{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:07:33Z","timestamp":1792026453364,"version":"4.4.0"},"reference-count":101,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>Gestational diabetes mellitus (GDM) is a common metabolic complication during pregnancy that poses significant risks to maternal and infant health and is closely associated with gut microbiota dysbiosis. This review systematically summarizes the mechanisms, characteristic alterations, and intervention strategies related to the interplay between gut microbiota and GDM. Studies have shown that women with GDM exhibit distinct structural and compositional dysbiosis of the gut microbiota, such as an altered Firmicutes\/Bacteroidetes ratio, reduced abundance of beneficial bacteria, and enrichment of pathogenic bacteria. This dysbiosis is associated with altered synthesis of metabolites such as short-chain fatty acids and bile acids, which may impair insulin signaling, compromise barrier function, and activate inflammatory responses, potentially playing a role in GDM pathogenesis. Furthermore, GDM-associated gut dysbiosis can be vertically transmitted to offspring, altering neonatal gut colonization and increasing long-term risks of metabolic and neurodevelopmental disorders. Diagnostic models based on gut microbiota features show promise for early GDM prediction. Interventions targeting the gut microbiota, including lifestyle modifications, probiotics\/prebiotics supplementation, and fecal microbiota transplantation, have demonstrated potential in improving glucose metabolism by modulating microbial composition. However, current research faces challenges such as high heterogeneity, unclear causal mechanisms, and difficulties in clinical translation. Future studies should integrate multi-omics approaches and prospective cohorts to elucidate the core mechanisms of gut microbiota in GDM and advance personalized prevention and management strategies.<\/jats:p>","DOI":"10.3389\/fmicb.2026.1789594","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:30:28Z","timestamp":1785393028000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The interplay between gut microbiota and gestational diabetes mellitus: mechanisms, characteristics, and intervention strategies"],"prefix":"10.3389","volume":"17","author":[{"given":"Feng","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Binhai County People\u2019s Hospital","place":["Binhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-he","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Affiliated Dongtai Hospital of Nantong University","place":["Dongtai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Juan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Affiliated Dongtai Hospital of Nantong University","place":["Dongtai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory, Affiliated Dongtai Hospital of Nantong University","place":["Dongtai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Binhai County People\u2019s Hospital","place":["Binhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-xiu","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory, Affiliated Dongtai Hospital of Nantong University","place":["Dongtai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Binhai County People\u2019s Hospital","place":["Binhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3390\/microorganisms13010112","article-title":"Evaluation of Faecal microbiota following probiotics in infants of mothers with gestational diabetes mellitus trial: protocol for double-blind placebo-controlled randomized trial","volume":"13","author":"Athalye-Jape","year":"2025","journal-title":"Microorganisms"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1420664","DOI":"10.3389\/fmolb.2024.1420664","article-title":"Gestational diabetes mellitus: impacts on fetal neurodevelopment, gut dysbiosis, and the promise of precision medicine","volume":"11","author":"Biete","year":"2024","journal-title":"Front. 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Biotechnol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e1011193","DOI":"10.1371\/journal.pcbi.1011193","article-title":"Individualized network analysis reveals a link between the gut microbiome, diet intervention and gestational diabetes mellitus","volume":"19","author":"Liu","year":"2023","journal-title":"PLoS Comput. Biol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/s41387-024-00346-7","article-title":"Gestational diabetes exacerbates intrauterine microbial exposure induced intestinal microbiota change in offspring contributing to increased immune response","volume":"14","author":"Liu","year":"2024","journal-title":"Nutr. 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Biochem."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"e0091424","DOI":"10.1128\/msphere.00914-24","article-title":"Multiple perinatal characteristics affect the association between maternal diabetes status and early neonatal gut microbiota","volume":"10","author":"Liu","year":"2025","journal-title":"MSphere"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"e70148","DOI":"10.1111\/1753-0407.70148","article-title":"Vertical transmission of gut Dysbiosis from mothers with gestational diabetes to infants","volume":"17","author":"Low","year":"2025","journal-title":"J. Diabetes"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1175065","DOI":"10.3389\/fmicb.2023.1175065","article-title":"Gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus","volume":"14","author":"Lyu","year":"2023","journal-title":"Front. 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Metab. Syndr."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.diabres.2018.02.008","article-title":"The effects of synbiotic supplementation on insulin resistance\/sensitivity, lipid profile and total antioxidant capacity in women with gestational diabetes mellitus: a randomized double blind placebo controlled clinical trial","volume":"138","author":"Nabhani","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13034-023-00589-9","article-title":"Maternal weight, gut microbiota, and the association with early childhood behavior: the PREOBE follow-up study","volume":"17","author":"Nieto-Ruiz","year":"2023","journal-title":"Child Adolesc. Psychiatry Ment. 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Microbiol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1186\/s12916-025-04061-7","article-title":"Circulating linoleic acid and its interplay with gut microbiota during pregnancy for gestational diabetes mellitus","volume":"23","author":"Qiu","year":"2025","journal-title":"BMC Med."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"106674","DOI":"10.1016\/j.jsbmb.2025.106674","article-title":"Gut microbiome-derived metabolites and their impact on gene regulatory networks in gestational diabetes","volume":"247","author":"Sabarathinam","year":"2025","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.2337\/dc13-2817","article-title":"Gut dysbiosis and detection of \"live gut bacteria\" in blood of Japanese patients with type 2 diabetes","volume":"37","author":"Sato","year":"2014","journal-title":"Diabetes Care"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.3390\/nu16142300","article-title":"Association of Vegetables-Fruits Dietary Patterns with gestational diabetes mellitus: mediating effects of gut microbiota","volume":"16","author":"Shan","year":"2024","journal-title":"Nutrients"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1397675","DOI":"10.3389\/fcimb.2024.1397675","article-title":"Delivery mode and maternal gestational diabetes are important factors in shaping the neonatal initial gut microbiota","volume":"14","author":"Shi","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"2792","DOI":"10.3390\/nu12092792","article-title":"Gestational diabetes mellitus affects offspring's epigenome. Is there a way to reduce the negative consequences?","volume":"12","author":"S\u0142upecka-Ziemilska","year":"2020","journal-title":"Nutrients"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"18566","DOI":"10.1038\/s41598-025-03767-1","article-title":"The gut dysbiosis of mothers with gestational diabetes and its correlation with diet","volume":"15","author":"Sohrabi","year":"2025","journal-title":"Sci. Rep."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1210\/clinem\/dgad107","article-title":"Association of Gestational Diabetes with the dynamic changes of gut microbiota in offspring from 1 to 6 months of age","volume":"108","author":"Song","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3345\/cep.2025.01074","article-title":"Gut microbiota and metabolomic alterations in newborns of mothers with gestational diabetes mellitus","volume":"69","author":"Su","year":"2025","journal-title":"Clinical and Experimental Pediatrics."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"921464","DOI":"10.3389\/fendo.2022.921464","article-title":"A maternal higher-complex carbohydrate diet increases bifidobacteria and alters early life acquisition of the infant microbiome in women with gestational diabetes mellitus","volume":"13","author":"Sugino","year":"2022","journal-title":"Front. 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