{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T16:20:48Z","timestamp":1772122848643,"version":"3.50.1"},"reference-count":115,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ulcerative colitis (UC), a globally prevalent immune-mediated colonic disorder, is fundamentally linked to intestinal dysbiosis. Despite the exponential growth in related papers, systematic, data-driven bibliometric analyses including global productivity trends, international collaboration networks, citation impact distributions, and the temporal evolution of research topics remain lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a comprehensive bibliometric analysis of 5,879 articles and reviews sourced from the Web of Science Core Collection (WOSCC) and Dimensions (2004\u20132025). Publication outputs, international collaboration networks, institutional productivity, and keyword evolution were visualized using R-bibliometrix, VOSviewer, and CiteSpace. Lotka's law and Bradford's law were applied to assess author and journal productivity distributions, respectively. Burst detection algorithms identified emerging research frontiers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Annual publications demonstrated exponential growth, escalating from 36 in 2004 to a projected 819 in 2024. Geographically, China dominated absolute output (\n                      <jats:italic>n<\/jats:italic>\n                      = 2,559), followed by the USA (\n                      <jats:italic>n<\/jats:italic>\n                      = 1,181), with these two nations collectively accounting for 63.6% of global publications, justifying their prominence as the two major hubs in this research field. Harvard Medical School exhibited the highest citation efficiency (296.6 citations per publication), contrasting with volume leaders like Zhejiang University (92 publications). Co-occurrence clustering revealed 18 distinct knowledge domains, converging on five accelerating frontiers: \u201cfecal microbiota transplantation (FMT),\u201d \u201cshort-chain fatty acids,\u201d \u201ctraditional Chinese medicine,\u201d \u201cintestinal barrier mechanisms,\u201d and \u201cnanoparticle-based microbiota modulation.\u201d Burst analysis confirmed these themes-initiated citation surges post-2017, with \u201cnanoparticles\u201d and \u201cintestinal barrier\u201d exhibiting the strongest recent momentum (2023\u20132025), indicating a paradigm shift from descriptive microbiome profiling to mechanistic, precision-targeted interventions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The UC-microbiome research agenda has transitioned from correlative association studies to multi-layered therapeutic modulation. Future efforts should prioritize standardizing FMT protocols through randomized controlled trials, establishing multi-ethnic longitudinal cohorts to address population-specific microbiome signatures, elucidating dose\u2013response relationships of microbial metabolites, and converging nanodelivery systems with microbiome engineering to optimize therapeutic precision and sustain remission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmicb.2026.1765748","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:54:41Z","timestamp":1772121281000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut microbiota and ulcerative colitis: a bibliometric analysis of knowledge structure, research hotspots, and future directions"],"prefix":"10.3389","volume":"17","author":[{"given":"Zhen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of General Surgery, Jinhua Central Hospital Pan\u2018an Branch, Pan'an","place":["Jinhua, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangcheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Center, The Second People's Hospital of Lishui","place":["Lishui, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yitong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second People's Hospital of Lishui","place":["Lishui, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"947669","DOI":"10.3389\/fpsyg.2022.947669","article-title":"Global research mapping of psycho-oncology between 1980 and 2021: a bibliometric analysis","volume":"13","author":"Ahmad","year":"2022","journal-title":"Front. 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