{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T06:23:39Z","timestamp":1787207019643,"version":"build-2736575974"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the protective effects of zinc gluconate (ZnG) against antibiotics and peptidoglycan (PGN) induced intestinal injury by targeting gut barrier integrity, macrophage, and gut microbiota homeostasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty four C57BL\/J mice were randomly divided into four groups: normal group (NC), antibiotic cocktail group (ABX), model group (ABX+PGN), and ZnG treatment group (ZnG+ABX\/PGN). An antibiotic associated dysbiosis model was established via oral gavage of an antibiotic cocktail, followed by intraperitoneal injection of PGN (10 mg\/kg) to simulate Gram positive (G\n                      <jats:sup>+<\/jats:sup>\n                      ) bacteria associated challenge in antibiotic associated colitis (AAC) after microbiota disruption. Subsequently, ZnG was administered for therapeutic intervention. Parameters assessed included general condition of mice, intestinal permeability, barrier integrity, macrophage polarization, and gut microbiota composition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results indicated that ZnG significantly increased the body weight of the mice treated with ABX and PGN. It also markedly alleviated pathological and ultrastructural damage in the colon. ZnG improved intestinal permeability by reducing serum diamine oxidase (DAO) levels and restored intestinal integrity by upregulating tight junction proteins (TJs), including zonula occludens-1 (ZO-1), Occludin, and mucin 2 (MUC2). In addition, ZnG modulated the macrophage immunity by regulating the expression of polarization associated proteins (iNOS\/ARG-1) and inhibited activation of the TLR2-NF-\u03baB signaling pathway. Microbiota analysis revealed that ZnG increased gut microbial diversity while modulating the microbial community structure and its predicted functional potential in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings demonstrate that ZnG exhibits therapeutic potential for AAC through modulation of gut microbiota, enhancement of gut barrier, and regulation of immune responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmicb.2026.1791355","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T05:26:29Z","timestamp":1787203589000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Zinc gluconate ameliorates antibiotics\/PGN-induced intestinal injury via modulating the gut barrier, macrophages immunity and gut microbiota"],"prefix":"10.3389","volume":"17","author":[{"given":"Xia","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]},{"name":"Difficult and Critical Illness Center, Pediatric Clinical Medical Research Center of Guangxi, The First Afflicted Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]},{"name":"Difficult and Critical Illness Center, Pediatric Clinical Medical Research Center of Guangxi, The First Afflicted Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]},{"name":"Difficult and Critical Illness Center, Pediatric Clinical Medical Research Center of Guangxi, The First Afflicted Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]},{"name":"Difficult and Critical Illness Center, Pediatric Clinical Medical Research Center of Guangxi, The First Afflicted Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liancheng","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]},{"name":"Difficult and Critical Illness Center, Pediatric Clinical Medical Research Center of Guangxi, The First Afflicted Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]},{"name":"Difficult and Critical Illness Center, Pediatric Clinical Medical Research Center of Guangxi, The First Afflicted Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture, Guangxi Academy of Fishery Sciences","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwen","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]},{"name":"Difficult and Critical Illness Center, Pediatric Clinical Medical Research Center of Guangxi, The First Afflicted Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"04212","DOI":"10.7189\/jogh.14.04212","article-title":"Zinc supplementation for acute and persistent watery diarrhoea in children: a systematic review and meta-analysis","volume":"14","author":"Ali","year":"2024","journal-title":"J. Glob. Health"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1136\/bmj.324.7350.1345","article-title":"Managing antibiotic associated diarrhoea","volume":"324","author":"Barbut","year":"2002","journal-title":"BMJ"},{"key":"B3","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1021\/acscentsci.1c00200","article-title":"Bacterial peptidoglycan fragments differentially regulate innate immune signaling","volume":"7","author":"Bersch","year":"2021","journal-title":"ACS Cent. Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s10534-025-00761-y","article-title":"Zinc deficiency and zinc\/copper ratio imbalance in autism spectrum disorder: a reanalysis of six multinational studies","volume":"39","author":"Bj\u00f8rklund","year":"2026","journal-title":"Biometals"},{"key":"B5","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40104-023-00962-w","article-title":"Zinc glycine chelate ameliorates DSS-induced intestinal barrier dysfunction via attenuating TLR4\/NF-\u03baB pathway in meat ducks","volume":"15","author":"Chang","year":"2024","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e0048321","DOI":"10.1128\/Spectrum.00483-21","article-title":"Effect of long-term and short-term imbalanced Zn manipulation on gut microbiota and screening for microbial markers sensitive to zinc status","volume":"9","author":"Chen","year":"2021","journal-title":"Microbiol. Spectr."},{"key":"B7","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/s41579-023-00933-y","article-title":"Antibiotic perturbations to the gut microbiome","volume":"21","author":"Fishbein","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"283","DOI":"10.3390\/antibiotics9060283","article-title":"Iron chelation in murine models of systemic inflammation induced by gram-positive and gram-negative toxins","volume":"9","author":"Fokam","year":"2020","journal-title":"Antibiotics"},{"key":"B9","doi-asserted-by":"publisher","first-page":"718093","DOI":"10.3389\/fnut.2021.718093","article-title":"Present and future therapeutic approaches to barrier dysfunction","volume":"8","author":"Fortea","year":"2021","journal-title":"Front. Nutr."},{"key":"B10","doi-asserted-by":"publisher","first-page":"a002907","DOI":"10.1101\/cshperspect.a002907","article-title":"Molecular basis of the core structure of tight junctions","volume":"2","author":"Furuse","year":"2010","journal-title":"Cold Spring. Harb. Perspect. Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"e00521","DOI":"10.1128\/mSphere.00521-18","article-title":"Marginal zinc deficiency and environmentally relevant concentrations of arsenic elicit combined effects on the gut Microbiome","volume":"3","author":"Gaulke","year":"2018","journal-title":"mSphere"},{"key":"B12","doi-asserted-by":"publisher","first-page":"119754","DOI":"10.1016\/j.lfs.2021.119754","article-title":"Berberine and\/or zinc protect against methotrexate-induced intestinal damage: role of GSK-3\u03b2\/NRF2 and JAK1\/STAT-3 signaling pathways","volume":"281","author":"Hassanein","year":"2021","journal-title":"Life Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1093\/ecco-jcc\/jjz193","article-title":"Zinc deficiency activates the IL-23\/Th17 axis to aggravate experimental colitis in mice","volume":"14","author":"Higashimura","year":"2020","journal-title":"J. Crohns. Colitis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/s41575-023-00766-3","article-title":"Paracellular permeability and tight junction regulation in gut health and disease","volume":"20","author":"Horowitz","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"eadu3919","DOI":"10.1126\/sciadv.adu3919","article-title":"Lysosomal zinc nanomodulation blocks macrophage pyroptosis for counteracting atherosclerosis progression","volume":"11","author":"Hu","year":"2025","journal-title":"Sci. Adv."},{"key":"B16","doi-asserted-by":"publisher","first-page":"5431","DOI":"10.1038\/s41467-023-41168-y","article-title":"Aryl hydrocarbon receptor utilises cellular zinc signals to maintain the gut epithelial barrier","volume":"14","author":"Hu","year":"2023","journal-title":"Nat. Commun."},{"key":"B17","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s10787-017-0309-4","article-title":"Antioxidant and anti-inflammatory effects of zinc","volume":"25","author":"Jarosz","year":"2017","journal-title":"Zinc-dependent NF-\u03baB signaling. Inflammopharmacology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1385591","DOI":"10.3389\/fnut.2024.1385591","article-title":"The nutritional roles of zinc for immune system and COVID-19 patients","volume":"11","author":"Jin","year":"2024","journal-title":"Front. Nutr."},{"key":"B19","doi-asserted-by":"publisher","first-page":"136678","DOI":"10.1016\/j.foodchem.2023.136678","article-title":"Metal-binding peptides and their potential to enhance the absorption and bioavailability of minerals","volume":"428","author":"Joshua Ashaolu","year":"2023","journal-title":"Food Chem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1097\/INF.0000000000003994","article-title":"Incidence and risk factors for antibiotic-associated diarrhea among hospitalized children","volume":"42","author":"Kaya","year":"2023","journal-title":"Pediatr. Infect. Dis. J."},{"key":"B21","doi-asserted-by":"publisher","first-page":"5389","DOI":"10.2147\/JIR.S470520","article-title":"Restore intestinal barrier integrity: an approach for inflammatory bowel disease therapy","volume":"17","author":"Kong","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1007\/s13312-025-00173-8","article-title":"An update on WHO recommendations on childhood pneumonia and diarrhea (2024)","volume":"62","author":"Kundu","year":"2025","journal-title":"Indian Pediatr."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1093\/infdis\/jiac082","article-title":"Gastrointestinal microbiome disruption and antibiotic-associated diarrhea in children receiving antibiotic therapy for community-acquired pneumonia","volume":"226","author":"Kwon","year":"2022","journal-title":"J. Infect. Dis."},{"key":"B24","doi-asserted-by":"publisher","first-page":"e91091","DOI":"10.1371\/journal.pone.0091091","article-title":"Effect of dietary zinc oxide on morphological characteristics, mucin composition and gene expression in the colon of weaned piglets","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS ONE"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1093\/ecco-jcc\/jjac019","article-title":"Tollip orchestrates macrophage polarization to alleviate intestinal mucosal inflammation","volume":"16","author":"Liu","year":"2022","journal-title":"J. Crohns. Colitis."},{"key":"B26","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-012418-012718","article-title":"Diversity, mechanisms, and significance of macrophage plasticity","volume":"15","author":"Locati","year":"2020","journal-title":"Ann. Rev. Pathol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"106971","DOI":"10.5498\/wjp.v15.i8.106971","article-title":"Diamine oxidase as a biomarker for depression and disease activity in inflammatory bowel disease: a cross-sectional observational study","volume":"15","author":"Lyu","year":"2025","journal-title":"World J. Psychiatry."},{"key":"B28","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1007\/s10238-024-01496-9","article-title":"Intestinal permeability disturbances: causes, diseases and therapy","volume":"24","author":"Macura","year":"2024","journal-title":"Clin. Exp. Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"616506","DOI":"10.3389\/fendo.2021.616506","article-title":"Impaired intestinal barrier and tissue bacteria: pathomechanisms for metabolic diseases","volume":"12","author":"Massier","year":"2021","journal-title":"Front. Endocrinol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1021\/acsabm.5c01869","article-title":"A fibrous dressing integrating advanced nanomicro hybrid structure with effective drug delivery for accelerated wound healing","volume":"9","author":"Meng","year":"2026","journal-title":"ACS Appl. Bio. Mater."},{"key":"B31","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1111\/jam.14661","article-title":"Gut dysbacteriosis and intestinal disease: mechanism and treatment","volume":"129","author":"Meng","year":"2020","journal-title":"J. Appl. Microbiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1649658","DOI":"10.3389\/fnut.2025.1649658","article-title":"Roles of zinc and zinc transporters in development, progression, and treatment of inflammatory bowel disease (IBD)","volume":"12","author":"Mitchell","year":"2025","journal-title":"Front. Nutr."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1645900","DOI":"10.3389\/fvets.2025.1645900","article-title":"Impact of zinc oxide on gut health, immunity, and growth in weaned piglets: exploring potential modes of action","volume":"12","author":"Ng'ang'a","year":"2025","journal-title":"Front. Vet. Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s13099-025-00768-3","article-title":"Murine model of antibiotic-associated Staphylococcus aureus gastrointestinal infections (SAGII) and colonization","volume":"17","author":"Niamba","year":"2025","journal-title":"Gut. Pathog."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e323","DOI":"10.1097\/PCC.0b013e31824fbd90","article-title":"Prophylactic zinc supplementation reduces bacterial load and improves survival in a murine model of sepsis","volume":"13","author":"Nowak","year":"2012","journal-title":"Pediatr. Crit. Care Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1016\/j.lfs.2006.07.032","article-title":"Zinc L-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-kappaB activation","volume":"79","author":"Odashima","year":"2006","journal-title":"Life Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s00281-024-01026-5","article-title":"The role of the mucosal barrier system in maintaining gut symbiosis to prevent intestinal inflammation","volume":"47","author":"Okumura","year":"2024","journal-title":"Semin. Immunopathol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"e1260","DOI":"10.1002\/mbo3.1260","article-title":"Impact of antibiotics on the human microbiome and consequences for host health","volume":"11","author":"Patangia","year":"2022","journal-title":"Microbiologyopen"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.3390\/nu15081885","article-title":"Preliminary comparison of fractional absorption of zinc sulphate, zinc gluconate, and zinc aspartate after oral supple-mentation in healthy human volunteers","volume":"15","author":"Piacenza","year":"2023","journal-title":"Nutrients"},{"key":"B40","doi-asserted-by":"publisher","first-page":"9768","DOI":"10.3390\/nu7125497","article-title":"Chronic Zinc Deficiency Alters Chick Gut Microbiota Composition and Function","volume":"7","author":"Reed","year":"2015","journal-title":"Nutrients"},{"key":"B41","doi-asserted-by":"publisher","first-page":"eadp4119","DOI":"10.1126\/sciadv.adp4119","article-title":"Antibiotics damage the colonic mucus barrier in a microbiota-independent manner","volume":"10","author":"Sawaed","year":"2024","journal-title":"Sci. Adv."},{"key":"B42","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3389\/fimmu.2017.00191","article-title":"A potential role of salmonella infection in the onset of inflammatory bowel diseases","volume":"8","author":"Schultz","year":"2017","journal-title":"Front. Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1186\/s12866-020-01999-x","article-title":"Gut microbiota characteristics in mice with antibiotic-associated diarrhea","volume":"20","author":"Shao","year":"2020","journal-title":"BMC Microbiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"e2023062307","DOI":"10.1542\/peds.2023-062307","article-title":"Clostridioides difficile infection in children: recent updates on epidemiology, diagnosis, therapy","volume":"152","author":"Shirley","year":"2023","journal-title":"Pediatrics"},{"key":"B45","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/s12276-023-00960-y","article-title":"Intestinal mucus components and secretion mechanisms: what we do and do not know","volume":"55","author":"Song","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s10238-024-01302-6","article-title":"Role of zinc in health and disease","volume":"24","author":"Stiles","year":"2024","journal-title":"Clin. Exp. Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1007\/s00253-022-11795-4","article-title":"Peptidoglycan-based immunomodulation","volume":"106","author":"Sun","year":"","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"819722","DOI":"10.3389\/fnut.2022.819722","article-title":"Coated zinc oxide improves growth performance of weaned piglets via gut microbiota","volume":"9","author":"Sun","year":"","journal-title":"Front. Nutr."},{"key":"B49","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jpeds.2020.01.044","article-title":"Pediatric antibiotic prescribing in China according to the 2019 world health organization access, watch, and reserve (AWaRe) antibiotic categories","volume":"220","author":"Wang","year":"","journal-title":"J. Pediatr."},{"key":"B50","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1097\/01.CCM.0000109775.22138.8F","article-title":"Peptidoglycan of Staphylococcus aureus causes inflammation and organ injury in the rat","volume":"32","author":"Wang","year":"2004","journal-title":"Crit. Care Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3390\/vetsci9090507","article-title":"Marginal zinc deficiency aggravated intestinal barrier dysfunction and inflammation through ETEC virulence factors in a mouse model of diarrhea","volume":"9","author":"Wang","year":"2022","journal-title":"Vet. Sci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1407091","DOI":"10.3389\/fmicb.2024.1407091","article-title":"Protective effect of zinc gluconate on intestinal mucosal barrier injury in antibiotics and LPS-induced mice","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Microbiol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"563784","DOI":"10.3389\/fimmu.2020.563784","article-title":"Excretory\/secretory products from trichinella spiralis adult worms attenuated DSS-induced colitis in mice by driving PD-1-mediated M2 macrophage polarization","volume":"11","author":"Wang","year":"","journal-title":"Front. Immunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"132","DOI":"10.3945\/jn.113.181487","article-title":"Zinc absorption by young adults from supplemental zinc citrate is comparable with that from zinc gluconate and higher than from zinc oxide","volume":"144","author":"Wegm\u00fcller","year":"2014","journal-title":"J. Nutr."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1111\/jgh.70315","article-title":"The incidence and risk factors of antibiotic-associated diarrhea in critically Ill patients: a systematic review and meta-analysis","volume":"41","author":"Wei","year":"2026","journal-title":"J. Gastroenterol. Hepatol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s12011-023-03715-y","article-title":"Dietary zinc ameliorates TNBS-induced colitis in mice associated with regulation of Th1\/Th2\/Th17 balance and NF-\u03baB\/NLRP3 signaling pathway","volume":"202","author":"Wen","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1146\/annurev-nutr-122019-120635","article-title":"Dietary and physiological effects of zinc on the immune system","volume":"41","author":"Wessels","year":"2021","journal-title":"Annu. Rev. Nutr."},{"key":"B58","doi-asserted-by":"publisher","first-page":"e2209936120","DOI":"10.1073\/pnas.2209936120","article-title":"Microbiota-induced active translocation of peptidoglycan across the intestinal barrier dictates its within-host dissemination","volume":"120","author":"Wheeler","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1607045","DOI":"10.3389\/fmicb.2025.1607045","article-title":"Effect of dietary zinc supplementation on the gastrointestinal microbiome and host gene expression in the Shank3B-\/- mouse model of autism spectrum disorder","volume":"16","author":"Wong","year":"2025","journal-title":"Front. Microbiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1093\/tropej\/fmy069","article-title":"Effects of zinc combined with probiotics on antibiotic-associated diarrhea secondary to childhood pneumonia","volume":"65","author":"Xiang","year":"2019","journal-title":"J. Trop. Pediatr."},{"key":"B61","doi-asserted-by":"publisher","first-page":"119157","DOI":"10.1016\/j.jep.2024.119157","article-title":"Luteolin modulates macrophage phenotypic switching via the AMPK-PPAR\u03b3 pathway to alleviate ulcerative colitis in mice","volume":"339","author":"Yang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"103751","DOI":"10.1016\/j.ebiom.2021.103751","article-title":"MUC2 and related bacterial factors: therapeutic targets for ulcerative colitis","volume":"74","author":"Yao","year":"2021","journal-title":"EBioMedicine"},{"key":"B63","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1002\/fsn3.3114","article-title":"Effects of fruits and vegetables on gut microbiota in a mouse model of metabolic syndrome induced by high-fat diet","volume":"11","author":"Yu","year":"2023","journal-title":"Food Sci. Nutr."},{"key":"B64","doi-asserted-by":"publisher","first-page":"6213","DOI":"10.1007\/s12011-025-04635-9","article-title":"Nano zinc oxide restores gut barrier integrity and modulates microbiota to mitigate TNBS-induced colitis in mice","volume":"203","author":"Yu","year":"2025","journal-title":"Biol. Trace Elem. Res"},{"key":"B65","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1017\/S0007114509289033","article-title":"Supplemental zinc reduced intestinal permeability by enhancing occludin and zonula occludens protein-1 (ZO-1) expression in weaning piglets","volume":"102","author":"Zhang","year":"2009","journal-title":"Br. J. Nutr."},{"key":"B66","doi-asserted-by":"publisher","first-page":"111014","DOI":"10.1016\/j.cbi.2024.111014","article-title":"Biochanin a ameliorates DSS-induced ulcerative colitis by improving colonic barrier function and protects against the development of spontaneous colitis in the Muc2 deficient mice","volume":"395","author":"Zhang","year":"","journal-title":"Chem. Biol. Interact."},{"key":"B67","doi-asserted-by":"publisher","first-page":"123090","DOI":"10.1016\/j.lfs.2024.123090","article-title":"Zinc pyrithione ameliorates colitis in mice by interacting on intestinal epithelial TRPA1 and TRPV4 channels","volume":"358","author":"Zhang","year":"","journal-title":"Life Sci."},{"key":"B68","doi-asserted-by":"publisher","first-page":"105772","DOI":"10.1016\/j.psj.2025.105772","article-title":"Zn glycine mitigates the LPS-induced hepatic injury and inflammation through NrF2\/NF\u03baB signaling in geese","volume":"104","author":"Zulfiqar","year":"2025","journal-title":"Poult. Sci."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2026.1791355\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T05:26:30Z","timestamp":1787203590000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2026.1791355\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":68,"alternative-id":["10.3389\/fmicb.2026.1791355"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2026.1791355","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,20]]},"article-number":"1791355"}}