{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:19:19Z","timestamp":1787026759626,"version":"build-2736575974"},"reference-count":87,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    The colonization of the infant gut microbiome during the critical window of 0\u20133 years is influenced by a multitude of prenatal, environmental and host factors, and may be crucial for life-long health. The infant gut microbiome is highly dynamic, with bifidobacteria\n                    <jats:italic>-<\/jats:italic>\n                    dominance generally established during birth and lactation, followed by transition to a more stable and adult-like composition reached around 3 years of age. Bifidobacteria-dominance in infancy is considered protective as they not only display both anti-inflammatory and immunomodulatory effects but also foster the establishment of other beneficial species via cross-feeding interactions. As predominance of bifidobacteria is considered the marker of a healthy breastfed infant, the use of bifidobacteria-based probiotics for the prevention of gut dysbiosis and related conditions has been investigated. This clinically oriented summary highlights the unmet research needs of\n                    <jats:italic>Bifidobacterium animalis<\/jats:italic>\n                    subsp.\n                    <jats:italic>lactis<\/jats:italic>\n                    , BB-12\n                    <jats:sup>\u00ae<\/jats:sup>\n                    (BB-12), a well-studied probiotic added to baby formulas, dietary supplements, and fermented milk products; several potentially beneficial attributes, including acid and bile tolerance, strong adherence properties, pathogen inhibition, and immune modulation are considered. Clinical studies have demonstrated the safety and beneficial effects of BB-12 in infants and children across multiple disorders and highlight the need for improved clinical and regulatory guidelines.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1773473","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:40:46Z","timestamp":1771483246000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Health benefits of Bifidobacterium animalis subsp. lactis BB-12 in infants and children: a mini-review"],"prefix":"10.3389","volume":"17","author":[{"given":"Carlos Patricio Acosta Rodr\u00edguez","family":"Bueno","sequence":"first","affiliation":[{"name":"Hospital Infantil de M\u00e9xico Federico G\u00f3mez","place":["Ciudad de M\u00e9xico, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailim Carias","family":"Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Santa Fe de Bogot\u00e1","place":["Bogot\u00e1, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Guyonnet","sequence":"additional","affiliation":[{"name":"Opella","place":["Neuilly-Sur-Seine, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Pouteau","sequence":"additional","affiliation":[{"name":"Opella","place":["Neuilly-Sur-Seine, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.12938\/bmfh.2020-034","article-title":"Development of the gut microbiota and dysbiosis in children.","volume":"40","author":"Akagawa","year":"2021","journal-title":"Biosci. 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