{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T08:36:06Z","timestamp":1775032566331,"version":"3.50.1"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Sediment is the sink of antibiotic resistance genes (ARGs) in aquatic systems. The pollution of ARGs in sediments is becoming severe and complicated. However, the relationships between heavy metals\/antibiotics with ARGs in sediments are unclear. Thus, we collected river sediment samples to investigate the effects of 18 antibiotics\/8 heavy metal (loid)s on ARGs' contamination. Results showed that tetracycline, lipopeptide and sulfonamide were 100% detection, where tetracyclines were the most abundant, ranging from 44 ng\/g to 408 ng\/g dw. Meanwhile, arsenic, zinc, and cadmium were the most seriously contaminated with the concentrations of 4\u2013812 mg\/kg, 155\u20136158 mg\/kg, 0.1\u201323 mg\/kg, respectively. The abundance of ARGs (\n                    <jats:italic>tetA, sul1, sul2<\/jats:italic>\n                    , and\n                    <jats:italic>qnrA<\/jats:italic>\n                    ) were not only closely with antibiotics, but also significantly positively correlated with heavy metals. What's more, the heavy metals had significant positive correlations with MGEs such as plasmids, integrons, and efflux pumps, suggesting that heavy metals could potentially drive the propagation of ARGs in sediments. The rand-forest model showed the heavy metal (loid)s contributed up to 70% to the ARGs pollution in sediments. This study extends our understanding of the correlation between ARGs and heavy metals\/antibiotics and emphasizes the importance of considering co-existing heavy metals in the ARG pollution in coastal watersheds.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1777820","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:42:41Z","timestamp":1775022161000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Co-contamination of metal (loid)s and antibiotics induced the enrichment of antibiotic resistance genes in the coastal industrial basin"],"prefix":"10.3389","volume":"17","author":[{"given":"Changpeng","family":"Sang","sequence":"first","affiliation":[{"name":"Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education","place":["China), School of Environmental Science and Technology, China"]},{"name":"Key Laboratory of Pollution Ecology and Environmental Engineering","place":["Institute of Applied Ecology, Chinese Academy of Sciences, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyue","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education","place":["China), School of Environmental Science and Technology, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrui","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education","place":["China), School of Environmental Science and Technology, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meihua","family":"Lian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Wastewater Treatment Technology of Liaoning Province, Shenyang Ligong University","place":["Shenyang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiheng","family":"Li","sequence":"additional","affiliation":[{"name":"School of Environmental Science and Engineering, Zhejiang Gongshang University","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pollution Ecology and Environmental Engineering","place":["Institute of Applied Ecology, Chinese Academy of Sciences, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.cell.2007.03.004","article-title":"Molecular mechanisms of antibacterial multidrug resistance","volume":"128","author":"Alekshun","year":"2007","journal-title":"Cell"},{"key":"B2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1128\/AEM.67.1.22-32.2001","article-title":"Molecular ecology of tetracycline resistance: development and validation of primers for detection of tetracycline resistance genes encoding ribosomal protection proteins","volume":"67","author":"Aminov","year":"2001","journal-title":"Appl. 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