{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:39:01Z","timestamp":1791589141585,"version":"4.3.4"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Gut microbiota and their metabolites play a central regulatory role in uric-acid\u2013related metabolic diseases, serving as a crucial interface linking purine metabolism with host inflammatory responses. This review synthesizes current evidence on microbial community alterations, metabolic functional shifts, and receptor-mediated signaling mechanisms in hyperuricemia, gout, and uric acid nephropathy. Studies demonstrate that gut microbes can directly degrade purine substrates, modulate uric acid transporters and metabolic enzyme activity, and regulate host pathways through metabolites such as short-chain fatty acids, bile acids, and indole derivatives acting on receptors including GPR41 and GPR43. These interactions collectively shape the dynamic balance between uric acid production and excretion. Probiotic and prebiotic interventions, such as\n                    <jats:italic>Lactobacillus fermentum<\/jats:italic>\n                    GR-3,\n                    <jats:italic>Lactobacillus johnsonii<\/jats:italic>\n                    YH1136, and\n                    <jats:italic>Lactobacillus gasseri<\/jats:italic>\n                    PA-3, effectively improve uric acid dysregulation via the gut\u2013kidney and gut\u2013liver axes, underscoring their therapeutic potential. In parallel, emerging metabolite- and receptor-targeted strategies provide new opportunities for precision intervention in uric-acid\u2013related metabolic disorders. Future work should emphasize mechanistic causality and individualized host\u2013microbe interactions within the microbe\u2013metabolite\u2013host signaling network to support clinical translation of microbiota-based therapies.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1781413","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:41:50Z","timestamp":1778823710000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The roles of gut microbiota and their metabolites in uric acid\u2013related metabolic diseases: mechanisms and therapeutic targets"],"prefix":"10.3389","volume":"17","author":[{"given":"Haochen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Binzhou Medical University Hospital","place":["Binzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Binzhou Medical University Hospital","place":["Binzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Binzhou Medical University Hospital","place":["Binzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Binzhou Medical University Hospital","place":["Binzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Binzhou Medical University Hospital","place":["Binzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"100438","DOI":"10.1016\/j.metop.2025.100438","article-title":"Interactions between serum uric acid and gut microbiota: implications for metabolic health","volume":"29","author":"Ali","year":"2025","journal-title":"Metabol. 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