{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:58:56Z","timestamp":1781647136477,"version":"3.54.5"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Pasteurellosis caused by\n                    <jats:italic>Phocoenobacter atlanticus<\/jats:italic>\n                    subsp.\n                    <jats:italic>atlanticus<\/jats:italic>\n                    has a serious effect on Atlantic salmon welfare and the Norwegian aquaculture industry. Understanding the mechanisms underlying bacterial virulence through bioinformatic and functional analyses is an important contribution to vaccine development and prevention of disease. The genome of a clinical isolate of\n                    <jats:italic>Ph. atlanticus<\/jats:italic>\n                    subsp.\n                    <jats:italic>atlanticus<\/jats:italic>\n                    was sequenced and through\n                    <jats:italic>in silico<\/jats:italic>\n                    analysis 16 proteins were predicted to be adhesins, which are known virulence factors and may serve as potential vaccine targets. Expression levels of two such adhesins, a maltoporin-like protein and a 47 kDa outer membrane protein (Omp47), were studied following broth culture of the bacteria at 15\u00b0C, 20\u00b0C and 30\u00b0C and found to increase significantly over time during exponential growth phase from 20\u00b0C and higher (Omp47) and at 30\u00b0C (maltoporin). This could reflect field observations indicating higher frequency of pasteurellosis outbreaks following thermal delousing treatments. Further research on these target proteins may provide an important basis for development of vaccines against pasteurellosis in Atlantic salmon.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1793695","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:29:50Z","timestamp":1779110990000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Virulence factors of Phocoenobacter atlanticus subspecies atlanticus: in search of vaccine targets"],"prefix":"10.3389","volume":"17","author":[{"given":"Rebecca Marie","family":"Ellul","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Bergen","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hara","family":"Tselepidaki","sequence":"additional","affiliation":[{"name":"Institute of Marine Biology, Biotechnology and Aquaculture (IMBBC), Hellenic Center for Marine Research (HCMR)","place":["Heraklion, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kon","family":"Dahle","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Bergen","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5vard","family":"Skaar","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Bergen","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Frantzen","sequence":"additional","affiliation":[{"name":"STIM\/ACD Pharma AS","place":["Oslo, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyri Teien","family":"Haugland","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Bergen","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"R\u00f8nneseth","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Bergen","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/jfd.12366","article-title":"Pasteurellosis in lumpsucker cyclopterus lumpus, farmed in norway","volume":"39","author":"Alarc\u00f3n","year":"2016","journal-title":"J. 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