{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T17:21:09Z","timestamp":1769448069696,"version":"3.49.0"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    <jats:italic>Pasteurella multocida<\/jats:italic>\n                    (\n                    <jats:italic>Pm<\/jats:italic>\n                    ) is a significant cause of respiratory disease in beef cattle, with serious consequences for the cattle industry. The bacterial quorum-sensing (QS) system is used for communication and regulation of various processes, including bacterial growth, virulence, biofilm formation and antimicrobial resistance. This study investigated the effects of the C6 signaling molecule on\n                    <jats:italic>Pm<\/jats:italic>\n                    resistance to the antimicrobial enrofloxacin (ENR). Bacteria were divided into groups, with one group (\n                    <jats:italic>Pm<\/jats:italic>\n                    -E1) treated with sub-inhibitory concentrations of ENR, a second treated with sub-inhibitory concentrations of ENR\u202f+\u202f200\u202f\u03bcM C6 (\n                    <jats:italic>Pm<\/jats:italic>\n                    -E2), and a control group (\n                    <jats:italic>Pm<\/jats:italic>\n                    -YQ). Transcriptomic, proteomic, and metabolomic sequencing of the bacteria was then performed. The results showed that C6 increased the minimum inhibitory concentration of ENR against\n                    <jats:italic>Pm<\/jats:italic>\n                    from 0.25\u202f\u03bcg\/mL to 1\u202f\u03bcg\/mL. Differentially expressed genes (DEGs), proteins (DEPs), and metabolites (DEMs), with 798 DEGs, 249 DEPs, and 499 DEMs identified in the\n                    <jats:italic>Pm<\/jats:italic>\n                    -YQ vs.\n                    <jats:italic>Pm<\/jats:italic>\n                    -E1 group, while the\n                    <jats:italic>Pm<\/jats:italic>\n                    -E1 vs.\n                    <jats:italic>Pm<\/jats:italic>\n                    -E2 group contained 784 DEGs, 301 DEPs, and 397 DEMs. Further analysis of the DEGs, DEPs, and DEMs suggested potential mechanisms by which C6 might induce\n                    <jats:italic>Pm<\/jats:italic>\n                    resistance to ENR through regulating the SOS response, CpxAR two-component system, and the ABC transporter system. These findings not only provide insight into the QS-mediated drug resistance mechanisms in\n                    <jats:italic>Pm<\/jats:italic>\n                    , but also highlight the potential of targeting the QS system for the development of novel interventions to control pasteurellosis and counteract antimicrobial resistance.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1766173","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T07:19:35Z","timestamp":1769411975000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Regulation of drug resistance to enrofloxacin in Pasteurella multocida strains from cattle by quorum-sensing acyl-homoserine lactone signaling molecules"],"prefix":"10.3389","volume":"17","author":[{"given":"Miao","family":"Sun","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Inner Mongolia Minzu University","place":["Tongliao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zipeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Inner Mongolia Minzu University","place":["Tongliao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongxu","family":"Han","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Inner Mongolia Minzu University","place":["Tongliao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinran","family":"Ge","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Inner Mongolia Minzu University","place":["Tongliao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhalantun Vocational College","place":["Hulunbuir, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianing","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Inner Mongolia Minzu University","place":["Tongliao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Inner Mongolia Minzu University","place":["Tongliao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengli","family":"Chen","sequence":"additional","affiliation":[{"name":"Tongliao Agriculture and Animal Husbandry Development Center","place":["Tongliao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boran","family":"Xu","sequence":"additional","affiliation":[{"name":"Tongliao Agriculture and Animal Husbandry Development Center","place":["Tongliao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kexin","family":"Ao","sequence":"additional","affiliation":[{"name":"Animal Disease Prevention and Control Center of Horqin District","place":["Tongliao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dahan","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Inner Mongolia Minzu University","place":["Tongliao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Inner Mongolia Minzu University","place":["Tongliao, China"]},{"name":"Inner Mongolia Engineering Technology Research Center for Prevention and Control of Beef Cattle Diseases","place":["Tongliao, China"]},{"name":"Beef Cattle Industry School of Inner Mongolia Autonomous Region","place":["Tongliao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Inner Mongolia Minzu University","place":["Tongliao, China"]},{"name":"Inner Mongolia Engineering Technology Research Center for Prevention and Control of Beef Cattle Diseases","place":["Tongliao, China"]},{"name":"Beef Cattle Industry School of Inner Mongolia Autonomous Region","place":["Tongliao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"901","DOI":"10.3390\/microorganisms12050901","article-title":"Enrofloxacin, effective treatment of Pseudomonas aeruginosa and Enterococcus faecalis infection in Oreochromis niloticus","volume":"12","author":"Aboyadak","year":"2024","journal-title":"Microorganisms."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"3232","DOI":"10.1038\/s41467-018-05675-7","article-title":"Self-organization of active particles by quorum sensing rules","volume":"9","author":"B\u00e4uerle","year":"2018","journal-title":"Nat. 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