{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:46:46Z","timestamp":1782283606361,"version":"3.54.5"},"reference-count":114,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Cardiovascular disease (CVD) is one of the leading causes of death worldwide and poses a severe threat to human health. Recent years have witnessed a growing interest in how the gut microbiota regulates the cardiovascular system.\n                    <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    (\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    ), a key constituent of this community, has become a focus of research on CVD prevention owing to its critical role in maintaining gut homeostasis, modulating metabolism, and regulating immunity. This review details the beneficial effects and mechanisms of action of\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    in CVD.\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    protects against conditions such as hypertension, atherosclerosis, heart failure, and abdominal aortic aneurysm by repairing the gut barrier, balancing glucose and lipid metabolism, regulating immune-inflammatory responses, and producing protective metabolites such as short-chain fatty acids. However, in pathological states, such as a damaged gut barrier or low-fiber diets,\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    can over-proliferate, accelerate mucus breakdown, and exacerbate inflammation and disease progression\u2014revealing a \u201cdouble-edged sword\u201d character. Furthermore, diet, medications, and an individual\u2019s baseline gut microbiota directly modulate their abundance, underscoring the need for personalized approaches. Future studies should focus on clarifying strain differences, establishing safe dosing, and optimizing delivery systems to advance the clinical application of\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    in CVD therapy.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1786914","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:50:34Z","timestamp":1782280234000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Akkermansia muciniphila in cardiovascular diseases: opportunities and challenges"],"prefix":"10.3389","volume":"17","author":[{"given":"Shihao","family":"Li","sequence":"first","affiliation":[{"name":"The Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University","place":["Xuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanmeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University","place":["Taizhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Sha","sequence":"additional","affiliation":[{"name":"The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University","place":["Taizhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University","place":["Taizhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Chu","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University","place":["Xuzhou, China"]},{"name":"The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University","place":["Taizhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2552344","DOI":"10.1080\/19490976.2025.2552344","article-title":"Membrane vesicles produced by next-generation probiotics from the gut as innovative tools for human health","volume":"17","author":"Abraham","year":"2025","journal-title":"Gut Microbes"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1016\/j.molmet.2017.10.003","article-title":"A polyphenol-rich cranberry extract reverses insulin resistance and hepatic steatosis independently of body weight loss","volume":"6","author":"Anhe","year":"2017","journal-title":"Mol. 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