{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:09:46Z","timestamp":1790809786781,"version":"4.1.0"},"reference-count":82,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Several\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    strains were isolated from freshwater sediments collected in the Laxenburg ponds (Lower Austria). Genome sequencing and bioinformatics analyses revealed biosynthetic gene clusters (BGCs) that may specify production of chemically diverse secondary metabolites. Various culture conditions were employed to induce metabolite production, and subsequent LC-MS analyses facilitated the identification of the produced compounds and their correlation with the corresponding BGCs. These analyses of sediment-derived\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    spp. highlight their extensive biosynthetic potential, revealing a diverse range of bioactive secondary metabolites, including siderophores, antibiotics, and other compounds with potential therapeutic applications. Genomes of two\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    isolates, one of them representing a potentially new species, harbored several uncharacterized BGCs that may specify biosynthesis of novel secondary metabolites. Although targeted overexpression of pathway-specific regulators from these BGCs did not yield additional metabolites, whereas knockout experiments led to metabolic changes, presumably reflecting regulatory or compensatory interactions between multiple biosynthetic pathways. Continued exploration of these strains and their BGCs may lead to the discovery of new bioactive molecules with pharmaceutical and biotechnological applications.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1793713","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T05:23:10Z","timestamp":1776662590000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Unveiling the genomes and secondary metabolomes of Streptomyces spp. from freshwater sediments"],"prefix":"10.3389","volume":"17","author":[{"given":"Inmaculada","family":"Tocino-M\u00e1rquez","sequence":"first","affiliation":[{"name":"Division of Pharmacognosy, Department of Pharmaceutical Sciences, University of Vienna","place":["Vienna, Austria"]},{"name":"Doctoral School in Microbiology and Environmental Science, University of Vienna","place":["Vienna, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Zehl","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna","place":["Vienna, Austria"]},{"name":"Institute of Science and Technology Austria","place":["Klosterneuburg, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovana","family":"Batajic","sequence":"additional","affiliation":[{"name":"Division of Pharmacognosy, Department of Pharmaceutical Sciences, University of Vienna","place":["Vienna, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"S\u00e9neca","sequence":"additional","affiliation":[{"name":"Centre for Microbiology and Environmental Systems Science, University of Vienna","place":["Vienna, Austria"]},{"name":"Joint Microbiome Facility of the Medical University of Vienna and the University of Vienna","place":["Vienna, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Pjevac","sequence":"additional","affiliation":[{"name":"Centre for Microbiology and Environmental Systems Science, University of Vienna","place":["Vienna, Austria"]},{"name":"Joint Microbiome Facility of the Medical University of Vienna and the University of Vienna","place":["Vienna, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Murillo-Alba","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Armilla","place":["Granada, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Armilla","place":["Granada, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga N.","family":"Sekurova","sequence":"additional","affiliation":[{"name":"Division of Pharmacognosy, Department of Pharmaceutical Sciences, University of Vienna","place":["Vienna, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey B.","family":"Zotchev","sequence":"additional","affiliation":[{"name":"Division of Pharmacognosy, Department of Pharmaceutical Sciences, University of Vienna","place":["Vienna, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/ja.2011.59","article-title":"Physiological role of germicidins in spore germination and hyphal elongation in Streptomyces coelicolor A3(2).","volume":"64","author":"Aoki","year":"2011","journal-title":"J. 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