{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T07:26:24Z","timestamp":1784445984987,"version":"3.55.0"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Ocean warming, disease, and pollution have contributed to global declines in coral abundances and diversity. In the Caribbean, corals previously dominated reefs, providing an architectural framework for diverse ecological habitats, but have significantly declined due to infectious disease and anthropogenic climate change. Key species like the coral\n                    <jats:italic>Acropora cervicornis<\/jats:italic>\n                    are critically endangered, prompting researchers to focus on scientific endeavors to identify factors influencing coral disease resistance and resilience. We previously showed that disease susceptibility, growth rates, and bleaching risk were all associated with the abundance of a single bacterial parasite,\n                    <jats:italic>Candidatus<\/jats:italic>\n                    Aquirickettsia rohweri which proliferates\n                    <jats:italic>in vivo<\/jats:italic>\n                    under nutrient enrichment. Yet how nutrients influence parasite physiology\n                    <jats:italic>in vivo<\/jats:italic>\n                    remains unknown. Here, we analyzed parasite gene expression from a disease-susceptible\n                    <jats:italic>A. cervicornis<\/jats:italic>\n                    genotype exposed to ambient or nutrient enrichment conditions. Electron microscopy showed that\n                    <jats:italic>Ca.<\/jats:italic>\n                    A. rohweri was abundant in coral tissue and densely packed in mucocytes prior to nutrient enrichment. Under ambient conditions, the parasite upregulated genes involved in translation, protein maintenance, and cell envelope integrity, consistent with a conserve-and-maintain strategy. Nutrient enrichment induced expression of genes associated with central metabolism, nutrient import, stress response, host interaction, and two-component systems. Together, these results indicate that nutrient enrichment activates a growth-and-exploitation strategy, likely exacerbating parasitic pressure on\n                    <jats:italic>A. cervicornis<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1754183","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:24:56Z","timestamp":1776317096000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating Candidatus Aquirickettsia rohweri gene expression upon nutrient enrichment in disease-susceptible Acropora cervicornis"],"prefix":"10.3389","volume":"17","author":[{"given":"Lauren","family":"Speare","sequence":"first","affiliation":[{"name":"School of Biological Sciences, Georgia Institute of Technology","place":["Atlanta, Georgia"]},{"name":"Department of Microbiology, Oregon State University","place":["Corvallis, OR, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Grace","family":"Klinges","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Oregon State University","place":["Corvallis, OR, United States"]},{"name":"Island Conservation","place":["Santa Cruz, CA, United States"]},{"name":"Mote Marine Laboratory","place":["Sarasota, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Duke","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Oregon State University","place":["Corvallis, OR, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erinn M.","family":"Muller","sequence":"additional","affiliation":[{"name":"Mote Marine Laboratory","place":["Sarasota, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Vega Thurber","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Oregon State University","place":["Corvallis, OR, United States"]},{"name":"Marine Science Institute, University of California at Santa Barbara","place":["Santa Barbara, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"ref1","first-page":"1","volume-title":"Wiley StatsRef: Statistics Reference Online","author":"Anderson","year":"2017"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/s41396-021-01077-8","article-title":"The coral symbiont Candidatus Aquarickettsia is variably abundant in threatened Caribbean acroporids and transmitted horizontally","volume":"16","author":"Baker","year":"2022","journal-title":"ISME J."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2566","DOI":"10.1128\/jb.00038-11","article-title":"An Agrobacterium VirB10 mutation conferring a type IV secretion system gating defect","volume":"193","author":"Banta","year":"2011","journal-title":"J. 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