{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:59:48Z","timestamp":1775804388566,"version":"3.50.1"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    To investigate the pathogenicity of\n                    <jats:italic>Pasteurella multocida<\/jats:italic>\n                    (Pm) Type B in large-eared white rabbits, the Pm strain C45-2 (C45-2) was used to infect rabbits. The clinical symptoms and post-mortem pathological changes of the rabbits were observed. Multiple tissues were collected from the deceased rabbits for pathological sectioning and immunohistochemical (IHC) staining. Additionally, quantitative real-time PCR (qPCR) was employed to detect the load of C45-2 in each tissue. The results showed that the minimum lethal dose (MLD) of the C45-2 to rabbits was 5\u202fCFU. After infection, the rabbits exhibited typical Pm infection symptoms, including hemorrhage in multiple tissues and splenomegaly with dark coloration. The results of IHC and qPCR indicated that the C45-2 was more concentrated in the heart, spleen, and intestinal lymph node tissues of the infected rabbits. This study evaluated the pathogenicity of the C45-2 in infected rabbits, providing fundamental support for in-depth research on the pathogenic mechanism and vaccine development of Pm Type B.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1796165","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:04:35Z","timestamp":1775801075000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Study on the pathogenicity of Pasteurella multocida Type B in large-eared white rabbits"],"prefix":"10.3389","volume":"17","author":[{"given":"Haoran","family":"Zhao","sequence":"first","affiliation":[{"name":"China Institute of Veterinary Drug Control","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Wei","sequence":"additional","affiliation":[{"name":"China Institute of Veterinary Drug Control","place":["Beijing, China"]},{"name":"College of Veterinary Medicine, Qingdao Agricultural University","place":["Qingdao, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Feng","sequence":"additional","affiliation":[{"name":"China Institute of Veterinary Drug Control","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxia","family":"Ren","sequence":"additional","affiliation":[{"name":"China Institute of Veterinary Drug Control","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"China Institute of Veterinary Drug Control","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Ma","sequence":"additional","affiliation":[{"name":"China Institute of Veterinary Drug Control","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[{"name":"China Institute of Veterinary Drug Control","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junping","family":"Li","sequence":"additional","affiliation":[{"name":"China Institute of Veterinary Drug Control","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wensheng","family":"Yao","sequence":"additional","affiliation":[{"name":"China Institute of Veterinary Drug Control","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"China Institute of Veterinary Drug Control","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.vaccine.2013.11.068","article-title":"Development of immunization trials against Pasteurella multocida","volume":"32","author":"Ahmad","year":"2014","journal-title":"Vaccine"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"109773","DOI":"10.1016\/j.vetmic.2023.109773","article-title":"Genomic profiling of Pasteurella multocida isolated from feedlot cases of bovine respiratory disease","volume":"283","author":"Alhamami","year":"2023","journal-title":"Vet. 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