibo","family":"Li","sequence":"additional","affiliation":[{"name":"Chongqing Public Health Medical Center","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei","place":["Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Institute of Modern Biopharmaceuticals, Southwest University","place":["Chongqing, China"]},{"name":"Chongqing Public Health Medical Center","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"126615","DOI":"10.1016\/j.micres.2020.126615","article-title":"Mycobacterium tuberculosis Raf kinase inhibitor protein (RKIP) Rv2140c is involved in cell wall arabinogalactan biosynthesis via phosphorylation.","volume":"242","author":"Abo-Kadoum","year":"2021","journal-title":"Microbiol. 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