{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:48:12Z","timestamp":1785296892289,"version":"3.55.0"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Inner Mongolia University Biology High-Level Talent Introduction Initiative","award":["10000-22120301\/011"],"award-info":[{"award-number":["10000-22120301\/011"]}]},{"name":"Dairy Cattle and Sheep Biological Breeding Platform Program","award":["2023KJHZ0019"],"award-info":[{"award-number":["2023KJHZ0019"]}]},{"name":"Inner Mongolia Autonomous Region Science and Technology Plan Project","award":["2025KYPT0131"],"award-info":[{"award-number":["2025KYPT0131"]}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"crossref","award":["2025LHMS03012"],"award-info":[{"award-number":["2025LHMS03012"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"crossref"}]},{"name":"2024 Inner Mongolia University \u201cSteed Plan\u201d High-Level Talent Funding","award":["10000-A24103030"],"award-info":[{"award-number":["10000-A24103030"]}]},{"name":"2030 Scientific and Technological Innovation Major Project","award":["2022ZD0401403"],"award-info":[{"award-number":["2022ZD0401403"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Intake of plant polysaccharides are associated with a reduced risk of ulcerative colitis (UC).\n                    <jats:italic>Eucommia<\/jats:italic>\n                    polysaccharides (EUPs) are promising nutritional supplements with notable antibacterial, anticancer, and anti-inflammatory properties. They exhibit a moderate molecular weight and are resistant to gastric acid degradation. Yet, the action mechanisms of microorganisms and metabolites in EUPs for UC treatment remain incompletely elucidated. The current study was formulated to assess the therapeutic efficacy of EUPs against fecal microbiota transplantation (FMT)-induced colitis, focusing on comparing the effects of low-dose and high-dose EUPs. After East Frisian sheep received dextran sulfate sodium (DSS) intervention, their fecal microbiota was used to prepare fecal bacterial suspensions for mouse FMT. Administration of high-dose EUPs alleviated key colitis symptoms, improved colonic epithelial barrier, preserved microbial diversity, and significantly reduced harmful bacterial (e.g.,\n                    <jats:italic>g_Klebsiella and g_unidentified_Enterobacteriaceae<\/jats:italic>\n                    ). Furthermore, this treatment significantly enriched the bile secretion pathways, particularly those involving deoxycholic acid (DCA) and hyodeoxycholic acid (HDCA). Additionally, DCA and HDCA were significantly negatively correlated with\n                    <jats:italic>g_unidentified_Enterobacteriaceae<\/jats:italic>\n                    and\n                    <jats:italic>g_Klebsiella<\/jats:italic>\n                    , and these two bile acids were also negatively correlated with key genes associated with the IL-17 signaling pathway. Overall, this study elucidates that EUPs ameliorate FMT-induced colitis in a mouse model via restoring gut microbes and metabolites and modulating the IL-17 pathway, thereby providing novel insights into therapeutic strategies for UC.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1769429","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:51:58Z","timestamp":1774421518000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Eucommia polysaccharides alleviate experimental colitis by reshaping colonic microbiota composition, metabolites, and modulating the IL-17 signaling pathway"],"prefix":"10.3389","volume":"17","author":[{"given":"Wenna","family":"Yao","sequence":"first","affiliation":[{"name":"Research Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]},{"name":"The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Yan","sequence":"additional","affiliation":[{"name":"Research Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]},{"name":"The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruilin","family":"Du","sequence":"additional","affiliation":[{"name":"Research Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]},{"name":"The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Research Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]},{"name":"The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]},{"name":"The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bincheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]},{"name":"The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Cheng","sequence":"additional","affiliation":[{"name":"Research Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]},{"name":"The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Research Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]},{"name":"The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqin","family":"Bao","sequence":"additional","affiliation":[{"name":"Research Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]},{"name":"The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihe","family":"Li","sequence":"additional","affiliation":[{"name":"Research Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]},{"name":"The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongli","family":"Song","sequence":"additional","affiliation":[{"name":"Research Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University","place":["Hohhot, China"]},{"name":"The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University","place":["Hohhot, 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