{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:50:04Z","timestamp":1793145004418,"version":"4.5.0"},"reference-count":149,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>LaeA is a global transcriptional regulator that differentially modulates expression of an impressive variety of secondary metabolite gene clusters in fungi, acting as a positive regulator fo some while repressing others. This regulator controls the production of fungal cellulolytic\/ligninolytic enzymes and citric acid secretion in Ascomycetes. Also, it regulates the biosynthesis of siderophores and the antitumor agent ganoderic acid in Basidiomycetes. This regulator contains an S-adenosylmethionine-binding motif, suggesting a function as a methyltransferase, although its specific methylation substrate has not been identified. LaeA is a core component of the velvet complex, a five-membered proteins assembly that regulates fungal responses to light and environmental stresses. Within this complex, LaeA interacts with VeA, VosA and other velvet components forming dimers and trimers and the complexes bind to an eleven-nucleotide consensus sequence in the promoter of target genes. This article reviews current knowledge of LaeA and VeA mediated regulation, discusses outstanding challenges in the field, and highlights its potential in optimizing fungal metabolism, its biotechnological applications and its role in the control of fungal infections.<\/jats:p>","DOI":"10.3389\/fmicb.2026.1764309","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:47:12Z","timestamp":1773038832000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["The global regulator LaeA controls expression of genes involved in diverse primary and secondary metabolites biosynthesis and their secretion in fungi"],"prefix":"10.3389","volume":"17","author":[{"given":"Juan Francisco","family":"Mart\u00edn","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular, \u00c1rea de Microbiolog\u00eda, Universidad de Le\u00f3n","place":["Le\u00f3n, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Kosalkov\u00e1","sequence":"additional","affiliation":[{"name":"\u00c1rea de Biotecnolog\u00eda, Cesefor Parque Cient\u00edfico de Le\u00f3n","place":["Le\u00f3n, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Liras","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular, \u00c1rea de Microbiolog\u00eda, Universidad de Le\u00f3n","place":["Le\u00f3n, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1534\/g3.112.005140","article-title":"Functional analyses of Trichoderma reesei LAE1 reveal conserved and contrasting roles of this regulator","volume":"3","author":"Aghcheh","year":"","journal-title":"G3 (Bethesda)"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e67144","DOI":"10.1371\/journal.pone.0067144","article-title":"The putative protein methyltransferase LAE1 of Trichoderma atroviride is a key regulator of asexual development and mycoparasitism","volume":"8","author":"Aghcheh","year":"","journal-title":"PLoS One"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e112799","DOI":"10.1371\/journal.pone.0112799","article-title":"The VELVET an orthologue VEL1 of Trichoderma reesei regulates fungal development and is essential for cellulase gene expression","volume":"9","author":"Aghcheh","year":"2014","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.fbr.2021.12.003","article-title":"Ganoderma lucidum, a potential pleiotropic approach of ganoderic acids in health reinforcement and factors influencing their production","volume":"39","author":"Ahmad","year":"2022","journal-title":"Fungal Biol. 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